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AMPK

AMPK

AMPK inhibitors are compounds that target and inhibit AMP-Activated Protein Kinase (AMPK), an enzyme that plays a critical role in cellular energy homeostasis. AMPK is activated in response to low energy levels in cells and helps regulate processes such as glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Inhibiting AMPK is important for studying its role in metabolic diseases, cancer, and aging. At CymitQuimica, we offer a range of AMPK inhibitors to support your research in metabolism, oncology, and age-related diseases.

Found 158 products of "AMPK"

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  • Ampkinone
    Targetmol
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    Ampkinone

    CAS:
    <p>Ampkinone is an indirect AMPK activator.</p>
    Formula:C31H23NO6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:505.52

    Ref: TM-T10312

  • MARK-IN-1
    Targetmol
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    MARK-IN-1

    CAS:
    <p>MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50&lt;0.25 nM).</p>
    Formula:C22H23F2N7OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:471.53

    Ref: TM-T11945

  • MARK-IN-2
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    MARK-IN-2

    CAS:
    <p>MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).</p>
    Formula:C18H18ClF2N5OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:425.88

    Ref: TM-T11946

  • 10Z-Hymenialdisine
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    10Z-Hymenialdisine

    CAS:
    <p>Pan kinase inhibitor</p>
    Formula:C11H10BrN5O2
    Purity:98%
    Color and Shape:Light Yellow Solid
    Molecular weight:324.13

    Ref: TM-T22470

  • PF-06679142
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    PF-06679142

    CAS:
    <p>PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.</p>
    Formula:C20H17F2NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:357.35

    Ref: TM-T24622

  • MK-0626
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    MK-0626

    CAS:
    <p>MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.</p>
    Formula:C22H24F2N6O2
    Purity:99.47% - >99.99%
    Color and Shape:Solid
    Molecular weight:442.46

    Ref: TM-T68863

  • AMPK-α1β1γ1 activator 1
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    AMPK-α1β1γ1 activator 1

    CAS:
    <p>AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1</p>
    Formula:C25H24ClNO9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:517.91

    Ref: TM-T83125

  • ZLN024
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    ZLN024

    CAS:
    <p>ZLN024 is an activator of AMPK allosteric.</p>
    Formula:C13H13BrN2OS
    Purity:99.751%
    Color and Shape:Solid
    Molecular weight:325.22

    Ref: TM-T13411

  • AMPK activator 7
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    AMPK activator 7

    CAS:
    <p>AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.</p>
    Formula:C23H22F3N3O5
    Color and Shape:Solid
    Molecular weight:477.43

    Ref: TM-T63117

  • AMPK-IN-1
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    AMPK-IN-1

    CAS:
    <p>AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.</p>
    Formula:C24H18ClN3O3
    Color and Shape:Solid
    Molecular weight:431.87

    Ref: TM-T73224

  • Demethyleneberberine chloride
    Targetmol
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    Demethyleneberberine chloride

    CAS:
    <p>Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-</p>
    Formula:C19H18ClNO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:359.8

    Ref: TM-T78095

  • HDAC11-IN-2
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    HDAC11-IN-2

    CAS:
    <p>HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.</p>
    Formula:C25H35N3O3
    Color and Shape:Solid
    Molecular weight:425.564

    Ref: TM-T205581

  • Equisetin
    Targetmol
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    Equisetin

    CAS:
    <p>Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria &amp; HIV-1 integrase; not antibacterial to Gram-negative.</p>
    Formula:C22H31NO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:373.49

    Ref: TM-T11219

  • EGFR-IN-146
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    EGFR-IN-146

    CAS:
    <p>EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.</p>
    Formula:C20H16N4
    Color and Shape:Solid
    Molecular weight:312.368

    Ref: TM-T206146

  • NPC26
    Targetmol
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    NPC26

    CAS:
    <p>NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.</p>
    Formula:C19H23N3O5S2
    Color and Shape:Solid
    Molecular weight:437.533

    Ref: TM-T204250

  • Aldometanib
    Targetmol
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    Aldometanib

    CAS:
    <p>Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.</p>
    Formula:C27H43Cl2IN2
    Purity:99.32% - 99.55%
    Color and Shape:Solid
    Molecular weight:593.46

    Ref: TM-T60122

  • XMD-17-51 Trifluoroacetate
    Targetmol
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    XMD-17-51 Trifluoroacetate

    CAS:
    <p>XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.</p>
    Formula:C23H25F3N8O3
    Purity:99.65%
    Color and Shape:Solid
    Molecular weight:518.49

    Ref: TM-T9191

  • AMPK activator C2
    Targetmol
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    AMPK activator C2

    CAS:
    <p>AMPK activator C2 is an AMPK allosteric activator.</p>
    Formula:C7H6NO6P
    Purity:98%
    Color and Shape:Solid
    Molecular weight:231.1

    Ref: TM-T23734

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