Deuterated Compounds

<p>Applications Dihydro-3-(3-pyridoyl)-2-(3H)-furanone-d4 is an intermediate in the synthesis of 1-(3-Pyridyl-d4)-1,4-butanediol (P992504). 1-(3-Pyridyl-d4)-1,4-butanediol is the labeled analogue of 1-(3-Pyridyl)-1,4-butanediol (P992500), a metabloite of NNK (M325750), a carcinogen that readily produces cancer in rats and hamsters.<br>References Koenigs, L., et al.: Drug Metab. Dispos., 25, 1407 (1997); Gu, J., et al.: Toxicol. Appl. Pharmacol., 165, 158 (2000); Jalas, J., et al.: Chem. Res. Toxicol., 18, 95(2005); Zhu, L., et al.: Drug Metab. Dispos., 34, 1672(2006)<br></p>

<p>Applications N-Methylacetamide-N-d1 (CAS# 3669-70-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Heptanoic-2,2,3,3-d4 Acid (CAS# 1219803-28-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications trans-2,cis-6-Nonadienal-D5 is a labelled analogue of trans-2,cis-6-Nonadienal (N649365). trans-2,cis-6-Nonadienal is an unsaturated aldehyde that is responsible for the cucumber smell of Synura petersenii, a freshwater colonial flagellate. trans-2,cis-6-Nonadienal is also a common natural and drinking water contaminant.<br>References Berra, T., et al.: Trans. Am. Fish. Soc., 111, 78 (1982); Kynclova, A., et al.: Nova Hedw. Bei., 136, 283 (2010); Ömür-Özbek, P. &amp; Dietrich, A.: Environ. Sci. Tech., 39, 3957 (2005)<br></p>

<p>Applications (E)-4-(Dimethylamino)but-2-enoyl Chloride-d6 is an intermediate used in the synthesis of Afatinib-d6 (A355303), which is the d6 labeled analogue of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br>References Schroeder, J., et al.: PCT Int. Appl. WO 2007085638 A1 20070802. Aug 2, 2007;<br></p>

<p>Applications 3,4-Dimethylphenol-13C8 is the isotope labelled analog of 3,4-Dimethylphenol. 3,4-Dimethylphenol is a reagent in the synthesis of vialinin A analogs with a potent inhibitory activity of tumor necrosis factor-a production.<br>References Ye, Y.Q., et al.: Bioorg. Med. Chem. Lett., 22, 2385 (2012);<br></p>

<p>Applications 1-Bromo-3,5-difluorobenzene-d3 (CAS# 1219798-73-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications n-Tetratriacontane-d70 (CAS# 1219805-47-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Diethylamine-13C4 Hydrochloride is the labelled salt of Diethylamine (D443485).<br></p>

<p>Applications L-Propoxyphene-d5 Hydrochloride is the isotope labelled analog and L-isomer of Propoxyphene Hydrochloride (P831500); a controlled substance (opiate) and analgesic (narcotic). The α-DL-and D-diastereoisomers possess marked analgesic activity in contrast to the β-diastereoisomers which are substantially inactive. Oral administration of L-Propoxyphene Hydrochloride enhances the analgesic activity of D-Propoxyphene Hydrochloride.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971); McEwan, B., et al.: Anal. Profiles Drug Subs., 1, 301 (1972); Murphy, P.J., et al.: J. Pharmacol. Exp. Ther., 199, 415 (1976)<br></p>

<p>Applications Choline-d13 Bromide (cas# 203645-64-1) is a useful research chemical.<br></p>

<p>Applications Secobarbital-d5 (1-methyl-d3-butyl-2,2-d2) (CAS# 1219803-94-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Anthraquinonesulfonic Acid Sodium Salt-d7, is the labeled analogue of Anthraquinone-2-sulfonic Acid Sodium Salt (A679280), which is used as a dopant to enhance membrane integration with electrocatalysis.<br>References Zhao,F., Liu, L., Yang, F., Ren, N.: Chem. Eng. J., 230, 491 (2013);<br></p>

<p>Applications DL-Leucine-d10 (CAS# 29909-01-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Phenylalanine-3-13C (CAS# 286425-42-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Hydroxypyridine-N-oxide-d5 is the labelled analogue of 2-Hydroxypyridine-N-oxide (H953633), a reactant that is useful along wtih (S)-1-phenylethylamine and EDC·HCl for the synthesis of AZD8186, a potent and selective Inhibitor of PI3Kβ and PI3Kδ.<br>References B. Barlaam., et al.: J. Med. Chem., 58, 943-62 (2015);<br></p>

<p>Applications 1-Bromooctane-d17 (CAS# 126840-36-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Acetamidine-d3 Hydrochloride is a useful compound in the synthesis of 3-​Chloro-​3-​methyl-​d3-​diazirine (CAS# 35496-73-2).<br>References Liu, M. T. H., et al.: J. Org. Chem., 45, 4515 (1980)<br></p>

