Organosilicon Compounds

<p>Applications 4-[[[(1,1-Dimethylethyl)diphenylsilyl]oxy]methyl]-2,2-dimethyl-1,3-dioxolane is an intermediate in the synthesis of 1,2-Dioleoyl-rac-glycerol (D482175), which is an analog of 1,3-Dioleoylglycerol (D484210) which is used in the synthesis of amphiphilic gadolinium complexes as MRI contrast agents.<br>References Accardo, A., et. al.: J. Mater. Chem. B., 1, 617 (2013)<br></p>

<p>Applications (4-Ethynylphenyl)trimethylsilane (cas# 16116-92-0) is a useful research chemical.<br></p>

<p>Applications Benzo[b]thien-3-ylboronic acid is used in the synthesis and evaluation of dual wavelength fluorescent benzo[b]thiophene boronic acid derivatives for sugar/glycoprotein sensing.<br>References Akay, S., et al.: Chem. Biol. Drug Des., 70, 279 (2007)<br></p>

<p>Applications Furan-2-boronic acid<br></p>

<p>Applications 3-(2-Hydroxypropan-2-yl)phenylboronic acid<br></p>

<p>Applications N-Pentylboronic Acid is used in the synthesis of (-)-Δ8-THC and (-)-Δ9-THC. Also it aids in the synthesis of boronic acid inhibitors of endothelial lipase.<br>References O'Connell, D. et al.: Bioorg. Med. Chem. Lett., 22, 1397 (2012); Cheng, L. et al.: Org. Lett., 15, 764 (2013);<br></p>

<p>Applications Dimethoxy(methyl)silane (cas# 16881-77-9) is a useful research chemical.<br></p>

<p>Applications Trimethylboroxin (50% Solution in THF) is used in a diverse array of areas, including as a polymerization additive. Trimethylboroxin is also used in the preparation of CBS catalysts for asymmetric reductions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gilmore, N., et al.: Tetrahedron Asy., 14, 2115 (2003); Najera, C., et al.: Adv. Synth. Catal., 346, 1798 (2004);<br></p>

<p>Applications Bromotrimethylsilane is used as a reagent in the synthesis of α-carboxy nucleoside phosphonate analogs as HIV reverse transcriptase-targeting agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Keane, S.J., et al.: J. Org. Chem., ahead of print (2014)<br></p>

<p>Applications Methylboronic Acid is a methylated derivative of boronic acid, a building block towards various intermediates in suzuki coupling.<br>References Baker, J. O., et al.: Biochem.. 22, 2098 (1983); Garner, C.W., et al.: J. Biol. Chem., 255, 5064 (1980)<br></p>

<p>Applications 4-(Dihydroxyborophenyl)acetylene is a reagent used in organic synthesis . It is used in the preparation of purine analogs as PI4K IIIβ inhibitors used in cancer treatment. As well, used in the preparation of demethylase inhibitors for their potential as anti-tumor drugs.<br>References Sala, M. et al. Bioorg. Med. Chem. Lett., 26, 2706 (2016); Wu, F. et al.: J. Med. Chem., 59, 253 (2016);<br></p>

<p>Applications Ethynylboronic Acid MIDA Ester is a useful reagent in preparatino of borono-substited 1(2H)-isoquinolinones by rhodium-catalyzed cycloaddition.<br>References Wang, H., et al.: J. Am. Chem. Soc., 134, 19592 (2012);<br></p>

<p>Applications Isopropenylboronic Acid Pinacol Ester, can be used as an intermediate in the synthesis of variety of cyclic and acyclic organic compounds. It is also shown that the α-Substituted Allyl/Croty of this compound can be used for highly Diastereo- and Enantioselective allylboration of aldehydes.<br>References Salaun, J. et al.: Topics in Curr. Chem. 1, 144 (1988); Chen, J. et al.: J. Amer. Chem. Soci., 135, 5316 (2013);<br></p>

<p>Applications Ethynyltrimethylsilane is used in the production of novel histone deacetylase inhibitors for the treatment of Freidreich’s ataxia. It also aids in the preparation of conjugated polymers with sn anthracene backbone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xu, C. et al.: Pharmaceu. 4, 1578 (2011); Kobayashi, E. et al.: J. Polym. Sci. Part A: Polym. Chem., 28, 2641 (1990);<br></p>

