Organic Halides

<p>1-(5-Chloro-2-hydoxyphenyl)ethanone is a potent inhibitor of the antiapoptotic protein survivin. It binds to the carbonyl group of the molecule, which is located on the intramolecular hydrogen bond surface. This leads to conformational changes in the molecule and ternary complex formation, which eventually leads to apoptosis protein aggregation and activation. 1-(5-Chloro-2-hydoxyphenyl)ethanone has been shown to inhibit prostate cancer cells and has also been studied in clinical trials for its anticancer properties.</p>

<p>Boc-Leu-Lys-Arg-AMC is a synthetic substrate that has been used in a number of clinical studies to identify the serine proteases that are involved in autoimmune diseases. It is a synthetic peptide composed of the amino acid sequence found in soybean trypsin. The peptide was shown to have high salt tolerance and was able to be hydrolyzed by polyclonal antibodies with specificity for amyloid protein, suggesting it may be useful as a biochemical marker for Alzheimer's disease. Boc-Leu-Lys-Arg-AMC has also been shown to be an efficient substrate for collagenase, which is an enzyme that breaks down collagen and causes tissue damage. This property makes this compound useful as a proteolytic agent for the removal of unwanted scar tissue or other lesions from diseased organs. Boc-Leu-Lys-Arg-AMC also has an optimum pH level of 7.5 and is active against influenza</p>

<p>Neuromedin B is a peptide hormone that is produced by the hypothalamus and regulates many physiological processes such as energy metabolism, appetite, and sleep. Neuromedin B is a member of the family of guanine nucleotide-binding proteins (G proteins) that bind to G protein-coupled receptors on the surface of cells. It has been shown to stimulate calcium release from intracellular stores in response to an increase in cytosolic Ca2+. Neuromedin B has been shown to have anti-inflammatory effects on infectious diseases such as meningitis, sepsis, and tuberculosis, which may be due to its ability to inhibit neutrophil migration. Neuromedin B also stimulates hippocampal formation activity in rats during the rotarod test, which may be due to its effects on dopamine release.</p>

<p>Please enquire for more information about Matrix Protein M1 (58-66) (Influenza A virus) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-Bromo-2-(methylthio)pyrimidine is a synthetic compound that has been used to synthesize palladium complexes. It can also be used in the synthesis of vitamin B1, which is an essential nutrient for humans and animals. 5-Bromo-2-(methylthio)pyrimidine binds with magnesium and reacts with sulfoxide, nucleophilic attack and electronegativity. 5-Bromo-2-(methylthio)pyrimidine is activated by 2-chlorobenzothiazole and hydrogen chloride, which leads to nucleophilic attack on the electrophilic carbon atom. This causes a displacement reaction with the elimination of chlorine gas and production of dihydro.</p>

<p>Please enquire for more information about 4-Chloro-2-iodo-phenol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Des-Gly10,D-Tyr5,D-His(Bzl)6,Pro-NHEt 9)-LHRH trifluoroacetate salct including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Big Endothelin-3 (22-41) amide (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 6-Chloro-1,7-naphthyridin-4-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (D-Arg2)-Dermorphin (1-4) amide trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-Chloro-2,4-pentanedione is a model system that has been used to study the reaction mechanism of the intramolecular hydrogen transfer. This molecule was found to be more reactive in the presence of sodium carbonate and anhydrous sodium, which is due to protonation of the hydroxyl group on the ethylene diamine. 3-Chloro-2,4-pentanedione reacts with carbon disulphide and ethylene diamine to form 2,5-dimethylhexane-1,6-diol. 3D molecular docking analysis has shown that this compound binds to the ryanodine receptor and may be a potential therapeutic agent for patients with carcinoma cell lines.</p>

<p>1,1,2,2,2-Pentafluoroethanesulfonyl Chloride (PFES) is a perfluorinated compound that reacts with hydrogen fluoride to produce a colorless solution. PFES has been shown to be an effective catalyst for the reaction of naphthalene and hydrogen chloride. In addition, PFES is used as a reagent in the synthesis of amides and other functional groups as well as being a precursor for the production of low energy fluoropolymers. It is also used in the manufacture of fire-fighting foams.</p>

<p>Please enquire for more information about Amyloid beta-Protein (1-11) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Neuronostatin-19 (human, canine, porcine) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3,5-Dichloro-4-methylpyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Mca-Gly-Ala-Lys-Arg-His-Arg-Lys-Val-NH2 trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about VIP (4-28) (human, mouse, rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Intermediate in the synthesis of canagliflozin</p>

<p>4-Fluoro-3-methylnitrobenzene is a carbazole that is used as a pesticide. It has been shown to be effective against typhimurium and other bacteria. The mechanism of action of this compound may involve nitrenium ion formation, which is an intermediate in the reaction of ammonium nitrate with calcium carbonate. 4-Fluoro-3-methylnitrobenzene has two isomers: 4-fluoro-3-methylnitrobenzoic acid and 4-fluoronitrobenzoic acid, but only the former reacts with ammonium nitrate. The reaction time for this compound to form carcinogenic nitrosamines can vary from about one day to several months. Chemical shift data for this compound reveal its radical mechanism, which explains its low efficiency. This compound also has optical properties that can cause fluorescence or phosphorescence when exposed to ultraviolet light or laser beams, respectively.</p>

