ATM/ATR
ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.
Found 77 products for "ATM/ATR".
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ATR kinase-IN-3
CAS:ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.Formula:C24H27F2N9O2Color and Shape:SolidMolecular weight:511.53ATR-IN-17
CAS:ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).Formula:C22H28N6O2SColor and Shape:SolidMolecular weight:440.56(S)-WSD0628
CAS:(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.Formula:C23H23F2N5O2Color and Shape:SolidMolecular weight:439.458ATR-IN-19
CAS:ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].Formula:C18H19N7OSColor and Shape:SolidMolecular weight:381.45ATR-IN-12
ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.Formula:C22H27N5O3SColor and Shape:SolidMolecular weight:441.55ATR-IN-11
ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.Formula:C25H30N6O2Color and Shape:SolidMolecular weight:446.54XRD-0394
CAS:XRD-0394 is a highly effective and selective dual inhibitor of ATM and DNA-PKcs, exhibiting oral bioactivity. It notably increases tumor cell destruction both in vitro and in vivo when combined with therapeutic ionizing radiation. Furthermore, XRD-0394 enhances the efficacy of PARP and topoisomerase I inhibitors in vitro [1].Formula:C26H30FN5O4SMolecular weight:527.61Decarbamoylmitomycin C
CAS:Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.Formula:C14H17N3O4Color and Shape:SolidMolecular weight:291.302ATR-IN-14
CAS:ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.Formula:C20H20FN7OColor and Shape:SolidMolecular weight:393.42ATM Inhibitor-1
CAS:ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.Formula:C27H36N6O3Purity:98%Color and Shape:SolidMolecular weight:492.61KU 59403
CAS:KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Formula:C29H32N4O4S2Purity:99.10% - 99.79%Color and Shape:SolidMolecular weight:564.719ATR-IN-32
CAS:ATR-IN-32 is an orally active ATR inhibitor that effectively suppresses the proliferation of MIA PaCa-2 cells. It significantly inhibits tumor growth in mice bearing LOVO and HT-29 xenografts. ATR-IN-32 is applicable for studying cancers mediated by the ATR protein kinase, such as colorectal cancer and pancreatic cancer.Formula:C22H24N6O2Molecular weight:404.47ATM-IN-13
CAS:ATM-IN-13 (A36) is an orally active selective ATM kinase inhibitor with a human IC50 of 0.3 nM. It disrupts the ATM-mediated DNA double-strand break repair signaling pathway, reduces phosphorylation levels of ATM and p53, and inhibits the ATM-dependent DNA damage response. ATM-IN-13 is applicable in colorectal cancer research.Formula:C27H33N5OMolecular weight:443.58WSD0628
CAS:WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Formula:C23H23F2N5O2Color and Shape:SolidMolecular weight:439.46ATM Inhibitor-3
ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.Formula:C25H29FN6O3Color and Shape:SolidMolecular weight:480.53ATM Inhibitor-2
ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).Formula:C26H31N7O3Color and Shape:SolidMolecular weight:489.57ATM Inhibitor-4
ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.Formula:C26H29FN6O3Color and Shape:SolidMolecular weight:492.55
