Deuterated Compounds

<p>Applications 1-Bromo-3,4-difluorobenzene-d3 (CAS# 1219799-14-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled δ-Valerolactone used in the synthesis of various antibiotics including the ionophore antibiotic X-14547A. Also used in the preparation of polyesters via copolymerization.<br>References Nicolaou, K. et al.: J. Org. Chem., 50, 1440 (1985); Parrish, B. et al.: J. Polym. Sci. Polym, Chem., 40, 1983 (2002);<br></p>

<p>Applications n-Octyl-1,1-d2 Alcohol (CAS# 78510-02-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethanethiol-13C2, is the labeled analogue of Ethanethiol (E676470), is used in the evaluation and application of static headspace-multicapillary column-gas chromatography-ion mobility spectrometry for complex sample analysis.<br>References Denawaka, C., et al.: J. Chromat. A., 1338, 136 (2014)<br></p>

<p>Applications Nonyl 4-Hydroxybenzoate-d4 is labelled Nonyl 4-Hydroxybenzoate which was used to prepare 4-[(aminosulfonyl)oxy] benzoic acid derivatives as potent inhibitors of the enzyme estrone sulfatase (ES). It was also used to synthesize sulfonylbenzoic acid esters as potential inhibitors of oestrone sulphatase with antitumor activities.<br>References Ahmed, S., et al.: Bioorg. Med. Chem. Lett., 12, 2391 (2002); Owen, C., et al.: J. Pharm. Pharmacol., 55, 85 (2002)<br></p>

<p>Applications A labelled tryptophan metabolite, is a precursor of kynurenic acid, which is an antagonist of N-methyl-aspartate receptor. An amino acid produced in the body from tryptophan.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990), Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003), Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003), Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007),<br></p>

<p>Applications 4-Cholesten-3-one-4-13C (CAS# 68165-57-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3,5-Difluorobenzoic-d3 Acid (CAS# 934397-71-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications (Bromomethyl)cyclohexane-d11 is the isotope labelled analog of (Bromomethyl)cyclohexane. (Bromomethyl)cyclohexane is a reagent that is used in the synthesis of cyano thiouracils as SecA inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chaudhary, A. S., et al.: Bioorg. Med. Chem., 23, 105 (2015);<br></p>

<p>Applications 1-Bromotetradecane-14,14,14-d3 (CAS# 347840-09-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-2-Hydroxyhexanoic-6,6,6-d3 Acid (CAS# 1219798-84-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled impurity of Cefoperazone.<br>References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347 (1982),<br></p>

<p>Applications Bis(2-hydroxyethyl)-1,1,2,2-d4-amine (CAS# 352431-07-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tetrahydrofuran-2,2,5,5-d4 (CAS# 20665-63-8) is a useful isotopically labeled research compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications D-Phenyl-d5-alanine-N-t-BOC (CAS# 1213661-19-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Benzyl- 2-thiophenecarboxylic Acid-d7 is labelled 4-Benzyl- 2-thiophenecarboxylic Acid (B315140) which is a derivative of 2-Thenoic Acid (T343505), used in the synthesis of pharmaceutical and biologically active compounds. 2-Thenoic Acid is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.<br>References huyop, F. Z., et al.: Malaysian J. Biochem. Mol. Bio., 2, 9 (1997)<br></p>

<p>Applications 1,4-Butane-d8-dithiol (CAS# 1219805-46-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Nitro-1-pyrenol is a urinary hydroxylated metabolites used as a biomarkers of exposure of polycyclic aromatic hydrocarbons. This is the labeled analog.<br>References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999);<br></p>

<p>Stability Hygroscopic<br>Applications Phenylboronic Acid-d5 is the isotope labelled analog of Phenylboronic Acid (P319590); a compound used in the organic synthesis of various pharmaceutical goods.<br>References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930)<br></p>

