Deuterated Compounds

Applications Monocrotaline-d4 is labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),

Applications 1,6-Dibromohexane-d12 (CAS# 169397-96-0) is a useful isotopically labeled research compound.

Applications Labelled 2-Furfurylthiol Acetate (F864600). 2-Furfurylthiol Acetate is a sulfur-substituted furan derivative used as flavouring agent. 2-Furfurylthiol Acetate is a precursor to furfurylmercaptan which is very prone to oxidation to the disulfide. We will provide a detailed procedure for the preparation of the thiol from the thioacetate with spectral data upon request.
References Engel, K., et al.: J. Agric. Food Chem., 39, 2249 (1991), Jones, M., et al.: J. Exp. Bot., 55, 1903 (2004), Gershater, M., et al.: J. Biol. Chem., 282, 21460 (2007),

Applications Isotope labelled N-Fmoc-glycine is an N-Fmoc-protected form of Glycine (G615990). Glycine is a nonessential amino acid that acts as an inhibitory neyrotransmitter in the vertebrate central nervous system. Glycine also posesses cytoprotective against oxidant damage in the kidney.
References Eulenberg, V., et al.: Trend. Biochem. Sci., 30, 325 (2005); Gundersen, R., et al.: Acta Anaesth. Scand., 49, 1108 (2005); Lockart, R. & Eagle, H.: Science, 129, 252 (1959); Sogabe, K., et al.: Kidn. Int., 50, 845 (1996)

Applications 1-(3,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol-d6 is an isotopic analog of 1-(3,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol (D474175) and a Miconazole (M342505) impurity.

Applications 2-Phenylethyl Acetate-d3 (CAS# 1219805-43-2) is a useful isotopically labeled research compound.

Applications Benzyl-2,3,4,5,6-d5-amine (CAS# 1219802-81-9) is a useful isotopically labeled research compound.

Applications Decanoic-9,9,10,10,10-d5 Acid (CAS# 1219803-00-5) is a useful isotopically labeled research compound.

Applications Ethyl-d5 Butyrate is the labeled analogue of Ethyl Butyrate (E900690), which is used in the preparation of novel 2-cyanopyrimidines as cathespin K inhibitors. Also used in the synthesis of pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of β-1,6-glucan.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References By Rankovic, Z. et al.: Bioorg. Med. Chem. Lett.,, 20, 1524 (2010); Takeshita, H. et al.: Bioorg. Med. Chem. Lett., 20, 3893 (2010)

Applications 1-Bromohexane-6,6,6-d3 (CAS# 350818-70-1) is a useful isotopically labeled research compound.

Applications 1-Chloropropane-d7 (CAS# 761374-88-3) is a useful isotopically labeled research compound.

Applications Palmitoyl-L-carnitine-d3 Hydrochloride is labelled Palmitoyl-L-carnitine Hydrochloride (P155050), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.
References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)

Applications 6-Chloro-1-hexyl-3,3,4,4,5,5-d6 Alcohol (CAS# 1219794-83-8) is a useful isotopically labeled research compound.

Applications Dichloroprop-d7 can be obtained from Phenol-d5 (P318003) which is purified here for molecular genetics applications. It is naturally found in tea leaves and plants, and has uses in the synthesis of antioxidant compounds due to the antioxidant activity caused by the phenol moiety. This structure also allows it to be used for syntheses of anti-bacterial & anti-carcinogenic compounds. This is the labelled analog.
References Nam, S. et al.: J. Agri. Chem., 60, 9097 (2012); Xia, J. et al.: J. Agri. Chem., 57, 99 (2009); Khanal, P. et al.: Carcinogenesis, 32, 545 (2011);

Applications Ethyl-1,1-d2 Alcohol-OD (CAS# 22544-42-9) is a useful isotopically labeled research compound.

Applications Erythromycin Ethyl Succinate-13C,d3 is the deuterated form of Erythromycin Ethyl Succinate (E649985), which is a derivative of Erythromycin (E649950), an antibiotic.
References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979); Serisier, D. et al.: J. Am. Med. Assoc., 309, 1206 (2013);

Applications Heptanoic-7,7,7-d3 Acid (CAS# 156779-04-3) is a useful isotopically labeled research compound.

Applications Monobutyl sulfate-D9 is a labelled analogue of Monobutyl sulfate (M525130). Monobutyl sulfate is used as a wetting agent in the mercerization (a treatment that gives cotton its shiny appearance and also functions to increase its strength) of cotton. Monobutyl sulfate is also used in the polymerization of tetrahydrofuran.
References Pruckmayr, G. & Wu, T.: Macromolecules, 11, 662 (1978); Shenai, V., Int. Dyer Text. Print. Bleach. Finish., 158, 246 (1977)

Applications n-Heptylbenzene-2,3,4,5,6-d5 (CAS# 1219799-19-5) is a useful isotopically labeled research compound.

Applications 2-Mercaptoethanol (D6, 98%) (cas# 203645-37-8) is a useful research chemical.

Applications 1,3-Dimethoxybenzene-d10 (CAS# 340257-57-0) is a useful isotopically labeled research compound.

