PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(171 products)
- ATM/ATR(72 products)
- DNA-PK(49 products)
- EGFR(590 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(231 products)
- S6 Kinase(7 products)
- gsk-3(110 products)
- mTOR(163 products)
Show 2 more subcategories
Found 1005 products of "PI3K/Akt/mTOR Signaling"
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IGF-1R modulator 1
CAS:<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Formula:C22H17N3O4Color and Shape:SolidMolecular weight:387.39Icotinib
CAS:Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Formula:C22H21N3O4Purity:99.76% - 99.94%Color and Shape:SolidMolecular weight:391.421-Azakenpaullone
CAS:1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.Formula:C15H10BrN3OPurity:99.73%Color and Shape:Tan SolidMolecular weight:328.16Ref: TM-T6358
1mg79.00€5mg160.00€10mg250.00€25mg464.00€50mg655.00€100mg938.00€200mg1,264.00€1mL*10mM (DMSO)187.00€CNX-1351
CAS:<p>CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.</p>Formula:C30H35N7O3SPurity:99.66% - 99.83%Color and Shape:SolidMolecular weight:573.71TAK-285
CAS:TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Formula:C26H25ClF3N5O3Purity:99.73%Color and Shape:SolidMolecular weight:547.96Ref: TM-T6039
1mg38.00€5mg80.00€10mg120.00€25mg216.00€50mg354.00€100mg512.00€200mg727.00€1mL*10mM (DMSO)96.00€Icotinib Hydrochloride
CAS:Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.Formula:C22H22ClN3O4Purity:99.89%Color and Shape:SolidMolecular weight:427.88UNC-CA359
CAS:UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.Formula:C18H14ClN3O2Color and Shape:SolidMolecular weight:339.78Tyrphostin AG 112
CAS:Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formula:C13H8N4OPurity:99.14%Color and Shape:SolidMolecular weight:236.23GSK3-IN-2
CAS:<p>GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.</p>Formula:C17H19N3OSPurity:98.8%Color and Shape:SolidMolecular weight:313.42PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Formula:C20H13ClF2N4O4SPurity:96.16%Color and Shape:SolidMolecular weight:478.86Ref: TM-T12459
1mg55.00€5mg138.00€10mg215.00€25mg358.00€50mg512.00€100mg692.00€200mg888.00€1mL*10mM (DMSO)144.00€PI3Kdelta inhibitor 1
CAS:PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.Formula:C27H38N6O5SPurity:98%Color and Shape:SolidMolecular weight:558.69Mutated EGFR-IN-3
CAS:Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Formula:C31H29FN4O2Purity:98%Color and Shape:SolidMolecular weight:508.59Mutated EGFR-IN-2
CAS:Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.Formula:C29H35FN8O3Purity:98%Color and Shape:SolidMolecular weight:562.64VP3.15
CAS:VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).Formula:C20H22N4OSPurity:98%Color and Shape:SolidMolecular weight:366.48PI3K-IN-28
CAS:PI3K-IN-28, a potent PI3K inhibitor with low toxicity in MCF-10a, has IC50 values of 5.8, 2.3, 7.9 μM and high selectivity index of 39.Formula:C26H16F9N3O3S2Color and Shape:SolidMolecular weight:653.54CAY10717
CAS:CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.Formula:C29H25F3N6O3Color and Shape:SolidMolecular weight:562.54DNA-PK-IN-5
CAS:DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.Formula:C21H22N8O2Color and Shape:SolidMolecular weight:418.45EphB1-IN-1
CAS:EphB1-IN-1 is a potent inhibitor of EphB1, exhibiting IC50 values of 3.0 nM for EphB1 G703C, 15 nM for EphB1 T697G, and 220 nM for EphB1 WT.Formula:C16H12Cl2N4O2Color and Shape:SolidMolecular weight:363.2PI3Kα/mTOR-IN-1
CAS:PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.Formula:C16H18N6OPurity:99.89%Color and Shape:SolidMolecular weight:310.35MS 154N
CAS:MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.Formula:C47H56ClFN8O8Color and Shape:SolidMolecular weight:915.45