<p>Applications 2-Mercaptoethanol-1,1,2,2-d4 (CAS# 284474-53-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Mercaptopropionic-2,2,3,3-d4 Acid (CAS# 1141488-67-6) is a useful isotopically labeled research compound. It is used for structural proteomics interactions.<br>References Petrotchenko, E., et.al., Mol. Cell Proteomics, 8,273-286,(2009);<br></p>

<p>Applications Levulinic-d5 Acid is labelled Levulinic Acid (L379500) which is derived from the degredation of cellulose and is a potential precursor to biofuels. Levulinic acid. It is also a photosensitizer for photodynamic therapy.<br>References Serrano-Ruiz, J.C., et al.: Catalysis., 195, 162 (2012); Liedtke, A.J. et al.: Tetrahedron., 68, 10049 (2012);<br></p>

<p>Applications Thymine-alpha,alpha,alpha,6-d4 Glycol (mixture of diastereomers) (CAS# 132523-94-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Pyridylcarbinol-d6 (cas# 1189493-62-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl-1,1-d2-methylamine (CAS# 223459-63-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(1,1-Dimethylethyl)-4-iodo-2,5-dimethoxy-benzene-d6 is labelled 1-(1,1-Dimethylethyl)-4-iodo-2,5-dimethoxy-benzene which is an intermediate used to prepare heterocyclic tyrosine kinase inhibitors.<br>References Spada, A., et al.: PCT Int. Appl., WO 9220642 A1 19921126 (1992)<br></p>

<p>Applications Quinaldic-d6 Acid (CAS# 1219802-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3,5-Trimethylbenzene-2,4,6-d3 (CAS# 38574-14-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,12-Dibromododecane-d24 (CAS# 1044544-84-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications beta-Iminodi(propionic-2,2,3,3-d4 Acid) (CAS# 1219803-81-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Amino-2,2,6,6-tetramethylpiperidine-d17; 1-15N-1-oxyl (CAS# 97461-87-5) is a useful isotopically labeled research compound that is used in various experiments, such as, synthesis of two cysteine-specific spin labels.<br>References Wu,G. J. Label. Compd.Radiopharm., 12,1173-1181,(1995);<br></p>

<p>Applications N2-Acetyl Acyclovir Benzoate-d5 is the isotope labelled analog of N2-Acetyl Acyclovir Benzoate (A167975); a derivative of Acyclovir (A192400) which is an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Also an antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992); Ashton, D.S., et al.: J. Chromatogr. A, 707, 367 (1995)<br></p>

<p>Applications Ethyl Glyoxylate-13C4 is an isotope labelled analog of Ethyl Glyoxylate. Ethyl Glyoxylate is used as a reagent in the synthesis of a new class of cinnamyl-triazole compounds which can be used as selective inhibitors of human aromatase (cytochrome P 450 19A1).<br>References McNulty, J., et al.: Bioorg. Med. Chem. Lett., 24, 4586 (2014)<br></p>

<p>Applications Heptanoic-2,2-d2 Acid (CAS# 64118-38-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromoundecane-d23 (CAS# 349553-92-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-Methoxybenzimidazole-4,6,7-d3 (CAS# 1219805-69-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol-d3 is the isotope labelled analog of α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol (D473780); a reagent in the synthesis of Medetomidine (M203250) which is an α2-adrenergic agonist. Also a sedative and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010<br></p>

<p>Applications Cyclohexanecarboxylic-1-d1 Acid (CAS# 933-37-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4,4-Bis(4-aminophenylsulfonyl)-azobenzene-d16 is the isotope labelled analog of 4,4-Bis(4-aminophenylsulfonyl)-azobenzene. 4,4-Bis(4-aminophenylsulfonyl)-azobenzene is synthesized from dapsone (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.<br>References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),<br></p>

<p>Applications An intermediate in the production of labelled Enrofloxacin.<br>References Chao, Q., et al.: J. Med. Chem., 52, 7808 (2009), Bebbington, D., et al.: Bioorg. Med. Chem. Lett., 19, 3586 (2009),<br></p>

