Deuterated Compounds

<p>Applications α-Methylstyrene-d5 Oxide is labelled α-Methylstyrene Oxide (M325390) which is structurally similar to rac Styrene Oxide (S687795), a major (toxic) metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Shen, S. et al.: Drug Metab. Disp., 38, 1934 (2010); Carlson, G.P. et al.: J. Toxicol. Env. Health, 73, 1689 (2010)<br></p>

<p>Applications Methyl Methacrylate-3,3-d2 (CAS# 55063-97-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl Cyanoacetate-13C3 is an intermediate used in the synthesis of 3-Hydroxypropionic Acid-13C3 Sodium Salt (H952481), which is an isotope labelled analogue of 3-Hydroxypropionic Acid Sodium Salt (H952480), which is beta hydroxy acid derived from plants and crops such as corn. 3-Hydroxypropionic Acid is used in the preparation of acrylates and biodegradable polymer polyester.<br>References Wang, Y. et al.: Biomacromol., 3, 828 (2002); Jiang, X. et al.: Appl. Microbiol. Biotech., 82, 995 (2009);<br></p>

<p>Applications 6-Chloro1,4-dihydro-1-methyl-4-phenyl-4-quinazolinol-13CD3 is the isotope labelled analog of 6-Chloro1,4-dihydro-1-methyl-4-phenyl-4-quinazolinol. 6-Chloro1,4-dihydro-1-methyl-4-phenyl-4-quinazolinol is used in hydroxyglycine reactions in determining a new synthetic route for phenylquinazoline derivatives.<br>References Hoefnagel, A.J., et al.: Tetrahedron, 49, 6899 (1993)<br></p>

<p>Applications Ethylenediaminetetraacetic-d12 Acid (CAS# 203806-08-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,3-Dihydro-5-benzofuranethanol-d4 (cas# 1185079-36-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Phthalic Acid Bis(3,7-dimethyloctyl) Ester-d4 is the isotope labelled analog of Phthalic Acid Bis(3,7-dimethyloctyl) Ester (P384535); a diester derivative of Phthalic Acid (P384480) which can be used as a plasticizer for PVC-type compositions.<br>References Takeuchi, H., et al. Jpn. Kokai Tokkyo Koho. JP 2001002829 A 20010109. Jan 9, 2001<br></p>

<p>Applications Ethynyl-2-13C-benzene, is the labeled analogue of Ethynylbenzene (E932150), which is an aromatic hydrocarbon, is important in the petrochemical industry as an intermediate in the production of styrene, which in turn is used for making polystyrene, a common plastic material.<br>References Xiang, J., et al.: Tetrahedron Lett, 37, 5269 (1996);<br></p>

<p>Applications Phenol-2,4,6-d3,OD (CAS# 80441-87-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications D-4-Hydroxyphenyl-d4-alanine-2,3,3-d3 (CAS# 1426174-46-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Dimethoxybenzene-2,4,5,6-d4 (CAS# 362049-44-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications (E)-4-(Dimethylamino)but-2-enoyl Chloride-d6 is an intermediate used in the synthesis of Afatinib-d6 (A355303), which is the d6 labeled analogue of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br>References Schroeder, J., et al.: PCT Int. Appl. WO 2007085638 A1 20070802. Aug 2, 2007;<br></p>

<p>Applications Tetramethyl-d12-ammonium Bromide (CAS# 284474-82-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Chlorotoluene-d7 (CAS# 1219804-88-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(Phenyl-d5)-3-buten-2-one (cas# 56187-93-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Nitrotoluene-alpha,alpha,alpha-d3 (CAS# 23346-24-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications N,N'-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2'-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide-d4 is labelled N,N'-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2'-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide (E676300) which is an impurity of Bosentan (B675900), a mixed endothelin receptor antagonist.<br>References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)<br></p>

