Organometallic Ligands

<p>(1S,2S,3S,4R)-3-[(1E,3E)-5-(3-Chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3-methylpenta-1,3-dien-1-yl]-2,3,4-trimethyl-5-oxocyclohexyl acetate is a synthetic organic compound, classified as a complex polyunsaturated ester. It originates from intricate chemical synthesis processes that involve the assembly of various functional groups, each contributing to its chemical reactivity and biological activity. The compound exhibits a unique mode of action, potentially interacting with specific enzymes or receptors due to its structural configuration, such as the presence of a cyclohexyl ring and multiple double bonds, which may facilitate binding or catalysis.</p>

<p>ICG-001 is a small molecule inhibitor that specifically targets the Wnt/β-catenin signaling pathway. This compound is derived from a rational drug design approach aimed at disrupting the interaction between β-catenin and its coactivator cyclic AMP response element-binding protein (CBP). By selectively inhibiting this interaction, ICG-001 effectively downregulates the transcriptional activity mediated by β-catenin without affecting its structural role in cell adhesion.</p>

<p>Lp-PLA2-IN-1 is a small molecule inhibitor, which is derived from chemical synthesis, designed to specifically inhibit the activity of lipoprotein-associated phospholipase A2 (Lp-PLA2). This enzyme is involved in the hydrolysis of oxidized phospholipids on low-density lipoproteins (LDL), leading to the production of pro-inflammatory mediators. The mode of action involves the selective binding to the active site of Lp-PLA2, thus preventing the enzyme from catalyzing its reaction and subsequently reducing the formation of pro-inflammatory lysophosphatidylcholine and oxidized free fatty acids.<br><br>The primary application of Lp-PLA2-IN-1 is in the study of cardiovascular diseases, where Lp-PLA2 has been identified as a biomarker and therapeutic target due to its role in the pathogenesis of atherosclerosis. By inhibiting Lp-PLA2, this compound aids in reducing vascular inflammation, thereby potentially decreasing the risk of atherosclerotic plaque development and rupture. Researchers utilize this inhibitor to validate the involvement of Lp-PLA2 in disease states and to explore therapeutic strategies aimed at mitigating cardiovascular risk factors.</p>

<p>PF 06371900 is an investigational therapeutic agent, which is a synthetic small-molecule inhibitor. It is derived from advanced chemical synthesis designed to target specific molecular pathways. The mode of action involves selective binding and inhibition of a particular enzyme, which plays a critical role in the proliferation of certain cancer cells. By inhibiting this enzyme, PF 06371900 disrupts the cellular processes required for tumor growth and survival.</p>

<p>Please enquire for more information about EN460 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PX 20350 is a synthetic antimicrobial compound, specifically designed for use in various scientific and industrial applications. This compound is derived from advanced chemical synthesis techniques and is structured to target and inhibit microbial growth effectively. The mode of action of PX 20350 involves disrupting cell wall integrity and interfering with essential microbial metabolic processes, which leads to the eradication of a wide range of bacteria and fungi.</p>

<p>Gne 220 hydrochloride is a synthetic small molecule compound, which is developed through advanced chemical synthesis processes. This compound serves as an inhibitor of specific cellular receptors, acting through targeted interaction with these receptors to modulate their signaling pathways effectively. The inhibition mechanism involves the competitive binding to the receptor sites, significantly impacting downstream biological processes.</p>

<p>5-(5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl)pyridine-3-sulfonamide is a quinazoline derivative, which is a synthetic compound developed through rational drug design. The source of this compound is primarily through organic synthesis involving multi-step chemical reactions tailored to introduce functional groups that are critical for its biological activity.</p>

<p>Ciliobrevin D is a small molecule inhibitor, which is derived from synthetic chemical sources, specifically designed to target the function of dynein, a motor protein. It acts by inhibiting the ATPase activity of dynein, which is critical for its motor functions including cargo transport along microtubules. By impeding this action, Ciliobrevin D serves as a valuable tool in cellular and molecular biology research to probe the roles of dynein in various cellular processes.<br><br>Used primarily in the study of cytoskeletal dynamics and intracellular transport mechanisms, Ciliobrevin D facilitates the investigation of dynein-related pathways. It is instrumental in elucidating the roles of dynein in processes such as mitosis, ciliary and flagellar motion, and neuronal function. Researchers employ this inhibitor to dissect the contributions of dynein-mediated transport in normal physiology and in disease states where motor protein function may be compromised, thus offering insights into potential therapeutic targets.</p>

