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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • PI3K-IN-26
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    PI3K-IN-26

    CAS:
    <p>PI3K-IN-26 is an effective PI3K inhibitor. PI3K-IN-26 inhibits the proliferation of SU-DHL-6 cells, IC50= 36 nM.</p>
    Formula:C21H18N6OS
    Color and Shape:Solid
    Molecular weight:402.47

    Ref: TM-T61966

  • EGFR-IN-133
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    EGFR-IN-133

    CAS:
    <p>EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.</p>
    Formula:C27H29F2N7O3
    Color and Shape:Solid
    Molecular weight:537.56

    Ref: TM-T201790

  • EGFR-IN-132
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    EGFR-IN-132

    CAS:
    <p>EGFR-IN-132 (Compound 23) is an EGFR inhibitor effective against various EGFR mutations including the wild-type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with IC50 values of 1.6, 0.025, 0.019, 0.022, and 0.029 nM, respectively. This compound demonstrates favorable pharmacokinetics with high oral bioavailability.</p>
    Formula:C27H31N7O3
    Color and Shape:Solid
    Molecular weight:501.58

    Ref: TM-T201638

  • EGFR-IN-139
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    EGFR-IN-139

    CAS:
    <p>EGFR-IN-139 (compound PD 18) is an EGFR inhibitor with IC50 values of 12.88 nM (wild type), 10.84 nM (L858R/T790M), and 42.68 nM (L858R/T790M/C797S). It demonstrates significant anticancer activity against the A549 and H1975 cancer cell lines, which express high levels of EGFR. EGFR-IN-139 exhibits strong selectivity for cancer cells and can be utilized in research on non-small cell lung cancer (NSCLC).</p>
    Formula:C27H25ClN2O4
    Color and Shape:Solid
    Molecular weight:476.951

    Ref: TM-T204772

  • Tarloxotinib bromide
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    Tarloxotinib bromide

    CAS:
    <p>Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2.</p>
    Formula:C24H24Br2ClN9O3
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:681.77

    Ref: TM-T13088

  • CymitQuimica logo
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    Vps34-IN-3

    <p>Vps34-IN-3 is a potent, selective, and orally bioavailable inhibitor of VPS34 kinase .</p>
    Formula:C14H20N4O2
    Color and Shape:Solid
    Molecular weight:276.33

    Ref: TM-T60506

  • CymitQuimica logo
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    EGFR-IN-18

    <p>EGFR-IN-18 strongly inhibits L858R/T790M/C797S mutant EGFR (4.9 nM) and also targets wild-type EGFR (47 nM).</p>
    Formula:C33H28N6O3S
    Color and Shape:Solid
    Molecular weight:588.68

    Ref: TM-T64170

  • PI3kδ inhibitor 1
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    PI3kδ inhibitor 1

    CAS:
    <p>PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).</p>
    Formula:C28H33FN6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:504.60

    Ref: TM-T12463

  • PI4KIIIbeta-IN-11
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    PI4KIIIbeta-IN-11

    CAS:
    <p>PI4KIIIbeta-IN-11 is a PI4KIIIβ inhibitor (mean pIC50=9.1) that can be used to study diseases caused by RNA viruses and Plasmodium falciparum.</p>
    Formula:C33H39N7O3
    Color and Shape:Solid
    Molecular weight:581.71

    Ref: TM-T64106

  • SST0116CL1
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    SST0116CL1

    CAS:
    <p>SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT). It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.</p>
    Formula:C22H31ClN4O6
    Color and Shape:Solid
    Molecular weight:482.96

    Ref: TM-T200022

  • EGFR-IN-149
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    EGFR-IN-149

    CAS:
    <p>EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.</p>
    Formula:C16H15N3OS
    Color and Shape:Solid
    Molecular weight:297.375

    Ref: TM-T205658

  • NS-062
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    NS-062

    CAS:
    <p>NS-062 is an orally effective, irreversible covalent inhibitor targeting EGFR, demonstrating antiproliferative activity in the resistant double mutant H1975 cells with an IC50 of 0.19 μM. It also exhibits antitumor activity in a murine H1975 xenograft model.</p>
    Formula:C28H30Cl2F2N6O4
    Color and Shape:Solid
    Molecular weight:623.48

    Ref: TM-T201773

  • PF-5177624
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    PF-5177624

    CAS:
    <p>PF-5177624 is a selective and potent PDK1 inhibitor inducing anti-tumor activity in breast cancer cells.</p>
    Formula:C25H25FN8O2
    Color and Shape:Solid
    Molecular weight:488.52

    Ref: TM-T70911

  • GSK-3β inhibitor 25
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    GSK-3β inhibitor 25

    CAS:
    <p>GSK-3β inhibitor25 (Compound 6h) exhibits weak inhibitory activity against GSK-3β with an IC50 greater than 100 μM.</p>
    Formula:C16H15NOS
    Color and Shape:Solid
    Molecular weight:269.361

    Ref: TM-T204501

  • EGFR-IN-159
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    EGFR-IN-159

    CAS:
    <p>EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.</p>
    Formula:C21H23N3O5
    Color and Shape:Solid
    Molecular weight:397.424

    Ref: TM-T206989

  • 4-FPBUA
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    4-FPBUA

    CAS:
    <p>4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.</p>
    Formula:C31H23FO7
    Color and Shape:Solid
    Molecular weight:526.51

    Ref: TM-T89888

  • DNA-PK-IN-2
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    DNA-PK-IN-2

    CAS:
    <p>DNA-PK-IN-2 is an inhibitor of the DNA-PK enzyme complex, useful in cancer research.</p>
    Formula:C20H23N5O3
    Color and Shape:Solid
    Molecular weight:381.43

    Ref: TM-T61633

  • HER2-IN-8
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    HER2-IN-8

    CAS:
    <p>HER2-IN-8 is an inhibitor of HER-2 that can be used in the study of cancer and inflammation-related diseases.</p>
    Formula:C26H25F2N9O3
    Color and Shape:Solid
    Molecular weight:549.53

    Ref: TM-T63881

  • NSC381467
    Targetmol
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    NSC381467

    CAS:
    <p>NSC381467: Potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>
    Formula:C20H16O7
    Color and Shape:Solid
    Molecular weight:368.34

    Ref: TM-T61441

  • PD-M6
    Targetmol
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    PD-M6

    CAS:
    <p>PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.</p>
    Formula:C30H39N9O6
    Color and Shape:Solid
    Molecular weight:621.69

    Ref: TM-T207406