Polycyclic Compounds

<p>Stability Hygroscopic<br>Applications 3-Oxo-2,3-dihydro-1H-indazole-5-carboxylic acid (cas# 787580-93-2) is a useful research chemical.<br></p>

<p>Applications 5-(2-Bromo-1-oxobutyl)-8-hydroxy-2(1H)-quinolinone is an intermediate in the synthesis of metabolites of procaterol hydrochloride (Meptin) (P155490), a β2-adrenergic agonist used in the treatment of asthma.<br>References Yoshizaki, S., et al.: Chem. Pharma. Bull., 26, 1611 (1978);<br></p>

<p>Applications 2-Deuteroindole is a useful reagent in the preparation of deuterated labeled indoles.<br>References Lautie, M. F., et al.: J. Label. Compd. Radiopharm., 16, 735 (1979); Ibaceta-Lizana, J. S. L., et al.: J. Chem. Soc. Perkin Trans 2., 9, 1221 (1987)<br></p>

<p>Applications 2-amino-N-(quinolin-8-yl)acetamide (cas# 587832-36-8) is a useful research chemical.<br></p>

<p>Applications 2,5-Dimethyl-2,3-dihydro-1H-indole (cas# 90874-56-9) is a useful research chemical.<br></p>

<p>Applications 5-Fluoro-8-nitroquinoline (cas# 152167-85-6) is a useful research chemical.<br></p>

<p>Applications 5-Aminotricyclo[3.3.1.13,7]decane-1,3-diol is an intermediate used in the synthesis of Hydroxy Vildagliptin (V305035), which is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-​4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.<br>References Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)<br></p>

<p>Applications tert-​Butyl 5-​(4,​4,​5,​5-​tetramethyl-​1,​3,​2-​dioxaborolan-​2-​yl)​isoindoline-​2-​carboxylate is a reactant in the synthesis of tyrosine kinase inhibitors in the treatment of proliferative diseases.<br>References WO Patent 2014089324 (2014); CN 104016979 (2014);<br></p>

<p>Applications 6-Fluoroquinoline, is a versatile building block used in the synthesis of various chemical compounds.<br></p>

<p>Applications 2,6-Dichloro-9-nitroso-9H-purine is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Chloroisoindoline hydrochloride (cas# 912999-79-2) is a useful research chemical.<br></p>

<p>Applications 4-Chloro-1-hydroxy-7-isoquinolinesulfonyl Chloride (cas# 223671-81-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,2'-Bipyridine-4,4'-dicarboxylic acid<br></p>

<p>Applications (2R,3aR,7aR)-Octahydroindole-2-carboxylic Acid Hydrochloride is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Vincent, M., et al.: Drug Design Disc., 9, 11 (1992), Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications 4-Hydroxy-quinoline-6-carboxylic acid<br></p>

<p>Applications Tert-Butyl 4-(Aminomethyl)Indoline-1-Carboxylate (cas# 1086392-32-6) is a useful research chemical.<br></p>

<p>Applications 2-​Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.<br></p>

<p>Applications 3-Hydroxy-2,3-dihydro-1H-indol-2-one is a useful reagent for the distereoselective preparation of spiro[furo[3,4-c]chromene-1,3'-indoline]triones.<br>References Lei, C. W., et al.: Org. Biomol. Chem., 18, 845 (2020)<br></p>

<p>Applications 6-Azabicyclo[3.2.1]octane is used in preparation of substituted Piperidine Carboxamides for use as 11βHSD1 modulators for use in treating metabolic disorders.<br>References Kilburn, John P., et al.: PCT Int. Appl., (2007);<br></p>

<p>Applications 1,10-Phenanthroline-d8 (CAS# 90412-47-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications (Z)-9-(2-Propen-1-ylidene)-2-(trifluoromethyl)-9H-thioxanthene is an intermediate used in the synthesis of (E/Z)-Flupentixol-d4 Dihydrochloride (F597982), which is a neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.<br>References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),<br></p>

<p>Applications Indolyl-3-(ethyl-β-bromide) (cas# 3389-21-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,4-Diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (cas# 119752-83-9) is a useful research chemical.<br></p>

<p>Applications 3-(4-Aminobutyl)-1H-indole-5-carbonitrile could be a useful reagent for preparing CNS agents.<br>References Boettcher, H., et al.: Ger. Offen. (1992), DE 4101686 A1<br></p>

<p>Applications tert-Butyl 1,6-Diazaspiro[3.4]octane-1-carboxylate is a reactant in the preparation of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.<br>References Sippy, K.B., et. al.: Bioorg. Med. Chem. Lett., 19, 1682 (2009)<br></p>

<p>Applications 3-(quinolin-2-yl)propanoic acid (cas# 39111-94-9) is a useful research chemical for biological study. In particular it has been used in identifying structure-activity relationship of HDAC6 zinc-finger ubiquitin binding domain inhibitors.<br>References Ferreira, F., et al.: J. Med. Chem, 61, 4517 (2018)<br></p>

<p>Applications 6-Hydroxyindole-2-carboxylic acid (cas# 40047-23-2) is a useful research chemical.<br></p>