Applications Butyryl-d7 Chloride is an isotope labelled compound of Butyryl Chloride (B810510). Butyryl Chloride is used in the synthesis of chromones which are involved in the relaxing of smooth muscle. Also used in the synthesis of antiproliferative agents based on anilines.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rodriguez-Ramos, F. et al.: Bioorg. Chem., 50, 17 (2013); Cazares-Marinero, J. et al.: J. Org. Chem., 744, 92 (2013);

Applications N-Butyrylglycine-2,2-d2 (CAS# 1219799-10-6) is a useful isotopically labeled research compound.

Applications N,N-Dimethylaniline-2,3,4,5,6-d5 (CAS# 87385-38-4) is a useful isotopically labeled research compound.

Applications 4-Chlorohippuric Acid-d4 is the isotope labelled analog of 4-Chlorohippuric Acid (C367420); a derivative of Hippuric Acid (H356700) and the major metabolite in human urine.
References Köppel, C., et al.: Arzneimittel-Forsch., 36, 1116 (1986); Oelschläger, H., et al.: Die Pharmazie, 53, 620 (1998)

Applications Chlorobenzene-3,5-d2 (CAS# 59164-10-2) is a useful isotopically labeled research compound.

Applications n-Hexadecyl-15,15,16,16,16-d5 Alcohol (CAS# 1219799-21-9) is a useful isotopically labeled research compound.

Applications Bis(6-methylheptyl) Phthalate-3,4,5,6-d4 (CAS# 2209087-06-7) is a useful isotopically labeled research compound.

Applications 1-Iodopropane-2,2,3,3,3-d5 (CAS# 1095269-04-7) is a useful isotopically labeled research compound.

Applications N-Boc-piperazine-d4 is a deuterium labelled analogue of N-Boc-piperazine (B662000).

Applications rac 3-Hydroxybutyric Acid-d2 Sodium Salt is the labeled analogue of rac 3-Hydroxybutyric Acid Sodium Salt (H833020), an optically active 3-hydroxybutyric acids are key intermediates of the biosynthesis and metabolism of fatty acids and exist widely in biological systems.
References Freeman, J., et al.: Pediatrics, 102, 1358 (1998), Thio, L., et al.: Neurology, 54, 325 (2000), Rho, J., et al.: Epilepsia, 43, 358 (2002)

Applications Anisole-d3 (methyl-d3) (CAS# 4019-63-0) is a useful isotopically labeled research compound.

Applications 2,6-Dimethyl-d6-nitrobenzene (CAS# 285138-83-2) is a useful isotopically labeled research compound.

Applications (2S,2'S)-Ethambutol-d10 (1,1,1',1',2,2'-d6; ethylene-d4) (CAS# 1129526-24-4) is a useful isotopically labeled research compound.

Applications Phenyl Ether-13C12 is an intermediate used in the synthesis of Decabromodiphenyl Ether-13C12 (D212852), which is the labeled analogue of Decabromodiphenyl Ether (D212850), which is a brominated flame retardant that is used in conjunction with antimony trioxide in high impact polystyrene.
References Keum, Y.S., et al.: Environ. Sci. Technol., 39, 2280 (2005); Egeback, A.L., et al.: Chemosphere., 86, 264 (2012);

Applications Isopropyl Diphenyl Phosphate-d10 is a labelled analogue of Isopropyl Diphenyl Phosphate (I824470) which is a chemical reagent used in the synthesis of H-phosphonate synthesis of oligonucleotides. Also used in the preparation of flame retardants.
References Butt, C. et al.: Env. Sci. Tech., 48, 10432 (2014); Powles, N. et al.: Prg. Biomol. Chem., 10, 5940 (2012);

Applications Benzilic-d10 Acid (rings-d10) (CAS# 1219799-12-8) is a useful isotopically labeled research compound.

Applications 4-(Oxiranylmethyl)morpholine-d5 Hydrochloride is an intermediate for the synthesis of 2-NP-AMOZ-d5 (N894952), which is a labelled derivatized of AMOZ (A634600), a metabolite of Nitrofuran.
References Vroomen, L., et al.: Toxicol. Appl. Pharmacol., 95, 53 (1988), Delatour, T., et al.: J. Agric. Food Chem., 51, 6371 (2003), Stadler, R., et al.: Analyst, 129, 276 (2004),

Applications Ethyl 2-Cyanoacetate-13C 15N, is the labeled analogue of Ethyl Cyanoformate (E907820), which can be used as an intermediate for insecticide, such as Fipronil (F342202).
References Cole, L., et al.: Pestic. Biochem. Physiol., 46, 47 (1993), Cole, L., et al.: Life Sci., 56, 757 (1995), Hosie, A., et al.: Br. J. Pharmacol., 115, 909 (1995),

Applications Fumaric Acid Monomethyl Ester-13C4, is the labeled analogue of Fumaric Acid Monomethyl Ester (F500390). monomethyl ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite.
References de Jong, R. et al.: Eur. J. Immunol., 26, 2067 (1996); Litjens, N.H.R. et al.: Br. J. Dermatol., 154, 211 (2006); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Tang, H. et al.: Biochem. Biophys. Res. Comm., 375, 562 (2008);

Applications N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid-d15 (CAS# 1219794-63-4) is a useful isotopically labeled research compound.

