Deuterated Compounds

Applications n-Pentyl-d11 chloroformate is labelled n-Pentyl chloroformate which can be used to synthesize 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase.
References Kim, I., et al.: J. Med. Chem., 47, 2110 (2004); Hammock, B., et al.: PCT Int. Appl. (2006), WO 2006045119 A2 20060427.

Applications 1,2-Propylene-d6 Carbonate (cas# 202480-74-8) is a compound useful in organic synthesis.

Applications (4-Carboxybutyl-d4)triphenylphosphonium Bromide is a reactant in the preparation of deuterated nocloprost.
References Krause, W., et. al.: Prostaglandins, 40, 283 (1990)

Applications 3,4-Difluorobenzoic-d3 Acid (CAS# 1219798-70-5) is a useful isotopically labeled research compound.

Stability Easily Oxidized
Applications 1-Bromo-4-nitrobenzene-d4 (cas# 350820-19-8) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Heptanoic Acid (D13, 98%) (cas# 130348-93-5) is a useful research chemical.

Applications Decanoic-10,10,10-d3 Acid is the isotope labelled analog of Decanoic Acid (D212525); a compound used in the manufacturing of esters for artificial fruit flavors and perfumes.
References Oro, L., et al.: Acta Pharmacol. Toxicol., 18, 141 (1961)

Applications 2-((Hexyl-d4)oxy)tetrahydropyran is a proposed intermediate in the synthesis of 1-Octen-3-one-D4 (O239252), a labelled analogue of 1-Octen-3-one (O239250). 1-Octen-3-one is a volatile unsaturated ketone that has a strong mushroom-like odour. 1-Octen-3-one is also a flavour component of the Agaricus bisporus mushroom and is used in a variety of food products.
References Culleré, L., et al.: Anal. Chim. Acta, 563, 51 (2006); Fickert, B. & Schieberle, P.: Food/Nahrung, 42, 371 (1998); Husson, F., et al.: Proc. Biochem., 37, 177 (2001)

Applications 5-Bromo Pentane-1,1,1,2,2,3,3,4,4-d9 is a isotope labeled building block.

Applications Isotope labelled L-Isomer of D-Idose (I175050), a monosaccharide that has is an important component of dermatan sulfate and heparan sulfate.
References Olsen, S.G., et al.: J. Biol. Chem., 264, 15982 (1989);

Applications Cyclopropyl Methyl Ketone-d8 (CAS# 1219799-33-3) is a useful isotopically labeled research compound.

Applications n-Butyl-1,1,2,2-d4 Alcohol (CAS# 118104-91-9) is a useful isotopically labeled research compound.

Applications 2-Nitrotoluene-3,4,5,6-d4 (CAS# 115049-76-8) is a useful isotopically labeled research compound.

Applications Nicotinic Acid Riboside-d4 Methyl Ester Triflate O-Acetate is an intermediate used in the synthesis of Nicotinic Acid Riboside-d4 Methyl Ester Triflate (N429407), which is the labelled analogue of an effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells.
References Belenky, P. et al.; J. Biol. Chem. 284, 158 (2009); Yang, T. et al.: J. Med. Chem., 50, 6458 (2007);

Applications N,N-Dimethyl-d6-acetamide (CAS# 31591-08-9) is a useful isotopically labeled research compound.

Applications Bromocyclopropane-d5 is labelled bromocyclopropane (B682760) which is used as a reagent to synthesize substituted (carboxycyclopropyl)glycines as potent and selective group II metabotropic glutamate receptor antagonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ornstein, P., et al.: J. Med. Chem., 41, 358 (1998)

Applications 4,4'-Dihydroxybiphenyl-d8 (rings-d8) (CAS# 612480-60-1) is a useful isotopically labeled research compound.

Applications Labelled Bromomethylcyclopropane.

Applications N-((7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methyl)acetamide-13C2 is an intermediate in the synthesis of Midazolam-13C2 the labeled analogue of Midazolam (M343000), an anesthetic; anticonvulsant; sedative; hypnotic.
References Dundee, J. W., et al.: Drugs, 28, 519 (1984); Lahat, E., et al.: Br. Med. J., 321, 83 (2000)

Applications 2-Chlorotoluene-d7 (CAS# 84344-05-8) is a useful isotopically labeled research compound.

Applications Pyridine-15N, is the labeled analogue of Pyridine (P991280), a basic six-membered heterocyclic ring. Pyridine is a base structure present in many biologically active compounds like the vitamins niacin and pyridoxal. Pyridine is used in dehalogenation reactions and can be used as a base in condensation reactions.
References Egyed, J. et al.: Bull. Soc. Chim. Fra., 11, 3014 (1973); Li, Y. et al.: Wuli HUa. Xueb., 14, 1048 (1998);

Applications 2,3-Dimethylphenol-13C4 is an isotope labelled analog of 2,3-Dimethylphenol. 2,3-Dimethylphenol is a useful synthetic intermediate. It was used in the synthesis of hydroxychalcones and flavones with antiinflammatory activities. It was also used to prepare 3,3-bisaryloxindole analogs as mineralocorticoid receptor antagonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ballesteros, J., et al.: J. Med. Chem., 38, 2794 (1995); Neel, D., et al.: Bioorg. Med. Chem. Lett., 15, 2553 (2005)

Applications 1,3-Cyclohexanedione-1,2,3-13C3 (cas# 1184998-71-7) is a compound useful in organic synthesis.

