Deuterated Compounds

<p>Applications (S)-Carbidopa Methyl-d3 Ester N-cyclohexylidene is the labeled analogue of (S)-Carbidopa Methyl Ester N-cyclohexylidene (C176015), an impurity of Carbidopa (C175915), a prodrug inhibitor of aromatic amino acid decarboxylase.<br>References Sletzinger, M., et al.: J. Med. Chem., 6, 101 (1963)<br></p>

<p>Applications n-Butyl-1,1,2,2-d4 Alcohol (CAS# 118104-91-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phthalic Acid Bis(3,7-dimethyloctyl) Ester-d4 is the isotope labelled analog of Phthalic Acid Bis(3,7-dimethyloctyl) Ester (P384535); a diester derivative of Phthalic Acid (P384480) which can be used as a plasticizer for PVC-type compositions.<br>References Takeuchi, H., et al. Jpn. Kokai Tokkyo Koho. JP 2001002829 A 20010109. Jan 9, 2001<br></p>

<p>Applications Compound has been shown to reversibly block voltage-dependent potassium channels, and is also a common impurity from the synthesis of compounds found in hair dyes<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Williams, D.M., et al.: J. Biol. Chem., 275, 38127 (2000), Munoz-Caro, C., et al.: Biophys. Chem., 96, 1 (2002),<br></p>

<p>Applications Ethynyl-2-13C-benzene, is the labeled analogue of Ethynylbenzene (E932150), which is an aromatic hydrocarbon, is important in the petrochemical industry as an intermediate in the production of styrene, which in turn is used for making polystyrene, a common plastic material.<br>References Xiang, J., et al.: Tetrahedron Lett, 37, 5269 (1996);<br></p>

<p>Applications N-Acetylglycine N-Methylamide-d8 is an isotopic analog of N-Acetylglycine N-Methylamide (7606-79-3).<br></p>

<p>Applications Ethyl 2-Bromo-2-methyl-d3-propionate-3,3,3-d3 (CAS# 64768-38-3) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications N-Hexane (D14, 98%) (cas# 21666-38-6) is a useful research chemical.<br></p>

<p>Applications 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>

<p>Applications Cyclopropyl-2,2,3,3-d4 Methyl Ketone (CAS# 350818-63-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications (E)-4-(Dimethylamino)but-2-enoyl Chloride-d6 is an intermediate used in the synthesis of Afatinib-d6 (A355303), which is the d6 labeled analogue of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br>References Schroeder, J., et al.: PCT Int. Appl. WO 2007085638 A1 20070802. Aug 2, 2007;<br></p>

<p>Applications 1-​Chloro-​2-​phenyl-diazene-13C6 is an intermediate in synthesizing N-Acetyl-S-(phenyl-13C6)-L-cysteine (A187357), a labelled N-Acetyl-S-phenyl-L-cysteine (P335600). It is an important metabolite of Benzene.<br>References Muller, G., et al.: Anal. Hazard. Subst. Biol. Mater., 5, 143 (1997)<br></p>

<p>Applications Choline-d13 Bromide (cas# 203645-64-1) is a useful research chemical.<br></p>

<p>Applications 3-Chloropyridine-d4 (CAS# 1001003-95-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications o-Tolyl-d7 Isocyanate (CAS# 1219802-73-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Glutamic Acid Dimethyl Ester-13C5 Hydrochloride is an intermediate used in the synthesis of Folic Acid-13C5 (F680303), which is vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>

<p>Applications n-Tridecyl-d27 Alcohol (CAS# 203633-18-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Secobarbital-d5 (1-methyl-d3-butyl-2,2-d2) (CAS# 1219803-94-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzyl-alpha,alpha-d2 Bromide (CAS# 51271-29-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Phenylalanine-3-13C (CAS# 286425-42-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled 1,2-Hexanediol is used in the synthesis of sulfamidates which lead a simple route into β-amino acids. Also used in the controlled growth of GE nanowires.<br>References Nicolaou, K. et al.: Angew. Chem. Int. Ed., 41, 834 (2002); Lotty, O. et al.: J. Mat. Chem. C., Mat. Optic. Electro. Devices., 1, 4450 (2013);<br></p>