<p>Nebicapone is a pharmaceutical compound that functions as a catechol-O-methyltransferase (COMT) inhibitor. Developed through synthetic chemistry processes, it has been formulated to study its effects on neurotransmitter metabolism. By inhibiting COMT, Nebicapone decreases the breakdown of catecholamines such as dopamine. This mechanism of action leads to increased levels of these neurotransmitters in the central nervous system, making it a valuable tool for understanding neurological functions and disorders.</p>

<p>Clothiapine is a psychotropic agent, which is a type of drug used in psychiatry. It is sourced from the dibenzothiazepine class of compounds. As a thioxanthene derivative, clothiapine acts as a dopamine receptor antagonist, specifically targeting D2 receptors. This mode of action results in its antipsychotic effects by modulating neurotransmitter pathways in the brain, particularly those involving dopamine, which is often implicated in psychiatric disorders.</p>

<p>AMT Hydrochloride is a synthetic tryptamine compound, which is derived from chemical synthesis methods. It is an analogue of alpha-methyltryptamine (AMT), specifically the hydrochloride salt form, enhancing its stability and solubility for laboratory settings. The mode of action involves acting as a non-selective agonist at serotonin receptors, primarily targeting the 5-HT2C and 5-HT2A receptors. This interaction results in psychoactive effects through the modulation of neurotransmitter systems, impacting serotonin pathways.</p>

<p>C8 Ceramide (d17:1/8:0) is a synthetic analog of natural ceramide, which is a type of sphingolipid. It is derived through chemical synthesis, mimicking the structure of naturally occurring ceramides found in cell membranes and the stratum corneum of the skin. The product incorporates a short acyl chain, which affects its solubility and facilitates specific experimental applications.</p>

<p>MS 15203 is a specialized biochemical reagent, which is a synthetically derived compound with a high degree of purity suitable for laboratory applications. This product functions primarily through specific interactions with biological molecules, allowing it to facilitate precise biochemical reactions or analyses. Its molecular design provides consistency in performance, making it a reliable component in various experimental protocols.</p>

<p>ML348 is a chemical compound that functions as a potent MDM2 antagonist, which originates from advanced medicinal chemistry research focused on cancer therapeutics. MDM2 is a primary negative regulator of the tumor suppressor protein p53, and ML348 disrupts the interaction between MDM2 and p53, thereby enhancing p53's tumor-suppressing activities.</p>

<p>(2,5-Dioxopyrrolidin-1-yl) 4-[4-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutyl]-1,4-diazoniabicyclo[2.2.2]octan-1-yl]butanoate, dibromide is a chemical compound that functions as a bifunctional cross-linking agent. It is synthesized through the reaction of specific amine and carboxylic acid compounds under controlled conditions. The compound features N-hydroxysuccinimide esters and quaternary diazabicyclooctane groups, enhancing its reactivity and solubility.</p>

<p>Gpr84 antagonist 8 is a small molecule inhibitor, which is synthetically derived, with a specific mode of action targeting the G protein-coupled receptor 84 (GPR84). This antagonist functions by inhibiting the receptor's signaling pathways, which are primarily associated with the modulation of inflammatory and metabolic processes. GPR84 is activated by medium-chain fatty acids and plays a significant role in immune cell regulation, particularly in monocytes and macrophages.</p>

<p>SRT3025 Hydrochloride is a synthetic small molecule, which is developed as an activator of the SIRT1 enzyme. SRT3025 is derived from chemical synthesis, designed specifically to modulate enzymatic activity associated with aging and metabolic regulation. The compound functions by enhancing the deacetylase activity of the SIRT1 enzyme, a member of the sirtuin family, which plays a crucial role in cellular processes related to longevity and metabolic regulation.</p>

<p>ML150 is a chemical compound, which is a synthetic molecule developed through advanced organic synthesis. The product operates as an allosteric inhibitor of a specific enzyme, modulating its activity through non-competitive binding. This mechanism allows for a highly selective interaction with the enzyme, altering its conformation and thereby influencing its function in a controlled manner.</p>

<p>Hdhodh-in-1 is an advanced analytical tool designed for conducting multidimensional data analysis, which is sourced from integrative computational methodologies. With a focus on high-dimensional datasets, it operates through a sophisticated algorithm that efficiently processes and integrates various data types, including genomic, proteomic, and metabolomic information.</p>