<p>Applications 3-O-tert-Butyldimethylsilyl-cholest-5-ene-3-ol 24-(2-hydroxyisopropyl) 24-Phenyl Sulfinate is an intermediate in the preparation of Campesterol (C155360).<br></p>

<p>Applications 5-Aminoboronphthalide is used as a reactant in the preparation of 2,1-benzoxaborole peptide isoquinoline derivatives as HCV NS3 protease inhibitors. It is also used as reactant in the synthesis of nanocarrier for chemomechanically driven guest delivery fueled by intracellular ATP.<br>References Li, X., et al.: Bioorg. Med. Chem. Lett., 21, 2048 (2011); Biswas, S., et al.: Nat. Chem., 5, 613 (2013);<br></p>

<p>Applications 2-Carboxyfuran-5-boronic acid, pinacol ester<br></p>

<p>Applications Allylboronic acid pinacol ester<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-(Cyanophenyl)boronic Acid Pinacol Ester is used to prepare arylparacyclophanes via Suzuki aryl cross-coupling of bromoparacyclophane with arylboronic acid and arylboronates. It’s also used to prepare tyrosine-modified analogs of α4β7 integrin inhibitor biotin-R8ERY.<br>References Roche, A., et al.: Org. Biomol. Chem.,, 3, 515 (2005); Papst, S., et al.: Bioorg. Med. Chem., 20, 5139 (2012)<br></p>

<p>Applications (2-Ethynylphenyl)boronic acid<br></p>

<p>Applications 1,1,1,5,7,7,7-Heptamethyl-3,3-bis[(trimethylsilyl)oxy]tetrasiloxane is used in the analysis of organosilicon compounds (eg hexamethyldisiloxane) using gas chromatography or mass spectrometry.<br>References Wurst, M., et al.: Chromatographia, 6, 359 (1973), Wurst, M.: Chemicky Prumysl, 22, 124 (1972)<br></p>

<p>Applications Tetrabutylammonium tetrafluoroborate (cas# 429-42-5) is a useful research chemical.<br></p>

<p>Applications m-Carborane, 98% (cas# 16986-24-6) is a useful research chemical.<br></p>

<p>Applications Benzothiophene-5-boronic acid<br></p>

<p>Applications 3,4-Dihydro-2H-1,4-benzoxazine-7-boronic acid pinacol ester is a useful intermediate for the synthesis of naphthamides which functions as VEGFR-2 kinase inhibitors for cancer treatment.<br>References Lv, Y., et al.: ACS Med. Chem. Lett., 5, 592 (2014)<br></p>

<p>Applications (2,3,4-Trimethoxyphenyl)boronic Acid is a reagent used in the synthesis of heteroaryl, mono and bicyclic compounds which may be used as inhibitors for EGF and PDGF receptor tyrosine kinases. Also used in the synthesis of non-steroidal CYP 17 inhibitors in the treatment of prostate cancer<br>References Hutschenreuter, T. et al.: J. Enz. Inhib. Med. Chem., 19, 17 (2004);<br></p>

<p>Applications 2-tert-Butyldimethylsilyloxyethyl Tosylate is an intermediate in the synthesis of Everolimus (E945400), which is Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),<br></p>

<p>Applications (5-Formylfuran-2-yl)boronic Acid is a reagent used in Suzuki cross-couplings with deactivated aryl bromides and activated aryl chlorides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trinh, T. N., et al.: Org. Biomol. Chem., 12, 9562-9571 (2014);<br></p>

<p>Applications 3-Formylphenylboronic Acid is a reactant in the synthesis of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gosmini, R., et. al.: J. Med. Chem., 57, 8111 (2014)<br></p>

<p>Applications 1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-ol is used as a reagent in the synthesis of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease.<br>References Ding, C.Z., et al.: Bioorg. Med. Chem. Lett., 20, 7317 (2010)<br></p>

