gsk-3
GSK-3 inhibitors are compounds that target Glycogen Synthase Kinase 3 (GSK-3), an enzyme involved in numerous cellular processes, including glycogen metabolism, gene transcription, and cell proliferation. GSK-3 is implicated in various diseases, such as diabetes, neurodegenerative disorders, and cancer. Inhibitors of GSK-3 are important tools for exploring these pathways and developing potential therapies. At CymitQuimica, we provide GSK-3 inhibitors to support your research in metabolic diseases, neurobiology, and oncology.
Found 110 products for "gsk-3".
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GSK-3β inhibitor 6
GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM.Formula:C20H17BrN4Color and Shape:SolidMolecular weight:393.28Laduviglusib dihydrochloride
CAS:Laduviglusib [CHIR 99021; CHIR99021; CHIR-99021; CT99021; CT 99021; CT-99021] is a potent, selective small-molecule inhibitor of glycogen synthase kinase 3 (GSK-3) with the formula C22H18ClN5O. It is used extensively in biomedical research to explore the role of GSK-3 in various cellular processes and diseases.Formula:C22H20Cl4N8Molecular weight:538.26GSK3β-IN-1
CAS:GSK3β-IN-1 (compound 1) is an inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 value of 65 nM, and it is utilized in Alzheimer's disease research.Formula:C17H13FN2O4SColor and Shape:SolidMolecular weight:360.36GSK3β-IN-2
CAS:GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.Formula:C25H18N4OColor and Shape:SolidMolecular weight:390.437GSK-3β inhibitor 26
CAS:GSK-3β inhibitor26 (Compound D14) is a GSK-3β inhibitor with an IC50 of 18.23 μM. This compound is applicable in research related to cancer, inflammation, and neurodegenerative diseases.Formula:C15H11N3O3Color and Shape:SolidMolecular weight:281.26615-Bromo-3-indoxylacetate
CAS:5-Bromo-3-indoxylacetate acts as an inhibitor of GSK-3, with a pIC50 value of 3.39.Formula:C10H8BrNO2Color and Shape:SolidMolecular weight:254.08GSK-3β inhibitor 25
CAS:GSK-3β inhibitor25 (Compound 6h) exhibits weak inhibitory activity against GSK-3β with an IC50 greater than 100 μM.Formula:C16H15NOSColor and Shape:SolidMolecular weight:269.361GSK3-IN-9
CAS:GSK3-IN-9 (0713) is a selective inhibitor of glycogen synthase kinase 3 (GSK3). It holds potential for research into fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood epilepsy, intellectual disabilities, diabetes, acute myeloid leukemia (AML), autism, and mental disorders.Formula:C18H20N4OColor and Shape:SolidMolecular weight:308.3776GSK-3β inhibitor 20
CAS:GSK-3β inhibitor20 (compound 3A) is an effective inhibitor of GSK-3β, exhibiting an IC50 value of 74.4 nM.Formula:C22H21N5O2SColor and Shape:SolidMolecular weight:419.50GSK3β-IN-3
CAS:GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50= 0.90 μM) that demonstrates good blood-brain barrier permeability (Pe= 10.7 x 10^-6 cm/s). It effectively reduces tau protein phosphorylation in the BR5706 strain and decreases Aβ aggregate deposition in the CL2006 strain, indicating its potential as a candidate for Alzheimer's disease (AD) research.Formula:C14H15ClN2O2SColor and Shape:SolidMolecular weight:310.799
