Other Inhibitors

<p>Skp2 inhibitor 1 is a Skp2-Cks1 interaction inhibitor (IC50: 2.8μM) with antitumor activity and can be used to study cancer.</p>

<p>VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.</p>

<p>BLU2864: oral PRKACA inhibitor, IC50=0.3 nM, potential in cancer/poly. kidney disease research.</p>

<p>ELOVL1-IN-2 weakly inhibits ELOVL1 enzyme (IC50: 21 μM) and shows moderate potency in HEK293 cells (IC50: 6.7 μM).</p>

<p>Glycosyltransferase-IN-1 is a glycosyltransferase inhibitor with bacteriostatic activity, inhibiting MSSA, MRSA, Bacillus subtilis, and Enterobacteriaceae.</p>

<p>OB-1 is a STOML3 inhibitor that interferes with the self-association of stomatin, inhibiting fat formation and blocking lipid droplet growth.</p>

<p>O-Propargyl-Puromycin (OP-puro) is a potent protein synthesis inhibitor, a puromycin acetylene analog.</p>

<p>NRX-1532 is a small molecule β-catenin:β-TrCP interaction enhancer.</p>

<p>MV151 is a fluorescent proteasome inhibitor that targets all active subunits of the proteasome and immunoproteasome in living cells.</p>

<p>Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor that reduces the cytotoxicity induced by statins in human skeletal muscle cells.</p>

<p>YTH-IN-1 is an inhibitor of the five YTH structural domains in the human.The YTH family of proteins is an N 6-methyladenosine (m6A) reader in gene expression.</p>

<p>ARN19702: orally active, brain-penetrant, selective NAAA inhibitor, IC50 230 nM, broad analgesic profile.</p>

<p>Sebetralstat (KVD900) is an inhibitor of plasma kallikrein and can be used in studies about metabolic diseases.</p>

<p>TEM1/CD248 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 73.6 kDa and the accession number is Q91V98.</p>

<p>β-Apo-13-carotenone is a naturally occurring β-apocarotenoid, and is a RXRα antagonist.</p>

<p>(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM).</p>

<p>BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively.</p>

<p>Haloxon is an organophosphorus anthelmintic. Haloxon is used against nematodes of the abomasum and small intestine in ruminants.</p>

<p>Calcitriol Impurities A refers to the contaminants found in Calcitriol, the hormonally active metabolite of vitamin D3, which serves to activate the vitamin D receptor.</p>

<p>Beraprost sodium is a stable and orally active prodrug of PGI2.</p>

<p>β-Zearalenol, a non-steroidal estrogenic mycotoxin synthesized by Fusarium species, potentially influences transcription and affects gene expression on the translational level.</p>

<p>DNMDP is a phosphodiesterase 3A inhibitor with clear cell-selective cytotoxicity. DNMDP binding to PDE3A promotes interaction between PDE3A and Schlafen 12.</p>

<p>A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.</p>

<p>Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.</p>

<p>Daphnin is one of the main coumarin bioactive ingredients with antibacterial activity. Daphnine is isolated from the entire Daphne fragrance, which is a folk medicine used in China to relieve fever.</p>

<p>Demethyl 8-Epidiosbulbin E acetate is a structural analog of 8-Epidiosbulbin E acetate, a furan analog found in Dioscorea bulbifera L. 8-Epidiosbulbin E acetate is a furan analog found in Dioscorea bulbifera L. It is a structural analog of 8-Epidiosbulbin E acetate.</p>

<p>L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 µM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine.</p>

<p>GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. GAS6 Protein, Human, Recombinant (His) is expressed in HEK293 cells.</p>

<p>2-Selenouracil is a specialized photosensitizer for photodynamical therapy.</p>

<p>SPL-410 is a highly potent,selective and orally active inhibitor of hydroxyethylamine based SPPL2a (Signal Peptide Peptidase Like 2a)(IC50 of 9 nM).</p>

<p>BFCAs-1 is a polyamine polycarboxylic bifunctional chelating agent (BFCAs) with a broad range of applications in biology, chemistry, medicine and diagnostic imaging.</p>

<p>Norbiotinamine, a biotin alternative, is a sulfur-containing organic compound with a structure similar to that of biotin.</p>

<p>Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.</p>

<p>(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, a constrained phenylalanine (Phe) analogue, can adopt beta-bend and helical structures, thereby facilitating a preferred side-chain orientation within the peptide.</p>

