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ATM/ATR

ATM/ATR

ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.

Found 71 products of "ATM/ATR"

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  • CGK733
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    CGK733

    CAS:
    <p>CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.</p>
    Formula:C23H18Cl3FN4O3S
    Purity:98% - 99.67%
    Color and Shape:Solid
    Molecular weight:555.84

    Ref: TM-T1821

  • Adefovir dipivoxil
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    Adefovir dipivoxil

    CAS:
    <p>Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against</p>
    Formula:C20H32N5O8P
    Purity:98% - 99.80%
    Color and Shape:It Has Broad-Spectrum Antiviral Activity
    Molecular weight:501.47

    Ref: TM-T1675

  • KU60019
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    KU60019

    CAS:
    <p>Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.</p>
    Formula:C30H33N3O5S
    Purity:95.9% - 99.36%
    Color and Shape:Solid
    Molecular weight:547.67

    Ref: TM-T2474

  • VE-821
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    VE-821

    CAS:
    <p>VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).</p>
    Formula:C18H16N4O3S
    Purity:97.19% - 99.97%
    Color and Shape:Solid
    Molecular weight:368.41

    Ref: TM-T3032

  • AZ32
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    AZ32

    CAS:
    <p>AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of &lt;6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.</p>
    Formula:C20H16N4O
    Purity:98.68% - 99.68%
    Color and Shape:Solid
    Molecular weight:328.37

    Ref: TM-T4443

  • Elimusertib
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    Elimusertib

    CAS:
    <p>Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in</p>
    Formula:C20H21N7O
    Purity:98.72% - 99.84%
    Color and Shape:Solid
    Molecular weight:375.43

    Ref: TM-T7318

  • Dactolisib
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    Dactolisib

    CAS:
    <p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>
    Formula:C30H23N5O
    Purity:97.64% - 99.85%
    Color and Shape:Solid
    Molecular weight:469.54

    Ref: TM-T2235

  • azd1390
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    azd1390

    CAS:
    <p>AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), &gt;10,000-fold selectivity vs. PIKK enzymes.</p>
    Formula:C27H32FN5O2
    Purity:97.41% - 99.72%
    Color and Shape:Solid
    Molecular weight:477.57

    Ref: TM-T5175

  • ETP-46464
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    ETP-46464

    CAS:
    <p>ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).</p>
    Formula:C30H22N4O2
    Purity:97.76%
    Color and Shape:Solid
    Molecular weight:470.52

    Ref: TM-T2084

  • Mirin
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    Mirin

    CAS:
    <p>Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.</p>
    Formula:C10H8N2O2S
    Purity:99.24%
    Color and Shape:Solid
    Molecular weight:220.25

    Ref: TM-T60273

  • ART0380
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    ART0380

    CAS:
    <p>ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.</p>
    Formula:C18H24N6O2S
    Purity:99.06% - >99.99%
    Color and Shape:Solid
    Molecular weight:388.49

    Ref: TM-T85731

  • SKLB-197
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    SKLB-197

    CAS:
    <p>SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.</p>
    Formula:C25H24N6O
    Color and Shape:Solid
    Molecular weight:424.5

    Ref: TM-T62290

  • ATR-IN-10
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    ATR-IN-10

    CAS:
    <p>ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).</p>
    Formula:C27H24N4O
    Color and Shape:Solid
    Molecular weight:420.51

    Ref: TM-T62233

  • Ceralasertib formate
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    Ceralasertib formate

    CAS:
    <p>Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.</p>
    Formula:C21H26N6O4S
    Color and Shape:Solid
    Molecular weight:458.54

    Ref: TM-T26981

  • ATR-IN-15
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    ATR-IN-15

    CAS:
    <p>ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.</p>
    Formula:C19H22N8O
    Color and Shape:Solid
    Molecular weight:378.43

    Ref: TM-T61587

  • Gartisertib
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    Gartisertib

    CAS:
    <p>Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.</p>
    Formula:C25H29F2N9O3
    Purity:99.52%
    Color and Shape:Solid
    Molecular weight:541.55

    Ref: TM-T10407

  • ATR-IN-16
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    ATR-IN-16

    CAS:
    <p>ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.</p>
    Formula:C19H25N7O
    Color and Shape:Solid
    Molecular weight:367.45

    Ref: TM-T61432

  • ATR-IN-23
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    ATR-IN-23

    CAS:
    <p>ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces</p>
    Formula:C20H22N6O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:458.56

    Ref: TM-T78959

  • ATR-IN-6
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    ATR-IN-6

    CAS:
    <p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>
    Formula:C28H28FN7O2
    Color and Shape:Solid
    Molecular weight:513.57

    Ref: TM-T63555

  • ATR-IN-18
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    ATR-IN-18

    CAS:
    <p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>
    Formula:C19H22F3N7O5S
    Color and Shape:Solid
    Molecular weight:517.48

    Ref: TM-T63604