Polycyclic Compounds

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<p>1,4-Diazabicyclo[2.2.2]octane is an organic compound that belongs to the group of coordination compounds and has antimicrobial activity. It is a colorless solid with a melting point of -117°C and a boiling point of 245°C. The molecular geometry is planar, which means that all bonds are linear. The compound can be found in water vapor or as colloidal gold sols in reaction with water vapor. It can also be obtained by reacting triethylenediamine with hydrochloric acid at 100°C under vacuum conditions. 1,4-Diazabicyclo[2.2.2]octane has been shown to have antibiotic properties and is able to inhibit the growth of bacteria through coordination geometry and phase transition temperature effects on the bacterial cell membrane.</p>

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<p>Fraxinol is a natural lignan, which is a small class of polyphenols, derived from the inner bark of the Ash tree (Fraxinus species). Its primary action is believed to involve antioxidant and anti-inflammatory pathways, where it scavenages reactive oxygen species and modulates cytokine production. This activity suggests potential modulation of cellular oxidative stress responses, contributing to its therapeutic interest.</p>

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<p>6-Chloroindole-2-carboxylicacid is a potent inhibitor of β-lactamase enzymes. It has been shown to act as a competitive inhibitor with an affinity for the β-lactamase enzyme in the nanomolar range. 6-Chloroindole-2-carboxylicacid is also a potent compound that can be used in experiments and screening. It has been shown to bind to the β-lactamase enzyme, which inhibits its activity, leading to a decrease in fluorescence. 6-Chloroindole-2-carboxylicacid has also been shown to have an inhibitory effect on bacterial cells by inhibiting protein synthesis, DNA replication, and RNA transcription.</p>

<p>Please enquire for more information about 4,4'-Dithio-2,2'-bipyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-Hydroxyquinolin-2(1H)-one is a chalcone that can be synthesized from 2,5-dihydroxybenzaldehyde and quinoline. It is a bacteriostatic agent that inhibits bacterial growth by binding to the 50S ribosomal subunit, blocking the formation of an antibiotic-substrate complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. 5-Hydroxyquinolin-2(1H)-one has shown activity against methicillin resistant Staphylococcus aureus (MRSA) and methicillin resistant Enterococcus faecium. 5-Hydroxyquinolin-2(1H)-one also represses the expression of DNA topoisomerase II genes, which may be associated with its inhibitory effects on bacterial growth.</p>

<p>Neobyakangelicol is a phytochemical compound, which is a natural product derived from various plant species. Its source is predominantly the roots of certain medicinal plants that are known for their array of bioactive constituents. The mode of action of Neobyakangelicol primarily involves interacting with specific biochemical pathways, potentially including modulation of enzyme activity or receptor binding, which could result in diverse pharmacological effects.</p>

<p>1-(2,3-Dihydroxypropyl)-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione (theophylline) is a bronchodilator and anti-inflammatory agent. It is used to treat asthma and other respiratory conditions. Theophylline is structurally similar to caffeine and theobromine and has been shown to have a similar effect on the heart and blood vessels as these stimulants. It also stimulates the central nervous system in a manner similar to that of theobromine. Theophylline has shown some benefit in congestive heart failure patients but has not been proven effective for treating high blood pressure or fibrillation.</p>

<p>3-Chloro-1H-indole-2-carbaldehyde is a bifunctional reagent that can be used to form amides. It reacts with primary and secondary amines, as well as dialkyl and methylene amines, to produce the corresponding chloro-, phenylhydrazine-, or nitrosoaminoureas. This reaction is intramolecular and yields the desired product in high yield. The reactant can also be used as a chloride source. 3-Chloro-1H-indole-2-carbaldehyde is manufactured by reacting phenylhydrazine with chloroacetic acid in an organic solvent at room temperature (25°C).</p>