<p>Applications 1,6-Dibromohexane-d12 (CAS# 169397-96-0) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications Propyl-d7 β-D-Glucuronide Sodium Salt is a glucuronide of a short-chained aliphatic alcohol formed via glucuronidation in human liver microsomes in vitro.<br>References Jurowich, S. et al.: Alcohol, 32, 187 (2004);<br></p>

<p>Applications Choline-d13 Bromide (cas# 203645-64-1) is a useful research chemical.<br></p>

<p>Applications Labelled 2-Furfurylthiol Acetate (F864600). 2-Furfurylthiol Acetate is a sulfur-substituted furan derivative used as flavouring agent. 2-Furfurylthiol Acetate is a precursor to furfurylmercaptan which is very prone to oxidation to the disulfide. We will provide a detailed procedure for the preparation of the thiol from the thioacetate with spectral data upon request.<br>References Engel, K., et al.: J. Agric. Food Chem., 39, 2249 (1991), Jones, M., et al.: J. Exp. Bot., 55, 1903 (2004), Gershater, M., et al.: J. Biol. Chem., 282, 21460 (2007),<br></p>

<p>Applications (R)-Hydroxymelphalan-d4 Trifluoroacetic Acid Salt is the isotope labelled analog of (R)-Hydroxymelphalan Trifluoroacetic Acid Salt (H939845); the R-enantiomer of Hydroxymelphalan (H939850) which is an analog of the antineoplastic Melphalan (M216900).<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966); Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980)<br></p>

<p>Applications Secobarbital-d5 (1-methyl-d3-butyl-2,2-d2) (CAS# 1219803-94-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Phenylethyl Acetate-d3 (CAS# 1219805-43-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Phenylalanine-3-13C (CAS# 286425-42-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Hydroxychlorpropham Sulfate-d7 Triethylamine is an intermediate used in the synthesis of 4-Hydroxychlorpropham-d7 Sulfate Sodium Salt (H825077), which is derived from Isopropanol-d7 (I822752), a deuterated alcohol used in the study of lignite liquefaction.<br>References Kuznetov, P.N. et al.: Fuel, 70, 559 (1991);<br></p>

<p>Applications Prometon-d3 (methoxy-d3) (CAS# 1219803-43-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications An intermediate for the synthesis of aromatic analogs of retinal and retinoic acid.<br>References Pawson, B.A., et al.: J. Med. Chem., 22, 1059 (1979).<br></p>

<p>Applications 2-(Ethyl-d3) Isonicotinamide is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications Formamidine-13C Acetate (cas# 1215714-80-9) is a compound useful in organic synthesis.<br></p>

<p>Applications rac-3-Acetylthio-2-methylpropionyl Chloride-d5 is deuterated version of (2R)-3-Acetylthio-2-methylpropionyl Chloride (A188675), which is a reactant used in the preparation of Captopril (C175750) and its analogs as inhibitors of angiotensin converting enzyme.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978); Hanessian, S., et al.: Bioorg. Med. Chem. Lett., 8, 2123 (1998);<br></p>

<p>Applications α-Naphthyl-d7 Glycidyl Ether is an intermediate in the synthesis of rac-Propranolol-d7 (P831803) which is the labeled analogue of Propranolol (P831800), a β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),<br></p>

<p>Applications 4-n-Butylanisole-2,3,5,6-d4 (CAS# 1219804-78-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromohexane-6,6,6-d3 (CAS# 350818-70-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Dodecane-d25-thiol (CAS# 869563-00-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromopropane-1,1,3,3,3-d5 (CAS# 163400-20-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Palmitoyl-L-carnitine-d3 Hydrochloride is labelled Palmitoyl-L-carnitine Hydrochloride (P155050), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Stability Moisture Sensitive<br>Applications Labelled Benzoyl Chloride. Used in the manufacturing of dye intermediates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-(1,4,5,6-tetrahydro-2-pyrimidinyl)​-phenol-d6 is labelled 3-(1,4,5,6-tetrahydro-2-pyrimidinyl)​-phenol (T293810) which is a useful synthetic intermediate.<br></p>

