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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1038 products of "PI3K/Akt/mTOR Signaling"

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  • CymitQuimica logo
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    iMDK quarterhydrate

    <p>iMDK quarterhydrate, PI3K inhibitor, blocks MDK growth; suppresses NSCLC safely with MEK inhibitor.</p>
    Formula:C21H15FN2O3S
    Color and Shape:Solid
    Molecular weight:380.91

    Ref: TM-T61627

  • ES-072
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    ES-072

    CAS:
    <p>ES-072, a selective inhibitor targeting the EGFR mutant (EGFR-T790M), is administered orally. By hindering EGFR-T790M activity, it activates GSK3α, which subsequently leads to the phosphorylation of PD-L1 at Ser279 and Ser283. This phosphorylation facilitates the recruitment of the E3 ubiquitin ligase ARIH1, resulting in the ubiquitination and proteasomal degradation of PD-L1. Such a process not only curtails the growth of cancer cells but also amplifies the anti-tumor immune response by diminishing PD-L1 levels. ES-072 has shown efficacy in impeding the proliferation of non-small cell lung cancer (NSCLC) cells.</p>
    Formula:C25H27F3N8O2
    Color and Shape:Solid
    Molecular weight:528.53

    Ref: TM-T200087

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    EGFR-IN-58

    <p>EGFR-IN-58 is a potent, selective, ATP-competitive inhibitor of EGFR. EGFR-IN-58 exhibits significant cytotoxicity against melanoma, colon and blood cancers.</p>
    Formula:C31H30FN7O
    Color and Shape:Solid
    Molecular weight:535.61

    Ref: TM-T63774

  • Tesevatinib tosylate
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    Tesevatinib tosylate

    CAS:
    <p>Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.</p>
    Formula:C31H33Cl2FN4O5S
    Color and Shape:Solid
    Molecular weight:663.59

    Ref: TM-T201865

  • PI3Kδ-IN-23
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    PI3Kδ-IN-23

    CAS:
    <p>PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.</p>
    Formula:C30H30N6O5
    Color and Shape:Solid
    Molecular weight:554.596

    Ref: TM-T204114

  • DNA-PK-IN-6
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    DNA-PK-IN-6

    CAS:
    <p>DNA-PK-IN-6 inhibits DNA-PKcs, disrupting tumor DNA repair and triggering apoptosis; enhances radiotherapy and targets various tumors (WO2021197159A1).</p>
    Formula:C19H21N7O
    Color and Shape:Solid
    Molecular weight:363.42

    Ref: TM-T61370

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    EGFR/BRAF-IN-1

    <p>EGFR/BRAF-IN-1 inhibits EGFR/BRAF (BRAFV600E IC50: 45 nM, GI50: 35 nM) and has antioxidant properties.</p>
    Formula:C26H28ClN3O4
    Color and Shape:Solid
    Molecular weight:481.97

    Ref: TM-T63189

  • 5-Bromo-3-indoxylacetate
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    5-Bromo-3-indoxylacetate

    CAS:
    <p>5-Bromo-3-indoxylacetate acts as an inhibitor of GSK-3, with a pIC50 value of 3.39.</p>
    Formula:C10H8BrNO2
    Color and Shape:Solid
    Molecular weight:254.08

    Ref: TM-T205502

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    HER2-IN-9

    <p>HER2-IN-9, an oral HER2 inhibitor (IC50: 0.03 μM), hinders growth and spread of HER2+ breast cancer.</p>
    Formula:C19H14BrF3N2O
    Color and Shape:Solid
    Molecular weight:423.23

    Ref: TM-T62271

  • DNA-PK-IN-8
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    DNA-PK-IN-8

    CAS:
    <p>DNA-PK-IN-8: Potent, selective oral DNA-PK inhibitor, IC50 = 0.8 nM, boosts anti-cancer effects with Doxorubicin.</p>
    Formula:C19H22N8O2
    Color and Shape:Solid
    Molecular weight:394.43