<p>Applications (±)-N-(2,6-Dimethylphenyl)-1-iso-propyl-d7-2-piperidinecarboxamide (CAS# 1276197-11-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Acetic Acid is used for analysis and profiling of biological samples resolved through NMR spectroscopy. It helps with the labelling of RNA for high resolution NMR.<br>References Cahoreau, E. et al.: Anal. Bio., 427, 158 (2012);<br></p>

<p>Applications Fmoc-Phe-OH - 13C9, 15N is a useful labeled chemical.<br></p>

<p>Stability Volatile<br>Applications N-Pentane-D12 (D, 98%) (cas# 2031-90-5) is a useful research chemical.<br> E3<br></p>

<p>Applications (4-n-Nonylphenoxy)acetic-alpha,alpha-d2 Acid (CAS# 1219798-75-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,5-Dibromopentane-1,1,5,5-d4 (CAS# 1219803-90-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Bromopropionic-2,2,3,3-d4 Acid is the labeled analog of 3-Bromopropionic acid (B687705). 3-Bromopropionic Acid is used as a reagent in the synthesis of nitrogen containing diselenides which exhibit antioxidant activity. Also used as a reagent in the synthesis of indolin-2-one-based multi-targeted receptor tyrosine kinase inhibitors as potential anticancer agents.<br>References Nascimento, V., et al.: Eur. J. Med. Chem., 87, 131 (2014); Zhang, L., et al.: Eur. J. Med. Chem., 82, 139 (2014)<br></p>

<p>Applications 2-Hydroxyethyl Nortadalafil-d4 is the isotope labelled analog of 2-Hydroxyethyl Nortadalafil (H942245); a derivative of Tadalafil (T004500) which is a compound used for the treatment of erectile dysfunction. Also a phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003); Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005); Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005)<br></p>

<p>Applications Phenol-2,4,6-d3,OD (CAS# 80441-87-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Hexadecanoyl-2-amino-1,3-propane-d5-diol (CAS# 949524-35-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(2-Pyridinyl)benzotriazole-15N3 (cas# 1189465-04-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Glyceryl Trihexadecanoate-13C2 [1,3-Di(hexadecanoate-1-13C)] (CAS# 339080-65-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5-Methyl-2(1H)-pyridinone-d6 is a reagent used in the preparation of substituted N-aryl pyridinones as fibrotic inhibitors.<br></p>

<p>Applications Anteisoheneicosanoic acid-d3 is labelled Anteisoheneicosanoic acid which is used in cosmetics as it allows hair fiber to lie flat and parallel with respect to each other while its removal formed coarse tangled bundles, aligned in disorderly manner.<br>References Tanamachi, H., et al.: J. Cosmetic Sci., 61, 147 (2010); Breakspear, S., et al.: PMSE Preprints, 90, 276 (2004)<br></p>

<p>Applications A labelled major (toxic) metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Shen, S. et al.: Drug Metab. Disp., 38, 1934 (2010); Carlson, G.P. et al.: J. Toxicol. Env. Health, 73, 1689 (2010)<br></p>

<p>Applications 2-Naphthylhydrazine-D3 is an intermediate used in the synthesis of Indocyanine Green-d12 (I697002), which is an isotopic analog of Indocyanine Green (I697000), a tricarbocyanine type of dye with infrared absorbing properties that can be used as a diagnostic aid (blood volume determination, cardiac output, hepatic function).<br>References Papageorgiou, P., et al.: Br. J. Dermatol., 142, 973 (2000), Dreno, B., et al.: Dermatology, 203, 135 (2001), Gollnick, H., et al.: Drugs, 63, 1579 (2003), Seaton, E., et al.: Lancet, 362, 1347 (2003)<br></p>

<p>Applications L-Proline-d3-N-Fmoc was used to prepare potent bombesin-like peptides for GRP-receptor targeting of tumors. It was also used to synthesize tetrapeptide aldehyde inhibitors of dengue virus NS3 protease.<br>References Nock, B., et al.: J. Med. Chem., 48, 100 (2005); Yin, Z., et al.: Bioorg. Med. Chem. Lett., 16, 40 (2006)<br></p>