<p>Applications Tetramethyl-d12-urea (CAS# 51219-89-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Di-n-decyl Phthalate-3,4,5,6-d4 (CAS# 1276197-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Dichlorobenzene (D4, 98%) (cas# 2199-70-4) is a useful research chemical.<br></p>

<p>Applications 3,4-Dichloroaniline-d2 (cas# 1219803-22-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(Ethyl-d3) Isonicotinamide is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications Anamorelin-d6 is labelled Anamorelin (A617045) which is a novel non-peptidic ghrelin mimetic and growth hormone secratogogue.<br>References Garcia, Jose M., et al.: Growth. Horm. IGF. Res., 19(3), 267-273 (2009)<br></p>

<p>Applications Hexanedioic-d8 Acid Dihydrazide (CAS# 1202865-37-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromopropane-2,2,3,3,3-d5 is an isotope labelled analog of 1-Bromopropane (B687135); a solvent used for the cleaning of metal surfaces and removal of soldering residues from electronic circuit boards. It is anticipated to be a human carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lingyo, Zh., et al.: Toxicology, 304, 76 (2013); Samukawa, M., et al.: Archives Internal Med., 172(16), 1257 (2012)<br></p>

<p>Applications α-Naphthyl-d7 Glycidyl Ether is an intermediate in the synthesis of rac-Propranolol-d7 (P831803) which is the labeled analogue of Propranolol (P831800), a β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).<br>References Bond, et al.: Nature, 213, 721 (1967), Hansteen, V., et al.: Br. Med. J., 284, 155 (1982), Diamond, S., et al.: J. Clin. Pharmacol., 28, 193 (1988),<br></p>

<p>Applications n-Nonanoic-9,9,9-d3 acid is labelled n-Nonanoic Acid (N649385) which is commonly used in conjunction with glyphosate, a non-selective herbicide, for a quick burn-down effect in the control of weeds in turfgrass. It is also used in the preparation of plasticizers and lacquers.<br>References Pline, W., et al.: Weed Technol., 14, 667 (2000); Frade, J., et al.: Anal. Bioanal. Chem., 395, 2167 (2009)<br></p>

<p>Applications D-Alanine-2-d1 (CAS# 56595-54-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Hydroxyquinoline-d6 is labelled 3-Hydroxyquinoline (H953140) which is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.<br>References Riego, E. et al.: Tetrahedron, 61, 1407 (2005); Kanou, M. et al.: Fund. Clin. Pharmacol., 16, 513 (2002)<br></p>

<p>Applications 2-Bromoacetamide-13C2 is the labelled form of 2-Bromoacetamide (B679063). 2-Bromoacetamide is a disinfectant by-product.<br>References Lv, Lu., et al.: Environ. Pollut., 205, 291-298 (2015).<br></p>

<p>Applications 1-Dodecane-d25-thiol (CAS# 869563-00-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chlorobenzoyl Chloride-d4 is an intermediate for the synthesis of Clofentezine-d8 (C585616), which is a labelled form of Clofentezine which is used in agriculture for the protection of ornamentals, food and non-food crops in the field. Used as a standard for Pesticide detection. Clofentezine is used in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Bakirci, G.T., et al.; Food. Chem., 135, 1901 (2012); Ay, R., et al.: Insect. Sci., 18, 503 (2011);<br></p>

<p>Applications 1,3-Diethylbenzene-2,4,5,6-d4 (CAS# 1219803-29-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dimethyl Heptanedioate-2,2,6,6-d4 (CAS# 120811-82-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl 3-Hydroxy-3-methyl-d3-butyrate-4,4,4-d3 (CAS# 30385-86-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Benzene-1,2,4,5-d4 (CAS# 14919-17-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methylcyclopentane-d12 (CAS# 144120-51-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-(Carboxymethyl)-N,N,N-trimethyl-d9-ammonium Chloride (CAS# 285979-85-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Hexadecanoate-d31 (CAS# 467235-83-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications o-Xylene-alpha,alpha,alpha,alpha',alpha',alpha'-d6 (CAS# 25319-54-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Bromo-2-(ethyl-d3)pyridine is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications iso-Propylamine-d9 (CAS# 1219794-73-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Indole-2,4,5,6,7-d5-3-acetic-alpha,alpha-d2 Acid (CAS# 1173020-21-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Testosterone Hexanoate-d11 is the isotopic analog of Testosterone Hexanoate. Testosterone Hexanoate is a metabolite of testosterone(T155000), which is used in analytical studies to determine the use of anabolic steroid esters and related compounds in equine hair sample though ultra high performance liquid chromatography-tandem mass spectrometry.<br>References Gray, B.P., et al.: Analtica Chemica Acta, 787, 163 (2013); McKinney, A., et al.: Bioanalysis 1, 785 (2009)<br></p>

