Organic Halides

<p>Applications A reagent used in the preparation of prodrugs of diacidic nonpeptide angiotensin II antagonist as well as pyrrolothiazole platelet activating factor antagonist.<br>References Aungst, B.J. et al.: Pharmac. Res., 12, 763 (1996); Davidsen, S.K. et al.: J. Med. Chem., 37, 4423 (1994);<br></p>

<p>Applications Diamino-5-phenylthiazole Hydrobromide is an phenylthiazole derivative used in the preparation of antiallergic and antiinflammatory agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ban, M. et al.: Bioorg. Med. Chem., 6, 1069 (1998);<br></p>

<p>Applications Chloramine-T Trihydrate is used as a safe and convenient electrocyclisation (oxidizing) agent in the preparation of 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine derivatives.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mal, S., et al.: Tetrahedron Lett., 56, 2896-2901 (2015)<br></p>

<p>Applications 2,4,5,6-Tetrachloro-m-xylene, is an intermediate for the synthesis of pesticides and metabolites. It can also be used for the preparation of Quinol nitrates.<br>References Suzuki, H., et al.: J. Chem. Soci. Comm., 51 (1957); Snyder, J. L., et al.: Anal. Chem., 64, 1940 (1992);<br></p>

<p>Applications tert-Butylhydrazine Hydrochloride is a a hydrazine compound used in organic synthesis for aromatic nucleophilic N-N exchange reaction. tert-Butylhydrazine Hydrochloride is also used in the preparation of insect growth regulator.<br>References Hojo, M. et al.: Synthesis, 6, 481 (1990); Zhang, J. et al.: Huax. Shijie, 36, 576 (1995);<br></p>

<p>Stability Moisture Sensitive<br>Applications Tri-n-octylchlorotin is an octyltin compound used to study the growth and fatty acid of the microscopic fungus Cochliobolus lunatus. It is also an organotin reagents used to covalently functionalize oxide nanostructures and multi-walled C nanotubes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Felczak, A., et al.: Process Biochem., 49, 295-300 (2014); Gomathi, A., et al.: J. Mater. Chem., 19, 988-995 (2009);<br></p>

<p>Applications Ethylenebis(tetrabromophthalimide) is an additive fire retardant that is added to a polymer mixture to produce a blend. Ethylenebis(tetrabromophthalimide) is used in high impact polystyrene (HIPS), polyethylene, polypropylene, thermoplastic polyesters, polyamide, ethylene propylene-diene terpolymers (EPDM rubbers) and other synthetic rubbers, polycarbonate, ethylene copolymers, ionomer resins, epoxies, and textile treatments.<br>References Clausen, E., et al.: Anal. Chem., 327, 297 (1987);<br></p>

<p>Applications 2-Amino-6-(chloromethyl)-4(3H)-pteridinone is a reagent/intermediate used in the preparation of Folic Acid (F680300) and its derivatives.<br>References Qi, Y., et al.: Faming Zhuanli Shenqing. CN 103755706 A 20140430. Apr 30, 2014;<br></p>

<p>Applications Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.<br>References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)<br></p>

<p>Applications (R,R)-Ethambutol Dihydrochloride shows antitumor properties when complexed with platinum. Also an isomer of Ethambutol (E889800), an antibacterial (tuberculostatic).<br>References Coluccia, M. et al.: Anticanc. Res., 11, 281 (1991); Wilkinson, et al.: J. Med. Chem., 5, 835 (1962), Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971), Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)<br></p>

<p>Applications Epichlorohydrin is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 30, 63 (1948),<br></p>

<p>Applications 4-Aminomethyl Benzamidine Dihydrochloride is a small molecule CXCR4 antagonist.<br>References Zhan, Weiqiang, et al.: J. of Med. Chem., 50(23), 5655-5664 (2007)<br></p>

<p>Applications 5,6-dibromonicotinic acid (cas# 29241-64-3) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-3,3,3-trifluoropropene is a useful research chemical for organic synthesis and other chemical processes.<br>References Zhao, Q., et al.: Tetrahedron, 74, 6033 (2018); Zhang, M., et al.: Nat. Commun., 9, 1 (2018); Hou, X., et al.: Org. Process Res. Dev., 20, 989 (2016)<br></p>