    Ref: TM-T61828

  • Andamertinib
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    Andamertinib

    CAS:
    <p>Andamertinib is an EGFR inhibitor with antitumor activity.</p>
    Formula:C31H36N8O3
    Color and Shape:Solid
    Molecular weight:568.669

    Ref: TM-T206579

  • EGFR-IN-135
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    EGFR-IN-135

    <p>EGFR-IN-135 (compound 3d) is an EGFR inhibitor with an IC50 value of 0.086 µM. It inhibits cell growth and arrests the cell cycle in the S phase in breast cancer cell lines.</p>
    Formula:C12H14N4OS2
    Color and Shape:Solid
    Molecular weight:294.4

    Ref: TM-T201484

  • Tyrphostin 63
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    Tyrphostin 63

    CAS:
    <p>Tyrphostin 63 (compound 13) is an epidermal growth factor receptor (EGFR) inhibitor, with an IC50 of 375 μM and a Ki of 123 μM.</p>
    Formula:C10H8N2O
    Color and Shape:Solid
    Molecular weight:172.183

    Ref: TM-T204167

  • EGFR-IN-125
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    EGFR-IN-125

    CAS:
    <p>EGFR-IN-125 (example 37) is a potent EGFR inhibitor with IC50 values of &lt;0.3 nM for EGFR(d746-750/T790M/C797S), 0.52 nM for EGFR(L858R/T790M/C797S), 0.5 nM for EGFR(d746-750/C797S), 0.69 nM for EGFR(L858R/C797S), and 0.92 nM for EGFR (wild type).</p>
    Formula:C30H26N8O
    Color and Shape:Solid
    Molecular weight:514.58

    Ref: TM-T204450

  • PI3K-IN-27
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    PI3K-IN-27

    CAS:
    <p>PI3K-IN-27 is a potent PI3K inhibitor, relevant for cancer and immune disease research. See patent WO2021233227A1.</p>
    Formula:C30H26F2N6O2S
    Color and Shape:Solid
    Molecular weight:572.63

    Ref: TM-T64052

  • PI3Kβ-IN-1
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    PI3Kβ-IN-1

    CAS:
    <p>PI3Kβ-IN-1 is a selective, orally active PI3Kβ inhibitor (IC50: 2 nM).</p>
    Formula:C25H14F2N8
    Color and Shape:Solid
    Molecular weight:464.43

    Ref: TM-T62948

  • ETP-47037
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    ETP-47037

    CAS:
    <p>ETP-47037: strong PI3Kα inhibitor (IC50: 0.99 nM), also targets PI3Kβ, δ, γ; may protect telomeres.</p>
    Formula:C20H27N9O3S
    Color and Shape:Solid
    Molecular weight:473.55

    Ref: TM-T63072

  • GSK3-IN-9
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    GSK3-IN-9

    CAS:
    <p>GSK3-IN-9 (0713) is a selective inhibitor of glycogen synthase kinase 3 (GSK3). It holds potential for research into fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood epilepsy, intellectual disabilities, diabetes, acute myeloid leukemia (AML), autism, and mental disorders.</p>
    Formula:C18H20N4O
    Color and Shape:Solid
    Molecular weight:308.378

    Ref: TM-T205647

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    EGFR-IN-48

    <p>EGFR-IN-48: potent EGFR inhibitor, oral, IC50: 0.193-66.7 nM, blocks EGFR mutants &amp; BaF3/PC-9 cell proliferation.</p>
    Color and Shape:Solid

    Ref: TM-T64255

  • EGFR-IN-34
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    EGFR-IN-34

    <p>EGFR-IN-34 is a low-toxicity, acrylamide derivative antitumor agent that is a potent inhibitor of EGFR.</p>
    Formula:C26H27ClN6O2
    Color and Shape:Solid
    Molecular weight:490.98

    Ref: TM-T63300