ATM/ATR
ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.
Found 78 products for "ATM/ATR".
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SKLB-197
CAS:SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.Formula:C25H24N6OPurity:99.53%Color and Shape:White SolidMolecular weight:424.4977ATR-IN-10
CAS:ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).Formula:C27H24N4OColor and Shape:SolidMolecular weight:420.51ATR-IN-23
CAS:ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and inducesFormula:C20H22N6O3S2Purity:98%Color and Shape:SolidMolecular weight:458.56ATR-IN-16
CAS:ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.Formula:C19H25N7OColor and Shape:SolidMolecular weight:367.45ATR-IN-5
CAS:ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.Formula:C27H32F3N9OColor and Shape:SolidMolecular weight:555.6ATR-IN-22
CAS:ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM andFormula:C25H31N7OPurity:98%Color and Shape:SolidMolecular weight:445.56ATR-IN-21
CAS:ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].Formula:C23H27N7OPurity:98%Color and Shape:SolidMolecular weight:417.51ATR-IN-13
CAS:ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).Formula:C24H24FN9OColor and Shape:SolidMolecular weight:473.51ATR-IN-29
CAS:ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].Formula:C19H22N8OPurity:98%Color and Shape:SolidMolecular weight:378.43AZ 5704
CAS:AZ 5704 (compound 74) is a selective and orally active ATM inhibitor (IC50 = 0.6 nM), which can enhance the anti-tumor activity of irinotecan.Formula:C23H23FN6O2Purity:99.69%Color and Shape:White SolidMolecular weight:434.47ATM-IN-1
CAS:ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.Formula:C30H36N6O3Color and Shape:SolidMolecular weight:528.65(S)-Ceralasertib
CAS:(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.Formula:C20H24N6O2SColor and Shape:SolidMolecular weight:412.51ATR-IN-6
CAS:ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.Formula:C28H28FN7O2Color and Shape:SolidMolecular weight:513.57ATR-IN-18
CAS:ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.Formula:C19H22F3N7O5SColor and Shape:SolidMolecular weight:517.48ATR-IN-20
ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.Formula:C29H31N5O4SColor and Shape:SolidMolecular weight:545.65ATR-IN-8
CAS:ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.Formula:C20H22N6O2SColor and Shape:SolidMolecular weight:410.49Camonsertib
CAS:Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.Formula:C21H26N6O3Purity:98.44% - 99.93%Color and Shape:Yellow SolidMolecular weight:410.4695AZ31
CAS:AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,Formula:C24H28N4O3Purity:98.1%Color and Shape:SolidMolecular weight:420.5041Lartesertib
CAS:Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancerFormula:C23H21FN6O3Purity:99.80%Color and Shape:White SolidMolecular weight:448.4496ATM Inhibitor-2
ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).Formula:C26H31N7O3Color and Shape:SolidMolecular weight:489.57
