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gsk-3

gsk-3

GSK-3 inhibitors are compounds that target Glycogen Synthase Kinase 3 (GSK-3), an enzyme involved in numerous cellular processes, including glycogen metabolism, gene transcription, and cell proliferation. GSK-3 is implicated in various diseases, such as diabetes, neurodegenerative disorders, and cancer. Inhibitors of GSK-3 are important tools for exploring these pathways and developing potential therapies. At CymitQuimica, we provide GSK-3 inhibitors to support your research in metabolic diseases, neurobiology, and oncology.

Found 110 products for "gsk-3".

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  • KenPaullone
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    KenPaullone

    CAS:
    KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.
    Formula:C16H11BrN2O
    Purity:97.14% - 98.99%
    Color and Shape:Solid
    Molecular weight:327.18

    Ref: TM-T2247

  • CHIR 98024
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    CHIR 98024

    CAS:
    CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.
    Formula:C20H17Cl2N9O2
    Purity:99.45%
    Color and Shape:Solid
    Molecular weight:486.314

    Ref: TM-T3074

  • 1-Azakenpaullone
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    1-Azakenpaullone

    CAS:
    1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.
    Formula:C15H10BrN3O
    Purity:99.73%
    Color and Shape:Yellow Solid
    Molecular weight:328.163

    Ref: TM-T6358

  • GSK3-IN-3
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    GSK3-IN-3

    CAS:
    GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.
    Formula:C24H35N3O4
    Purity:98.16%
    Color and Shape:Solid
    Molecular weight:429.5524

    Ref: TM-T73331

  • MAO-B-IN-43
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    MAO-B-IN-43

    MAO-B-IN-43 (4) is a potent inhibitor of hMAO-B and a mild inhibitor of GSK3β kinase, with Ki values for hMAO-A and hMAO-B of 0.044 μM and 0.004 μM, respectively. This compound is applicable in the study of neurodegenerative diseases.
    Formula:C14H11Cl2N3O
    Molecular weight:308.16

    Ref: TM-T207394

  • GSK3-IN-2
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    GSK3-IN-2

    CAS:
    GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.
    Formula:C17H19N3OS
    Purity:99.51%
    Color and Shape:Solid
    Molecular weight:313.417

    Ref: TM-T73270

  • MRT80
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    MRT80

    CAS:
    MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.
    Formula:C15H15N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:281.31

    Ref: TM-T28108

  • TCS 2002
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    TCS 2002

    CAS:
    GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.
    Formula:C18H14N2O3S
    Color and Shape:Solid
    Molecular weight:338.38

    Ref: TM-T22157

  • ZDWX-25
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    ZDWX-25

    CAS:
    ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.
    Formula:C17H15N3O3
    Color and Shape:Solid
    Molecular weight:309.32

    Ref: TM-T60748

  • 18BIOder
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    18BIOder

    CAS:
    18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.
    Formula:C9H7ClN2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:210.617

    Ref: TM-T24969

  • BRD3731
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    BRD3731

    CAS:
    BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.
    Formula:C24H31N3O
    Color and Shape:Solid
    Molecular weight:377.5224

    Ref: TM-T61578

  • 3F8
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    3F8

    CAS:
    3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in
    Formula:C15H14N2O4
    Purity:98.17% - 98.25%
    Color and Shape:Yellow Solid
    Molecular weight:286.2827

    Ref: TM-T22180

  • GSK-3β inhibitor 23
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    GSK-3β inhibitor 23

    CAS:
    GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.
    Formula:C18H13Cl2N5O2S
    Color and Shape:Solid
    Molecular weight:434.299

    Ref: TM-T204398

  • VP3.15
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    VP3.15

    CAS:
    VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).
    Formula:C20H22N4OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:366.48

    Ref: TM-T13310

  • GSK-3β inhibitor 24
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    GSK-3β inhibitor 24

    GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.
    Formula:C26H18N4O3
    Color and Shape:Solid
    Molecular weight:434.446

    Ref: TM-T204492

  • Cazpaullone
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    Cazpaullone

    CAS:
    Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.
    Formula:C16H10N4O
    Color and Shape:Solid
    Molecular weight:274.28

    Ref: TM-T26959

  • TC-G 24
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    TC-G 24

    CAS:
    GSK-3β inhibitor
    Formula:C15H11ClN4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:330.73

    Ref: TM-T23436

  • BRD1652
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    BRD1652

    CAS:
    BRD1652 is a highly selective and potent GSK3 inhibitor.
    Formula:C20H20F3N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:375.39

    Ref: TM-T26896

  • PfGSK3/PfPK6-IN-2
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    PfGSK3/PfPK6-IN-2

    CAS:
    PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.
    Formula:C24H25Cl2N5OS
    Color and Shape:Solid
    Molecular weight:502.46

    Ref: TM-T72629

  • TWS-119 TFA
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    TWS-119 TFA

    CAS:
    TWS-119 is a GSK-3β inhibitor; activates Wnt/β-catenin to induce differentiation; enhances T-cell antitumor activity and protects BBB.
    Formula:C22H16F6N4O6
    Purity:99.65%
    Color and Shape:White Solid
    Molecular weight:546.38

    Ref: TM-T70520