Deuterated Compounds

Applications di(Dodecanedioic-d20 Acid 1-Methyl Ester) Barium is a labeled salt analogue of Dodecanedioic Acid 1-Methyl Ester (D494535), which is used in cosmetic compostions.
References Lodyato, V., et al.: Bioorg. Med. Chem. Lett., 13, 1179 (2003); Lodyato, V., et al.: Bioorg. Med. Chem. Lett., 14, 4253 (2004)

Applications 1-Iodopropane-2,2-d2 (CAS# 25493-15-6) is a useful isotopically labeled research compound.

Applications 1-Bromoheptane-6,6,7,7,7-d5 (CAS# 1219805-66-9) is a useful isotopically labeled research compound.

Applications 4-Hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-15N-1-oxyl (CAS# 90429-66-6) is a useful isotopically labeled research compound that is used in various spectroscopic analysis.
References Bales, B. et.al., Appl.Magn.Reson.,48,1399-1445,(2017);

Applications Methylcyclohexane-d11 (ring-d11) (CAS# 352431-19-7) is a useful isotopically labeled research compound.

Applications 1-Bromohexane-4,4,5,5,6,6,6-d7 (CAS# 1276197-43-3) is a useful isotopically labeled research compound.

Applications 1,10-Decane-d20-diol (CAS# 347841-78-5) is a useful isotopically labeled research compound.

Applications Ethyl-2-d1 Alcohol (CAS# 6181-08-4) is a useful isotopically labeled research compound.

Applications 1-[(4-Chlorophenyl)methyl]-3,3-dimethyl-2-oxocyclopentanecarboxylic Acid-d6 Methyl Ester is an intermediate in the synthesis of Isotope labelled Metconazole (M225795), an conazole based fungicide used for the control of black sigatoka disease on banana.

Applications n-Octylbenzene-d22 (CAS# 1219799-28-6) is a useful isotopically labeled research compound.

Applications Metabolite of oleic and linoleic acids.
References Jin, S.J., et al.: Biochem., 29, 8540 (1990).

Applications L-Alanine-N,N,O-d3 (CAS# 19470-97-4) is a useful isotopically labeled research compound.

Applications 3-Ethoxyacrylic Acid Ethyl Ester-13C2 is an intermediate used in the synthesis of 2-Chloro-5-thiazolecarboxylic Acid-13C3,15N (C411468), which is an isotopically labeled analog of 2-Chloro-5-thiazolecarboxylic Acid (C411465), which was studied as one of the metabolites of thiamethoxam, clothianidin, and dinotefuran in mice.
References Ford, K., et al.: Chem. Res. Toxicol., 19, 1549 (2006);

Applications 2,3-dihydro-8-(boronic acid)-1,4-Dioxino[2,3-b]pyridine-d4 is labelled 2,3-dihydro-8-(boronic acid)-1,4-Dioxino[2,3-b]pyridine (D448690) which is a derivative of 2,3-dihydro-1,4-Dioxino[2,3-b]pyridine. 2,3-dihydro-1,4-Dioxino[2,3-b]pyridine is used to prepare benzanilide derivatives for use as anticancer agents.

Applications Phenmetetrazine-d5 Hydrochloride is the labelled form of Phenmetetrazine Hydrochloride (P296400). Phenmetetrazine is an analog of Phenmetrazine (P314500, HCl salt) which is an anorexic.
References Klosa, et al.: J. Prakt. Chem., 21, 12 (1963); Leibowitz, S.F., et al.: Eur. J. Pharmacol., 53, 69 (1978)

Applications (±)-1-Phenylethan-1-d1-ol (CAS# 3101-96-0) is a useful isotopically labeled research compound.

Applications Piperazine-d10 (CAS# 362049-61-4) is a useful isotopically labeled research compound.

Applications m-Cresol-d8 (CAS# 302911-90-6) is a useful isotopically labeled research compound.

Applications DL-Leucine-d7 (iso-propyl-d7) (CAS# 259225-40-6) is a useful isotopically labeled research compound.

Applications (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile-d1 is the deuterated form of (2S)-1-(2-Chloroacetyl)-2-9-pyrrolidinecarbonitrile (C363780), which is a key intermediate for dipeptidyl peptidase IV inhibitor Vildagliptin (V305000).
References Singh, S.K., et al.: Beil. J. Org. Chem., 4, 20 (2008);

Applications N-Methylacetamide-2,2,2-d3 (CAS# 3669-69-0) is a useful isotopically labeled research compound.

Applications Isotope labelled benzyl bromide is a compound used in organic synthesis for the introduction of the benzyl protecting group for alcohols and carboxylic acids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kudou, N., et al.: Euro. J. Med. Chem., 60, 76 (2013); Cahiez, G., et al.: Advan. Synthesis. Catalysis., 354, 1519 (2012);

Applications 1-Bromotridecane-d27 (CAS# 349553-91-9) is a useful isotopically labeled research compound.