<p>Applications α-Tetralone-13C6 (cas# 189811-58-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d16;1-15N-1-oxyl (CAS# 80404-14-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-(Ethyl-d3) Isonicotinamide is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications 5-Formylfuran-2-carboxylic Acid-13C6 is an isotope labelled form of 5-Formylfuran-2-carboxylic Acid(F700500).<br>References Nocito, F., et al.: ACS Omega, 3, 18724 (2018); Chen, G., et al.: Ind. Eng. Chem. Res., 57, 16172 (2018)<br></p>

<p>Applications 3,5-Dimethylbenzoyl Chloride-d9 is an intermediate in the synthesis of Methoxyfenozide-d9 (M262768), deuterium labelled Methoxyfenozide (M262765). It is used primarily as an insecticide, and pesticide.<br>References Zhao, Q., et al.: J. Agricul, Food Chem., 56, 10799 (2008)<br></p>

<p>Applications Hexanedioic-d8 Acid (CAS# 52089-65-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Propio-d5-phenone (CAS# 342610-99-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications α-Naphthyl-d7 Glycidyl Ether is an intermediate in the synthesis of rac-Propranolol-d7 (P831803) which is the labeled analogue of Propranolol (P831800), a β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),<br></p>

<p>Applications 4-Oxo-2,2,6,6-tetramethylpiperidine-d17 (CAS# 52168-48-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Dodecane-d25-thiol (CAS# 869563-00-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Abiraterone Ethyl Ether-d5 is the labeled analogue of Abiraterone Ethyl Ether (A108525), an impurity of Abiraterone (A108490), a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.<br>References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389(2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)<br></p>

<p>Applications Tridecanoic-2,2-d2 Acid (CAS# 64118-44-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Testosterone Octanoate-d15 is the isotope analog of Testosterone Octanoate. Testosterone Octanoate is a metabolite of tesosterone (T155000), which is used in biological studies to determine the hemolytic and lipophilic activity of this anabolic steroid.<br>References Biagi, G.L., et al.: J. Med. Chem., 13, 944 (1970); Biagi, G. L., et al.: J. Med. Chem., 18, 873 (1975)<br></p>

<p>Applications 3-((2-((2-Chloroethyl)amino)ethyl)amino)propyl Ethyl Phosphate Dihydrochloride-d4, a deuterium labelled 3-((2-((2-Chloroethyl)amino)ethyl)amino)propyl Ethyl Phosphate Dihydrochloride (C984605), is a derivative of Cyclophosphamide Monohydrate (C988580), a known human carcinogen that is widely used in cancer chemotherapy because it can cross-link DNA causing strand breakage and mutation.<br>References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)<br></p>

<p>Applications 2-(3,4-Dihydroxyphenyl-13C6)ethylamine HCl (CAS# 335080-94-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzene-1,2,4,5-d4 (CAS# 14919-17-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Hydroxy Nicorandil-d4 is the isotope labelled analog of 6-Hydroxy Nicorandil (H948550); a metabolite of the antianginal Nicorandil (N398500).<br>References Frydman, A., et al.: Am. J. Cardiol., 63, 25J (1989); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008); Sudo, H., et al.: Biol. Pharm. Bull., 31, 2079 (2008); Iida, S., et al.: Brit. J. Clin. Pharmacol., 66, 352 (2008); Eguchi, Y., et al.: Ther. Res., 29, 316 (2008)<br></p>

<p>Applications The four-center reactions of alkanol-alkoxide negative ions with alkyl ethers and ortho-acetates. An ion cyclotron resonance study.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ethylene Glycol Dilaurate-d4 is a deuterated version of Ethylene Glycol Dilaurate (E917476), a pearling agents for cosmetics.<br>References Onozaki, T., et al.: Journal of SCCJ, 15, 38-44 (1981)<br></p>

<p>Applications 1-Bromooctadecane-d37 (CAS# 187826-28-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Piperazine-N,N'-bis(2-ethanesulfonic Acid)-d18 (CAS# 352534-95-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,5-Dibromopyridine-d3 (CAS# 1219799-05-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromoundecane-11,11,11-d3 (CAS# 1219805-63-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl 3-Amino-4-methylbenzoate-D6 is an intermediate in the synthesis of Nilotinib-d6 (N465303), which is the labeled analogue of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications (±)-2-Chlorobutane-d9 (CAS# 175540-77-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications iso-Propylamine-d9 DCl (CAS# 1219798-50-1) is a useful isotopically labeled research compound.<br>Chemical Name: iso-Propylamine-d9 DCl (CAS# 1219798-50-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate is an impurity in the synthesis of Sorafenib (S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.<br>References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003), Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004), Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004), Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006),<br></p>