<p>Endogenous fatty acid glycerol ester</p>

<p>PF-06747711 is an effective and selective retinoic acid receptor-related orphan C2 inverse agonist (IC50: 4.1 nM). PF-06747711 also has anti-skin inflammatory activity.</p>

<p>TCblR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-58 KDa and the accession number is Q9NPF0.</p>

<p>N3PT is a potent and selective inhibitor of transketolase(TK) with IC50 of 22 nM for Apo-TK)</p>

<p>CMK, an RSK2 kinase inhibitor, shows similar potency but less chemical stability compared with FMK.</p>

<p>3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.</p>

<p>3-Methoxyphenylacetic acid belongs to the class of organic compounds known as anisoles. 3-Methoxyphenylacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa).3-Methoxyphenylacetic acid (m-Methoxyphenylacetic acid), a m-hydroxyphenylacetic acid (m-OHPAA) derivative, is a phytotoxin in Rhizoctonia solani. 3-Methoxyphenylacetic acid is used to develop a toxin-mediated bioassay for resistance to rhizoctonia root rot</p>

<p>Isopulegol has antioxidant, and neuroactive properties. It also has gastroprotective effects induced by isopulegol appear to be mediated, at least in part, by endogenous prostaglandins, K+ATP channel opening and antioxidant proprieties related to GSH increased.</p>

<p>Anisylacetone (Anisylacetone) is an effective lure for the male melon fly.</p>

<p>PRGL493 blocks ACSL4, halts PC3/MDA-MB-231 cancer cell spread, and inhibits MA-10 tumor progesterone. Effective in mouse PC3 tumor model at 0.25 mg/kg.</p>

<p>4-Ethoxycoumarin has antimicrobial activity.</p>

<p>Dextromethorphan is a noncompetitive NMDA receptor antagonist and sigma-1 agonist that was approved by the FDA in 1958 for use as a cough suppressant.Cost-effective and quality-assured.</p>

<p>n-Hexyl-β-D-Maltopyranoside is a useful organic compound for research related to life sciences. The catalog number is TF0027 and the CAS number is 870287-95-9.</p>

<p>Isobornyl methacrylate is a useful organic compound for research related to life sciences. The catalog number is T65257 and the CAS number is 7534-94-3.</p>

<p>Expression System: P. pastoris (Yeast)&lt;br&gt;Activity: Not Tested</p>

<p>4-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,5-dione is a useful organic compound for research related to life sciences and the catalog number is T64594.</p>

<p>Secretin,porcine is a useful organic compound for research related to life sciences and the catalog number is T65428.</p>

<p>3-Methylbenzophenone is a useful organic compound for research related to life sciences. The catalog number is T67599 and the CAS number is 643-65-2.</p>

<p>2,5-Diaminobenzoic acid is a useful organic compound for research related to life sciences. The catalog number is T67030 and the CAS number is 610-74-2.</p>

<p>6-Chloropyrimidin-4-amine is a useful organic compound for research related to life sciences. The catalog number is T66144 and the CAS number is 5305-59-9.</p>

<p>Biotin-C4-amide-C5-NH2 is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs).</p>

<p>Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66601 and the CAS number is 1243308-37-3.</p>

<p>3-Oxobutanamide is a useful organic compound for research related to life sciences. The catalog number is T64972 and the CAS number is 5977-14-0.</p>

<p>Undecyl-β-D-Selenomaltoside is a useful organic compound for research related to life sciences. The catalog number is TF0049 and the CAS number is 1423294-14-7.</p>

<p>N-(3-(Dimethylamino)propyl)tetradecanamide is a useful organic compound for research related to life sciences. The catalog number is T66531 and the CAS number is 45267-19-4.</p>

<p>H-L-Photo-lysine: photo-cross-linker, diazirine-lysine for protein interaction studies in vitro/cells.</p>

<p>etilefrine pivalate is a useful organic compound for research related to life sciences. The catalog number is T68067 and the CAS number is 100696-30-8.</p>

<p>3,5-Dimethyl-4-methoxy-2-pyridinemethanol is a useful organic compound for research related to life sciences. The catalog number is T67354 and the CAS number is 86604-78-6.</p>

<p>5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66771 and the CAS number is 1240948-77-9.</p>