<p>Applications Ethyl-alpha,alpha-d2-benzene-d5 (CAS# 84272-90-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled tert-Butylbenzene is a component of the model diesel fuel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xiao, Jing, et al.: Indus. &amp; Eng. Chem. Res., 51(8), 3436-3443 (2012)<br></p>

<p>Applications Isotope labelled 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol, the novel raw material for deodorants application and is widely used as a cosmetic emollient. 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol reliably inhibits the odor-causing bacteria, yeast and fungi on the skin.<br>References Nagao, S.: Frag. J., 34, 39 (2006); Lawan, K. et al.: J. Health Sci., 23, 1 (2009); Leschke, M.: SOFW J., 136, 10 (2010);<br></p>

<p>Applications 17beta-Dihydroequilin-2,4,16,16-d4 (CAS# 350819-99-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Suberylglycine-2,2-d2 (CAS# 1219799-02-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Glyceryl-d5 Trihexadecanoate (CAS# 60763-98-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,3-Dibromo-1-propan-1,1,2,3,3-d5-ol is a labelled analogue of 2,3-Dibromo-1-propanol (D425522), which is a metabolite of the flame retardant tris(2,3-dibromopropyl) phosphate (T775560), previously shown to be a mutagen and carcinogen in experimental animals. It is also an intermediate in synthesizing Bis(2,3-dibromopropyl) Phosphate-d10 (B426237), which an isotope labelled analog of Bis(2,3-dibromopropyl) Phosphate. Bis(2,3-dibromopropyl) Phosphate is a derivative of Tris(2,3-dibromopropyl) Phosphate, a widely used flame retardant in plastic and textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pandith, A.H., et al.: Org. Chem. Int., 17, (2010); Dixon, D., et al.: Toxicol. Pathol., 36,428 (2008);Eustis, S.L., et al.: Toxiciol. Sci., 26, 41 (1994); Elliott, W.C., et al.: Life. Sci., 7, 1107 (1983);<br></p>

<p>Applications Phenelzine-d5 Sulfate (phenyl-d5) (CAS# 1219798-40-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Fluorobenzyl-d6 Alcohol (CAS# 1071809-48-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Phenyldodecane-d30 (CAS# 352431-29-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Carcinogenic compound commonly found in hair dyes and henna ink, also a commonly used synthetic intermediate<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mulyono; T., et al.: J. Biosci. Bioeng., 103, 147 (2007), Mosley-Foreman, C., et al.: Food Chem. Toxicol., 46, 3780 (2008), Patel, A.K., et al.: J. Agric. Food Chem., 56, 9236 (2008), Akyuz, M., et al.: J. Pharm. Biomed. Anal., 47, 68 (2008),<br></p>

<p>Applications Labelled Cortisol-d4 21-Sulfate (C696320). Cortisol 21-Sulfate is a phase II metabolite of Cortisol (H714615).<br>References Spielgelhalder, B., et al.: J. Steroid Biochem., 7, 749 (1976), Vanluchene, E., et al.: J. Chromatogr., 456, 175 (1988), Choi, M., et al.: Steroids, 65, 54 (2000),<br></p>

<p>Applications Labelled Farnesyl Pyrophosphate. Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras.<br>References Correll, C., et al.: J. Biol. Chem., 269, 17390 (1994), Moura, I., et al.: Antimicrob. Agents Chemother., 45, 2553 (2001), Gana-Weisz, M., et al.: Clin. Cancer Res., 8, 555 (2002),<br></p>

<p>Applications 4-Fluorobenzyl-2,3,5,6-d4-amine (CAS# 1219798-96-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled analogue of Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);<br></p>

<p>Applications n-Tetracontane-d82 (CAS# 1219802-99-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2E)-3-(Phenyl-d5)-2-propenoic Acid is labeled (2E)-3-(Phenyl)-2-propenoic Acid (P336185) which is used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines. Also used in the N-methylation of amides and O-methylation of carboxylic acids.<br>References Kunishima, M. et al.: Tetrahedron, 55, 13159 (1999); Xia, Q. et al.: Org. Lett., 15, 3326 (2013);<br></p>

<p>Applications n-Hexadecyl-16,16,16-d3 Alcohol (CAS# 75736-52-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isobutylsuccinic Acid-d9 is labelled Isobutylsuccinic Acid (I780660) which was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.<br>References Groutas, W., et al.: Bioorg. Med. Chem., 3, 375 (1995);<br></p>

<p>Applications 1-Iodopropane-1,1-d2 (CAS# 25493-14-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dodecanoic-2,2-d2 Acid (CAS# 64118-39-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Dimethyl Phthalate (D477975). It is used as insect repellent.<br>References Iselin, B., et al.: Helv. Chim. Acta., 40, 373 (1957),<br></p>