ATM/ATR
ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.
Found 71 products of "ATM/ATR"
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FEN1-IN-1
CAS:<p>FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.</p>Formula:C15H12N2O5SPurity:99.65% - 99.80%Color and Shape:SolidMolecular weight:332.33Garcinone C
CAS:<p>Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.</p>Formula:C23H26O7Purity:99.13% - 99.92%Color and Shape:SolidMolecular weight:414.45Elimusertib hydrochloride(1876467-74-1 free base)
<p>Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor</p>Formula:C20H22ClN7OPurity:98.8% - 99.03%Color and Shape:SolidMolecular weight:411.89GJ071 oxalate
CAS:<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Formula:C20H29N3O7SPurity:99.97%Color and Shape:SolidMolecular weight:455.53Antitumor agent-28
CAS:<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Formula:C25H32N6O4SColor and Shape:SolidMolecular weight:512.63Abd110
CAS:<p>Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].</p>Formula:C41H42N8O7SColor and Shape:SolidMolecular weight:790.89ATM Inhibitor-8
<p>ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value of</p>Formula:C26H34N6O2Purity:98%Color and Shape:SolidMolecular weight:462.59ATM Inhibitor-9
<p>ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].</p>Formula:C25H32N6O2Purity:98%Color and Shape:SolidMolecular weight:448.56Berzosertib
CAS:<p>Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C24H25N5O3SPurity:97.34% - >99.99%Color and Shape:SolidMolecular weight:463.55Hexapeptide-11
CAS:<p>Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.</p>Formula:C36H48N6O7Purity:98%Color and Shape:SolidMolecular weight:676.8CA-M11
<p>CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.</p>Formula:C34H46N2O6SColor and Shape:SolidMolecular weight:610.80Ceralasertib
CAS:<p>Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.</p>Formula:C20H24N6O2SPurity:98% - 99.99%Color and Shape:SolidMolecular weight:412.51AZD0156
CAS:<p>AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.</p>Formula:C26H31N5O3Purity:99.13% - 99.87%Color and Shape:SolidMolecular weight:461.56PIK-93
CAS:<p>PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.</p>Formula:C14H16ClN3O4S2Purity:97.72%Color and Shape:SolidMolecular weight:389.88KU60019
CAS:<p>Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.</p>Formula:C30H33N3O5SPurity:95.9% - 99.36%Color and Shape:SolidMolecular weight:547.67GJ103 sodium salt
CAS:<p>GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.</p>Formula:C16H13N4NaO3SPurity:99.70% - 99.91%Color and Shape:SolidMolecular weight:364.36NU6027
CAS:<p>NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-</p>Formula:C11H17N5O2Purity:98.36%Color and Shape:SolidMolecular weight:251.29KU-55933
CAS:<p>KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.</p>Formula:C21H17NO3S2Purity:97.21% - >99.99%Color and Shape:SolidMolecular weight:395.49AZD-7648
CAS:<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Formula:C18H20N8O2Purity:99.03% - 99.85%Color and Shape:SolidMolecular weight:380.4AZ20
CAS:<p>AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.</p>Formula:C21H24N4O3SPurity:98% - 99.69%Color and Shape:SolidMolecular weight:412.51