Applications Chlorobenzene-4-d1 (CAS# 13122-34-4) is a useful isotopically labeled research compound.

Applications N,N'-Dibenzylethylene-d4-diamine (CAS# 1219795-20-6) is a useful isotopically labeled research compound.

Applications 4-Aminophenol-13C6 is carbon-13 labeled 4-Aminophenol (A618920), a nephrotoxic metabolite of Acetaminophen (A161220) and Phenacetin (P294580) (1). 4-Aminophenol is also used as a N-formylating agent for solvent-and catalyst-free N-formylations of amines at ambient condition (2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Watanabe, et al.: Drug Metab. Dispos., 38, 1532 (2010)(2) Batuta, S. and Begum, N. A. Synth. Commun. 47, 137-147 (2017)

Applications N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N,4-dimethyl-1-naphthalenemethanamine-d3 is an isotope labelled impurity of Terbinafine (T107500), an orally active, antimycotic allylamine and a specific inhibitor of squalene epoxidase.
References Petranyi, G., et al.: Science, 224, 1239 (1984); Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985); Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999);

Applications Potassium Octadecanoate-2,2-d2 (CAS# 352438-86-9) is a useful isotopically labeled research compound.

Applications 1,4-Dibromobutane-1,1,4,4-d4 (CAS# 36684-45-4) is a useful isotopically labeled research compound.

Applications 1-Bromononane-1,1,2,2-d4 (CAS# 284474-44-8) is a useful isotopically labeled research compound.

Applications Di-n-propyl-d14-amine (CAS# 345909-05-9) is a useful isotopically labeled research compound.

Applications Ethyl 2-Hydroxybutyrate-d5 is labelled Ethyl 2-Hydroxybutyrate (E918860) which is used to prepare 1,5-diarylpyrazole derivatives with herbicidal activities. It is also used in the synthesis of antagonists benzofuranylpiperidines and benzothiophenylpiperidines.
References Kudo, N., et al.: Chem. Pharm. Bull., 47, 857 (1999); Watanabe, Y., et al.: J. Heterocyclic Chem., 30, 445 (1993)

Applications 1,10-Dibromodecane-d20 (CAS# 150017-88-2) is a useful isotopically labeled research compound.

Applications A deuterated alcohol used in the study of lignite liquefaction.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kuznetov, P.N. et al.: Fuel, 70, 559 (1991);

Applications (R)-Telaprevir-d4 is the labeled analog of (R)-Telaprevir, an enantiomer of Telaprevir (T015650). Telaprevir is an known inhibitor of the hepatitis C virus NS3-4A protease. It is a COVID19-related research product.
References Francois, J., et al.: J. Medn. Chem., 52. 7993 (2009); Kieffer, T., et al.: Hepatology, 46, 631 (2007), Zhou, Y., et al.: Antimicrob. Agents Chemother., 52, 110 (2008), Hezode, C., et al.: N. Engl. J. Med., 360, 1839 (2009);

Applications Bis(3-methyl-2-pentyl) Phthalate-d4, is the labeled analogue of Bis(3-methyl-2-pentyl) Phthalate (B486015), used as a plasticizer to impart softness and flexibility to PVC products.
References Pierson, J. F., et al.: Angewandte Makromolekulare Chemie, 38, 167 (1979); Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);

Applications Ethyl-alpha,alpha-d2-benzene (CAS# 1861-01-4) is a useful isotopically labeled research compound.

Applications DL-4-Hydroxyphenyl-d4-alanine-2,3,3-d3 (CAS# 402835-78-3) is a useful isotopically labeled research compound.

Applications 2-Chloro-4-diethylamino-6-methylamino-s-triazine-d10 is the isotope labelled analog of 2-Chloro-4-diethylamino-6-methylamino-s-triazine (C364315); a compound that can exhibit virucidal activity in plants. It can be used as a herbicide and plantgrowth inhibitor.
References Dove, S., et al.: Wiss. Z. Karl Marx Univ. Math. Naturwiss., 31, 313 (1982); Gysin, H. and Knusli, E.: No Corporate Source data available. CH 342785 19600115. Jan 15, 1960

Applications Bis(2-Heptyl) Phthalate-d4, is the labeled analogue of Bis(2-Heptyl) Phthalate (B443780), a phthalate ester used as plasticizers and additives.
References Peterson, J.C., et al.: Int. J. Envrion. Anal. Chem., 18, 237 (1984);

Applications Isotope Labelled D-Altrose (A575700) is the epimer of D-glucose at C3 and have recently been discovered to possess antioxidant properties by the suppression of reactive oxygen species production in mitochondria due to competition with D-glucose at the cellular level.
References Ishihara, Y., et al.: J. Biosci. Bioeng., 112, 638 (2011); Fukumoto, T., et al.: Planta., 234, 1083 (2011);

Applications n-Heptyl-1-d1 Alcohol (CAS# 38007-42-0) is a useful isotopically labeled research compound.

