Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1544 products of "Cytoskeletal Signaling"
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αvβ1 integrin-IN-1
CAS:αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.
Formula:C26H34N6O6SPurity:99.74% - >99.99%Color and Shape:SolidMolecular weight:558.65PKC-IN-1
CAS:PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Formula:C25H37FN8O2Purity:98% - 98.79%Color and Shape:SolidMolecular weight:500.61Nrf2/HO-1 activator 1
CAS:Compound 24: Potent Nrf2/HO-1 activator with neuroprotective, antioxidant properties; useful in PD research.Formula:C21H18O5Color and Shape:SolidMolecular weight:350.3616,16-Dimethyl prostaglandin E2
CAS:16,16-Dimethyl prostaglandin E2 regulates hematopoietic stem cells via EP2/EP4 and Wnt, taken orally.Formula:C22H36O5Purity:98%Color and Shape:SolidMolecular weight:380.52OPN expression inhibitor 1
CAS:OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.Formula:C25H33N3O5Purity:99.78%Color and Shape:SolidMolecular weight:455.55Ref: TM-T62820
1mg126.00€5mg258.00€10mg385.00€25mg695.00€50mg1,009.00€100mg1,314.00€1mL*10mM (DMSO)259.00€GSD-11
GSD-11: Potent, selective anti-austerity agent; blocks Akt/mTOR pathway, hinders PANC-1 cell migration & colony growth. Promising for pancreatic cancer study.Formula:C20H28O2Color and Shape:SolidMolecular weight:300.44TPI-287
CAS:TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.Formula:C46H63NO15Color and Shape:SolidMolecular weight:869.99Mitotic kinesin-IN-1 hydrochloride
CAS:Mitotic kinesin-IN-1 hydrochloride (Example 80) is an inhibitor of mitotic kinesin, which suppresses cell proliferation by hindering mitosis. This compound is applicable in research related to cancer, cardiac hypertrophy, immune and inflammatory diseases, and fungal infections.Formula:C22H26ClF2N3OSColor and Shape:SolidMolecular weight:453.98Wikstrol A
CAS:Wikstrol A: antifungal, anti-mitotic, anti-HIV agent with various IC50/MDC values (67.8-131 µM) and deforms P. oryzae mycelia.Formula:C30H22O10Color and Shape:SolidMolecular weight:542.49PKCTheta-IN-2
CAS:PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor (IC50 = 0.25 nM) that suppresses IL-2 production in mice (IC50 = 682 nM).Formula:C24H23N5O2Color and Shape:SolidMolecular weight:413.47ETB
CAS:ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.Formula:C24H33NO6Molecular weight:431.52Auristatin S
CAS:AuristatinS is a potent anti-tumor agent that serves as an Auristatin payload. It effectively reduces the bystander effect and decreases off-target toxicity. In the Karpas/KarpasBVR cell model, AuristatinS exhibits excellent tolerability. It can be used as the cytotoxic component in antibody-drug conjugates (ADCs) for treating various types of cancer.Formula:C38H65N5O8Color and Shape:SolidMolecular weight:719.95DCEM1
CAS:DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.Formula:C22H23N3O2SColor and Shape:SolidMolecular weight:393.50Tubulin inhibitor 15
Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].Formula:C16H12FNO2Color and Shape:SolidMolecular weight:269.27Tubulin polymerization-IN-32
Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.Formula:C29H30N2O7Color and Shape:SolidMolecular weight:518.56Quinagolide hydrochloride
CAS:Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.Formula:C20H34ClN3O3SPurity:98%Color and Shape:SolidMolecular weight:432.02OXS007417
OXS007417 induces AML cell differentiation at 48 nM EC50 and shows potent in vivo antitumor effects.Formula:C20H14F3N3OColor and Shape:SolidMolecular weight:369.34AKT-IN-11
