ATM/ATR
ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.
Found 77 products for "ATM/ATR".
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KU60019
CAS:Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.Formula:C30H33N3O5SPurity:95.9% - 99.7%Color and Shape:Yellow SolidMolecular weight:547.67VE-821
CAS:VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).Formula:C18H16N4O3SPurity:97.19% - 99.97%Color and Shape:SolidMolecular weight:368.41CP-466722
CAS:CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.Formula:C17H15N7O2Purity:99.1% - 99.14%Color and Shape:SolidMolecular weight:349.3467KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.Formula:C21H17NO3S2Purity:97.21% - >99.99%Color and Shape:Yellow SolidMolecular weight:395.49GJ103 sodium salt
CAS:GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Formula:C16H13N4NaO3SPurity:99.70% - 99.91%Color and Shape:Orange SolidMolecular weight:364.354AZ20
CAS:AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.Formula:C21H24N4O3SPurity:98% - 99.69%Color and Shape:SolidMolecular weight:412.51NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Formula:C11H17N5O2Purity:98.36%Color and Shape:SolidMolecular weight:251.285ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Formula:C30H22N4O2Purity:97.76%Color and Shape:SolidMolecular weight:470.5213azd1390
CAS:AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.Formula:C27H32FN5O2Purity:97.41% - 99.72%Color and Shape:White SolidMolecular weight:477.5737Ceralasertib
CAS:Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.Formula:C20H24N6O2SPurity:98% - 99.99%Color and Shape:White SolidMolecular weight:412.509Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.5365Elimusertib
CAS:Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFormula:C20H21N7OPurity:98.72% - 99.98%Color and Shape:Yellow SolidMolecular weight:375.427AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Formula:C18H20N8O2Purity:99.03% - 99.85%Color and Shape:SolidMolecular weight:380.4038AZD0156
CAS:AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.Formula:C26H31N5O3Purity:99.13% - 99.87%Color and Shape:SolidMolecular weight:461.556Mirin
CAS:Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.Formula:C10H8N2O2SPurity:99.24%Color and Shape:SolidMolecular weight:220.248ART0380
CAS:ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.Formula:C18H24N6O2SPurity:99.06% - >99.99%Color and Shape:White SolidMolecular weight:388.49ATR-IN-23
CAS:ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and inducesFormula:C20H22N6O3S2Purity:98%Color and Shape:SolidMolecular weight:458.56Ceralasertib formate
CAS:Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.Formula:C21H26N6O4SColor and Shape:SolidMolecular weight:458.54SKLB-197
CAS:SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.Formula:C25H24N6OPurity:99.53%Color and Shape:White SolidMolecular weight:424.4977ATR-IN-10
CAS:ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).Formula:C27H24N4OColor and Shape:SolidMolecular weight:420.51
