Polycyclic Compounds

Applications Quinoline-4-carboxylic acid (cas# 486-74-8) is a useful research chemical.

Applications 2-amino-N-(quinolin-8-yl)acetamide (cas# 587832-36-8) is a useful research chemical.

Applications 2,5-Dimethyl-2,3-dihydro-1H-indole (cas# 90874-56-9) is a useful research chemical.

Applications Indole-3-acetonitrile is an indole derivative involved in the biosynthesis of the plant hormone indole acetic acid (I577340) via the indole-3-acetaldoxime pathway.
References Kong, W., et al.: Plant Cell Physiol, 56, 715-726 (2015)

Applications 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic acid ethyl ester is synthesized from 5-chloro-2-oxindole (C375030), which is used in the preparation of novel GSK-3β inhibitors as anticancer agents.
References Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);

Applications 6-Fluoroquinoline, is a versatile building block used in the synthesis of various chemical compounds.

Applications 5-Fluoro-8-nitroquinoline (cas# 152167-85-6) is a useful research chemical.

Applications 1-(2-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline (cas# 1017125-85-7) is a useful research chemical.

Applications 5-Aminotricyclo[3.3.1.13,7]decane-1,3-diol is an intermediate used in the synthesis of Hydroxy Vildagliptin (V305035), which is an impurity of Vildagliptin (V305000). Vildagliptin is a DPP-​4 enzyme inhibitor, has anti-oxidant properties and used as an apoptotic agent on pancreatic cancer . Vildagliptin is used to treat type 2 diabetes mellitus (T2DM) and improve the endothelial function of patients.
References Amritha, C.A., et al.: J. Clin. Diagn. Res., 9, FC14 (2015); Cosenso-Martin, L.N., et al.: Diabetol. Metab. Syndr., 7, 70/1 (2015)

Applications 6-[N,N-Di(2-hydroxybenzyl)amino]-2-[(3-hydroxypropyl)amino]-9-isopropylpurine (cas# 1076200-04-8) is a compound useful in organic synthesis.

Applications 8$l^{6}-thia-9-azatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2,4,6,10,12-hexaene-8,8-dione (cas# 1864-33-1) is a useful research chemical.

Applications 2,6-Dichloro-9-nitroso-9H-purine is a compound useful in organic synthesis.

Applications (1R,​4S)​-1,​3,​3-​Trimethylbicyclo[2.2.1]​heptan-​2-​one also known more commonly as (-)-Fenchone is a chiral intermediate of Fenchone and is currently being used for studies ranging from inhibitory effects of monoterpenes on human TRPA1 and odorant receptor of the malaria vector Anopheles gambiae.
References Rahman, S., et al. J. Biol. Chem., 292, 18916-23 (2017); Takaishi, M., et al.: J Physio. Sci., 64, 47-57 (2014)

Applications Methyl 2-(1-(Hex-5-en-1-yl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate is a useful intermediate for organic synthesis.

Stability Hygroscopic
Applications 5-Amino-6-nitroquinoline is a reagent used in the synthesis of benzodiazepine sulfonamide-based bombesin receptor 3 agonists. It is also used in the synthesis of quinoxalinediones.
References Liu, P. et al.: ACS. Med. Chem. Lett., 2, 933 (2011); Bigge, C. et al.: J. Med. Chem., 38, 5720 (1995);

Applications tert-​Butyl 5-​(4,​4,​5,​5-​tetramethyl-​1,​3,​2-​dioxaborolan-​2-​yl)​isoindoline-​2-​carboxylate is a reactant in the synthesis of tyrosine kinase inhibitors in the treatment of proliferative diseases.
References WO Patent 2014089324 (2014); CN 104016979 (2014);

Applications 2,6-Dimethylphenanthrene have been used in investigating Polycyclic Aromatic Hydrocarbons Profiles in Higher Plants Using Statistical Models.
References Sojinu O., et al.: Int. J. Phytoremediat., 15, 439-451 (2013)

Applications tert-Butyl 6-amino-3,4-dihydroquinoline-1(2H)-carboxylate (cas# 1152923-36-8) is a useful research chemical.

Applications 5,6,7,8-TETRAHYDROISOQUINOLIN-1-AMINE (cas# 75704-51-7) is a useful research chemical.

Applications tert-butyl 7-hydroxy-3,4-dihydroisoquinoline-2(1h)-carboxylate (cas# 188576-49-0) is a useful research chemical.

Applications 4-NITROQUINOLINE N-OXIDE (cas# 56-57-5) is a useful research chemical.

Applications 2-(chloroacetyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (cas# 111631-72-2) is a useful research chemical.

Applications 4-Hydroxy-quinoline-6-carboxylic acid

Stability Air Sensitive
Applications Alpha-Pyridoin (cas# 1141-06-6) is a useful research chemical.

Applications 2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline]-1',3'-dione (cas# 31267-07-9) is a useful research chemical.

Applications 3-(prop-2-en-1-yl)-1h-indole (cas# 16886-09-2) is a useful research chemical.

Applications 5-Chloroisoindoline hydrochloride (cas# 912999-79-2) is a useful research chemical.