<p>Applications 3-Bromopropionyl Chloride, is a versatile building blcok used in the synthesis of carbonyl compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-(p-Iodophenyl)butyric Acid is a reactant involved in the synthesis of meta- and paracyclophanes containing unsaturated amino acids and intramolecular Friedel-Crafts reactions for synthesis of 1-tetralones.<br>References Gibson, S., et al.: Tetrahedron, 60, 6945 (2004); Cui, D., et al.: Tetrahedron Lett., 44, 4007 (2003)<br></p>

<p>Applications 6-Chlorohexanoic Acid is used as the starting material in the synthesis of 2,6-Dichloro-N-(2,6-dimethylphenyl)hexanamide (D434225); an impurity of the local anesthetic Levobupivacaine (B689546). 6-Chlorohexanoic Acid is also used as a reagent in the synthesis of novel types of polyester glycodendrimers as potential inhibitors of urinary tract infections.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tullar, B., et al.: J. Med. Chem., 14, 891 (1971); Schmidt, A., et al.: Pharm. Res., 22, 2121 (2005); Twibanire, J.K., et al.: New J. Chem., 39, 4115 (2015)<br></p>

<p>Applications 4-Azido-2,3,5,6-tetrafluorobenzamide (cas# 122616-98-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4'-(Trifluoromethyl)-3-biphenylcarboxylic Acid functions as a reagent in the scalable development of GPR40 receptor agonist AMG 837. A potential antidiabetic agent.<br>References Houze, J. B., et al.; Bioorg. Med. Chem. Lett., 22, 1267 (2012); Walker, S. D., et al.: Org. Process Res. Dev., 15, 570 (2011)<br></p>

<p>Applications Bromochloroacetic acid is a halogenated disinfection byproduct commonly found in drinking water, fruit juice, and cheese. Bromochloroacetic acid has been shown to cause mesothelioma, fibroadenomas, and adenomas in rats<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hang, C., et al.: Sci Total Environ. 543, 425 (2016); Cardador, M. J. and Gallego, M.: Food Chem. 173, 685 (2015); Natl Toxicol Program Tech Rep Ser. 549, 1 (2009)<br></p>

<p>Applications Cyclopentyl chloride (cas# 930-28-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Air Sensitive<br>Applications 4,5-Dichloro-2-octyl-3(2H)-isothiazolone (cas# 64359-81-5) is a useful research chemical.<br></p>

<p>Applications Ethyl 4-Bromo-2-(methoxyimino)-3-oxobutyrate is an intermediate used in the synthesis of some thiophene analogs as anti-inflammatory agents.<br>References Pillai, A., et al.: Bioorg. Med. Chem., 13, 1275 (2005)<br></p>

<p>Applications 4-(Dimethylphosphinyl)benzenamine Hydrochloride is the salt form of 4-(Dimethylphosphinyl)benzenamine, a reactant in the preparation of 9-(arenethenyl)purines as dual Src/Abl kinase inhibitors.<br>References Huang, Wei-Sheng, et al.: J. of Med. Chem., 52(15), 4743-4756 (2009)<br></p>

<p>Applications 2-tert-butyl-2-[2-(4-chlorophenyl)ethyl]oxirane (cas# 80443-63-6) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Durban, M. et al.: Eur. J. Lipid. Sci. Tech., 105, 633 (2003);<br></p>

<p>Applications It is used in a new method for conjugation of carbohydrates to proteins using an aminooxy-thiol heterobifunctional linker.<br>References Tietze, L., et al.: Bioconjugate Chem., 2, 148 (1991), Peeters, C., et al.: Infect. Immun., 60, 1826 (1992), Brask, J., et al.: J. Pept. Sci., 6, 290 (2000),<br></p>

<p>Stability Volatile<br>Applications Trichloroethylene-d (CAS# 13291-68-4) was useful in an isotope exchange column study to understand the slow desorption of organic compounds in soils and sediments.<br>References Werth, C. J., et al.: ACS Division Environ. Chem., 37, 174 (1997)<br></p>