<p>Applications Di(methyl-d3)dimyristylammonium Chloride is labelled Dimethyldimyristylammonium Chloride (D472560) which is used as a surfactant.<br>References Cipiciani, A., et al.: Austr. J. Chem., 44, 1505 (1991); Hueck, H., et al.: Appl. Microbiol., 14, 308 (1966)<br></p>

<p>Applications Cyclopropyl-2,2,3,3-d4-methyl-d2 Alcohol (CAS# 1219805-67-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 8-Bromo-7-ethyl-3,7-dihydro-3-methyl-1H-purine-2,6-dione-d5, is the labeled analogue of (B684895), which is a substituted derivative of Xanthine (X499950).<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)<br></p>

<p>Applications Sodium n-Decyl-d21 Sulfate (CAS# 933826-83-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications trans-Stilbene-alpha,beta-13C2 (CAS# 153610-50-5) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications 1-Butan-d9-ol is the labeled form of 1-Butanol, which is used for the production of dimethylfuran for liquid fuels.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Roman-Leshkov, Y. et al.: Nature, 447, 982 (2007);<br></p>

<p>Applications 1-Bromopentadecane-1,1,2,2-d4 (CAS# 1219798-87-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dimethyl Hexanedioate-2,2,5,5-d4 (CAS# 76785-05-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexamidine-d12 Impurity A Hydrochloride is the labeled analogue of Hexamidine Impurity A Hydrochloride is an impurity of Hexamidine (H294205), an amidine compound use in the treatment of amyloid-related diseases; also use as preservative in cosmetics. Antiseptic.<br>References Taylor, P., et al.: J. Pharmaceut. Sci., 72, 1477 (1983); Granel, F., et al.: Clin. Infect. Diseases, 23, 839 (1996); Bailly, C., et al.: Biochem. J., 323, 23 (1997); Enyedy, I., et al.: J. Med. Chem., 44, 1349 (2001)<br></p>

<p>Applications Methyl(4-methylnaphthalen-1-ylmethyl)amine-d3 is the isotope analog of Methyl(4-methylnaphthalen-1-ylmethyl)amine. Methyl(4-methylnaphthalen-1-ylmethyl)amine is a reagent in the preparation of heterocyclic compounds as enoyl-acyl carrier protein reductase FabI inhibitors and antibacterial agents.<br>References Stuetz, A., et al.: J. Med. Chem., 29, 112 (1986); Berman, J., et al.: PCT Int. Appl., 2004:515512 (2004)<br></p>

<p>Applications N-Methyl-d3-epsilon-caprolactam (CAS# 203645-60-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications p-Xylene-alpha,alpha,alpha-d3 (CAS# 26204-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bis(p-cresyl) o-Cresyl Phosphate-d7 is labelled Bis(p-cresyl) o-Cresyl Phosphate (B419210), an isomer of Tricresyl phosphate (TCP) which is used as an anti-wear additive in aircraft turbine engine oil.<br>References De Nola, G., et al.: J. Chrmoat. A, 1200, 211 (2008)<br></p>

<p>Stability Hygroscopic<br>Applications L-3-(4-Hydroxy-3-methoxy-d3-phenyl)alanine (CAS# 586954-09-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Impurity in the production of labelled Phenylbutazone (P319572)<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>

<p>Applications Synaptamide-d4 is labelled Synaptamide (S910000) which is an endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. It has potent synaptogenic activity and structural similarity to anandamide. Synaptamide (S910000) is subjected to hydrolysis by fatty acid amide hydrolase, and can be oxygenated to bioactive metabolites.<br>References Kim, H., et al.: Prostaglandins Leukot Essent Fatty Acids, 88, 121 (2013); Burstein, S., et al.: Bioorg. Med. Chem., 16, 9644 (2008); Fu, J., et al.: J. Biol. Chem., 282, 1518 (2007)<br></p>