Applications Decanoyl-d3 Chloride is an intermediate in the synthesis of Decanoyl-10,10,10,d3-L-carnitine Chloride (D212582), a labelled metabolite of L-Carnitine (C184110) which is an essential cofactor of fatty acid metabolism. Also required for the transport of fatty acids through the inner mitochondrial membrane.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)

Applications Octahydro-1H-pyrrolo[3,4-b]pyridine-d2 Di-trifluoroacetate is an intermediate in the synthesis ofhybrid antibacterial agents that exhibits inhibitory activities towards DNA Polymerase-Topoisomerase.
References Zhi, C.X., et al.: J. Med. Chem., 49, 1455 (2006);

Applications N,N'-Bis(3-aminopropyl-d6)-1,3-propanediamine (CAS# 1219804-74-6) is a useful isotopically labeled research compound.

Applications 4-tert-Butyl-2-chlorophenol-d9 is the labelled analogue of 4-tert-Butyl-2-chlorophenol.

Applications p-O-Methyl-isoproterenol-d3 Hydrochloride is an isotopic analog of p-O-Methyl-isoproterenol Hydrochloride (M314735), which can be synthesized from 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone (C365325).

Applications N-Methyl-d3-acetamide (CAS# 3669-71-4) is a useful isotopically labeled research compound.

Applications Labelled 2-acetylthioethanesulfonic acid. Mesna (M225750) impurity.

Applications Decanoic-2,2-d2 Acid (CAS# 62716-49-8) is a useful isotopically labeled research compound.

Applications A labelled impurity of the anti-viral Lamivudine (L172500).
References Dwyer, O.: Synlett, 11, 1163 (1995);

Applications Wittig Reagent

Applications Naphthalene-1-d1 (CAS# 875-62-7) is a useful isotopically labeled research compound.

Applications Isotope labelled 4-Bromoaniline is a brominated aniline used as a building block in the preparation or pharmaceutial and organic compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Abdel-M. et al.: J. Org. Chem., 61, 3849 (1996); Sridhar, S.. et al.: Eur. J. Med. Chem., 36, 615 (2001);

Applications (±)-1-Phenylethan-2,2,2-d3-ol (CAS# 17537-32-5) is a useful isotopically labeled research compound.

Applications 1,3-Dimethylparabanic Acid-d6 is the labelled form of 1,3-Dimethylparabanic Acid (D474715). Chronic exposure to 1,3-Dimethylparabanic Acid can cause inhibition of growth population on rotifers while algae seems to be unaffected. Furthermore, 1,3-Dimethylparabanic Acid is a derivative of Caffeine (C080100).
References Zarrelli, a., et al.: Sci. Total Environ., 470, 453 (2014)

Applications 1-Bromo-2,3-dichlorobenzene-d3 (CAS# 1219805-59-0) is a useful isotopically labeled research compound.

Applications Vilazodone N-Oxide-d4 is the isotope labelled analog of Vilazodone N-Oxide (V265020); a metabolite of Vilazodone (V265000) which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Also an antidepressant.
References Bartoszyk, G., et al.: Eur. J. Pharmacol., 322, 147 (1997); Heinrich, T., et al.: J. Med. Chem., 47, 4684 (2004)

Applications N-Desmethyl Regorafenib (Pyridine)-N-oxide-d3 is the isotope labelled analog of N-Desmethyl Regorafenib (Pyridine)-N-oxide (D293280); a synthetic metabolite of Regorafenib (R143000) used for treatment and prevention of cancer.
References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011

Applications 1-Bromohexadecane-16,16,16-d3 (CAS# 284474-40-4) is a useful isotopically labeled research compound.

Applications Ethynylbenzene-13C2, is the labeled analogue of Ethynylbenzene (E932150), which is an aromatic hydrocarbon, is important in the petrochemical industry as an intermediate in the production of styrene, which in turn is used for making polystyrene, a common plastic material.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Xiang, J., et al.: Tetrahedron Lett, 37, 5269 (1996);

Applications Sodium Butyrate-4,4,4-d3 (CAS# 347840-05-5) is a useful isotopically labeled research compound.

Applications Sodium Butyrate-3,3,4,4,4-d5 (CAS# 204244-79-1) is a useful isotopically labeled research compound.

Applications N-(3-Methylbutyryl)glycine-2,2-d2 (CAS# 1219795-09-1) is a useful isotopically labeled research compound.

Applications 2-Nitroaniline-4,6-d2 (CAS# 1276197-41-1) is a useful isotopically labeled research compound.