<p>Stability Hygroscopic<br>Applications Methylbenzethonium Chloride is an anti-leishmanial agent, in the treatment of leishmaniasis, a zoonotic infection affecting people in tropical regions.<br>References El-On, J. et al.: Exp. Parasitol., 116, 156 (2007); Peniche, A. et al.: Antimicrob. Agents. Chemother., 58, 78 (2014);<br></p>

<p>Applications 1H,1H, 2H, 2H-Tridecafluoro-1-n-octanol is a material used to improve nanotube composites. It is also used in the synthesis of a recyclable fluorous hydrazine carbothioate compound with NCS to catalyze the acetalization of aldehydes.<br>References Deng, J. et alJ. App. Polym., 108, 2023 (2008); Zhu, Y. et al.: New. J. Chem., 37, 890 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications 3-Chloroperbenzoic Acid (Technical Grade, wet with water) (cas# 937-14-4) is useful as an allosteric modulator of nicotinic acetylcholine receptors for treating CNS disorders.<br> E0<br>References Bell, I. M., et al.: PCT Int. Appl. (2020), WO 2020223136 A1<br></p>

<p>Applications Dimethyldimyristylammonium Chloride is used as a surfactant.<br>References Cipiciani, A., et al.: Austr. J. Chem., 44, 1505 (1991); Hueck, H., et al.: Appl. Microbiol., 14, 308 (1966)<br></p>

<p>Applications Benzyl 2-Chloroethyl Ether is used in the synthesis of phosphane ligands with novel linker units that are complexed with rhodium to be used as building blocks for dendrimer catalysts. Also used in the formation of 2,6-diphenylpyrazine molecule derivatives which display cytotoxic properties.<br>References Findeis, R. et al.: Eur. J. Inorg. Chem., 1, 99 (2003); Dias, N. et al.: Eur. J, Med. Chem., 40, 1206 (2005);<br></p>

<p>Applications N-​(4-​Methyl-​2-​thiazolyl)​-guanidine hydrochloride is the hydrochloride base salt of N-​(4-​Methyl-​2-​thiazolyl)​-guanidine which is used as a test compound for various studies involving permeability through the blood-​brain barrier.<br>References Bolboaca, S.D., et al.: Int. J. Mol. Sci., 12, 4348-64 (2011); Dureja, H., et al.: Acta Pharm. 57, 451-67 (2007); Fu, X., et al.: nt. J. Mol. Sci., 10, 737-50 (2005)<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-(3-Chloropropyl)theobromine (cas# 74409-52-2) is a useful research chemical.<br></p>

<p>Applications 2-Bromopentane is a compound useful in organic synthesis, that has been used in the meta-selective C-H bond alkylation with Ruthenium catalysts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hofmann, N., Ackermann, L.: J. Am. Chem. Soc., 135, 5877 (2013)<br></p>

<p>Applications DL-2,4-Diaminobutyric Acid Dihydrochloride (cas# 65427-54-5) is a useful research chemical.<br></p>

<p>Applications Ethyl 2-Chloropropionate is used to elucidate structural and functional properties of the LRRK2 protein ATP-binding pocket, which plays a major role in the late-onset Parkinson Disease.<br>References Liu, Z. et al.: J. Biol. Chem., 289, 32937 (2014);<br></p>

<p>Applications Dibromoacetamide is a byproduct produced from water purifciation processes.<br>References Chuang, Y., et al.: Env. Sci. Tech., 53, 3729 (2019);<br></p>

<p>Applications 2,4-Diphenylpyrylium Tetrafluoroborate is derived from 4-Methoxy-3-buten-2-one (M261350), which is a reactant in the synthesis of hydroisoquinoline derivatives as an intermediate for the synthesis of manzamine.<br>References Mihara, Y., et. al.: Bull. Chem. Soc., 82, 1520 (2009)<br></p>

<p>Applications (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran is used as a reactant in the efficient synthesis of empagliflozin inhibitor of SGLT-2 utilizing AlCl3-promoted silane reduction of β-glycopyranoside.<br>References Wang, X., et al.: Org. Lett., 16, 4090 (2014);<br></p>

