Deuterated Compounds

Applications Labelled 1-Hexadecene. 1-Hexadecene is one of the alpha olefins used as comonomers in polymer such as low density polyethylenes for the properties of lighter, thinner, better flexibility and more tearing resistance.
References Conde, R., et al.: Phytomedicine, 18, 1197 (2011),

Applications 1,3,5-Triphenylbenzene-d18 (CAS# 34496-33-8) is a useful isotopically labeled research compound.

Applications Monocrotaline-d4 is labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),

Applications N,N'-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2'-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide-d4 is labelled N,N'-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2'-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide (E676300) which is an impurity of Bosentan (B675900), a mixed endothelin receptor antagonist.
References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)

Applications 3-Nitrofluoranthene-d9 (CAS# 350820-11-0) is a useful isotopically labeled research compound.

Applications Methyl 2-Diethoxyphosphoryl-2-methoxyacetate-d10 is the isotope labelled analog of Methyl 2-diethoxyphosphoryl-2-methoxyacetate which is a reagent in a Wittig reaction.
References Ribereau, P., et al.: Can. J. Chem., 61, 334 (1983);

Applications 3,5-Dihexanamido-2,4,6-triiodo-benzoic Acid-d22 is the isotope labelled analog of 3,5-Dihexanamido-2,4,6-triiodo-benzoic Acid (D448150); a derivative of 3,5-Diamino-2,4,6-triiodobenzoic Acid (D416820) which is a metabolite of Diatrizoate with mutagenic and cytotoxic properties.
References Kalsch, W., et al.: Sci. Total Environ., 225, 143 (1999); Parkesh, R., et al.: Org. Biomol. Chem., 4, 3611 (2006)

Applications 4-Chlorothiobenzamide-2,3,5,6-d4 (CAS# 1219802-58-0) is a useful isotopically labeled research compound.

Applications N,N-Dimethylaniline-d11 (CAS# 85785-00-8) is a useful isotopically labeled research compound.

Applications 1-Bromoundecane-1,1,2,2-d4 (CAS# 1219802-82-0) is a useful isotopically labeled research compound.

Applications N,N,N',N'-Tetramethyl-1,3-propanediamine-d18 (CAS# 1398065-52-5) is a useful isotopically labeled research compound.

Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.
References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);

Applications 1,14-Tetradecanedioic-d24 Acid (CAS# 130348-88-8) is a useful isotopically labeled research compound.

Applications 3-Aminopropionamide-2,2,3,3-d4 HCl (CAS# 1276197-35-3) is a useful isotopically labeled research compound.

Applications 1-Chlorobutane-d9 (CAS# 175540-76-8) is a useful isotopically labeled research compound.

Applications n-Nonyl-d19 Alcohol (CAS# 349553-86-2) is a useful isotopically labeled research compound.

Applications Used in the preparation of labelled indolizine compounds for use in antifungal combination therapy.

Applications A labelled metabolite of the antihypertensive agent, Labetalol (L096500). Ractopamine impurity.
References Gal, J., et al.: Res. Comm. Chem. Pathol. Pharmacol., 62, 3 (1988),

Applications 2-Chloroaniline-d6 (CAS# 1276197-37-5) is a useful isotopically labeled research compound.

Applications Cyclopropyl-d5-boronic Acid is a deuterated version of Cyclopropylboronic Acid (C988620), an organoboronic acid commonly used in highly efficient Suzuki coupling reactions.
References Ma, S. et al.: Adv. Synth. Cat., 348, 2114 (2006)

Applications Phenylboronic Acid-13C6 is the isotope labelled 13C6 analog of Phenylboronic Acid (P319590); a compound used in the organic synthesis of various pharmaceutical goods.
References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930)

Applications (±)-2-Iodobutane-d9 (CAS# 1219795-41-1) is a useful isotopically labeled research compound.

Applications n-Butyl-3,3,4,4,4-d5 Alcohol (CAS# 64118-16-7) is a useful isotopically labeled research compound.

Applications 1,3-Dioleoyl-2-stearoylglycerol-d5 is the isotope labelled analog of 1,3-Dioleoyl-2-stearoylglycerol (D484305); a triglyceride found in various natural sources such as coconut oil, palm oil, rice bran oil, sunflower oil and sesame oil.
References Reena, M.B. et al.: Eur. J. Lipid Sci. Technol., 111, 346 (2009); Huey, S. et al.: J. Food Sci., 74, E177 (2009)

Applications 4-n-Butyl-d9-aniline (CAS# 1219794-78-1) is a useful isotopically labeled research compound.

Applications 2-Phenylethyl Acetate-d3 (CAS# 1219805-43-2) is a useful isotopically labeled research compound.

