PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(171 products)
- ATM/ATR(72 products)
- DNA-PK(48 products)
- EGFR(591 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(233 products)
- S6 Kinase(8 products)
- gsk-3(110 products)
- mTOR(162 products)
Show 2 more subcategories
Found 1007 products of "PI3K/Akt/mTOR Signaling"
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PI3Kγ inhibitor 1
CAS:PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.Formula:C32H26N8O2SPurity:98%Color and Shape:SolidMolecular weight:586.67EGFR-IN-69
CAS:EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.Formula:C31H37Cl2N7O3SColor and Shape:SolidMolecular weight:658.64TWS-119
CAS:TWS-119 blocks GSK-3β, prompting neuronal formation in mouse stem cells.Formula:C22H16F6N4O6Color and Shape:SolidMolecular weight:546.38EGFR/HER2-IN-12
CAS:EGFR/HER2-IN-12 (compound 14b) serves as a dual inhibitor targeting EGFR and HER2, demonstrating 81% and 51% inhibition respectively at a concentration of 10 μM. This compound exhibits minimal toxicity towards A431 and MDA-MB-361 cancer cells [1].Formula:C25H17ClN4O3SMolecular weight:488.95BIBX 1382 Dihydrochloride
CAS:BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.Formula:C18H21Cl3FN7Color and Shape:SolidMolecular weight:460.76SPH5030
CAS:SPH5030 is an irreversible, selective inhibitor of HER2.Formula:C31H31FN8O3Color and Shape:SolidMolecular weight:582.63EGFR-IN-53
CAS:EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.34EAI001
CAS:EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.Formula:C19H15N3O2SPurity:99.94%Color and Shape:SolidMolecular weight:349.41DS21360717
CAS:DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.Formula:C21H23N7OPurity:98%Color and Shape:SolidMolecular weight:389.45BRD1652
CAS:BRD1652 is a highly selective and potent GSK3 inhibitor.Formula:C20H20F3N3OPurity:98%Color and Shape:SolidMolecular weight:375.39PKI-179
CAS:PKI-179: Dual PI3K/mTOR inhibitor, orally active, IC50s: 0.42-77 nM, targets E545K and H1047R, antitumor in vivo.Formula:C25H28N8O3Color and Shape:SolidMolecular weight:488.54LDC0496
CAS:LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.Formula:C32H35N5O3Color and Shape:SolidMolecular weight:537.65BAY 2476568
CAS:BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).Formula:C24H27FN4O4Color and Shape:SolidMolecular weight:454.49EGFR-IN-21
CAS:EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.Formula:C36H44BrN10O2PColor and Shape:SolidMolecular weight:759.68PfGSK3/PfPK6-IN-2
CAS:PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.Formula:C24H25Cl2N5OSColor and Shape:SolidMolecular weight:502.46EGFR-IN-63
CAS:EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).Formula:C20H12BrN5SColor and Shape:SolidMolecular weight:434.31PI3Kδ-IN-3
CAS:PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.Formula:C28H24N6O3Purity:99.8%Color and Shape:SolidMolecular weight:492.53EMI48
CAS:EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].Formula:C21H20N2O3Color and Shape:SolidMolecular weight:348.4OXA-01
CAS:OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC 50 values of 29 nM and 7 nM, respectively [1]. OXA-01 demonstrates broad anti-tumor activity.Formula:C21H20ClN5O2Color and Shape:SolidMolecular weight:409.87EphB1-IN-1
CAS:EphB1-IN-1 is a potent inhibitor of EphB1, exhibiting IC50 values of 3.0 nM for EphB1 G703C, 15 nM for EphB1 T697G, and 220 nM for EphB1 WT.Formula:C16H12Cl2N4O2Color and Shape:SolidMolecular weight:363.2
