PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Found 231 products of "PI3K"
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ARUK2001607
CAS:ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Formula:C14H13N3O2S2Purity:99.75%Color and Shape:SoildMolecular weight:319.40IHMT-PI3Kδ-372 S-isomer
CAS:IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.Formula:C26H23F2N7O2Purity:99.97%Color and Shape:SoildMolecular weight:503.5Ref: TM-T60196
1mg109.00€2mg163.00€5mg241.00€1mL*10mM (DMSO)294.00€10mg354.00€25mg532.00€50mg745.00€100mg1,018.00€(3S)-GSK-F1
CAS:(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.Formula:C27H18F5N5O4SPurity:99.04%Color and Shape:SoildMolecular weight:603.52Ref: TM-T67837
1mg70.00€5mg133.00€1mL*10mM (DMSO)182.00€10mg210.00€25mg371.00€50mg532.00€100mg837.00€PI3K-IN-46
CAS:PI3K-IN-46 is a specific inhibitor of PI3Kγ.Formula:C13H9N3OSPurity:97.26%Color and Shape:SoildMolecular weight:255.3Ref: TM-T64392
1mg62.00€1mL*10mM (DMSO)133.00€5mg149.00€10mg213.00€25mg319.00€50mg450.00€100mg605.00€PROTAC PI3Kα degrader-1
PROTACPI3Kα degrader-1 is a PI3Kα-targeting PROTAC degrader (DC50= 0.08 μM) that demonstrates notable selectivity in degrading PI3Kα over the PI3Kβ, PI3Kγ, and PI3Kδ isoforms. It degrades PI3Kα effectively in a time- and concentration-dependent manner and significantly inhibits the phosphorylation of AKT at the Ser473 site. Additionally, PROTACPI3Kα degrader-1 exhibits significant in vivo anticancer efficacy in HGC-27 and DOHH2 xenograft models.Color and Shape:Odour SolidPI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Formula:C20H15Cl2N5O3Purity:98%Color and Shape:SolidMolecular weight:444.27PF-06843195
CAS:PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Formula:C20H25F3N8O4Purity:98.01%Color and Shape:SolidMolecular weight:498.46Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formula:C36H56O13Purity:99.66% - 99.74%Color and Shape:SolidMolecular weight:696.82Ref: TM-T5S1982
1mg35.00€5mg77.00€10mg106.00€1mL*10mM (DMSO)107.00€25mg170.00€50mg253.00€100mg375.00€500mg892.00€VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Formula:C17H22N8OPurity:97.82% - 99.54%Color and Shape:SolidMolecular weight:354.41PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Formula:C22H24N2O3Purity:98.92%Color and Shape:SolidMolecular weight:364.44Ref: TM-T28416
1mg40.00€2mg57.00€5mg97.00€1mL*10mM (DMSO)105.00€10mg156.00€25mg255.00€50mg368.00€100mg510.00€200mg700.00€Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Formula:C23H30N8O3SPurity:98.28% - 99.64%Color and Shape:SolidMolecular weight:498.6Brevianamide F
CAS:Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.
Formula:C16H17N3O2Purity:97.30% - 98.82%Color and Shape:SolidMolecular weight:283.33Alpelisib
CAS:Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.Formula:C19H22F3N5O2SPurity:98% - 99.73%Color and Shape:SolidMolecular weight:441.47Ref: TM-T1921
2mg37.00€5mg52.00€1mL*10mM (DMSO)57.00€10mg69.00€25mg82.00€50mg90.00€100mg145.00€500mg424.00€PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Formula:C16H14BrN5O4S·HClPurity:97.82%Color and Shape:SolidMolecular weight:488.74YS-49
CAS:YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).Formula:C20H20BrNO2Purity:99.65%Color and Shape:SolidMolecular weight:386.28Ref: TM-T13376
1mg46.00€2mg58.00€1mL*10mM (DMSO)92.00€5mg95.00€10mg137.00€25mg260.00€50mg386.00€100mg560.00€500mg1,153.00€Glaucocalyxin A
CAS:Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.Formula:C20H28O4Purity:99.55% - 99.80%Color and Shape:SolidMolecular weight:332.43Rigosertib
CAS:Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.Formula:C21H25NO8SPurity:99.53%Color and Shape:SolidMolecular weight:451.49Flupentixol dihydrochloride
CAS:Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.Formula:C23H27Cl2F3N2OSPurity:98.76% - >99.99%Color and Shape:White Or Off-White SolidMolecular weight:507.43Erucic acid
CAS:Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).Formula:C22H42O2Purity:99.64%Color and Shape:Needles From Alcohol Liquid OthersolidMolecular weight:338.57NIBR-17
CAS:NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Formula:C18H20N8O2Purity:97.79%Color and Shape:SolidMolecular weight:380.4