Applications A labelled major adduct from alkylation of DNA by the genotoxic carcinogen, propylene oxide. Molecular dosimetry studies are used to find the amount present in tissues of F344 rats after inhalation exposure to propylene oxide
References Rios-Blanco, M.N. et al.: Carcinogen., 24, 1233 (2003); Segerback, D. et al.: Chem.-Biol. Inter., 115, 229 (1998);

Applications Octadecanoic-9,9,10,10-d4 Acid (CAS# 130048-57-6) is a useful isotopically labeled research compound.

Applications N,N-Diethylbenzamide-d5 is an intermediate in the synthesis of Benz[a]anthracene-7,12-dione-D4 (B197942), a polycyclic aromatic hydrocarbon that is present in the emission soot of biomass fuels combustion.

Applications 1-Iodopropane-d7 is the labelled analogue of 1-Iodopropane [I718790] which is used in the synthesis of a new class of cesium selective ionophores. Also used to preparation of secondary amines and diamines.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Casnati, A. et al.: J. Am. Chem. Soc., 117, 2767 (1995); Fukuyama, T. et al.: Tetrahedron Lett., 38, 5831 (1997);

Applications n-Butyl-4,4,4-d3-benzene (CAS# 109232-94-2) is a useful isotopically labeled research compound.

Applications m-Bromofluorobenzene-d4 is a labeled reagent useful for organic synthesis.

Applications 4-Fluorotoluene-alpha,alpha,alpha-d3 (CAS# 4202-91-9) is a useful isotopically labeled research compound.

Applications N-Boc-2-(methylthio)ethylamine-d3 is the isotope labelled analog of N-Boc-2-(methylthio)ethylamine (B657055); a compound used as a reagent in the synthesis of anthranilic diamide insecticides and new glycopeptidomimetics based on N-substituted oligoglycines bearing N-linked lactoside side chains.
References Hua, X., et al.: Austr. J. Chem., 67, 1491 (2014); Saha, U.K., et al.: J. Chem. Soc. Chem. Comm., no vol., 2571 (1995)

Applications Cycrimine Hydrochloride-d5 is the isotope labelled analog of Cycrimine Hydrochloride (C991450); a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.
References Das, M., et al.: Toxicol. Appl. Pharm., 39, 149 (1977); Vedasiromoni, J.R., et al.: Arch. Int. Pharmacod. T., 219, 64 (1976)

Applications Insecticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nishizawa, Y., et al.: Agric. Biol. Chem., 25, 605 (1961),

Applications 2-Propane-d7-thiol (CAS# 1219803-56-1) is a useful isotopically labeled research compound.

Applications Octanoic-8,8,8-d3 Acid (CAS# 156779-05-4) is a useful isotopically labeled research compound.

Applications Ammonium hydrogen phosphate-15N is the labelled analogue of Ammonium hydrogen phosphate (CAS:7722-76-1), a reagent that is useful for organic synthesis.

Applications N-Acetyl-DL-alanine-3,3,3-d3 is an isotopic analog of N-Acetyl-DL-alanine (A167965), a derivative of DL-Alanine (A481400) and is used as a reagent in the synthesis of potent new agents for the treatment of epilepsy.
References Conley, J.D., et al.: J. Med. Chem., 30, 567 (1987)

Applications Tetracosanoic-12,12,13,13-d4 Acid (CAS# 1219794-59-8) is a useful isotopically labeled research compound.

Applications trans,trans-Muconic-d4 Acid (CAS# 1955496-83-9) is a useful isotopically labeled research compound.

Applications Isotope labelled Cyclopropylmethyl Bromide is a reagent used in the synthesis of human dihydroorotate dehydrogensase inhibitors which are based on azole scaffolds. In addition it is used in the preparation of ([11C]CMDC) for PET imaging of mGlur2 which has been a proposed target in the treatment of schizophrenia.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sainas, S. et al.: Eur. J. Med. Chem., 129, 287 (2017); Ma, Y. et al.: Bioorg. Med. Chem., 25, 1014 (2017);

Applications n-Hexadecyl-2,2,16,16,16-d5 Alcohol (CAS# 1219799-18-4) is a useful isotopically labeled research compound.

Applications L-4-Hydroxyphenyl-2,6-d2-alanine (CAS# 57746-15-3) is a useful isotopically labeled research compound.

Applications 1,3-Propane-d6-dithiol (CAS# 1219803-51-6) is a useful isotopically labeled research compound.

Applications An intermediate for the synthesis of analogs of retinoid lactone.
References Lewin, A.H., et al.: Pharm. Res., 12, 983 (1995).

Applications 4'-Chloroacetophenone-2',3',5',6'-d4 (CAS# 284474-50-6) is a useful isotopically labeled research compound.

Applications 1-Bromopropane-2,2-d2 (CAS# 40422-15-9) is a useful isotopically labeled research compound.

Applications Ethyl-alpha-13C-benzene (CAS# 287399-32-0) is a useful isotopically labeled research compound.