AKT-IN-11 is one of the most potent antibacterial agents against human hepatocellular carcinoma Bel-7402 cell line (IC50: 1.15 μM).Formula:C27H27ClF3NO4Color and Shape:SolidMolecular weight:521.96EV206
CAS:EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.Formula:C21H19N3OColor and Shape:SolidMolecular weight:329.40NVP-BQS481
CAS:NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).Formula:C27H33F3N4O2Color and Shape:SolidMolecular weight:502.57SR121566A
CAS:SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).Formula:C20H25N5O4SPurity:98%Color and Shape:SolidMolecular weight:431.51L 734217
CAS:L 734217 is an antagonist of the fibrinogen receptor.Formula:C18H31N3O4Purity:98%Color and Shape:SolidMolecular weight:353.46Terpendole E
CAS:Terpendole E is an atypical L5 site inhibitor.Formula:C28H39NO3Color and Shape:SolidMolecular weight:437.61HPK1-IN-61
CAS:HPK1-IN-61 (Compound 1) serves as an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with a Ki of 0.4 nM, and also inhibits Abl with an IC50 of less than 0.51 nM. Additionally, HPK1-IN-61 displays inhibitory activity against LCK, with an IC50 of 24 nM.Formula:C23H22N4O2Color and Shape:SolidMolecular weight:386.45GLPG3312
CAS:GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, for SIK1, SIK2 and SIK3, anti-inflammatory and immunomodulatory .Formula:C23H21F2N5O3Purity:98.53%Color and Shape:SolidMolecular weight:453.44Zalunfiban dihydrochloride
Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.Formula:C16H20Cl2N8O2SColor and Shape:SolidMolecular weight:459.35α5β1 integrin agonist-1
CAS:α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Formula:C24H26FN5O9Color and Shape:SolidMolecular weight:547.49AChE/BChE-IN-23
AChE/BChE-IN-23 (Compound 6e) is a dual inhibitor of acetylcholinesterase and butyrylcholinesterase, exhibiting IC50 values of 0.91 μM for AChE, 1.19 μM for eqBChE, and 1.01 μM for hBChE. This compound also demonstrates antioxidant properties and inhibits the aggregation of Aβ1-42 and Tau proteins. Moreover, AChE/BChE-IN-23 prevents the activation of microglial cells by inhibiting the release of reactive oxygen species and mitochondrial damage. Additionally, it reduces the levels of the NLRP3 inflammasome in human microglial cells and reverses memory impairment in mice induced by scopolamine.Formula:C19H21N5O3Color and Shape:SolidMolecular weight:367.4HG-7-86-01
CAS:HG-7-86-01 is a selective type II tyrosine kinase inhibitor with antiproliferative activity against mutant T315I- Bcr-Abl for chronic myeloid leukemia (CML).Formula:C28H21F3N6O2SPurity:99.07%Color and Shape:SolidMolecular weight:562.57JC168
CAS:JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.Formula:C26H40O7Color and Shape:SolidMolecular weight:464.592Tyrosine kinase-IN-9
CAS:Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.Formula:C20H14ClN3O3Color and Shape:SolidMolecular weight:379.796Onalespib lactate
CAS:Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.Formula:C27H37N3O6Color and Shape:SolidMolecular weight:499.6ML175
CAS:ML175 is a specific inhibitor of glutathione transferase Omega 1-1 (GSTO1-1). Additionally, it significantly activates Akt and MEK1/2 kinases. ML175 can be utilized in research related to diseases such as Parkinson's.Formula:C13H13ClF3N3O4Color and Shape:SolidMolecular weight:367.71MKLP2-IN-1
CAS:MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.