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<p>4,6-Dichloroisatin is a pro-apoptotic compound that is synthesized from amino acids. It has been shown to have anticancer activity in human liver cancer cells, which may be due to its ability to induce apoptosis. 4,6-Dichloroisatin has also been shown to inhibit the production of electron transport chain proteins in the mitochondria by binding to their regulatory sites and inhibiting their phosphorylation. This inhibition of electron transport chain proteins leads to an accumulation of electrons that can react with molecular oxygen and produce reactive oxygen species (ROS). ROS are known for their ability to cause DNA damage and cell death through oxidative stress.</p>

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<p>3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-Quinolinone is a crystalline organic base. It is used as an intermediate in the synthesis of piperazine derivatives. 3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-Quinolinone can be used to acetylate phenols and amines. This compound also has been shown to be useful in the industrial production of carbostyril and other pharmaceuticals. 3,4-Dihydro-7-(4-chlorobutoxy)-2(1H)-Quinolinone is also a high yield coupling agent for the production of heterocyclic compounds such as 1,5,6,8-tetrahydropyrimidines and benzimidazoles.</p>

<p>7-Amino-4-(methoxymethyl)coumarin is a fluorogenic compound, which is synthesized chemically for bioanalytical applications. This compound serves as a substrate in enzyme assays and is particularly valuable in studying enzymatic activity due to its fluorescent properties.</p>

<p>Indole-7-methanol is a flavin cofactor that catalyses the formylation of indole-7-carboxylic acid. Indole-7-methanol can be synthesized by the conversion of indole-7-carboxaldehyde with formaldehyde and ammonium acetate. The macrocyclic, isomeric, and formylated forms of indole-7-methanol have been shown to have utilisation activity in the synthesis of various compounds. These reactions are catalyzed by flavins such as FAD or FMN. Mutant, unsymmetrical derivatives of indole-7-methanol are also known to undergo these types of reactions. The most common derivative is indirubin, which has been shown to inhibit DNA polymerase III and IV in vitro.</p>

<p>4-Methylquinoline is a natural compound that is structurally related to coumarin. It serves as an enzyme substrate for various types of enzymes, and has been shown to inhibit the activity of enzymes such as N-acetyltransferase, indoleamine 2,3-dioxygenase, and tryptophan 2,3-dioxygenase. 4-Methylquinoline has also been shown to be effective against infectious diseases such as toxoplasmosis and leishmaniasis. Furthermore, 4-methylquinoline has been shown to have anti-inflammatory properties in autoimmune diseases such as multiple sclerosis. The mechanism of action of 4-methylquinoline is not fully understood but it may interfere with the production of nitric oxide by inhibiting the enzyme nitric oxide synthase.</p>

<p>Please enquire for more information about tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-Azabicyclo[3,3,0]octane HCl is an inorganic base that is used as a catalyst for organic reactions. It is often used to convert ester hydrochlorides into chiral esters. 3-Azabicyclo[3,3,0]octane HCl has been shown to be a suitable reducing agent for the reduction of various substances. The reaction proceeds via an intramolecular process and can be used with various parameters. 3-Azabicyclo[3,3,0]octane HCl is crystalline and has a melting point of 179 degrees Celsius. It also has optical activity due to its chirality.</p>

<p>3-(2-Aminoethyl)-N-methyl-1H-indole-5-methanesulfonamide (AMIS) is an intermediate in the preparation of medicaments. It is a stable process and can be used as an intermediate for other compounds. AMIS is prepared by reacting methanesulfonic acid with methanol and ammonium carbonate, which produces methanesulfonamide, succinic acid and ammonium hydroxide. The reaction liquid is then heated to produce a crystalline solid. The crystals are then recrystallized to yield AMIS as a white solid.</p>

<p>4-Aminoquinoline-2-one is a nonsteroidal anti-inflammatory drug that has tuberculostatic activity. It binds to the nitrogen atoms of the enzyme dihydropteroate synthase, which is involved in the synthesis of folic acid and DNA. This leads to an increase in reactive oxygen species and inflammation, which causes disease activity. 4-Aminoquinoline-2-one has been shown to be synergistic with monoclonal antibodies when used as a treatment for inflammatory diseases. In order for 4-aminoquinoline-2-one to be taken up by cells, it must bind to cellular uptake proteins through hydrogen bonds or disulfide bonds.</p>