Applications Labelled Quipazine maleate (Q797500). Quipazine maleate is a non-selective serotonin receptor agonist. Quipazine increases renin release by a peripheral hemodynamic mechanism.
References Elliott, P.J., et al.: Neuropharmacol., 29, 949 (1990), Hashimoto, K., et al.: Eur. J. Pharmacol., 180, 273 (1990),

Applications Perfluorododecanoic Acid-13C is labeled P286255 which is fluorinated pollutant found in wastewater and industrial runoff. Potential risk factor for coronary heart disease.
References Mattsson, K. et al.: Env. Res., 142, 148 (2015); Yuan, G. et al.: Env. Sci. Tech., 50, 942 (2016);

Applications Labelled D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus.
References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);

Applications n-Hexadecyl-1,1,2,2-d4 Hexadecanoate-16,16,16-d3 (CAS# 1398066-15-3) is a useful isotopically labeled research compound.

Applications A labelled metabolite of Colchicine (C640000). Has shown anti-tumor activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Martinez, M. et al.: J. Appl. Toxicol., 15, 49 (1995); De Vincenzo, R. et al.: Oncol. Res., 11, 145(1999); Das, D. et al.: Biochim. Biophys. Acta., 1502, 351 (2000); Wagner, B. et al.: J. Biol. Chem., 275, 22461(2000);

Applications Formamide-1-d1 (CAS# 35692-88-7) is a useful isotopically labeled research compound.

Applications α-Cholesterol-d6 is labelled α-Cholesterol which is a stereoisomer of Cholesterol (C432501), a major component of all biological membranes and the principal sterol of the higher animals.
References Rosin, Z., et al.: Physiol. Chem., 124, 282 (1923), Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934), Gemant, et al.: Life Sci., 1, 233 (1962), Johnson, K., et al.: 4, 457 (1964),

Applications Hexanedioyl-d8 Chloride (CAS# 284487-62-3) is a useful isotopically labeled research compound.

Applications DL-Proline-2-d1 (CAS# 282729-06-0) is a useful isotopically labeled research compound.

Applications (±)-(1-Bromoethyl-2,2,2-d3)benzene (CAS# 23088-42-8) is a useful isotopically labeled research compound.

Applications 1,4-Butane-d8-diamine 2HCl (CAS# 284665-22-1) is a useful isotopically labeled research compound.

Applications Methyl Methacrylate-3,3-d2 (CAS# 55063-97-3) is a useful isotopically labeled research compound.

Applications 1-(2,6-Dichlorophenyl)piperazine-d8 Hydrochloride is the isotope analog of 1-(2,6-Dichlorophenyl)piperazine Hydrochloride. 1-(2,6-Dichlorophenyl)piperazine Hydrochloride is used in the preparation of pyrazolopyrimidones and pyrazolopyridones as tankyrase inhibitors which are useful in the treatment of cancer.
References Feng, J., et al.: PCT Int. Appl., 2013:1906020 (2013)

Applications Aclonifen-d5, is the labeled analogue of Aclonifen, which is used as a pesticide and herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Laini, A., et al.: Sci. Total Environ., 438, 312 (2012); Fantke, P., et al.: Enviorn. Int., 49, 9 (2012);

Applications 4-Cyano-4'-n-pentyl-d11-biphenyl (CAS# 57078-20-3) is a useful isotopically labeled research compound.

Applications tert-Butyl-1,1,1,3,3,3-d6 Alcohol (CAS# 53853-65-9) is a useful isotopically labeled research compound.

Applications Di(α-tocopherol) Phosphate-d12 is labelled Di(α-tocopherol) Phosphate (T526190) which is used as a vitamin E supplement.
References Libinaki, R., et al.: Food Chem. Toxicol., 44, 916 (2006)

Stability Light Sensitive
Applications Labelled 2-Ethylhexyl 2,3,4,5-Tetrabromobenzoate (E918780). 2-Ethylhexyl 2,3,4,5-Tetrabromobenzoate is a flame retardant.
References Gouteux, B., et al.: Environ. Sci. Technol., 42, 9039 (2008), Lee, E., et al.: J. Toxicol. Sci., 2010, 35, 535 (2010), Arp, H., et al.: J. Environ. Monit., 13, 505 (2011),

Applications N-Hexanoylglycine-2,2-d2 (CAS# 1256842-52-0) is a useful isotopically labeled research compound.