<p>Applications 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone is used as a reactant in the preparation of Indacaterol (I499745), a β-adrenoreceptor agonist.<br>References Baur, Francois, et al.: J. of Med. Chem., 53(9), 3675-3684 (2010)<br></p>

<p>Applications alpha-Furil Dioxime (cas# 23789-34-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 3-Bromo-4-fluoro-1H-indazole (cas# 885521-60-8) is a useful research chemical.<br></p>

<p>Applications Indole derivative with anticancer activity.<br>References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)<br></p>

<p>Stability Store under Argon<br>Applications 3,6-Thioxanthenediamine-10,10-dioxide (cas# 10215-25-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Dimethylquinoline, �� 95.0% (cas# 1198-37-4) is a useful research chemical.<br></p>

<p>Applications Indole derivative as substrate-binding; N297Q and I300V mutants of cytochrome P 450 2A6 display expansion of substrate specificity of cytochrome P 450 2A6 to oxidize substituted indoles.<br>References Gotoh, O., et al.: J. Biol. Chem., 267, 83 (1992), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001), Kim, D., et al.: Biochemistry, 43, 981 (2004),<br></p>

<p>Applications 5-Fluoroindole-3-butyric Acid is used in preparation of Aminochroman and Aminotetralin derivatives, which are useful in the treatment of serotonin-mediated disorders.<br>References Hatzenbuhler, N., et al.: PCT Int. Appl., (2005);<br></p>

<p>Applications 7-Chloro-2-[(E)-2-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]ethenyl]quinoline is a reagent in the synthesis of dithioacetals, which are intermediates in the preparation of potent LTD4 antagonist L-660,711.<br>References McNamara, J. M., et al.: J. Org. Chem., 54, 3718 (1989)<br></p>

<p>Applications 2-(1-Cyanoethyl)indole-13C215N is an isotope labelled intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.<br>References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),<br></p>

<p>Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Methylamide is a useful synthetic intermediate.<br></p>

<p>Applications 1,2,3,4,5,6,7,8-OCTAHYDROPHENANTHRENE (cas# 5325-97-3) is a useful research chemical.<br></p>

<p>Applications 2-(quinolin-4-yl)ethan-1-amine (cas# 860720-12-3) is a useful research chemical.<br></p>

<p>Applications 1,2,3,4-Tetrahydroisoquinoline-6,7-diol hydrobromide (cas# 52768-23-7) is a useful research chemical.<br></p>

<p>Applications XANTHENE-9-CARBOXAMIDE (cas# 5813-90-1) is a useful research chemical.<br></p>

<p>Applications (2R,3aS,7aS)-Octahydroindole-2-carboxylic Acid Hydrochloride is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Vincent, M., et al.: Drug Design Disc., 9, 11 (1992), Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications 5,7-dihydroxy-4-methyl-2H-chromen-2-one (cas# 2107-76-8) is a useful research chemical.<br></p>

<p>Applications 3,5-Diphenylpyrazole (cas# 1145-01-3) is a useful research chemical.<br></p>

<p>Applications 5-Nitroisoindoline is used as a reagent in organic synthesis of several compounds including that of biphenylcarboxamidoisoindoline derivatives, which act as apolipoprotein B secretion inhibitors, and of benzenesulfonamides which may act as antipsychotic agents.<br>References Yamada, H., et al.: Preparation of biphenylcarboxamidoisoindoline derivatives as apolipoprotein B secretion inhibitors, WO Patent 2002014277, Feb 21, 2002; Cooper, D., et al.: Preparation of benzenesulfonamides as antipsychotic agents, WO Patent 2003068732, Aug 21, 2003;<br></p>

<p>Applications 1H-Indole-3-carboxylic acid hydrazide<br></p>

<p>Applications 7-Phenyl-7H-purine (cas# 18346-05-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-hydroxyquinoline-2-carboxylic acid (cas# 75434-18-3) is a useful research chemical.<br></p>

<p>Applications 1-benzyl-1,2,3,4-tetrahydroisoquinoline hydrochloride (cas# 155413-72-2) is a useful research chemical.<br></p>

<p>Applications 4-Isoquinolin-4-yl-benzylamine is an analog of amino isoquinolin (A611600). Amino isoquinolin ( A611600) is used for synthesis of Rho kinase inhibitors.<br>References Kimura, K; Science, 273, 245 (1996);Amano, M; J Biol Chem 274, 32418 (1999)Gassel, M; J Mol Biol, 329, 1021 (2003);<br></p>

<p>Applications 9-Oxo-9H-thioxanthene-2-carboxylic acid (cas# 25095-94-7) is a useful research chemical.<br></p>

<p>Applications N’,N’-Dimethylindole-2-carboxamide (cas# 7511-14-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,5-Dichloro-4-pyridone-1-acetic acid<br></p>

<p>Applications 8-aza-9-boratricyclo[8.4.0.0,2,7]tetradeca-1(14),2,4,6,10,12-hexaen-9-ol (cas# 17012-25-8) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Isopropylamide is a useful synthetic intermediate.<br></p>