<p>Applications Nitrosyl Tetrafluoroborate is a reagent in the formation of miRNA-34a-conjugated magnetic nanovectors which shows therapeutic effects by inhibiting cellular migration and invasion through CD44 gene suppression.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lee, H., et al.: J. Nanosci. Nanotechnol., 16, 12939-12946 (2016);<br></p>

<p>Applications 1-Butenylboronic Acid is a reagent used in the synthesis of polyene natural products.<br>References Lee, S. J., et al.: J. Am. Chem. Soc., 130, 466-468 (2008)<br></p>

<p>Applications B-(9-Phenyl-9H-carbazol-3-yl)boronic Acid is used in the synthesis of alkyl-functionalized organic dyes.<br>References Lee, E. et al.: Bull. Kor. Chem. Soc., 33, 293 (2012);<br></p>

<p>Applications Stigmasteryl-O-tert-butyldimethylsilane Ferulate is an intermediate used in the synthesis of Stigmasteryl Ferulate (S686768), which is used for purification and identification of components of γ-oryzanol in rice bran oil.<br>References Xu, Z., et al.: J. Agric. Food Chem., 47, 2724 (1999);<br></p>

<p>Applications tert-Butyl-(3-iodo-1,1-dimethyl-propoxy)-dimethyl-silane (cas# 105262-85-9) is used as a reagent in the preparation of Methyl Acetoacetate.<br>References Heslin, J. C., et al.: J. Chem. Soc. [Perkin 1]. 6, 1417 (1988)<br></p>

<p>Applications 5-Bromopentylboronic Acid<br></p>

<p>Applications (3-Aminopropyl)trimethoxysilane is used in the synthesis of aspirin imprinted polymer on silica gel surface and appreciation on drug sustained release. Fluorine-doped; lectin functionalized ZnO nanoarrays as 3D nano-biointerface for bacterial detection.<br>References Lu, P., et al.: Gaofenzi Cailiao Kexue Yu Gongcheng, 33, 130 (2017); Zheng, L., Talanta, 167, 600 (2017)<br></p>

<p>Applications 4-Acetylphenylboronic acid4-Acetylphenylboronic Acid is used in several metal catalyzed cross-coupling reaction studies.<br>References Saito, S., et al.: J. Org. Chem., 2, 8024 (1997); Sakai, M., et al.: Organomet., 16, 4229 (1997); Molander, G., et al.: J. Org. Chem., 68, 4302 (2003);<br></p>

<p>Applications Perphenylcyclopentasilane is an intermediate in the synthesis of Cyclopentasilane (C988380), a reagent used for depositing silicon on surfaces for electronics applications.<br>References Morisaki, Y., et al.: Chem. Lett., 38, 498 (2009);<br></p>

<p>Stability Volatile<br>Applications Allyltrimethylsilane is used in the allylation of aldehydes, imines, allylic and benzylic alcohols, and chiral α-keto-amides that are derived from (S)-proline esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yadav, J.S., et al.: Tetrahedron Lett., 43, 3783 (2002); Aggarwal, V.K., et al.: Tetrahedron Lett., 37, 3745 (1996); Wang, D.K., et al.: J. Org. Chem., 64, 4233 (1999); Kaur, G., et al.: Tetrahedron Lett., 38, 2521 (1997); Soai, K., et al.: J. Chem. Soc., Chem. Commun., 15, 1016 (1984)<br></p>

<p>Applications tert-Butyl (Trimethylsilyl)acetate is used to prepare lithium enolates, and is also a useful synthetic intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rathke, M. &amp; Elghanian, R. tert-Butyl Trimethylsilylacetate In Handbook of Reagents for Organic Synthesis: Reagents for Silicon-Mediated Organic Synthesis; Fuchs, P.; Wiley, 2011; 147-148<br></p>

<p>Applications 3-[(tert-Butyldimethylsilyl)oxy]-1-propanal (cas# 89922-82-7) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications n-Octadecyltrichlorosilane (cas# 112-04-9) is a useful research chemical.<br> E0<br></p>

<p>Applications (4-((4aR)-7-(Benzyloxy)-3,4,4a,5-tetrahydro-2H-chromen-3-yl)phenoxy)(tert-butyl)dimethylsilane is an protected intermediate in the synthesis of isoflavone Daidzein (D103500) related compounds.<br></p>