Formula:C23H19BrFN3O2Color and Shape:SolidMolecular weight:468.318TTBK1/2-IN-1
CAS:TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.Formula:C17H16N4OColor and Shape:SolidMolecular weight:292.335APN/AKT-IN-1
APN/AKT-IN-1, a dual APN (IC50=0.21μM) & AKT (IC50=0.27μM) inhibitor, hinders GSK3β phosphorylation.Formula:C18H27N7O3Color and Shape:SolidMolecular weight:389.45GR 83895
CAS:GR 83895 is an antagonist of prototype fibrinogen receptor.Formula:C29H39N9O8SPurity:98%Color and Shape:SolidMolecular weight:673.74Myoseverin B
CAS:Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.Formula:C27H32N6O2Color and Shape:SolidMolecular weight:472.582Latrunculins A
CAS:Latrunculins A is a novel marine toxin, disrupts microfilament organization in cultured cells.Formula:C22H31NO6SColor and Shape:SolidMolecular weight:437.55HS-345
CAS:HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis). Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.Formula:C19H18N6O2SColor and Shape:SolidMolecular weight:394.45HSP90-IN-11
HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.Formula:C27H30FN3O6Color and Shape:SolidMolecular weight:511.54PI3K-IN-29
CAS:PI3K-IN-29: Strong PI3K block, inhibits Akt phosphorylation. IC50: U87MG 0.264µM, HeLa 2.04µM, HL60 1.14µM.Formula:C27H22ClN7O3SColor and Shape:SolidMolecular weight:560.03AM-9022
CAS:AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].Formula:C27H36F2N6O4SColor and Shape:SolidMolecular weight:578.67Tubulin inhibitor 16
Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].Formula:C16H12FNO2Color and Shape:SolidMolecular weight:269.27AKT-IN-10
CAS:AKT-IN-10, a potent AKT inhibitor, has potential for breast and prostate cancer research, impacting cell growth and survival pathways.Formula:C26H34ClN5O2Color and Shape:SolidMolecular weight:484.03Hsp90-IN-38
CAS:Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.
Formula:C28H35N3O5Color and Shape:SolidMolecular weight:493.595Antitubulin agent 1
Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.Formula:C21H19N3O3Color and Shape:SolidMolecular weight:361.39Monomethyl auristatin E intermediate-17
CAS:MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).Formula:C27H35NO7SMolecular weight:517.63EX05
CAS:EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.Formula:C26H30F2N4O5SColor and Shape:SolidMolecular weight:548.60AKT-IN-26
CAS:AKT-IN-26 (Compound 453) is an AKT inhibitor that binds to the Pleckstrin Homology (PH) domain of AKT. It is useful for research related to cell proliferation and cancer involving the AKT pathway.Formula:C21H17N5O4SColor and Shape:SolidMolecular weight:435.456HSP90-IN-32
CAS:HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Formula:C33H40N2O4Color and Shape:SolidMolecular weight:528.68Tubulin inhibitor 22
Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.Formula:C20H17BrFNO4Color and Shape:SolidMolecular weight:434.26FO-4-15
CAS:FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.Formula:C18H20N4O4SColor and Shape:SolidMolecular weight:388.44TTBK1/2-IN-3
CAS:TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).Formula:C21H22N4OColor and Shape:SolidMolecular weight:346.426ZLY06
CAS:ZLY06 is a dual agonist of peroxisome proliferator-activated receptors (PPAR) δ and γ with oral activity (PPAR δ: EC50=341 nM; PPARγ: EC50=237 nM). It mediates the upregulation of CD36 and induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1. Moreover, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, primarily by enhancing the β-oxidation of fatty acids and reducing hepatic lipid synthesis, thereby alleviating fatty liver disease.Formula:C25H26O6Color and Shape:SolidMolecular weight:422.47GSK3335103
CAS:GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formula:C27H36FN3O4Color and Shape:SolidMolecular weight:485.59G-9791
CAS:G-9791 is an effective and selective inhibitor of group-I PAK.Formula:C26H26ClFN6O2Purity:98%Color and Shape:SolidMolecular weight:508.98SF0166
CAS:SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Formula:C23H27F2N5O4Color and Shape:SolidMolecular weight:475.49PAK4-IN-6
CAS:PAK4-IN-6 is a selective degrader of PAK4 and can be utilized in the synthesis of PROTACs, such as CPS-021.Formula:C25H28N6O2Color and Shape:SolidMolecular weight:444.53POSH-IN-2
CAS:POSH-IN-2 (MIDI) is a mitochondrial fission inhibitor and a DRP1 inhibitor that effectively prevents mitochondrial fragmentation caused by cellular stress and genetic mitochondrial damage. It covalently interacts with DRP1-C367 to target the interaction of DRP1 with multiple receptors.Formula:C22H16N2O2Color and Shape:SolidMolecular weight:340.37YAP/TAZ-TEAD-IN-2
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that disrupts the interaction between YAP/TAZ and TEAD. It inhibits the transcriptional activity of TEAD with an IC50 of 1.2 nM. Additionally, YAP/TAZ-TEAD-IN-2 suppresses the expression of target genes (Cyr61, CTGF, AXL, and Survivin) and the proliferation of breast cancer cells.Formula:C19H20N2O3SColor and Shape:SolidMolecular weight:356.44Symplostatin 1
CAS:Symplostatin 1 is a dolastatin 10 analog from the marine cyanobacterium Symploca hydnoides.Formula:C43H70N6O6SColor and Shape:SolidMolecular weight:799.12Utrophin modulator 1
UM1 upregulates utrophin, has EC50 of 0.11 μM, useful in DMD research.Formula:C22H18N6OColor and Shape:SolidMolecular weight:382.42Uprosertib hydrochloride
CAS:Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).Formula:C18H17Cl3F2N4O2Purity:98%Color and Shape:SolidMolecular weight:465.71Lisavanbulin
CAS:Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.
