Organic Halides

<p>Applications 2,4-Dichloro-3,5-dinitrobenzotrifluoride is a reagent used in the synthesis of kinesin spindle protein inhibitors. Potential use as an alternative to neurotoxic MT inhibitors.<br>References Dong, J. et al.: Eur. J. Med. Chem., 70, 427 (2013);<br></p>

<p>Applications epi-5-Fluoro ADB is an analog of fluoronatied ADB-PINACA an analog of AKB48 in which the adamantyl group has been replaced with 1-amino-3,3-dimethyl-1-oxobutan-2-yl (ADB). epi-5-Fluoro ADB is a synthetic cannabinoid. Synthetic Cannabinoids<br>References Uchiyama, N., et al.: Forensic Toxicol., 30, 114 (2012)<br></p>

<p>Applications 1H,1H-Perfluoro-1-decanol (cas# 307-37-9) is a useful research chemical.<br></p>

<p>Applications trans-3-(2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-cyclopropanecarboxylic Acid is a reagent used in the synthesis of indanyl insecticides.<br></p>

<p>Applications 5-Chloronicotinic Acid is used as reagent/reactant luminescence and hydrothermal preparation of cobalt/cadmium/lead chloronicotinate phenanthroline MOF.<br>References Gao, Z.Q., et al.: J. Solid State Chem., 241, 121-130 (2016)<br></p>

<p>Applications 4-(Dimethylphosphinyl)benzenamine Hydrochloride is the salt form of 4-(Dimethylphosphinyl)benzenamine, a reactant in the preparation of 9-(arenethenyl)purines as dual Src/Abl kinase inhibitors.<br>References Huang, Wei-Sheng, et al.: J. of Med. Chem., 52(15), 4743-4756 (2009)<br></p>

<p>Stability Very Volatile<br>Applications 1,1-Dichloroethane is used as a chemical solvent in the preparation of precursors of quinolizine, isoquinoline and indole alkaloids(1). Groundwater contaminant, DDT biodegredation product(2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Butler, E. et al.: Env. Sci. Tech. 2000, 34 (3), pp 422–429.2. Ren, L. et al.: Chemosphere. 2017 Feb;168:244-253.3. Grewal, J. et al.: J. Environ. Sci. Health. B. 2016 Dec;51(12):809-816.<br></p>

<p>Applications Hydrogen Tetrafluoroborate(1-) is a useful building block for organic synthesis.<br>References Ohkuma, T., et al.: Journal of the American Chemical Society., 218, 8724 (2006)<br></p>

<p>Applications Benzyl 2-Chloroethyl Ether is used in the synthesis of phosphane ligands with novel linker units that are complexed with rhodium to be used as building blocks for dendrimer catalysts. Also used in the formation of 2,6-diphenylpyrazine molecule derivatives which display cytotoxic properties.<br>References Findeis, R. et al.: Eur. J. Inorg. Chem., 1, 99 (2003); Dias, N. et al.: Eur. J, Med. Chem., 40, 1206 (2005);<br></p>

<p>Applications Epichlorohydrin is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 30, 63 (1948),<br></p>

<p>Applications 3-Bromobenzyl bromide<br></p>

<p>Applications (1R,3S)-3-Aminocyclopentanol Hydrochloride is used to for the preparation of 6-Aminopyridin-3-ylthiazoles as a method of treating or ameliorating a syndrome, disorder or disease related rheumatoid arthritis or psoriasis.<br>References Goldberg, S., et al.: PCT Int. Appl., 793pp (2017)<br></p>

<p>Applications 4-Chloro-2,5-dimethoxyaniline was an analyte identified in a screening study of electronic nicotine delivery systems (ENDS), which are regulated tobacco products.<br>References Hung, P. H., et al.: J. Applied Toxic., 40, 1566 (2020)<br></p>

<p>Applications Fluorinert FC 40 is a colorless, thermally stable, fully- fluorinated liquid. A useful modifier for the design of soft porous polymers.<br>References Turani-i-Belloto, A., et al.: Polymers (Basel, Switzerland), 12, 1008 (2020)<br></p>