Applications An indole derivative used in synthesis of matrix metalloprotease inhibitors.
References Somei, M., et al.: Nat. Prod. Rep., 22, 73 (2005),

Applications 4-Chloro-1-hydroxy-7-isoquinolinesulfonyl Chloride (cas# 223671-81-6) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications 5-Bromo-4-chloro-3-indolyl caprylate (cas# 129541-42-0) is a useful research chemical.

Applications Indole derivative, as antiviral and antitumor agent.
References Borza, I., et al.: J. Med. Chem., 50, 901 (2007), Lefoix, M., et al.: Bioorg. Med. Chem., 16, 5303 (2008), Frost, J., et al.: J. Med. Chem., 51, 1904 (2008),

Applications 5-Amino-8-fluoroquinoline is an intermediate for organic synthesis. It functions as a reagent in the preparation of pyridoquinolinones and pyridoquinolinecarboxylates as bactericides.
References Lee, J. K., et al.: Bull. Korean Chem. Soc., 17, 90 (1996)

Applications m-Toluquinoline is a reagent used in the preparation of diarylmethylpiperazines as potent opioid receptor agonists with improved side effects. Also used in the preparation of novel pyrazine compounds derived from 2-phenylquinolin-7-yl which act as potent insulin-like growth factor-I receptor inhibitors.
References Plobeck, N. et al.: J. Med. Chem., 43, 3878 (2000); Mulvihill, M. et al.: Bioorg Med. Chem. Lett., 16, 1359 (2008);

Applications 2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine (cas# 16321-99-6) is a compound useful in organic synthesis.

Applications 2,2'-Bipyridine-4,4'-dicarboxylic acid

Applications 2,6-Dichloropurine-9-β-D-riboside (cas# 13276-52-3) is a compound useful in organic synthesis.

Applications 5-Cyano-2,3-dihydro-1H-indole

Applications 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester is used in the synthesis of antibacterials.
References Phillips, O. et al.: Exp. Opin. Ther. Pat., 19, 529 (2009);

Applications 5,6,7,8-Tetrahydroquinoline (cas# 10500-57-9) is a useful research chemical.

Applications 6-Bromo-3-cyanoindole

Applications 5,7-Dichloro-1,2,3,4-tetrahydro-2-(triphenylmethyl)-6-isoquinolinecarboxylic Acid, can be sued in the preparation of novel series of compounds which has been found to be a potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for treating dry eye.
References Zhong, M. et al,: ACS Med. Chem. Let. Vol. 3, page 203-206 (2012);

Applications 6-Fluoroquinolin-2(1H)-one

Applications 7-Deazapurine (cas# 18549-65-0) is a compound useful in organic synthesis.

Applications (2R,3aR,7aR)-Octahydroindole-2-carboxylic Acid Hydrochloride is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.
References Vincent, M., et al.: Drug Design Disc., 9, 11 (1992), Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)

Applications Tert-Butyl 4-(Aminomethyl)Indoline-1-Carboxylate (cas# 1086392-32-6) is a useful research chemical.

Applications 6-Bromo-1h-Pyrido[2,3-B][1,4]Oxazin-2(3h)-One (cas# 1245708-13-7) is a useful research chemical.

Applications 3,4-Dihydro-6-nitro-2(1H)-quinolinone is a useful intermediate for organic synthesis. It is used in the synthesis of triazolyl dihydroquinoliinones with anticonvulsant and antidepressant activity.
References Deng, X., et al.: Eur. J. Med. Chem., 73, 217 (2014)

Applications 2,2'-(2-Hydroxypropane-1,3-diyl)bis(1H-isoindole-1,3(2H)-dione) is a reagent used for the preparation of functionalized tripodal ligands and their metal complexes for imaging applications.
References Dunn, T.J., et al.: PCT Int. Appl., 1995:494561 (1995)

Applications 4,4-difluoro-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 1443981-83-6) is a useful research chemical.

Applications 4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 5488-36-8) is a useful research chemical.

Applications 2-[(Dimethylamino)methyl]indole (cas# 3978-16-3) is a compound useful in organic synthesis.
References Inion, H., et al.: Eur. J. Med. Chem., 10, 276 (1975),

Applications 2-chloro-1-{1H,2H,3H,4H,5H-pyrido[4,3-b]indol-2-yl}ethan-1-one (cas# 1087784-16-4) is a useful research chemical.

Applications 4,7-Dichloro-2-phenyl-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of phthalic compounds, phthalazines, and quinones with antimicrobial activity.
References Marriott, G. J., et al.: J. Chem. Soc., 134 (1939); Katayama, H., et al.: Tetrahedron., 63, 6642 (2007);

Applications 4,4'-Dicyano-2,2'-bipyridine is a photosensitizers for solar fuel generation
References Mills, I. N., et al.: Polyhedron, 82, 104 (2014)

Applications 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline

Applications 2-​Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.

Applications 9,10-Phenanthrenequinone is used in the formation of spirophosphoranes containing acyclic 5-methyl-2-phenyl-2H-1,2,3-diazaphosphol-4-yl substituent.
References Mironov, V. F., et al.: Russ. J. Electrochem., 88, 430-438 (2018)