Formula:C26H29N9O3Color and Shape:SolidMolecular weight:515.57Myosin modulator 1
CAS:Myosinmodulator 1 (Compound B141) is a myosin regulator that inhibits ATPase activity in rabbit psoas, porcine atrial, and porcine ventricular tissues, with IC25 values of 0.42, 0.13, and 3.09 μM, respectively. It also modulates cardiac contraction in Sprague Dawley rats.Formula:C18H14F3N5O2Color and Shape:SolidMolecular weight:389.33Alfalone
CAS:Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.Formula:C17H14O5Color and Shape:SolidMolecular weight:298.29Dictyostatin
CAS:Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.Formula:C32H52O6Color and Shape:SolidMolecular weight:532.756-B345TTQ
CAS:6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.Formula:C22H20BrNO4Color and Shape:SolidMolecular weight:442.303Macbecin I
CAS:Hsp90 inhibitorFormula:C30H42N2O8Purity:98%Color and Shape:SolidMolecular weight:558.66Des-ethyl-carafiban
CAS:Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.Formula:C22H23N5O5Color and Shape:SolidMolecular weight:437.448Tubulin polymerization-IN-8
CAS:Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.Formula:C21H24N4O4SColor and Shape:SolidMolecular weight:428.5RMS-07
CAS:RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.Formula:C35H40N8O2Color and Shape:SolidMolecular weight:604.74AMG28
CAS:AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.Formula:C20H20N4OColor and Shape:SolidMolecular weight:332.399Tubulin polymerization-IN-77
CAS:Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.Formula:C22H19BrF3NO7Color and Shape:SolidMolecular weight:546.288DN-F01
DN-F01 exhibits a potent calcium-dependent inhibitory effect on cardiac myofibrillar ATPase activity, with an IC50 of 11 ± 4 nmol/L.Formula:C22H16N2O2Color and Shape:SolidMolecular weight:340.37Coelogin
CAS:Coelogin is an orally effective bone-protective agent that activates ER-Erk and Akt-dependent signaling pathways, thereby stimulating osteoblast differentiation. It is utilized in osteoporosis research.Formula:C17H16O5Color and Shape:SolidMolecular weight:300.31Cemdomespib
CAS:Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.Formula:C24H30FNO6Color and Shape:SolidMolecular weight:447.5PP487
CAS:PP487 is a dual tyrosine kinase/PI(3)K inhibitor, exhibiting IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].Formula:C14H14BrN5OColor and Shape:SolidMolecular weight:348.2Epothilone E
CAS:Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumorFormula:C26H39NO7SColor and Shape:SolidMolecular weight:509.66Mps1-IN-8
CAS:Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].Formula:C35H47N8O6PColor and Shape:SolidMolecular weight:706.77Iroxanadine hydrobromide
CAS:Iroxanadine hydrobromide is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Formula:C14H21BrN4OColor and Shape:SolidMolecular weight:341.25Monorden diacetate
CAS:Monorden diacetate a Hsp90 Inhibitor. Monorden diacetate is a Promising Lead Compound for the Development of Novel Fungicides.Formula:C22H21ClO8Color and Shape:SolidMolecular weight:448.85Nrf2/HO-1 activator 2
Compound 13m, a difluoro derivative, activates Nrf2/HO-1, showing neuroprotective and antioxidant effects, useful in PD research.Formula:C20H16F2O5Color and Shape:SolidMolecular weight:374.33Sagopilone
CAS:Sagopilone: synthetic epothilone, inhibits cell division and induces apoptosis, effective in MDR tumors, not P-gp substrate.Formula:C30H41NO6SColor and Shape:SolidMolecular weight:543.71HSN748
CAS:HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.Formula:C27H24F3N7OColor and Shape:SolidMolecular weight:519.521Tubulin polymerization-IN-63
