Organometallic Ligands

PPARγ antagonist

ST 2825 is a synthetic dye, which is a laboratory-established chemical compound with specific staining properties. Its source lies in advanced organic chemistry techniques designed to produce bright and consistent coloration under various conditions. The mode of action involves the selective binding to certain cellular structures, facilitating the visualization of biological samples during microscopy.

Platinum-based anti-cancer agent; induces apoptosis

Durlobactam sodium is a β-lactamase inhibitor, which is a synthetic compound designed to enhance the efficacy of β-lactam antibiotics. It is sourced through chemical synthesis, allowing precise control over its structural and pharmacological properties. Durlobactam sodium functions by inhibiting the activity of β-lactamase enzymes produced by resistant bacterial strains. These enzymes typically degrade β-lactam antibiotics, rendering them ineffective. By blocking this enzymatic action, durlobactam sodium protects the antibiotic, restoring and even enhancing its bacterial killing ability.

Inhibitor of sulphonylurea receptor SUR1; hypoglycemic agent

ALK receptor tyrosine kinase inhibitor

Setmelanotide acetate is a synthetic peptide-based product, which is derived from a sequence optimized to activate the melanocortin 4 receptor (MC4R). This receptor is a critical component of the central nervous system pathways involved in energy homeostasis and body weight regulation. Setmelanotide acetate functions as an MC4R agonist with a selective binding profile that promotes receptor activation.

Serotonin 5-HT3 receptor antagonist; anti-emetic

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Telmisartan is a drug that belongs to the angiotensin II receptor antagonist class. It acts by blocking the binding of angiotensin II to its receptors, thereby inhibiting the activation of angiotensin-converting enzyme, thus causing the blood vessels to relax. Telmisartan has been shown to reduce blood pressure and improve lipid profiles in patients with hypertension and hyperlipidaemia. Furthermore, this drug has anti-inflammatory properties and with research may be useful in treating infectious diseases.

Baricitinib is a Janus kinase inhibitor (JAK) currently used as monotherapy in the treatment of rheumatoid arthritis. Barictinib is also recommened for the treatment of atopic dermatitis and systemic lupus erythematosus. In mice interestingly, the administration of baricitinib reduced the inflammatory effects induced by a high-sugar diet on the metabolism.
Baricitinib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

SC144 hydrochloride is a small molecule inhibitor, which is synthetically derived and developed to target specific signaling pathways in cancer cells. This compound acts as an inhibitor of gp130, a co-receptor involved in the interleukin-6 (IL-6) family cytokine signaling. It effectively disrupts the downstream activation of the JAK/STAT3 pathway, which is often upregulated in various cancer types, contributing to tumor growth and survival.

Olaparib is a small molecule inhibitor of DNA polymerase and topoisomerase, which are enzymes that maintain the integrity of DNA. Olaparib inhibits the proliferation of cancer cells by preventing the synthesis of DNA, RNA, and proteins. Olaparib has been shown to be effective against breast cancer tissues in mouse models. It also has minimal toxicity in humans and has been shown to inhibit the growth of diseased cells with significant cytotoxicity.

Amlodipine is a synthetic vasodilator that has antihypertensive and antianginal affects. It belongs to a group of drugs called calcium channel blockers and works by blocking the movement of calcium ions into cells in the heart and blood vessels. It is used for the treatment of hypertension and angina.

Cisapride is a type of drug that is used for the treatment of heartburn associated with gastroesophageal reflux disease. This drug acts as a serotonin 5-HT4 receptor agonist that promotes the release of acetylcholine neurotransmitters. This results in a relaxation of the pyloric sphincter and an increase in gastric emptying.

Rho/MRTF/SRF mediated gene transcription inhibitor

Baclofen is a GABA-ergic agonist drug that is used to manage severe spasticity of the cerebral and spinal origin in patients. The exact action of this drug is unclear however it is said that Baclofen inhibits the transmission of both mono- and polysynaptic reflexes at the spinal cord, relaxing spasticity.