ATM/ATR
ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.
Found 72 products for "ATM/ATR".
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Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formula:C23H26O7Purity:99.13% - 99.92%Color and Shape:SolidMolecular weight:414.45Elimusertib hydrochloride(1876467-74-1 free base)
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumorFormula:C20H22ClN7OPurity:98.8% - 99.03%Color and Shape:SolidMolecular weight:411.89Ref: TM-T10468
1mg34.00€5mg84.00€1mL*10mM (DMSO)92.00€10mg114.00€25mg224.00€50mg331.00€100mg470.00€200mg647.00€FEN1-IN-1
CAS:FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.Formula:C15H12N2O5SPurity:99.72% - 99.93%Color and Shape:White SolidMolecular weight:332.33ATM Inhibitor-9
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].Formula:C25H32N6O2Purity:98%Color and Shape:SolidMolecular weight:448.56GJ071 oxalate
CAS:GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.Formula:C20H29N3O7SPurity:99.93%Color and Shape:White SolidMolecular weight:455.53Ref: TM-T31932
1mg73.00€5mg149.00€1mL*10mM (DMSO)166.00€10mg213.00€25mg319.00€50mg450.00€100mg605.00€200mg802.00€Hexapeptide-11
CAS:Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Formula:C36H48N6O7Purity:98%Color and Shape:SolidMolecular weight:676.8Berzosertib
CAS:Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.Formula:C24H25N5O3SPurity:97.34% - >99.99%Color and Shape:SolidMolecular weight:463.55Ref: TM-T2669
1mg34.00€5mg71.00€1mL*10mM (DMSO)73.00€10mg96.00€25mg146.00€50mg213.00€100mg340.00€200mg497.00€500mg790.00€ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value ofFormula:C26H34N6O2Purity:98%Color and Shape:SolidMolecular weight:462.59ICT10336
ICT10336 is a hypoxia-reactive prodrug of the ATR inhibitor AZD6738. It specifically activates under hypoxic conditions in vitro, selectively releasing AZD6738. This action inhibits ATR activation at the T1989 and S428 phosphorylation sites, consequently disrupting HIF1a-mediated adaptation of hypoxic cancer cells and inducing cell death in both 2D and 3D cancer models. ICT10336 is also a metabolic substrate of CYPOR activity.Formula:C32H40N10O7SColor and Shape:SolidMolecular weight:708.28021CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Formula:C34H46N2O6SColor and Shape:SolidMolecular weight:610.80ATR-IN-9
CAS:ATR-IN-9 from patent WO2020087170A1 is a potent ATR kinase inhibitor with an IC50 of 10 nM.Formula:C22H27N7O2Color and Shape:SolidMolecular weight:421.505Abd110
CAS:Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].Formula:C41H42N8O7SColor and Shape:SolidMolecular weight:790.89Antitumor agent-28
CAS:Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.Formula:C25H32N6O4SColor and Shape:SolidMolecular weight:512.63GJ103 sodium salt
CAS:GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Formula:C16H13N4NaO3SPurity:99.70% - 99.91%Color and Shape:Orange SolidMolecular weight:364.36Ceralasertib
CAS:Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.Formula:C20H24N6O2SPurity:98% - 99.99%Color and Shape:White SolidMolecular weight:412.51AZD0156
CAS:AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.Formula:C26H31N5O3Purity:99.13% - 99.87%Color and Shape:SolidMolecular weight:461.56CP-466722
CAS:CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.Formula:C17H15N7O2Purity:99.1% - 99.14%Color and Shape:SolidMolecular weight:349.35KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.Formula:C21H17NO3S2Purity:97.21% - >99.99%Color and Shape:Yellow SolidMolecular weight:395.49AZ20
CAS:AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.Formula:C21H24N4O3SPurity:98% - 99.69%Color and Shape:SolidMolecular weight:412.51NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Formula:C11H17N5O2Purity:98.36%Color and Shape:SolidMolecular weight:251.29PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formula:C14H16ClN3O4S2Purity:97.72%Color and Shape:SolidMolecular weight:389.88Ref: TM-T2616
1mg42.00€5mg85.00€1mL*10mM (DMSO)94.00€10mg105.00€25mg200.00€50mg305.00€100mg427.00€200mg613.00€AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Formula:C18H20N8O2Purity:99.03% - 99.85%Color and Shape:SolidMolecular weight:380.4Ref: TM-T7122
1mg38.00€5mg84.00€1mL*10mM (DMSO)93.00€10mg113.00€25mg177.00€50mg295.00€100mg447.00€200mg650.00€CGK733
CAS:CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.Formula:C23H18Cl3FN4O3SPurity:98% - 99.67%Color and Shape:SolidMolecular weight:555.84Adefovir dipivoxil