Applications Dipotassium Cyclobutane-1,1-dicarboxylate-D2 is an intermediate in the synthesis of Carboplatin-d4 (C177502), which is an analog of Cisplatin with reduced nephrotoxicity. Antineoplastic.
References Harland, S.J., et al.: Cancer Res., 44, 1693 (1984), Smith, I.E., et al.: Cancer Treat. Rep., 69, 43 (1985), Lygidakis, N.J., et al.: Interferon Cytokine Res., 15, 467 (1995),

Applications 4-Nitrobiphenyl-d9 (CAS# 350818-59-6) is a useful isotopically labeled research compound.

Applications D,L-Azetidine-2-carboxylic Acid-d5 is a useful synthetic intermediate.

Applications 1-(4-Nitrophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Applications Labelled analogue trans-1,2-Dihydroxy-1,2-dihydronaphthalene, a metabolite of Naphthalene.
References Sun, Y. et al.: Arch. Toxicol., 80, 280 (2006); Cho, T. et al.: Drug Metab. Drug Interact., 22, 235 (2007); Iwamoto, N. et al.: J. Biol. Chem., 282, 33396 (2007);

Applications Isotope labelled Hexadecyltrimethylammonium Bromide (CTAB) (H293860), is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yu, H.-h., et al.: Gongneng Cailiao, 42, 2005 (2011),

Applications Isotope labelled Indene is an organic building block that has been used in the synthesis of isatins as selective inhibitors of carboxylesterases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hyatt, J.L., et. al.: J. Med. Chem., 50, 1876 (2007)

Applications Product formed by Cyclohexan-1,3-dione Hydrolase enzyme
References Torisu, K., et al.: Eur. J. Med. Chem., 40, 505 (2005), Rosenbaum, C., et al.: J. Med. Chem., 48, 1179 (2005), Huang, C., et al.: Bioorg. Med. Chem. Lett., 16, 507 (2006),

Applications 1-Bromoheptane-7,7,7-d3 (CAS# 344253-18-5) is a useful isotopically labeled research compound.

Applications 4-Chlorophenylamine-13C6 (cas# 89059-39-2) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications: An intermediate in the preparation of labelled thymidine derivatives
References el Kouni, M., et al.: Biochem. Pharmacol., 51, 1687 (1996),

Applications 1-Butane-d9-sulfonyl Chloride (CAS# 1219794-70-3) is a useful isotopically labeled research compound.

Applications 1-Bromononane-d19 (CAS# 1219805-90-9) is a useful isotopically labeled research compound.

Applications 1-Dodecan-d25-ol, is the labeleld isptope of Dodecanol, that can be used to make surfactants, lubricating oils,and pharmaceuticals, such as Brij L23-d25 (P688277).
References Richard Stephenson and James Stuart, "Mutual Binary Solubilities: Water-Alcohols and Water-Esters", J. Chem. Eng. Data, 1986, 31, 56-70

Applications Isotope labelled D-Fructose (F792500), a monosaccharide that naturally occurs in large number of fruits and plants.
References Shum, M., et al.: Am. J. Physiol., 304, 197 (2013); Zeng, S.S., et al.: J. Pharma. Biomed. Anal., 76, 87 (2013);

Applications (±)-Prasugrel-d3 (acetate-d3) (CAS# 1127253-02-4) is a useful isotopically labeled research compound. This compound can be used for treating percutaneous coronary intervention.
References Czarnik, A., U.S. Pat. Appl. Publ., 9,(2009);

Applications m-Toluidine-d7 (NH2) (CAS# 68408-25-3) is a useful isotopically labeled research compound. Due to the H-D reaction, this compound can be used as a mixed catalystic for its synergistic effect.
References Ito, N., et.al., Synthesis, 9, 1467-1478,(2008);

Applications 1,3,5-Tris(3-chloro-2-hydroxypropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione-d15 is an intermediate for the synthesis of Triglycidyl Isocyanurate-d15 (T793817). Isotope labelled Triglycidyl isocyanurate is a reagent used in the synthesis of N-Benzyl Metaxalone (B285000), which is a muscle relaxant used to relax muscles and relieve pain.
References Toth, P.E., et al.: Clin. Ther., 26, 1355 (2004)

Applications N-Decane-d22 was useful for neutron imaging of liquid swelling and surface phenomena during methane absorption in ethanol and n-​decane under high pressure.
References Vopicka, O., et al.: PLoS One, 15, 0238470 (2020)

Applications Cyclopentanone-d8 (CAS# 4477-17-2) is a useful isotopically labeled research compound.

Applications Dimethyl Hexanedioate-3,3,4,4-d4 (CAS# 55724-08-8) is a useful isotopically labeled research compound.

Applications 1-Bromoheptane-d15 (CAS# 98195-42-7) is a useful isotopically labeled research compound.

Applications n-Nonylbenzene-2,3,4,5,6-d5 (CAS# 20216-93-7) is a useful isotopically labeled research compound.