Applications 2-(Ethyl-d5)hexanoic Acid is an intermediate in the synthesis of Alexidine-d10 Dihydrochloride (A525002), which has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.
References Coburn, R.A., et al.: J. Med. Chem., 21, 8, 829 (1978), Takayama, K., et al.: J. Biol. Chem., 269, 2241 (1994), Faure, P., et al.: Biochimie, 86, 411 (2004),

Applications Tetrabromobisphenol A Diglycidyl Ether-d10 is the isotope labelled analog of Tetrabromobisphenol A Diglycidyl Ether (T291305); a brominated flame retardant (BFR) with good stability and a thermal decomposition temperature over 300°.
References Oleszek S., et al.: Waste Manag., 33, 1835 (2013); Jia, X., et al.: Henan Daxue Xuebao, Ziran Kexueban, 36, 44 (2006)

Applications 3-Amino-1-propanol-d6 is a deuterated version of 3-Amino-1-propanol (A628130) which is used in the synthesis of tetrathiafulvalenes displaying optical and electrochemical properties. Also used in the synthesis of lipid-like materials for the delivery and encapsulation of RNAi therapeutics.
References Ignatenko, E. et al.: Russ. J. Org. Chem., 49, 1379 (2013); Akinc, A. et al.: Nat. Biotech., 26, 561 (2008);

Applications Dimethyl chlorothiophosphate-D6 is a labelled analog of Dimethyl chlorothiophosphate (D473292). Dimethyl chlorothiophosphate is an organophosphorus reagent that is used to synthesize phosphorus analogues of γ-aminobutyric acid, compounds that exhibit anticonvulsant properties. Dimethyl chlorothiophosphate is also used as a reagent to synthesize Parathion (P192220), a widely used pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cates, L., et al.: J. Med. Chem., 27, 654 (1984); DeBruin, K. & Boros, E.: J. Org. Chem., 55, 609 (1990); Hall, S.: J. Am. Chem. Soci., 72, 2768 (1950); Kotronarou, A. & Hoffmann, M.: Env. Sci. Tech., 26, 1460 (1992)

Applications Fenuron-d5 (phenyl-d5) (CAS# 1219802-06-8) is a useful isotopically labeled research compound. It can be used for the preparation of difunctionalized indoles.
References Lv, H., et al.: Org. Biomol. Chem., 15, 8054 (2017)

Applications Isotope labelled analogue of a protected amino acid
References Villiers, B., et al.: ChemBioChem. 10, 671 (2009), Fransson, R., et al.: J. Med. Chem., 53, 2383 (2010), Watts, R., et al.: Biochem., 49, 2177 (2010),

Applications N,N-Bis(2-chloroethyl)benzenesulfonamide-d5 is the isotope labelled analog of N,N-Bis(2-chloroethyl)benzenesulfonamide (B418910); a novel intermediate in the synthesis of Cetirizine (C281100).

Applications 1-Bromopentadecane-d31 (CAS# 349553-93-1) is a useful isotopically labeled research compound.

Applications 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide (cas# 1189858-48-7) is a compound useful in organic synthesis.

Applications 3-Pentyl-2,2,3,4,4-d5 Alcohol (CAS# 144032-75-7) is a useful isotopically labeled research compound.

Applications 3-Pentanone-d10 (CAS# 54927-77-4) is a useful isotopically labeled research compound.

Applications Labelled Aldicarb Sulfoxide (A514665). Aldicarb Sulfoxide is an analog of Aldicarb (A514650) detected in agricultural products as pesticide residue.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),

Applications (±)-Carazolol-d7 is labelled (±)-Carazolol (C175810, HCl salt) which is a promising high-affinity beta-adrenergic receptor ligand for the noninvasive determination of beta receptor status using PET.
References Berridge, M.S., et al.: J. Nucl. Med., 35(10), 1665 (1994)

Applications Tryptamine-d5 is an isotope labelled form of Tryptamine (T894600). Tryptamine is a monoamine alkaloid found in plants. Tryptamine is commonly used in the preparation of biologically active compounds such as neurotransmitters and psychedelics.
References Nichols, D. E., et al.: Curr. Top. Behav. Neurosci., 36, 1 (2018); Espinoza, S., et al.: Top. Med. Chem., 23, 175 (2017)

Applications 2-Chloropropane-2-d1 (CAS# 53778-42-0) is a useful isotopically labeled research compound.

Applications 2,2-Bis(4-hydroxyphenyl)propanol-d11 is labelled 2,2-Bis(4-hydroxyphenyl)propanol (B447360) which is a metabolite of bisphenol A (B519495). It works as an endocrine disruptor.
References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993), Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Kitamura, S., et al.: Toxicol. Sci., 84, 249 (2005)

Applications n-Pentyl-d11 chloroformate is labelled n-Pentyl chloroformate which can be used to synthesize 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase.
References Kim, I., et al.: J. Med. Chem., 47, 2110 (2004); Hammock, B., et al.: PCT Int. Appl. (2006), WO 2006045119 A2 20060427.