<p>AZ-33 is a synthetically optimized biochemical compound, which is derived from naturally occurring plant alkaloids. With a robust mode of action, AZ-33 functions by selectively inhibiting specific enzymatic reactions, allowing precise modulation of metabolic pathways. This selectivity is achieved through its affinity for enzyme binding sites, where it interferes with substrate interactions.<br><br>The compound is used primarily in the field of biochemical research, where it serves as a critical tool in the exploration of metabolic processes and enzymatic functions. By providing insights into enzyme-related pathways, AZ-33 supports the development of potential therapeutic strategies and enhances the understanding of complex biochemical phenomena. Its applications extend to various domains, including pharmacology, molecular biology, and systems biology, making it an invaluable asset for exploratory research and experimental investigations in these fields.</p>

<p>Bitopertin is a glycine reuptake inhibitor, which is sourced from the development of selective central nervous system agents. It works by inhibiting the glycine transporter type 1 (GlyT1), thereby increasing extracellular glycine levels, particularly in regions with high densities of NMDA receptors. This modulation of glycine levels plays a crucial role in enhancing NMDA receptor function, which is pivotal for synaptic plasticity and neurotransmission.</p>

<p>TC-A2317 hydrochloride is a selective nicotinic acetylcholine receptor (nAChR) agonist, which is synthesized through chemical methods. It acts by specifically targeting nAChRs, which are ionotropic receptors predominantly found in the central nervous system and peripheral nervous system. These receptors are ligand-gated ion channels that, upon activation by agonists like TC-A2317 hydrochloride, result in increased neuronal excitability and neurotransmitter release.</p>

<p>PF-06263276 is an investigational compound, classified as a small molecule inhibitor, which is derived from pharmaceutical synthesis. It functions primarily through selective inhibition of specific kinases, potentially modulating signaling pathways involved in various cellular processes. The compound's mechanism of action involves binding to the ATP-binding site of target kinases, thus preventing phosphorylation events critical for signal transduction.</p>

<p>(+)-Etomoxir sodium salt hydrate is a chemical compound classified as a carnitine palmitoyltransferase 1 (CPT1) inhibitor, which is a compound derived synthetically. Its mode of action involves the inhibition of the enzyme CPT1, which is pivotal in the transport of long-chain fatty acids into the mitochondria for β-oxidation. This inhibition effectively blocks fatty acid oxidation pathways, leading to alterations in metabolic states.Etomoxir is commonly utilized in scientific research to study metabolic processes, particularly those related to energy metabolism and metabolic disorders. It serves as a valuable tool in exploring mechanisms involved in diabetes, obesity, and cardiovascular diseases by allowing researchers to scrutinize the metabolic adaptations to impaired fatty acid oxidation. Furthermore, it is used in cellular and animal models to investigate metabolic inflexibility and mitochondrial function. Its application extends to cancer research, where metabolic reprogramming is a focus, aiding in the understanding of tumor progression and potential therapeutic interventions targeting metabolic pathways.</p>

<p>Varlitinib is a small molecule tyrosine kinase inhibitor, which is derived from synthetic chemical processes. Its mode of action involves the selective inhibition of the human epidermal growth factor receptor (HER) family, including EGFR, HER2, and HER4, thereby disrupting key signaling pathways involved in cancer cell proliferation and survival. This multi-targeted approach allows Varlitinib to effectively impede the growth and spread of cancer cells by interfering with critical intracellular signaling networks.</p>

<p>Erastin2 is a small molecule, which is a synthetic compound designed to induce ferroptosis, a form of regulated cell death. It is derived through chemical synthesis and belongs to the class of compounds known as ferroptosis inducers. The mode of action of Erastin2 involves the selective inhibition of the cystine/glutamate antiporter, also known as the system Xc-. This inhibition leads to depletion of intracellular cysteine and subsequent disruption of glutathione synthesis, ultimately resulting in the accumulation of reactive oxygen species (ROS) and lipid peroxidation.</p>

<p>Iloperidone hydrochloride is an atypical antipsychotic medication, which is a synthetic compound derived from the chemical class of benzisoxazole derivatives. The mode of action involves its antagonistic effects on various neurotransmitter receptors in the central nervous system, notably the serotonin 5-HT2A and dopamine D2 receptors. This dual mechanism balances neurotransmitter activity, potentially mitigating both positive and negative symptoms associated with schizophrenia.</p>

<p>GQ-16 is a synthetic photoinitiator, which is typically derived from advanced chemical synthesis processes involving aromatic ketones or similar compounds. Its primary mode of action involves the absorption of ultraviolet (UV) light to generate free radicals. These radicals then initiate polymerization by opening the double bonds in monomers, leading to the formation of polymers.</p>