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<p>1-Methyl-1H-indole-3-carbohydrazide (MZ) is a potential anticancer drug that inhibits the growth of cancer cells. It binds to the colchicine binding site on the DNA, which prevents doxorubicin from binding and causing damage to the DNA. MZ has been shown to be effective against breast cancer and has been shown to inhibit tumor growth in mice by targeting cancer cells lines. MZ also inhibits proliferation of MDA-MB-231 cells in culture, as well as inhibiting cell cycle progression, leading to apoptosis. The molecular docking studies show that 1MZ binds to colchicine site on DNA with high affinity and specificity.</p>

<p>Vaginidiol is a coumarin derivative that inhibits the biosynthesis of estrogen, which is essential for normal development of female reproductive tissues. The structure of vaginidiol was elucidated by NMR and mass spectroscopy, and it was found to be a bergapten-coumarin derivative. Vaginidiol has been shown to have an inhibitory effect on the growth of plants. This compound can be synthesized in two steps from etoac extract by an asymmetric synthesis using potassium hydroxide as the catalyst.</p>

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<p>Please enquire for more information about 2-(2-Aminoethyl)-3',6'-bis(diethylaMino)spiro[isoindoline-1,9'-xanthen]-3-one including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 5-Bromo-3-[2-(1-pyrrolidinyl)ethyl]-1H-indole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Prenyletin methyl ether is a flavonoid compound, which is a naturally occurring polyphenolic molecule sourced primarily from specific plant species. This compound exerts its effects through a variety of biochemical interactions, notably influencing cellular signaling pathways, including antioxidative and anti-inflammatory processes.</p>

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<p>1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methyl-isoquinoline is a useful building block in the synthesis of various compounds such as pharmaceuticals and pesticides. It is an intermediate for the preparation of other valuable chemicals such as the antihistamine diphenhydramine, which is used to treat allergies. Tetrahydroisoquinoline can also be used as a reagent to synthesize other chemical compounds. This compound has been used in research as well as commercial applications. Tetrahydroisoquinoline is also a versatile scaffold that can be modified to produce different derivatives with different properties.</p>

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<p>Please enquire for more information about Methyl 3-amino-5-fluoro-1-methyl-1H-indole-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Byakangelicol methanolate is a bioactive compound, which is a derivative of furanocoumarins, typically found in various plant species. It is naturally sourced from Angelica plants, known for their rich profile of therapeutic compounds. The mode of action of Byakangelicol methanolate involves the inhibition of specific enzymes related to inflammatory pathways, potentially modulating immune responses and reducing inflammation. This compound is of significant interest due to its potential applications in developing treatments for inflammatory-related conditions and possibly other therapeutic areas. Research into Byakangelicol methanolate focuses on understanding its pharmacological properties and exploring its benefits within pharmaceuticals for treating a range of inflammatory disorders. Its ability to act on specific biological pathways might provide insights into new therapeutic mechanisms, making it a subject of interest for scientists investigating novel anti-inflammatory agents.</p>

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<p>Tetrahydroquinoline-3-carboxylic acid is a crystalline, water-soluble compound. It is an intermediate in the synthesis of l-phenylalanine, paraformaldehyde and formaldehyde. Tetrahydroquinoline-3-carboxylic acid can be hydrolyzed to produce formic acid and hydrogen chloride. This product is also optically active and can be used as an indicator for hydroiodic acid.</p>

<p>1-Benzylindole-3-carboxylic acid is a bioactive molecule that has been shown to inhibit the activity of histamine, which is a neurotransmitter involved in inflammatory reactions. 1-Benzylindole-3-carboxylic acid has an affinity ligand for binding to the H1 receptor and can be used as an antihistaminic agent. It also has antihistaminic effects by inhibiting the release of histamine from mast cells and basophils, which are two types of white blood cells that are involved in allergic reactions. The pharmacophore model for 1-benzylindole-3-carboxylic acid suggests that it could be used as an antihistamine or anticholinergic.</p>