<p>Applications N,N-Dimethyl-3-phenylpentan-3-amine Hydrochloride is a useful research chemical.<br></p>

<p>Applications 3-(Methylamino)propanoic acid HCl<br></p>

<p>Applications Ethyl hydrazinoacetate, HCl<br></p>

<p>Applications 1-Cyclopropyl-2-(2-fluorophenyl)-2-hydroxy-ethanone is a useful synthetic intermediate in the synthesis of Prasugrel (P701150, HCl); an antiplatelet agent.<br>References Wiviott, S.D., et al.: Circulation, 116, 2923 (2007); Xu, X., et al. Faming Zhuanli Shenqing. CN 102718642 A 20121010. Oct 10, 2012; Wang, G., et al. Faming Zhuanli Shenqing. CN 101402556 A 20090408. Apr 8, 2009<br></p>

<p>Applications 1-Chloro-4-(chlorophenylmethyl)benzene is used in the synthesis of novel benzhydrylpiperazine derivatives as cytotoxic compounds in the treatment of various cancers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gurdal, E. et al.: Drug Res., 63, 121 (2013); Yarim, M. et al.: Int. J. Mol. Sci., 13, 8071 (2013);<br></p>

<p>Applications Carboxymethoxyamine Hemihydrochloride (cas# 2921-14-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Dimethyldimyristylammonium bromide is a cationic surfactant used in the study of lipid raft domains in membranes.<br>References Uyama, M.; et al.: J. Oleo Sci., 67, 67 (2018).<br></p>

<p>Applications Octafluorocyclopentene (cas# 559-40-0) is a useful research chemical.<br></p>

<p>Applications 1H,1H-Perfluorohexan-1-ol is a reagent in the synthesis of environmentally safer fluoroalkyl ether synthons.<br>References Lazzari, D., et al.: J. Fluorine. Chem., 156, 34 (2013)<br></p>

<p>Impurity Bicalutamide EP Impurity D<br>Applications 5-Amino-2-cyanobenzotrifluoride (Bicalutamide EP Impurity D) is used for the preparation of benzene derivatives as non-steroidal androgen receptor modulators.<br>References Xiao, H.-Y., et al.: Bioorg. Med. Chem. Lett., 20, 4491 (2010),<br></p>

<p>Stability Light Sensitive<br>Applications 3-Chlorocyclohexene (cas# 2441-97-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,6-Dichlorophenol is a reagent used in the synthesis of α-chloroesters and chlorophenols as well as chlorinated pharmaceutical compounds such as the anti-HIV agent chloropeptin I.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deng, H. et al.: J. Am. Chem. Soc., 125, 9032 (2003); Hoke, J. et al.: App. Cat. B. Env., 1, 285 (1992); Reynolds, N. et al.: J. Am. Chem. Soc., 127, 16406 (2005);<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Chloro-5-(1-chloro-1,3-dihydro-3-oxo-1-isobenzofuranyl)-benzenesulfonyl Chloride is a useful synthetic intermediate.<br></p>

<p>Applications 2-Bromodibenzofuran is a brominated derivative of Dibenzofuran (D417185); a reagent in Friedel-Crafts acylation.<br>References Albrecht, W. L., et al.: J. Med. Chem., 20, 364 (1977)<br></p>

<p>Applications 6-Bromo-3H-isobenzofuran-1-one<br></p>

<p>Applications 2-Bromo-1-propanol is used in the epoxide productions from Flavobacterium.<br>References Geigert, J., et al.: Appl. Environ. Microbiol. Applied<br></p>

<p>Applications 4-Bromo-2-chlorophenol<br></p>

<p>Applications 4,4'-Bis(bromomethyl)-1,1'-biphenyl (cas# 20248-86-6) is a useful research chemical.<br></p>

<p>Applications 3-Bromobenzyl bromide<br></p>

<p>Applications 5-Amino-2-chlorobenzotrifluoride is a compound useful in organic synthesis. It also performs a radioprotective activity against ionizing radiations.<br>References Blickenstaff, R. T., et al.: J. Pharm. Sci., 83, 219 (1994); Kumari, P., et al.: Org. Biomol. Chem., 16, 2049 (2018)<br></p>