Applications 4-Fluorotoluene-alpha-d1 (CAS# 131088-90-9) is a useful isotopically labeled research compound. This compound can be used in to detect isotopic effects, and can be detected using NMR spectroscopy.
References Langen, H.,et.al., Z. Naturforsch.A., 46,1123-1130,(1991); Holland, H., et.al., J.Chem.Soc. Perkin Trans.1., 36,1107-1165,(2008);

Applications Tolcide 2230-d4 is derived from 2-Benzothiazolethiol-d4 (B206652), which is a useful building block in the synthesis of various pharmaceuticals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1,8-Dimethylnaphthalene-d12 (CAS# 104489-29-4) is a useful isotopically labeled research compound.

Applications Bromocyclopropane-d4 is labelled Bromocyclopropane (B682760) which is used as a reagent to synthesize substituted (carboxycyclopropyl)glycines as potent and selective group II metabotropic glutamate receptor antagonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ornstein, P., et al.: J. Med. Chem., 41, 358 (1998)

Applications Octadecylamine-d37 is the isotope labelled analog of Octadecylamine. Octadecylamine is used in biological studies for the formation of ion pairing as alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles.
References Castro, G.A., et al.: Int. J. Pharma., 381, 77 (2009);

Applications 6-Amino-5-nitrosouracil-13C,15N2 is an intermediate in the synthesis of Xanthine-13C15N2 (X499952), which is an isotope labelled analog of Xanthine (X499950), a substance that can be found in animal organs, yeast, potatoes, coffee beans, tea. Xanthine can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives that exhibits adenoside receptor antagonist properties.
References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)

Applications Isotope labelled Nitrobenzene (N493000), used mainly in the production of the chemical precursor aniline as well as in azobenzene synthesis (1). Also may be reduced through magnetic iron oxide nanocrystals (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References Cantillo, D. et al.: J. Org. Chem. 2013 May 3;78(9):4530-42.Yadav, G. et al.: Chem. Eng. J. 2013 Aug:221(1) pp500-511

Applications Bromobenzene-2,3,5,6-d4 (CAS# 64646-03-3) is a useful isotopically labeled research compound.

Applications Compound forms a complex with Mefenamic acid increasing its transdermal permeation properties
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fang, L., et al.: J. Pharm. Sci., 93, 144 (2004), Gibellini, F., et al.: Biochem. J., 415, 135 (2008),

Applications Labelled 2-Chloropyridine (C380605). (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during the decomposition of specific insecticides. 2-CPY was found to be genotoxic agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Demsia, G., et al.: Mutat. Res., 634, 32 (2007), Stapleton, D., et al.: Water Res., 43, 3964 (2009),

Applications (±)-1-Phenylethanol-d10 (CAS# 219586-41-1) is a useful isotopically labeled research compound.

Applications 4-(Trifluoromethoxy)benzoic Acid-13C is labeled 4-(Trifluoromethoxy)benzoic Acid (T790720) which is a substituted benzoic acid used in the preparation of a various biologically active compounds such as antifungal and antimalarial agents.
References Jiang, Y. et al.: Bioorg. Med. Chem. Lett., 21, 4471 (2011); Herrin, T.R. et al.: J. Med. Chem., 18, 1216 (1975);

Applications 2-Hexanone-1,1,1,3,3-d5 (CAS# 4840-82-8) is a useful isotopically labeled research compound.

Applications n-Octatriacontane-d78 (CAS# 1219803-25-4) is a useful isotopically labeled research compound.

Applications 2-Phenyl-d5-ethylamine (CAS# 912627-99-7) is a useful isotopically labeled research compound.

Applications 2,6-Dinitrotoluene-alpha,alpha,alpha-d3 (CAS# 93951-90-7) is a useful isotopically labeled research compound.

Applications Labelled (6R,7S)-Cefoperazone (C242890). (6R,7S)-Cefoperazone is the enantiomer of Cefoperazone (C242900) as an impurity.
References Fabre, H., et al.: J. Pharm. Sci., 73, 611 (1984), Strasters, J., et al.: Anal. Chem., 63, 2503 (1991), Chen, Z., et al.: World Notes Antibiot., 25, 249 (2004),

Applications Labelled analogue of Diethyl Hexyl Phosphate, an alkylphosphoric acid used in the extraction of uranium from molybednum. Diethyl Hexyl Phosphate is also used as a solid dispersing agent in certain food and beverage containers.
References Li, Z.: Youkuangye, 5, 14 (1986);

Applications 1,1-Dichloroethane (2,2,2-D3, 98%) (cas# 56912-77-7) is a useful research chemical.

Applications DL-4-Hydroxyphenylalanine-3,3-d2 (CAS# 35693-18-6) is a useful isotopically labeled research compound.

Applications 2,3,5-Trimethylphenol-d11 (CAS# 362049-46-5) is a useful isotopically labeled research compound.