<p>Applications 4-Chloropropiophenone is a useful synthetic intermediate. It can be used to prepare 4-Chloro Cathinone. It can also be used to synthesize bupropion (B689625) analogs.<br>References Carroll, F., et al.: J. Med. Chem., 52, 6768 (2009)<br></p>

<p>Applications Chlorthiamid<br></p>

<p>Applications 4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid is a photoreactive aromatic diazirine.<br>References Wiedmann, M .; J. Cell biol.; 104, 201 (1987).<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications Trichloroacetonitrile is a by-product of the chlorine disinfection of water and is commonly used as a fumigant. It is also used as a direct alkylating agent and reacts with primary and secondary aliphatic amines to produce N-substituted trichloroacetamidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Christ, S.: J. Toxicol. Env. Health A, 47, 233 (1996); Davies, M. &amp; Jenkin, D.: J. Chem. Soc., No vol. given, 2374 (1954); Grivas, J. &amp; Taurins, A.: J. Chem., 36, 771 (1958)<br></p>

<p>Applications 2,3,4-Trichlorophenylboronic acid (cas# 352530-21-3) is a useful research chemical.<br></p>

<p>Applications α-Chlorobenzyl 4-Fluorophenyl Ketone is derived from Benzyl 4-Fluorophenyl Ketone (B279785), which is used in preparation and evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors.<br>References Singh, S. et al.: Bioorg. Med. Chem., 12, 1881 (2004);<br></p>

<p>Applications DL-2,4-Diaminobutyric Acid Dihydrochloride (cas# 65427-54-5) is a useful research chemical.<br></p>

<p>Applications 1-(2,3-Dimethylphenyl)ethyl Chloride is an impurity of Medetomidine (M203250), an α2-Adrenergic agonist. Sedative; analgesic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987), Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987), Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988), Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996),<br></p>

<p>Stability Hygroscopic<br>Applications Hydrazine hydrochloride (cas# 2644-70-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,4-Diaminobutane is known to affect the development of plant root systems, it’s inhibition resulting in a more dominant ‘tap’ root system. 1,4-Diaminobutane is an amino acid degradation product. Used in the preparation of hexahydropyrimidines as novel hepatitis C virus inhibitors. Also a reagent in the synthesis of antibacterial castor oil-based polyurethane membranes.<br>References Ben-Hayyim G. et al.: FEBS Lett., 4, 145 (1994); Hwang, J. et al.: Eur. J. Med. Chem., 70, 315 (2013); Yari, A. et al.: J. Biomed. Mat. Res., 102A, 84 (2014);<br></p>

<p>Applications 2,4,6-Tribromoanisole is haloanisole often present in wine. 2,4,6-Tribromoanisole is one of the main agent responsible for the musty odor in wine sample<br>References Sanvicens, N. et al.: J. Agric. Food Chem., 54, 9176 (2006); Copete, M.L. et al.: Food Add. Contam. Part A Chem. Anal. Cont. Risk Assess., 26, 32 (209);<br></p>

<p>Applications 2-Bromoacetonitrile is a water disinfectant byproduct. 2-Bromoacetonitrile has been found to show mutagenic activity on Salmonella typhimurium strain TA100.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahmed, A.E., et. al.: Toxicol. Appl. Pharm., 100, 271 (1989); Le Curieux, F., et. al.: Mutat. Res-genet. Tox., 341, 289 (1995)<br></p>

<p>Applications 2,4-Dichlorobenzotrichloride is used in the synthesis of aromatic acid chlorides.<br>References Rondestvedt, C. et al.: J. Org. Chem., 41, 3574 (1976);<br></p>

<p>Applications 1-Amino-2,4-dibromo-anthraquinone is a useful compound to study the uPAR·uPA protein-protein interaction (PPI) involved in signaling and proteolytic events that lead to tumor invasion and metastasis. It is also used to evaluate potential renal toxicants based on a relationship between chemical-induced kidney weight gain and kidney histopathology in rats. 1-Amino-2,4-dibromo-anthraquinone is a reagent utilized in copper-catalyzed Ullmann condensation to synthesize anthraquinone derivatives as novel dyes.<br>References Malik, E. M., et al.: Dyes Pigm. 131, 33 (2016); Craig, E. A., et al.: J. Appl. Toxicol. 35, 729 (2015); Mani, T., et al.: Bioorg. Med. Chem 21, 2145 (2013)<br></p>