<p>Applications 4-Pyridylethylmercaptan, Hydrochloride (cas# 6298-11-9) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications Pentachloroacetone is a disinfection byproduct.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jeong, C., et al.: Environ. Sci. Technol., 46, 12120 (2012); Colman, J., et al.: Toxicol. Appl. Pharm., 254, 100 (2011)<br></p>

<p>Applications An oxidizing agent, especially in steroid synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,1-Dichloro-2-propanone is a disinfection byproduct in drinking water. It may cause bladder cancer and other adverse health effects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Farre, M., et al.: Water Sci. Tehnol., 12, 573 (2012); Catherine, M., et al.: Water Res., 47, 3231 (2013); Neale, P., et al.: Environ. Sci. Technol., 46, 10317 (2012)<br></p>

<p>Applications 5-Bromo-2-thiophenecarboxaldehyde is used in biological studies as anti-inflammatory and anti-tumor activity of the marine mangrove Rhizophora apiculata.<br>References Prabhu, V.V., et al.: J. Immunotoxicol., 9, 341 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Tris(1-chloro-2-propyl) Phosphate is a flame retardant of low hydrolytic stability, used in polyurethane (PU) rigid and flexible foam, PVC, EVA, phenolics and epoxy resin.<br>References Grump, D., et al.: Toxicol. Sci., 126, 140 (2012); Paciorek, S.J., et al.: J. Porous. Mater., 19, 161 (2012);<br></p>

<p>Stability Very Volatile<br>Applications 1,1-Dichloroethane is used as a chemical solvent in the preparation of precursors of quinolizine, isoquinoline and indole alkaloids(1). Groundwater contaminant, DDT biodegredation product(2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Butler, E. et al.: Env. Sci. Tech. 2000, 34 (3), pp 422–429.2. Ren, L. et al.: Chemosphere. 2017 Feb;168:244-253.3. Grewal, J. et al.: J. Environ. Sci. Health. B. 2016 Dec;51(12):809-816.<br></p>

<p>Applications (1R,3S)-3-Aminocyclopentanol Hydrochloride is used to for the preparation of 6-Aminopyridin-3-ylthiazoles as a method of treating or ameliorating a syndrome, disorder or disease related rheumatoid arthritis or psoriasis.<br>References Goldberg, S., et al.: PCT Int. Appl., 793pp (2017)<br></p>

<p>Applications 4-Chloropropiophenone is a useful synthetic intermediate. It can be used to prepare 4-Chloro Cathinone. It can also be used to synthesize bupropion (B689625) analogs.<br>References Carroll, F., et al.: J. Med. Chem., 52, 6768 (2009)<br></p>

<p>Applications 5-Chloro-1-Indanone is used as a reagent in the synthesis of novel tricyclic pyrazoles as CB1 and CB2 cannabinoid receptors. Also used in he synthesis of heteroarylmethylidene cubstituted compounds as selective inhibitors of aldosterone synthase.<br>References Ulmschneider, S. et al.: J. Med. Chem., 48, 1563 (2005); Ulmschneider, S. et al.: J. Med. Chem., 48, 1563 (2005);<br></p>

<p>Applications 3,5-Diiodothyronamine Hydrobromide is an intermediate in the synthesis of Thyronamines and related analogues.<br>References Hart, M. E., et al.: J. Med. Chem., 49, 1101 (2006);<br></p>

<p>Applications 4-[(2-chloroacetyl)amino]benzoic acid (cas# 4596-39-8) is a useful research chemical.<br></p>

<p>Applications 2,3-Dibromopropionamide (cas# 15102-42-8) is a useful research chemical.<br></p>

<p>Applications 4-Bromophenol is used as a reagent in Stille reactions.<br>References Littke, A.F. et al.: J. Am. Chem. Soc., 124, 6343 (2002);<br></p>

<p>Stability Moisture Sensitive<br>Applications A versatile phosphitylating agent for the phosphorylation of hydroxy amino acids and the preparation of protected phosphopeptides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liskamp, R.M.J., et al.: Recl. Trav. Chim. Pays-Bas, 109, 27 (1990)<br></p>

