PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Found 235 products for "PI3K".
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CAL-130 Racemate
CAS:CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Formula:C23H22N8OPurity:98%Color and Shape:SolidMolecular weight:426.47PI3Kδ-IN-17
CAS:PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing theFormula:C23H24F3N7O2Purity:98%Color and Shape:SolidMolecular weight:487.48SAR-260301
CAS:SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).Formula:C19H22N4O3Purity:99.74%Color and Shape:SolidMolecular weight:354.4Ref: TM-T16841
2mg43.00€5mg65.00€1mL*10mM (DMSO)71.00€10mg87.00€25mg173.00€50mg264.00€100mg371.00€200mg523.00€NVP-QAV-572
CAS:NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).Formula:C17H19F2N7O3S2Purity:98%Color and Shape:SolidMolecular weight:471.5GNE-490
CAS:GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Formula:C18H22N6O2SPurity:99.77%Color and Shape:White SolidMolecular weight:386.47Ref: TM-T22339
1mg52.00€5mg111.00€1mL*10mM (DMSO)120.00€10mg182.00€25mg289.00€50mg399.00€100mg530.00€MIPS-21335
CAS:MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ withFormula:C24H21N7O5Purity:98%Color and Shape:SolidMolecular weight:487.47PF-04979064
CAS:PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).Formula:C24H26N6O3Purity:99.98% - ≥98%Color and Shape:SolidMolecular weight:446.5GSK-F1
CAS:GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.Formula:C27H18F5N5O4SPurity:97.03%Color and Shape:SolidMolecular weight:603.52Ref: TM-T19840
1mg104.00€5mg215.00€1mL*10mM (DMSO)304.00€10mg318.00€25mg510.00€50mg692.00€100mg888.00€200mg1,251.00€PI3Kδ-IN-23
CAS:PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.Formula:C30H30N6O5Color and Shape:SolidMolecular weight:554.596PI3Kα-IN-19
CAS:PI3Kα-IN-19 (Compound 1) serves as an inhibitor of PI3Kα, specifically targeting the p110α catalytic subunit. PI3Kα, a frequently dysregulated kinase, is extensively utilized in cancer research [1].Formula:C28H28N6O3Molecular weight:496.56UNI418
CAS:UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).Formula:C22H16N6Color and Shape:SolidMolecular weight:364.40PI3Kδ-IN-27
CAS:PI3Kδ-IN-27 is a PI3Kδ inhibitor with an IC50 of 355.3 nM. It exhibits activity against SARS-CoV-2 and can be utilized in infection-related studies, such as those concerning COVID-19.Formula:C21H24N4O3Molecular weight:380.45PI3Kγ inhibitor 1
CAS:PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.Formula:C32H26N8O2SPurity:98%Color and Shape:SolidMolecular weight:586.67PI3kδ inhibitor 1
CAS:PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).Formula:C28H33FN6O2Purity:98%Color and Shape:SolidMolecular weight:504.60VVD-699
CAS:VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.Formula:C25H30ClFN2O6S2Color and Shape:SolidMolecular weight:573.097