CAS:Tubulin polymerization-IN-63 (compound 6) is an inhibitor of tubulin polymerization. It exhibits an IC50 value of 0.29 μM against MES-SA cells, making it suitable for use in cancer research.Formula:C20H24ClCuN5O2SColor and Shape:SolidMolecular weight:497.5Ethaboxam
CAS:Ethaboxam is a β-tubulin inhibitor and antifungal agent used against oomycete pathogens.Formula:C14H16N4OS2Purity:99.37%Color and Shape:SolidMolecular weight:320.43Ref: TM-T204712
1mg185.00€5mg459.00€10mg657.00€25mg1,026.00€50mg1,415.00€100mg1,872.00€200mg2,555.00€Ack1 inhibitor 1
CAS:Ack1 inhibitor 1 is a potent and selective orally active inhibitor of ACK1 kinase, with an IC50 value of 2.1 nM. It effectively inhibits the phosphorylation of ACK1 and the activation of downstream AKT, demonstrating anti-tumor activity [1].Formula:C39H40F3N7O4Color and Shape:SolidMolecular weight:727.77TACC3 inhibitor 2
CAS:TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.Formula:C20H22FN5O2Color and Shape:SolidMolecular weight:383.419SPA0355
CAS:SPA0355 is a thiourea derivative with antioxidant and anti-inflammatory properties. It inhibits RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclastogenesis in primary bone marrow-derived macrophages and suppresses the activation of MAPKs, Akt, and NF-κB pathways. Furthermore, SPA0355 enhances osteoblast differentiation by increasing alkaline phosphatase activity and mineralized nodule formation. It protects ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it a potential candidate for studying postmenopausal osteoporosis.Formula:C22H21N3O2SColor and Shape:SolidMolecular weight:391.486Tubulin polymerization-IN-74
CAS:Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.Formula:C14H11NSColor and Shape:SolidMolecular weight:225.309Tubulin polymerization-IN-34
"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."Formula:C31H35N3O6Color and Shape:SolidMolecular weight:545.63AL-GDa62
AL-GDa62, a gastric cancer treatment lead, has EC50 of 3.2 μM (MCF10A-WT) and 2 μM (MCF10A-CDH1 -/-).Formula:C24H28FN3OColor and Shape:SolidMolecular weight:393.5AChE/GSK-3β-IN-1
CAS:AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-Formula:C31H35N7O3SColor and Shape:SolidMolecular weight:585.72GSK3β-IN-2
CAS:GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.Formula:C25H18N4OColor and Shape:SolidMolecular weight:390.437Tubulin polymerization-IN-35
Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.Formula:C31H35N3O5Color and Shape:SolidMolecular weight:529.63NRX-2663
CAS:NRX-2663 boosts β-catenin binding to E3 ligase SCFβ-TrCP (Kd: 54.8 nM, EC50: 22.9 nM).Formula:C20H13F3N2O5Color and Shape:SolidMolecular weight:418.32DDO-6691
CAS:DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.Formula:C22H17N3O2SColor and Shape:SolidMolecular weight:387.45KY-02327 acetate
KY-02327 acetate inhibits Dvl-CXXC5, stabilizes Wnt/β-catenin signaling, and enhances osteoblast differentiation.Formula:C22H31N3O6Color and Shape:SolidMolecular weight:433.5XD23
CAS:XD23 is a potent osteosarcoma inhibitor that functions by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.Formula:C22H26ClN7O3Color and Shape:SolidMolecular weight:471.94Tubulin polymerization-IN-75
CAS:Tubulin polymerization-IN-75 (Compound 6) is an inhibitor of tubulin polymerization, with an IC50 value of 30 μM. It effectively suppresses the proliferation of cancer cells Huh7 and 293T, demonstrating IC50 values of 14.3 μM and 13.8 μM, respectively.Formula:C14H11NOColor and Shape:SolidMolecular weight:209.243Isodienestrol