<p>Stability Hygroscopic<br>Applications N-​Ethyl-​α-​methyl-​3-​(trifluoromethyl)​-benzeneethanamine hydrochloride has been used in case studies for the study of impulsivity, motor skills, and anxiogenic effects in the neuroscience community.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Whitney, K.N., et al.: Exp. Clin. Psychopharm., 21, 345-54 (2013); Arrant, A.E., et al.: Neuropharmacology, 65, 213-22 (2013)<br></p>

<p>Applications tert-Butyldiphenylchlorosilane is used to synthesize interphenylene phenyloxazoles, compounds that have antagonistic activity against thromboxane receptors which can be used for treatment of circulatory disorders, angina and stroke.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hadjipavlou–Litina, D. &amp; Kontogiorgis, C.: Int. Elect. J. Mol. Des., 1, 300 (2002); Misra, R., et al.: Bioorg. Med. Chem. Lett., 2, 937 (1992)<br></p>

<p>Applications α-Bromo-2,3,4,5,6-pentafluorotoluene, can be used as an organic fluorinated building blocks for chemical synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1-Chloro-6-iodohexane is used in studies to demonstrate the direct reduction of 1-Bromo-6-chlorohexane/1-Chloro-6-iodohexane at silver cathodes in Dimethylformamide.<br>References Rose, J.A., et al.: ?Electrochim. Acta, 218, 311-317 (2016)<br></p>

<p>Applications Methyl 2-Nitro-4-(trifluoromethyl)benzoate has been used in the synthesis of isoxazolinone antibacterial agents, using nitrogen as a replacement for the stereogenic center of the molecule. Also used in the preparation of benzo[b]azepines as inhibitors of cholesterol ester transfer.n<br>References Snyder, L. et al.: Bioorg. Med. Chem. Lett., 14, 4735 (2004);<br></p>

<p>Applications 2-Chloro-4-(tert-pentyl)phenol (cas# 5323-65-9) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications N-(2-Benzoyl-4-chlorophenyl)formamide is used as a reagent in the synthesis of 2-aminoindole compounds that can be used as antimalarial agents.<br>References Mazitschek, R., et al.: PCT Int. Appl. WO 2011053697 A1 20110505. May 5, 2011<br></p>

<p>Applications 2-Chlorobenzyl Chloride is a reagent in the synthesis of piperidine derivatives which are used as human heat shock protein 70 inhibitors for treatment of drug-resistant tumors. 2-Chlorobenzyl Chloride is also used as a reagent in the synthesis of benzothiazole derivatives bearing indole-based moiety which can exhibit anticancer activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeng, Y., et al.: Eur. J. Med. Chem., 97, 19 (2015); Ma, J., et al.: Eur. J. Med. Chem., 96, 173 (2015)<br></p>

<p>Applications Fadrozole hydrochloride is a very potent and selective inhibitory effect of the aromatase enzyme system.<br></p>

<p>Applications This compound is used in the synthesis of Diclazuril (D436200) and diclazuril derivatives.<br></p>

<p>Applications 9,9-Bis (4-Hydroxyphenyl) Fluorene is used in the production of polyarylene ethers and extensively used in the study of polymer electrolyte membranes with the potential for fuel cell application.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miyatake, K. et al.: J. Am. Chem. Soc., 129, 3879 (2007); Chikashige, Y. et al.: Macromolecules, 38, 7121 (2005);<br></p>

<p>Applications 2-hydroxy-5-iodobenzoic Acid is a reagent in various organic chemical reactions leading to pharmaceutical compounds. It is involved in the synthesis of labelled benzamide analogs for tumor imaging as well as the synthesis of the dye, Congo Red, for biological analyses.<br>References Tu, Z. et al.: J. Med. Chem., 50, 3194 (2007); Sellarajah, S. et al.: J. Med. Chem., 47, 5515 (2004);<br></p>

<p>Applications N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.<br>References Kojetin, D. et al.: ACS Chem. Biol., 6, 131 (2011); Grant, D. et al.: ACS Chem. Biol., 5, 925 (2010)<br></p>