<p>Applications Tuberculostearic Acid Methyl-d3 Ester is labelled Tuberculostearic Acid Methyl Ester (T897100), the methyl ester of Tuberculostearic Acid (T897090) which is a saturated fatty acid produced by Actinomycetales bacteria.<br>References Frencha, G., et al.: The Lancet, 330, 117 (1987)<br></p>

<p>Applications Ethylmethyl-d3-amine (CAS# 223459-64-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications L-Serine (1-13c, 99%) (cas# 81201-84-5) is a useful research chemical.<br></p>

<p>Applications 2-Phenylpropane-2-d1 (CAS# 4019-54-9) is a useful isotopically labeled research compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications DL-Phenylalanine-2-13C (CAS# 64193-01-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications bis(2-Chloroethoxy)-d8-methane (cas# 93966-78-0) is a useful research chemical.<br></p>

<p>Applications Sodium n-Octyl-d17 Sulfate (CAS# 1219802-16-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Cyclopropylethyl-1,1,2,2-d4-amine (CAS# 1219795-00-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,4-Di(methyl-d3)-naphthalene has been used in the preparation of di(trideuteriomethyl)naphthalene derivatives. 1,4-Di(methyl-d3)-naphthalene is a labeled analogue of 1,4-Dimethylnaphthalene (D476380), a polycyclic aromatic hydrocarbon (PAH) that has been found to retard the development of epidermoid carcinomas in hamster buccal pouch and alter the genes associated with the maintenance of a G1/S phase block possibly through the induction of the cell cycle inhibitors KRP1 and KRP2 in potatoes.<br>References Dizabo, P., et. al.: J. Labelled Compd., 2, 272 (1966); Malament, D.S., Shklar, G.: Carcinogenesis, 2, 723 (1981); Campbell, M.A., et. al.: Fuct. Interg. Genomics, 12, 533 (2012); Andrysik, Z., et. al.: Mutat. Res-Fund. Mol. M., 714, 53 (2011)<br></p>

<p>Applications N-Propionylglycine-2,2-d2 (CAS# 1256842-51-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromononane-9,9,9-d3 (CAS# 1219799-20-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Butyryl-2,2-d2 Chloride (CAS# 90587-10-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Nonen-1-ol-D2 is a labelled analogue of 2-Nonen-1-ol. 2-Nonen-1-ol is an unsaturated alcohol that has antimicrobial properties. 2-Nonen-1-ol is also used as a flavour and fragrance agent, and has a “green” odour.<br>References Gigot, C., et al.: Biotechnol. Agron. Soc. Environ., 14, 451 (2010); Kalua, C., et al.: J. Agr. Food Chem., 53, 8054 (2005); Serrazanetti, D., et al.: Food Cont., 34, 336 (2013)<br></p>

<p>Applications 1-Cyclopentylethanone-d4, is the labeled analogue of 1-Cyclopentylethanone (C988475), that can be used in the preparation of small molecule inhibitors of rifampicin resistant Staphylococcus aureus. An antibacterial agent. Also used in the synthesis of non-quinoline leukotriene D4 (LTD4) receptor antagonists.<br>References Arhin, F. et al.: Bioorg. Med. Chem., 14, 5812 (2006); Lau, C. et al.: Bioorg. Med. Chem. Lett., 5, 1615 (1995);<br></p>

<p>Applications Labelled Pipazetate Hydrochloride, a pyridobenzothiazine derivative an antiarrhythmic characteristics. Pipazetate is used as a cough supressant.<br>References Giuliano, H.: Arch. Int. Pharmacodyn. Ther., 188, 189 (1970); Hahn, K.J. et al.: Med. Pharmacol. Exp., 14, 87 (1966);<br></p>

<p>Applications Hexanenitrile-6,6,6-d3 (CAS# 1219805-03-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chlorotoluene-d7 (CAS# 84344-06-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-(Hydroxymethyl-d2)uracil-6-d1 (CAS# 352438-73-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Ethoxyethanol-1,1,2,2-d4 (CAS# 1219805-07-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzene-1,3-d2 (CAS# 14941-51-6) is a useful isotopically labeled research compound.<br></p>