CAS:Isodienestrol, a derivative of Diethylstilbestrol, acts as a microtubule (Microtubule) inhibitor. It is utilized in cancer research.Formula:C18H18O2Color and Shape:SolidMolecular weight:266.33KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formula:C23H20ClFO4Color and Shape:SolidMolecular weight:414.85Fradafiban
CAS:Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.Formula:C20H21N3O4Purity:98%Color and Shape:SolidMolecular weight:367.40Hsp110-STAT3 interaction-IN-1
CAS:Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.Formula:C23H31N3O4SColor and Shape:SolidMolecular weight:445.58Hsp90-IN-34
CAS:Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Formula:C22H14F2N6OColor and Shape:SolidMolecular weight:416.38Tasidotin hydrochloride
CAS:Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.Formula:C32H59ClN6O5Purity:98%Color and Shape:SolidMolecular weight:643.30C086
CAS:C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.Formula:C29H28O8Color and Shape:SolidMolecular weight:504.53Kolavenic acid analog
CAS:KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.Formula:C25H38O4Color and Shape:SolidMolecular weight:402.57PROTAC α-synuclein degrader 6
CAS:PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.
Formula:C37H39N5O9SMolecular weight:729.80KU-32
CAS:KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.Formula:C20H25NO8Purity:98%Color and Shape:SolidMolecular weight:407.41HSP90α-IN-1
CAS:HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.Formula:C19H16N4O2Color and Shape:SolidMolecular weight:332.356AMXI-5001 hydrochloride
AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.Formula:C25H21ClFN5O3Color and Shape:SolidMolecular weight:493.92Tubulin inhibitor 19
Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.Formula:C21H23NO5Color and Shape:SolidMolecular weight:369.41Hsp90-IN-37
CAS:Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.Formula:C12H15N3O2Color and Shape:SolidMolecular weight:233.266HSP90-IN-9
HSP90-IN-9: potent HSP90 inhibitor, dose-dependent fungicide, impedes biofilm/morphology with FLC, reverses FLC resistance.Color and Shape:SolidAntitumor agent-200
CAS:Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.Formula:C19H21FN2O3SeColor and Shape:SolidMolecular weight:423.34MT-134
MT-134 is a SkMII -specific inhibitor and has excellent exposure in muscles.Formula:C19H16N4O3Color and Shape:SolidMolecular weight:348.36β-Catenin modulator-8
CAS:β-Catenin modulator-8 (Compound Ⅸa) is a specific β-catenin modulator for use in cancer research.Formula:C17H20N2O2SPurity:99.97%Color and Shape:SolidMolecular weight:316.42Ref: TM-T205083
1mg201.00€5mg497.00€10mg701.00€25mg1,094.00€50mg1,508.00€100mg1,931.00€200mg2,637.00€Tau ligand-1
CAS:Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.Formula:C17H16FN3OColor and Shape:SolidMolecular weight:297.327PM-060184
CAS:PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.Formula:C31H45N3O7Purity:98%Color and Shape:SolidMolecular weight:571.7FPDT
FPDT combats glioblastoma by inhibiting the AKT pathway; IC50: >100 μM (astrocytes), 45-68 μM (GBM cells).Formula:C16H12FNO2SColor and Shape:SolidMolecular weight:301.34Tubulin polymerization-IN-33
Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.Formula:C27H28N2O6Color and Shape:SolidMolecular weight:476.52Icafolin-methyl
CAS:Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.Formula:C18H18F2N2O5Color and Shape:SolidMolecular weight:380.343NAP1051
CAS:NAP1051, a biomimetic analog of Lipoxin A4, serves an anti-tumor role by targeting the inflammatory tumor microenvironment. It inhibits the chemotaxis of neutrophils to fMLP and stimulates macrophage efferocytosis by activating AKT. NAP1051 is utilized in research on colorectal cancer.Formula:C23H34O5Color and Shape:SolidMolecular weight:390.51AS2521780