<p>C11 Topfluor dihydroceramide is a fluorescent lipid analog, which is synthesized as a derivative of natural sphingolipids, incorporating a bright fluorophore into the ceramide structure. This modification allows for the visualization of ceramide metabolism and distribution within cellular systems. The C11 Topfluor dihydroceramide retains the core structural components of ceramides while adding a fluorescent tag, enabling researchers to track its pathway and interactions in real-time using fluorescence microscopy.</p>

<p>NVP-BEP800 is a small molecule inhibitor, which is a synthetic compound designed to target specific proteins. This product is developed by Novartis and falls under the category of Hsp90 inhibitors. Hsp90, or Heat Shock Protein 90, is a molecular chaperone involved in the proper folding, stability, and function of many client proteins, many of which are implicated in cancer progression. NVP-BEP800 binds to the ATP-binding site of Hsp90, thereby inhibiting its chaperone activity.</p>

<p>Mardepodect hydrochloride is a small molecule compound, which is a synthetic derivative developed for pharmacological applications. It is sourced from chemical synthesis processes, enabling precise control over its structural and functional properties. The mode of action of Mardepodect hydrochloride involves modulation of specific receptor pathways, potentially affecting signaling mechanisms within cellular systems. This modulation can lead to alterations in various physiological processes, making it a compound of interest in therapeutic research.<br><br>The primary uses and applications of Mardepodect hydrochloride are in the realm of experimental and therapeutic research. It is particularly valuable in studies aiming to elucidate receptor functions and their downstream effects in various biological contexts. Researchers utilize this compound to investigate potential therapeutic pathways, with a focus on optimizing interventions for conditions that involve dysregulated receptor activity. Such studies contribute to the broader understanding of receptor-targeted therapies and the development of new pharmacological strategies.</p>

<p>CPA inhibitor is a biochemical compound designed to selectively inhibit carboxypeptidase A (CPA), a metalloenzyme implicated in various physiological and pathological processes. It is typically sourced from synthetic chemical libraries or derivative natural compounds, characterized by their high specificity and affinity for the active site of CPA. The mode of action involves binding to the metalloenzyme’s active site, thereby obstructing substrate access and reducing enzymatic activity.</p>

<p>M 1145 is a monoclonal antibody, which is derived from a highly specific and engineered immunoglobulin source. Its mode of action involves targeting and modulating specific immune cell receptors, disrupting signaling pathways that are critical for the activation and proliferation of these cells. As a result, it can effectively modulate immune responses, making it a promising candidate for therapeutic applications in autoimmune diseases and certain types of cancers.</p>

<p>1,2-Dimyristoyl-sn-glycero-3-phosphocholine-N,N,N-trimethyl-d9 is a deuterium-labeled phospholipid, which is a synthetic construct designed for biochemical research. This compound is sourced through chemical synthesis, where specific hydrogen atoms in the molecule are replaced with deuterium, enhancing its utility in specialized analytical techniques. The deuterium labeling facilitates the compound's use in nuclear magnetic resonance (NMR) spectroscopy, as it reduces background proton signals and enhances resolution.</p>

<p>Palonidipine is an experimental pharmaceutical compound classified as a calcium channel blocker, which is derived from synthetic chemical processes. This product functions by inhibiting the influx of calcium ions through L-type calcium channels located on the vascular smooth muscle cells and cardiac myocytes. By blocking these channels, Palonidipine causes vasodilation, reducing systemic vascular resistance, and thereby lowering blood pressure.</p>

<p>CRA 026440 is a synthetic compound utilized in biochemical research, functioning primarily as an enzyme inhibitor, derived from complex organic synthesis. This compound acts by binding to the active site of a target enzyme, thereby preventing substrate interaction and inhibiting its biological activity. This mode of action is critical for understanding enzyme mechanisms and regulating metabolic pathways in various research contexts.</p>

<p>5-Chloro-2-methyl-3-isothiazolone-d3 is a deuterated form of the chemical compound 5-chloro-2-methyl-3-isothiazolone, often employed in specialized research settings. This compound is derived synthetically and isotopically labeled for accurate tracking in various analytical applications. The incorporation of deuterium atoms in place of hydrogen allows for enhanced detection and precise identification in mass spectrometry-based analyses.</p>