<p>3,4-Dihydroisoquinolin-2(1H)-ylacetic acid is a chemical compound with the molecular formula of C8H11NO2. It is a useful scaffold for the synthesis of complex compounds and research chemicals. 3,4-Dihydroisoquinolin-2(1H)-ylacetic acid is also a versatile building block for the preparation of fine chemicals. It is used as a reaction component in many organic reactions and can be used as a speciality chemical or reagent due to its high quality.</p>

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<p>3-Oxabicyclo[3.1.0]hexane-2,4-dione is a cocatalyst with a molecular formula of C6H14O3. It is a synthetic compound that is used as an inhibitor in organic synthesis reactions and as a cocatalyst for the ring-opening polymerization of cyclic olefins. 3-Oxabicyclo[3.1.0]hexane-2,4-dione binds to the receptor subtype site on the benzene ring of benzoate, amines, and acid catalysts. This binding prevents the formation of an enzyme/substrate complex at the active site of the enzyme, inhibiting its activity and leading to cell death.</p>

<p>Fraxetin is a chemical compound known as a coumarin derivative, which is a natural product primarily sourced from various plant species. As a member of the coumarin family, fraxetin is often extracted from the roots, bark, and leaves of plant sources like Fraxinus species and other related flora. The compound operates through an array of biochemical pathways, prominently exhibiting antioxidant and anti-inflammatory properties. It acts by scavenging free radicals and modulating oxidative stress-related pathways, while also influencing the expression of various inflammatory cytokines.</p>

<p>5-Amino-8-hydroxyquinoline dihydrochloride (5-AQDH) is an anticancer drug that inhibits the activity of survivin, a protein that is overexpressed in cancer cells. It has been shown to be effective in vivo against melanoma tumor growth. 5-AQDH binds to the unpaired cysteine residues of the survivin molecule and inhibits its function by binding to the active site, blocking access to ATP and preventing DNA synthesis. The efficacy of 5-AQDH has been confirmed in vitro by studying the effect on cell viability and DNA synthesis, as well as by measuring plasma mass spectrometry data from melanoma patients. This drug is currently being investigated for its potential use as an anticancer agent.</p>

<p>2,3,3-Trimethyl 5-methoxy indolenine (TMMI) is a fluorescent probe that has been used in photodynamic therapy. TMMI is chemically stable and has an unsymmetrical heterocycle with optical properties that allow it to be excited by green light at wavelengths of 540 nm. TMMI can be used to image hypoxic regions of the brain. This molecule has also been used as an enhancement agent for neovascularization and angiography. TMMI can be synthesized using mesoporous silica nanoparticles and halogens such as chlorine or bromine.</p>

<p>Anhydrobyankangelicin is a coumarin derivative, which is a specialized type of organic compound commonly found in the plant family Apiaceae. This compound is biosynthetically sourced from the roots of plants such as Angelica species, where it is observed in varying concentrations. Anhydrobyankangelicin operates through interactions with several biological pathways, including modulating calcium channels and inhibiting certain enzymes involved in oxidative stress. This mechanism of action contributes to its efficacy in providing neuroprotective effects.</p>

<p>7,8-Methylenedioxycoumarin is a furanocoumarin compound, which is a type of organic molecule characterized by a coumarin core with an additional methylenedioxy group. It is primarily sourced from various plant species, particularly those in the Rutaceae family, where it is found in essential oils and extracts. The mode of action of 7,8-Methylenedioxycoumarin involves its natural fluorescing properties, making it highly valuable for use in various biochemical assays where visualization is key. Due to its unique chemical structure, it efficiently absorbs ultraviolet light and emits visible fluorescence, which is exploited in photochemistry and as a biological marker. Its applications extend to the fields of pharmaceuticals and environmental sciences, where it serves in drug development studies and as a tool for tracking organic pollutants in ecosystems. Researchers continue to explore its potential uses due to its distinctive chemical behavior and natural origin.</p>

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