CAS:Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity againstFormula:C20H32N5O8PPurity:98% - 99.80%Color and Shape:SolidMolecular weight:501.47KU60019
CAS:Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.Formula:C30H33N3O5SPurity:95.9% - 99.7%Color and Shape:Yellow SolidMolecular weight:547.67VE-821
CAS:VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).Formula:C18H16N4O3SPurity:97.19% - 99.97%Color and Shape:SolidMolecular weight:368.41AZ32
CAS:AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.Formula:C20H16N4OPurity:98.68% - 99.68%Color and Shape:SolidMolecular weight:328.37Elimusertib
CAS:Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFormula:C20H21N7OPurity:98.72% - 99.84%Color and Shape:SolidMolecular weight:375.43Ref: TM-T7318
1mg34.00€5mg74.00€1mL*10mM (DMSO)82.00€10mg105.00€25mg205.00€50mg340.00€100mg532.00€500mg1,144.00€Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.54azd1390
CAS:AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.Formula:C27H32FN5O2Purity:97.41% - 99.72%Color and Shape:White SolidMolecular weight:477.57Ref: TM-T5175
1mg84.00€2mg102.00€5mg152.00€1mL*10mM (DMSO)160.00€10mg215.00€25mg439.00€50mg560.00€100mg717.00€ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Formula:C30H22N4O2Purity:97.76%Color and Shape:SolidMolecular weight:470.52Mirin
CAS:Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.Formula:C10H8N2O2SPurity:99.24%Color and Shape:SolidMolecular weight:220.25Ref: TM-T60273
2mg34.00€5mg46.00€1mL*10mM (DMSO)49.00€10mg67.00€25mg112.00€50mg168.00€100mg239.00€200mg353.00€ART0380
CAS:ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.Formula:C18H24N6O2SPurity:99.06% - >99.99%Color and Shape:SolidMolecular weight:388.49Ref: TM-T85731
1mg66.00€5mg145.00€1mL*10mM (DMSO)158.00€10mg200.00€25mg356.00€50mg505.00€100mg708.00€200mg964.00€Gartisertib
CAS:Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.Formula:C25H29F2N9O3Purity:99.52%Color and Shape:SolidMolecular weight:541.55Ref: TM-T10407
1mg120.00€5mg289.00€1mL*10mM (DMSO)344.00€10mg485.00€25mg964.00€50mg1,414.00€100mg2,125.00€ATR-IN-23
CAS:ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and inducesFormula:C20H22N6O3S2Purity:98%Color and Shape:SolidMolecular weight:458.56SKLB-197
CAS:SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.Formula:C25H24N6OPurity:99.53%Color and Shape:White SolidMolecular weight:424.5Ref: TM-T62290
1mg77.00€5mg167.00€1mL*10mM (DMSO)178.00€10mg260.00€25mg522.00€50mg835.00€100mg1,341.00€ATR-IN-10
CAS:ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).Formula:C27H24N4OColor and Shape:SolidMolecular weight:420.51Ceralasertib formate
CAS:Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.Formula:C21H26N6O4SColor and Shape:SolidMolecular weight:458.54ATR-IN-15
CAS:ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.Formula:C19H22N8OColor and Shape:SolidMolecular weight:378.43ATR-IN-16
CAS:ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.Formula:C19H25N7OColor and Shape:SolidMolecular weight:367.45ATR-IN-5
CAS:ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.Formula:C27H32F3N9OColor and Shape:SolidMolecular weight:555.6ATR-IN-8
CAS:ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.Formula:C20H22N6O2SColor and Shape:SolidMolecular weight:410.49ATM-IN-1
CAS:ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.Formula:C30H36N6O3Color and Shape:SolidMolecular weight:528.65ATR-IN-13
CAS:ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).Formula:C24H24FN9OColor and Shape:SolidMolecular weight:473.51AZ 5704
CAS:AZ 5704 (compound 74) is a selective and orally active ATM inhibitor (IC50 = 0.6 nM), which can enhance the anti-tumor activity of irinotecan.Formula:C23H23FN6O2Purity:99.69%Color and Shape:White SolidMolecular weight:434.47ATR-IN-20
ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.Formula:C29H31N5O4SColor and Shape:SolidMolecular weight:545.65ATR-IN-21
CAS:ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].Formula:C23H27N7OPurity:98%Color and Shape:SolidMolecular weight:417.51ATR-IN-29
CAS:ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].Formula:C19H22N8OPurity:98%Color and Shape:SolidMolecular weight:378.43ATR-IN-22
CAS:ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM andFormula:C25H31N7OPurity:98%Color and Shape:SolidMolecular weight:445.56(S)-Ceralasertib
CAS:(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.Formula:C20H24N6O2SColor and Shape:SolidMolecular weight:412.51