<p>Applications 2-Aminobenzeneboronic acid pinacol ester is a reagent used to synthesize regiospecific quinolines. It can also be used to synthesize (±)-Epimeloscine and (±)-Meloscine.<br>References Zhang, H., et al.: J. Am. Chem. Soc. 133, 10376 (2011); Horn, J., et al.: Org. Lett 10, 4117 (2008)<br></p>

<p>Applications B-[3-[[2-Hydroxy-3-[3-(triethoxysilyl)propoxy]propyl]amino]phenyl]boronic acid was prepared for the use as porous polymeric monolith for the specific capture of cis-​diol-​containing flavone under neutral condition.<br>References Pan, J., et al.: Chem. Eng. J., 317, 317-330 (2017);<br></p>

<p>Applications tert-Butylmethoxydimethylsilane is used as a reactant in the preparation of chlorosilanes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Masaoka, S., et al.: J. Organomet. Chem., 691, 174 (2006);<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester<br></p>

<p>Applications 2-Cyclohexylvinylboronic Acid is used in the synthesis of vinylbenziodoxolones, a novel type of hypervalent iodine(III) reagents.<br>References Stridfeldt, E., et al.: Chem. Eur. J., 22, 16066-16070 (2016)<br></p>

<p>Stability Volatile<br>Applications Methoxytrimethylsilane (cas# 1825-61-2) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-phenyl-2-[(trimethylsilyl)oxy]acetonitrile (cas# 25438-37-3) is a useful research chemical.<br></p>

<p>Applications 3-((1-Oxo-1-(3-(trimethylsilyl)propoxy)propan-2-yl)thio)propanoic acid is useful reagent for organic reactions and synthesis.<br></p>

<p>Applications tert-Butyldimethyl(4-(nitrosophenyl)butoxy)silane is an intermediate used in the synthesis of (E)-S-(3-((4-((4-(4-hydroxybutyl)phenyl)diazenyl)phenyl)amino)-3-oxopropyl) methanesulfonothioate (H895230), which is a useful research chemical.<br></p>

<p>Applications (2,5-Dimethylphenyl)boronic Acid is a useful synthetic intermediate. It can be used to prepare fluorenones/indenofluorenediones.<br>References Liu, T., et al.: Org. Lett., 13, 2452 (2011)<br></p>

<p>Applications 2-(Ethenyloxy)-1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilane is a useful reagent for organic synthesis used as a reagent in aldol cascade reactions.<br>References Boxer, M., et al.: Journal of the American Chemical Society, 128, 48 (2006);<br></p>

<p>Applications 1,1,3,3-Tetramethyldisiloxane is an organosilane reducing agent and can be used in several reduction reactions including reductive formation of sulfides and reductive etherification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pesti, J., et al.: Org. Process Res. Dev., pages ahead of print (2016);<br></p>

<p>Applications 5-Pyrimidylboronic Acid, is one of the new heteroarylpyrimidine derivatives via Suzuki cross-coupling reactions.<br>References Saygili N, et al.: Org Biomol Chem. 2004 Mar 21;2(6):852-7. Epub 2004 Feb 23.<br></p>

<p>Applications 4-Carboxymethylphenylboronic acid<br></p>

<p>Applications trans-Campestanyl 3-(4-(tert-Butyldimethylsilyl)oxy)-ferulate is an intermediate used in the synthesis of trans-Campestanyl Ferulate (C155308), which is used for synthesis of trans-feruloyl-β-sitostanol.<br>References Condo, A., et al.: J. Agric. Food Chem., 49, 4961 (2001);<br></p>

<p>Applications TRIMETHYL(BROMODIFLUOROMETHYL)SILANE (cas# 115262-01-6) is a useful research chemical.<br></p>