<p>Benzyl 2-(2-aminoacetamido)acetate 4-methylbenzenesulfonate, catalog number T65216 and CAS number 1738-82-5, is a valuable organic compound for life sciences research.</p>

<p>4-Chloro-N-(4-hydroxyphenethyl)benzamide is a useful organic compound for research related to life sciences. The catalog number is T65966 and the CAS number is 41859-57-8.</p>

<p>7-(4-Bromobutoxy)-3,4-dihydroquinolin-2(1H)-one is a useful organic compound for research related to life sciences. The catalog number is T65919 and the CAS number is 129722-34-5.</p>

<p>MMPEP is both a selective non-competitive mGlu5 receptor antagonist with IC50 value of 36 nM and a mGlu4 receptor positive allosteric modulator.</p>

<p>Sinoporphyrin sodium hinders cell growth, induces early apoptosis, disrupts F-actin, impairs movement, and may treat cancer; it's a photosensitizer.</p>

<p>1H-Imidazo[4,5-c]quinoline, 1-(2-methylpropyl)-, 5-oxide is a useful organic compound for research related to life sciences and the catalog number is T64577.</p>

<p>ERK1/2 inhibitor 5 targets MAPK pathway, potentially aiding cancer and inflammation research.</p>

<p>Carbonylchlorohydrido[bis(2-(diphenylphosphinoethyl)amino]ruthenium(II) is a useful organic compound for research related to life sciences. The catalog number is T67264 and the CAS number is 1295649-40-9.</p>

<p>Rifamycin O is a useful organic compound for research related to life sciences. The catalog number is T65421 and the CAS number is 14487-05-9.</p>

<p>LysoFos Glycerol 12 is a useful organic compound for research related to life sciences. The catalog number is TF0073 and the CAS number is 1423237-43-7.</p>

<p>4,6-Dichloro-N-methylpicolinamide is a useful organic compound for research related to life sciences. The catalog number is T64568 and the CAS number is 1379324-09-0.</p>

<p>N-Cbz-L-histidine is a useful organic compound for research related to life sciences and the catalog number is T65767.</p>

<p>1H-Pyrazole-1-carboximidamide hydrochloride, catalog number T67134 and CAS number 4023-02-3, is a valuable organic compound for life sciences research.</p>

<p>Methanesulfonato(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences. The catalog number is T64628 and the CAS number is 1445085-77-7.</p>

<p>(S)-4-(Amino(carboxy)methyl)-3-methylbenzoic acid hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64800.</p>

<p>1-Acetyl-4-methylpiperazine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67190 and the CAS number is 144205-68-5.</p>

<p>BKM1740 induced apoptosis in prostate cancer (PCa) cells by repressing survivin at both the mRNA and protein levels in vitro.</p>

<p>Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine-(2-(2-aminoethyl)phenyl)palladium(II) chloride is a useful organic compound for research related to life sciences. The catalog number is T66227 and the CAS number is 1148148-01-9.</p>

<p>3-Bromocinnamic acid, predominantly trans is a useful organic compound for research related to life sciences and the catalog number is T67378.</p>

<p>5% Palladium on barium sulfate is a useful organic compound for research related to life sciences and the catalog number is T64543.</p>

<p>Zinc(II) sulfate is a useful organic compound for research related to life sciences and the catalog number is T65506.</p>

<p>Cinnamonitrile is a useful organic compound for research related to life sciences and the catalog number is T65077.</p>

<p>Equ c 1 Protein, Domestic horse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.1 kDa.</p>

<p>Ara h 3.01 Protein, Arachis hypogaea, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 59.3 kDa.</p>

<p>Bet v 4 Protein, Betula pendula, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 10.3 kDa and the accession number is Q39419-1.</p>

<p>NE97220 is a bioactive chemical.</p>

<p>Fel d 1 Protein, Felis domesticus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.6 kDa.</p>

<p>Expression System: P. pastoris (Yeast)&lt;br&gt;Activity: Not Tested</p>

<p>Asp f 24 Protein, Aspergillus Fumigatus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 26.3 kDa.</p>

<p>Met e 1 Protein, Metapenaeus ensis, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 32.7 kDa.</p>

<p>Car i 1 Protein, Carya illinoinensis, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 59.5 kDa.</p>

<p>Cor a 1 Protein, Corylus avellana, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.6 kDa and the accession number is Q9SWR4.</p>