<p>Applications β-Chlorolactic Acid (cas# 1713-85-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,5-Dinitrochlorobenzene is used to study strength and directionality of halogen bond are co-detected by the magnitude and size of the σ-hole.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kolar, M., et al.: Phys. Chem. Chem. Phys., 16, 9987 (2014);<br></p>

<p>Applications 2-(2-Chloro-4-iodophenylamino)-3,4-difluorobenzoic Acid (cas# 303175-44-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Aminomethyl Benzamidine Dihydrochloride is a small molecule CXCR4 antagonist.<br>References Zhan, Weiqiang, et al.: J. of Med. Chem., 50(23), 5655-5664 (2007)<br></p>

<p>Applications A reagent used in the preparation of prodrugs of diacidic nonpeptide angiotensin II antagonist as well as pyrrolothiazole platelet activating factor antagonist.<br>References Aungst, B.J. et al.: Pharmac. Res., 12, 763 (1996); Davidsen, S.K. et al.: J. Med. Chem., 37, 4423 (1994);<br></p>

<p>Stability Very Hygroscopic<br>Applications (S)-Isopropyl-2-aminopropanoate Hydrochloride, is a chemical reagent used in the synthesis of anti-HCV prodrugs based on imidazotriazine and pyrrolotriazine molecules.<br>References Tyndall, E. Bioorg. Med. Chem. Lett., 25, 869 (2015);<br></p>

<p>Applications 3,4,5-Trichlorocatechol has found to be toxic to marine algal.<br>References Ertuerk, M.D., et. al.: J. Mol. Graph. Model., 38, 90 (2012)<br></p>

<p>Applications Hexyl chloroformate is used as a derivatizing agent in organic synthesis, and is also used as a reagent to synthesize Dabigatran (D100090), an oral thrombin inhibitor used to prevent venous thromboembolism.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eerenberg, E., et al.: Circulation, 124, 1573 (2011); Eriksson, B., et al.: Lancet, 370, 949 (2007); Maurino, V., et al.: J. Am. Soc. Mass Spec., 10, 1328 (1999); Simpson, J., et al.: J. Am. Soc. Mass Spec., 6, 525 (1995); van Ryn, J., et al.: Thromb. &amp; Haemo., 103, 1116 (2010)<br></p>

<p>Stability Moisture Sensitive<br>Applications Chlorotrimethylsilane have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis. Chlorotrimethylsilane has been used for silylation and as a protection group in the process of various organic synthesis.<br> E0<br>References Casimiro, M., et al.: Org. Lett., 15, 2378 (2013); Lifchits, O., et al.: J. Am. Chem. Soc., 135, 6677 (2013);<br></p>

<p>Applications p-Chloroaniline Hydrochloride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ethyl hydrazinoacetate, HCl<br></p>

<p>Applications 2,4,5-Trifluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize quinolone antibacterial agnts.<br>References Sanchez, J., et al.: J. Med. Chem., 31, 983 (1988); Tran, T., et al.: Bioorg. Med. Chem. Lett., 14, 4405 (2004)<br></p>

<p>Applications 1-Chlorodecane is a reagent in the preparation of antimycobacterial agents. Also used in the synthesis of antimalarial atovaquone derivatives.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pathak, A. et al.: Bioorg. Med. Chem., 21, 1685 (2013); El Hage, S. et al.: Eur. J. Med. Chem., 44, 4778 (2009);<br></p>

<p>Applications Octafluorocyclopentene (cas# 559-40-0) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-1-(4-chlorophenyl)propan-1-one<br></p>

<p>Applications 4-Bromo-2,2-diphenylbutyric Acid (cas# 37742-98-6) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Chloro-3-nitrobenzoyl Chloride (cas# 38818-50-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4,4-diethylcyclohexan-1-amine hydrochloride (cas# 1087747-58-7) is a useful research chemical.<br></p>

<p>Applications 9-Fluorenemethanol is used in the design and in the synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells.<br>References Miyazaki, A., et al.: Tetrahedron Lett., 45, 6323 (2004)<br></p>