CAS:AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).Formula:C30H41N7OSPurity:98%Color and Shape:SolidMolecular weight:547.76Nic-15
CAS:Nic-15 (compound 4n) serves as an anti-constrictive agent targeting the low vascular characteristics of pancreatic tumors. These characteristics enable cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop resistance to treatment. Nic-15 modulates the PI3K/Akt/mTOR pathway and alleviates ER stress induced by Gemcitabine. It significantly inhibits migration and colony formation in MIA PaCa-2 and PANC-1 pancreatic cancer cells. When used in combination with Gemcitabine, Nic-15 effectively addresses resistance issues in pancreatic tumors. In xenograft models in vivo, Nic-15 notably enhances the efficacy of Gemcitabine.Formula:C25H26F2O3Color and Shape:SolidMolecular weight:412.47NRX-252114
CAS:NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).Formula:C22H12Cl2F3N3O2SPurity:99.70%Color and Shape:SolidMolecular weight:510.32AKT Kinase Inhibitor
CAS:AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.Formula:C16H19N7O3Purity:97.83% - 99.13%Color and Shape:SolidMolecular weight:357.37Ref: TM-T10276
1mg136.00€5mg329.00€10mg567.00€25mg887.00€50mg1,188.00€100mg1,605.00€1mL*10mM (DMSO)360.00€INS018 055
CAS:INS018 055 (TNIK&MAP4K4-IN-2) is a TNIK and MAP4K4 inhibitor with anti-fibrotic activity.Formula:C27H30FN7OPurity:98.53%Color and Shape:SolidMolecular weight:487.57NRX-103094
CAS:NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Formula:C20H11Cl2F3N2O4SPurity:99.13%Color and Shape:SolidMolecular weight:503.28NRX-1532
NRX-1532 is a small molecule β-catenin:β-TrCP interaction enhancer.Formula:C16H11F3N4O2Purity:98.95% - 99.94%Color and Shape:SolidMolecular weight:348.28Ref: TM-T61172
1mg156.00€5mg378.00€10mg630.00€25mg1,216.00€50mg1,634.00€100mg2,205.00€500mg4,418.00€1mL*10mM (DMSO)415.00€Ombrabulin
CAS:Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.Formula:C21H26N2O6Purity:98%Color and Shape:SolidMolecular weight:402.44Cercosporin
CAS:Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).Formula:C29H26O10Purity:98%Color and Shape:SolidMolecular weight:534.51ZW4864
CAS:ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.Formula:C33H43ClN6O3Color and Shape:SolidMolecular weight:607.224-Methylenecycloartanyl ferulate
CAS:24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.Formula:C41H60O4Color and Shape:SolidMolecular weight:616.927Tau tracer 2
CAS:Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].Formula:C15H9FN4Color and Shape:SolidMolecular weight:264.263Sevasemten
CAS:Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respectively.Formula:C16H11F4N5O2Color and Shape:SolidMolecular weight:381.28Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate
CAS:Methyl (6-chloro-1H-benzo[d]imidazol-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T65302 and the CAS number is 20367-38-8.Formula:C9H8ClN3O2Color and Shape:SolidMolecular weight:225.63CMX-2043
CAS:CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.Formula:C16H26N2O6S2Purity:98%Color and Shape:SolidMolecular weight:406.52Cevipabulin fumarate
CAS:Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).Formula:C22H22ClF5N6O5Purity:98%Color and Shape:SolidMolecular weight:580.89BCR-ABL-IN-8
CAS:BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].
Formula:C30H33N7O5Purity:98%Color and Shape:SolidMolecular weight:571.63
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