Organometallic Ligands

<p>ABTL-0812 is an investigational anticancer compound, which is a synthetic small molecule with a novel mechanism of action. It is derived from the research efforts focused on targeting key metabolic pathways in cancer cells. The mode of action of ABTL-0812 involves the modulation of the Akt/mTOR pathway, leading to the induction of autophagy-mediated cell death, a process that is selectively cytotoxic to cancer cells.</p>

<p>Inhibitor of IKKβ serine kinase</p>

<p>Prostaglandin F2α receptor agonist</p>

<p>5-HT2A/C serotonin receptor antagonist; anti-migraine agent; anti-histaminic</p>

<p>TD 139 is an advanced small molecule inhibitor, which is sourced from synthetic chemical libraries designed to bind specifically to galectin-3. Galectin-3 is a type of protein that plays a significant role in various biological processes, including inflammation, fibrosis, and cancer progression. By inhibiting galectin-3, TD 139 interferes with its signaling pathways, thereby mitigating pathological processes associated with these conditions.</p>

<p>Apraclonidine is an alpha adrenoreceptor agonist that is used in the treatment of raised intraocular pressure. This drug’s mechanism of action is not fully understood however, animal and human studies suggested that Apraclonidine reduces aqueous humor production and increases uveoscleral outflow.</p>

<p>Dual inhibitor of thromboxane receptor and DP2 postanoid receptor</p>

<p>Anticholinergic drug; antagonist at muscarinic acetylcholine receptors</p>

<p>Antagonist of proto-oncogene MDM2 and its interaction with p53</p>

<p>Ubenimex is a protease inhibitor drug that is being studied for the treatment of acute myelocytic leukemia. This drug is an aminopeptidase N, B and leukotriene A4 hydrolase inhibitor. It is also used in the treatment of hypercholesterolaemia.</p>

<p>Acipimox is a niacin derivative that is used as a hypolipidemic agent. Acipimox prevents the liver from producing triglycerides and from secreting VLDL, which indirectly results in a slight decrease in LDL and an increase in HDL. Also, it stimulates leptin release and improves insulin sensitivity.</p>

<p>Inhibitor of Flk-1/KDR receptor tyrosine kinases, a vascular endothelial growth factor receptor (VEGF) receptor expressed on precursor and mature forms of endothelial cells. SU 5416 also inhibits other tyrosine kinases, including c-KIT and FLT-3. Has therapeutic potential as an anti-angiogenic agent for the treatment of cancer.</p>

<p>CLP257 is a synthetic compound characterized as an inhibitor of chloroplastic RNA polymerase. It is derived from a systematic chemical synthesis process involving the rational design of inhibitory molecules targeting chloroplastic transcriptional machinery. This product acts by binding to the RNA polymerase complex, effectively disrupting the transcription process within chloroplasts. The inhibition occurs through allosteric modulation, where CLP257 induces conformational changes that impede the enzyme's ability to synthesize RNA.</p>

<p>(S)-2-Amino-3-(methylamino)propanoic acid hydrochloride is a synthetic compound often used in scientific research. It is derived from non-proteinogenic amino acids and has important implications for the study of neurotoxicology. This compound mimics the structural properties of certain naturally occurring amino acids, which allows it to act as a significant tool for understanding biological pathways affected by neurotoxins.</p>

<p>Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.</p>

<p>Modulator of S1P receptor</p>

<p>Agonist of H3 and H4 receptors</p>

<p>Bexarotene is a retinoid and antineoplastic agent that is used for the treatment of solid tumours and t-cell lymphomas. It inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin and research has shown that it induces tumor regression in vivo in some animal models.</p>

<p>Moracin C is a prenylated flavonoid, which is a type of naturally occurring compound. It is derived from the Morus genus, commonly known as mulberry trees. This compound functions primarily as an antioxidant, showing activity that may protect cells from oxidative stress by neutralizing free radicals.</p>

<p>Inhibitor of Hsp90 chaperone protein; anti-neoplastic</p>