<p>Please enquire for more information about [2-(Difluoromethyl)phenyl]boronic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>O-Benzyl psilocin is a form of the hallucinogenic drug psilocybin. Psilocybin and other related substances are classified as indole alkaloids, which are synthesised by the enzyme tryptophan decarboxylase. O-Benzyl psilocin is synthesised in a two-step reaction that involves catalytic hydrogenation of 4-hydroxyindole to 4-hydroxyphenylacetaldehyde followed by formylation of the latter with formic acid or paraformaldehyde. It was first isolated from sheep's blood serum in 1958 and has been used as an immunogen to produce antisera against cocaine and serotonin. This substance also utilizes a number of endogenous substances for its metabolism, including dopamine, serotonin, noradrenaline, and adrenaline.</p>

<p>(2-Hydroxyphenyl)boronic acid is an organic compound that contains a boronate ester group and a hydroxyl group. It is used in the synthesis of lysine-containing peptides, proteins, and other compounds. (2-Hydroxyphenyl)boronic acid is synthesized by cross-coupling reactions using palladium-catalyzed coupling reactions. The most common type of reaction is the Suzuki coupling reaction, which involves the addition of an aryl halide to an aryl or vinyl boronate ester. This reaction is carried out at elevated temperature in organic solvents such as tetrahydrofuran or dioxane. The yield for this reaction can be improved by using catalytic amounts of palladium acetate, which speeds up the rate at which the reaction occurs. The use of catalysts also decreases the need for high temperatures, making it possible to perform this process at</p>

<p>Please enquire for more information about 2-[4-(tert-Butyldimethylsilyloxymethyl)-2-nitrophenoxy]acetic Acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>cis-1-Propene-1-boronicacid is a chiral, pyranoside compound that can be synthesized from the reaction of 2,3,4,5-tetrahydropyran with boron trichloride. cis-1-Propene-1-boronicacid has been shown to be useful for the palladium catalyzed cross coupling reactions. cis-1-Propene-1-boronicacid has been shown to react with cyclopentenone and alkylate different functional groups such as amines and alcohols. cis-1 -Propene 1 boronic acid has been used in peptidomimetics as well as in nature.</p>

<p>Please enquire for more information about 2-(Dimethylaminocarbonyl)ethylboronic acid, pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 9,12-Diiodo-1,2-carborane including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ethoxyphenylboronic acid is a triazine compound which inhibits inflammation by inhibiting the kinase that catalyzes the phosphorylation of arachidonic acid. It also inhibits lipid kinase, which is involved in the metabolism of lipids, and it has been shown to inhibit cancer cell growth through hydrogen bond interactions with DNA. Ethoxyphenylboronic acid has been shown to have anti-inflammatory properties and may be useful for the treatment of inflammatory diseases such as arthritis. The compound can also inhibit hydrogen peroxide-induced oxidative damage in cells, due to its ability to release intracellular glutathione.</p>

<p>Triisopropylsilylacetylene is an aliphatic hydrocarbon with a reactive site that can be used in the synthesis of other chemical compounds. It has been shown to have an inhibitory effect on the formation of reactive oxygen species and inflammation in mice, which may be due to its ability to reduce the production of inflammatory mediators such as prostaglandin E2. Triisopropylsilylacetylene also has a hydroxyl group, which allows it to act as an anti-inflammatory agent by inhibiting the enzyme cyclooxygenase. Additionally, triisopropylsilylacetylene has a carbonyl group, which gives it aromatic properties that can be used for synthetic purposes.</p>

<p>Please enquire for more information about 1H-Benzo[d]imidazol-6-ylboronic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-(Hydroxymethyl)phenylboronic acid is an organic compound that has been identified as a reactive, fatty acid. It has shown antibacterial efficacy against gram-positive and gram-negative bacteria in the presence of nanogels. 4-(Hydroxymethyl)phenylboronic acid is also a cross-linking agent that can be used to form hydrogels for tissue engineering applications. This chemical is being studied as a potential treatment for inflammatory bowel disease and diabetes mellitus. 4-(Hydroxymethyl)phenylboronic acid has been shown to have anti-cancer properties by inhibiting the proliferation of cancer cells and inducing apoptosis. The molecule also undergoes structural analysis using confocal microscopy.</p>

<p>Please enquire for more information about 4-(N-Methylamino)phenylboronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(Ethylsulfonyl)phenylboronicacid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>