<p>Applications Benzene-1,2,4,5-d4 (CAS# 14919-17-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl-1,1-d2 Alcohol-OD (CAS# 22544-42-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Erythromycin Ethyl Succinate-13C,d3 is the deuterated form of Erythromycin Ethyl Succinate (E649985), which is a derivative of Erythromycin (E649950), an antibiotic.<br>References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979); Serisier, D. et al.: J. Am. Med. Assoc., 309, 1206 (2013);<br></p>

<p>Applications Heptanoic-7,7,7-d3 Acid (CAS# 156779-04-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Piperonyl Methoxyethyl Ether-d3 is the isotope labelled analog of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly.<br>References Motoyama, N., et al.: Rev. Pestic. Toxicol., 1, 173 (1991)<br></p>

<p>Applications 2-Phenylpropane-2-d1 (CAS# 4019-54-9) is a useful isotopically labeled research compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Eicosanoic-2,2-d2 Acid (CAS# 232600-70-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Monobutyl sulfate-D9 is a labelled analogue of Monobutyl sulfate (M525130). Monobutyl sulfate is used as a wetting agent in the mercerization (a treatment that gives cotton its shiny appearance and also functions to increase its strength) of cotton. Monobutyl sulfate is also used in the polymerization of tetrahydrofuran.<br>References Pruckmayr, G. &amp; Wu, T.: Macromolecules, 11, 662 (1978); Shenai, V., Int. Dyer Text. Print. Bleach. Finish., 158, 246 (1977)<br></p>

<p>Applications n-Heptylbenzene-2,3,4,5,6-d5 (CAS# 1219799-19-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,6-Diethylaniline-15N (CAS# 287488-24-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Cyclopropylethyl-1,1,2,2-d4-amine (CAS# 1219795-00-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications An intermediate of Rosuvastatin (R700500).<br></p>

<p>Applications 1,3-Dimethoxy-5-(propyl-2,2,3,3,3-d5)benzene is an intermediate used in the synthesis of Cannabidivarin-D5 (C175292), which is a labelled analogue of Cannabidivarin (C175390), a plant cannanbinoid and a homologue of Cannabidiol (C175300), the non psychoactive component of cannabis that exhibits anxiolytic properties. Cannabidivarin also has anticonvulsant effects on animals.<br>References Amada, N., et al.: PeerJ., 1, e214 (2013); Guimaraes, F., et al.: Psychopharmacology, 100, 558 (1990); Malfait, A., et al.: P. Natl. Acad. Sci., 97, 9561 (2000)<br></p>

<p>Applications 2-Mercaptoethanol (D6, 98%) (cas# 203645-37-8) is a useful research chemical.<br></p>

<p>Applications Butyryl-2,2-d2 Chloride (CAS# 90587-10-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications D-Methionine-d3 is used for detection D- and L-enantiomers of methionine and [2H3]methionine in plasma by gas chromatography-mass spectrometry of methylated/N-acylated derivatives.<br>References Hasegawa, H., et al.: J. Chromatogr. B: 823, 203 (2005);<br></p>

<p>Applications 5-(Hydroxymethyl-d2)uracil-6-d1 (CAS# 352438-73-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzyl-alpha,alpha-d2-amine (CAS# 15185-02-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Pramaxo impurity C-D6 labelled. (6S)-N6-[3-[[(6S)-2-Amino-4,5,6,7-tetrahydro-6-benzothiazolyl]amino]-1-ethyl-2-methylpropyl]-4,5,6,7-tetrahydro-2,6-benzothiazolediamine-D6 can be byproduct of process for the preparation of pramipexole and salts thereof by reductive amination of (diamino)tetrahydrobenzothiazole with propanal.<br>References Deo, K., et al.: Indian Pat. Appl., IN 2013MU02843 A 20150703 (2015)<br></p>