<p>(2Z)-2-(8-Methoxy-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,8,10,12-hexaen-2-ylidene)acetic acid is a synthetic small molecule, designed as a specialized compound for targeting specific biochemical pathways. It is derived through precision chemical synthesis, ensuring high purity and efficacy. The compound acts by modulating certain receptor activities, altering signal transduction mechanisms at a cellular level. This modulation may influence various biological processes, making it a candidate for research in therapeutic applications.</p>

<p>ML 3403 is a small-molecule inhibitor that targets specific protein kinases, designed for biochemical and cellular research. It is a synthetic compound derived through rigorous medicinal chemistry optimization, focusing on achieving high specificity and potency. The mode of action involves competitive inhibition of the ATP-binding sites of targeted kinases, thereby blocking their catalytic activity and subsequent signaling pathways.</p>

<p>ML365 is an advanced data analysis tool developed to support machine learning workflows. It is designed using proprietary algorithms from cutting-edge computational research, intended to optimize and automate various stages of the machine learning pipeline with exceptional efficiency.</p>

<p>GNE-9278 is a small molecule inhibitor, which is a synthetic compound with a specific mechanism of action. It operates by selectively targeting and inhibiting a particular protein kinase involved in oncogenic signaling pathways. This inhibition disrupts aberrant signaling cascades that are crucial for tumor growth and progression, thereby exerting antitumor effects.</p>

<p>NPE-caged-HPTS is a photoreactive fluorescent pH indicator, which is a synthetic compound with a precisely engineered molecular structure. Its source originates from organic chemistry laboratories specializing in the development of photolabile caged compounds. The mode of action involves a photochemical reaction induced by ultraviolet light, which cleaves the caging group, releasing the active form of the pH-sensitive fluorescent dye, 8-hydroxypyrene-1,3,6-trisulfonic acid (HPTS).</p>

<p>CDK12-IN-3 is a selective inhibitor targeting Cyclin-Dependent Kinase 12 (CDK12). It is synthesized as a small molecule compound designed for research and therapeutic exploration. The action of CDK12-IN-3 involves the inhibition of CDK12, a kinase crucial for regulating transcription elongation and mRNA processing, particularly in genes with large transcription units. By inhibiting CDK12, CDK12-IN-3 affects the transcriptional program responsible for DNA damage response and repair pathways.<br><br>The applications of CDK12-IN-3 are primarily within cancer research, where it serves as a valuable tool to study the role of CDK12 in tumorigenesis. Given the involvement of CDK12 in maintaining genomic stability, its inhibition provides insights into vulnerabilities in cancer cells that can be exploited for therapeutic interventions. Research employing CDK12-IN-3 can lead to the development of novel strategies for targeting cancers with specific genetic backgrounds or resistance mechanisms. As a research compound, CDK12-IN-3 facilitates both basic science and translational studies aiming to improve our understanding of cancer biology and treatment options.</p>

<p>Consists of a long alkyl tail and amidosulfobetaine headgroup.  Used as rehydration buffer for proteomic sample preparation from Leishmania donovani.  Also used for protein solubilisation.</p>

<p>ABT 925-d6 fumerate is a deuterated chemical compound, which serves as a stable isotope-labeled reagent. It is synthesized through the substitution of hydrogen atoms with deuterium in the fumerate moiety, offering increased stability for analytical applications. The incorporation of deuterium enhances the compound's resistance to metabolic degradation and allows for precise tracking in biological systems via mass spectrometry.</p>

<p>Please enquire for more information about ML753286 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PF 998425 is a synthetic compound used as a potent biochemical agent, which is developed through advanced organic synthesis processes. Its mode of action involves selective modulation of specific receptors within biological systems. As a receptor modulator, PF 998425 interacts intricately with its target sites, facilitating the study of signal transduction pathways and receptor-ligand interactions.</p>

<p>PF-04929113 (Mesylate) is a small molecule inhibitor, which is derived from synthetic sources, designed to target the phosphoinositide 3-kinase (PI3K) pathway with high specificity and potency. This compound exerts its mode of action through the inhibition of PI3K activity, a pivotal signaling molecule involved in multiple cell processes including growth, metabolism, and survival. By blocking PI3K, PF-04929113 disrupts downstream signaling pathways, leading to reduced cellular proliferation and inducing apoptosis in cancer cells.</p>

<p>DO34 analog is a biochemical compound, which is synthesized from organic sources to mimic specific biochemical pathways. Its mode of action involves selective modulation or inhibition of enzyme activity, allowing researchers to study various biological processes in vitro and in vivo. The compound is often utilized in fields such as biochemistry, pharmacology, and molecular biology for its ability to influence cellular mechanisms.</p>