<p>Please enquire for more information about Thrombin Receptor Antagonist trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Amino-3,5-dibromobenzonitrile is an electrophile that is used to synthesize various boronic acid derivatives. It also inhibits butyrylcholinesterase and 2-aminobenzonitrile, enhancing the activity of organophosphorus cholinesterase inhibitors. 2-Amino-3,5-dibromobenzonitrile has been shown to react with nucleophiles at the alpha position to form a stable intermediate. This reaction has been shown to be reversible in aqueous solution. The compound has been evaluated as a potential chemotherapeutic agent against cancer cells in vitro.</p>

<p>Please enquire for more information about ([13C6]Leu10)-CRF (human, rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Orexin A (17-33) trifluoroacetate salt H-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu is a peptide fragment that belongs to the orexin family. It is a potent antagonist of the G protein coupled receptors, which are responsible for mediating the effects of endogenous and exogenous ligands. Orexin A (17-33) trifluoroacetate salt H has been shown to have cytosolic interactions with calcium ions, regulating their concentration in the cytosol. It also affects choline levels and increases intracellular calcium concentrations. The peptide also potentiates responses to cocaine and other drugs that target GPCRs. This drug has been shown to be active against xestospongin, an antibiotic that inhibits protein synthesis</p>

<p>Please enquire for more information about 1-(5-Bromopyrimidin-2-yl)ethanone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-Bromoimidazo[1,2-b]pyridazine (BIPM) is an analog of etoposide and has been shown to be a potent inhibitor of tyrosine kinases. BIPM selectively inhibits the activity of multikinase enzymes such as c-kit, PDGFRβ, and VEGFR2. In addition, BIPM has been shown to inhibit the proliferation of cancer cells by inducing apoptosis and cell cycle arrest in mcf-7 cells. This drug is not toxic to normal cells and shows a favorable safety profile when tested on animals.</p>

<p>Protease-activated receptor 1 (PAR-1) selective activating peptide, TFA salt. 98%.</p>

<p>N-(2-Bromoethoxy)phthalimide is a chemical compound that has been shown to inhibit the activity of histone deacetylases. Histones are proteins that regulate gene expression and play an important role in the regulation of DNA transcription. The enzyme histone deacetylase (HDAC) removes acetyl groups from these proteins, which can lead to changes in gene expression and misregulation of cellular processes. HDACs have been linked to autoimmune diseases, such as arthritis and multiple sclerosis, because they can cause inflammation by affecting the production of inflammatory cytokines. N-(2-Bromoethoxy)phthalimide is able to inhibit HDACs by forming covalent bonds with the lysine residues on these enzymes. This inhibition causes modifications that affect the interaction between HDACs and their substrates, preventing them from modifying histones or interacting with other proteins.</p>

<p>3-Fluorobenzoyl chloride is an inhibitor of AMPK. It binds to the ATP-binding site of the enzyme and inhibits phosphorylation, leading to decreased activity. 3-Fluorobenzoyl chloride has been shown to reduce the growth of cancer cells in vitro and in vivo by increasing the levels of a protein called p27KIP1. This protein regulates cell cycle progression and prevents cancer cells from entering into mitosis. 3-Fluorobenzoyl chloride also binds to factor receptors and inhibits kinase selectivity, which causes increased glucose uptake in adipocytes. The fluorine atom on this molecule increases its lipophilicity, which makes it more potent than other inhibitors that do not contain fluorine atoms.</p>

<p>Please enquire for more information about Tyr-(D-Dab 4,Arg5,D-Trp8)-cyclo-Somatostatin-14 (4-11) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Phenylacetyl-(D-Arg2·28,p-chloro-Phe6, Homoarg 9·29,Tyr(Me)10, Abu 15, Nle 27)-GRF (1-29) amide (human) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Pro3)-Dynorphin A (1-11) amide trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cis-Heptachlor epoxide is a metabolite of heptachlor, which is a pesticide. Cis-heptachlor epoxide has been detected in the blood of pregnant women, and in fetal cord blood. It has also been found in the liver microsomes of rats treated with heptachlor. Cis-heptachlor epoxide is an intermediate in the metabolism of heptachlor, but it can also be formed by hydrolysis of other pesticides containing chlorine atoms such as DDT and endosulfan. Cis-heptachlor epoxide is toxic to plants and animals, causing liver damage and inhibiting cellular respiration. There are no known studies on its toxicity to humans.</p>

<p>Please enquire for more information about (D-Trp6,D-Leu7)-LHRH trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H-Ala-2-chlorotrityl resin (200-400 mesh) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Gly14)-Humanin (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about HIV-1 gag Protein p24 (65-73) (isolates MAL/U455) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Biotinyl-Substance P trifluoroacetate salt Biotinyl-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 trifluoroacetate salt is a biotin conjugated Substance P analog. It is designed to bind to the amino acid sequences in the brain that are responsible for controlling and regulating pain. The drug's amino acid sequence was designed by accessing databases of amino acid sequences from all known organisms. The drug is administered as a sequence of cassettes, each containing an acid molecule that can be transferred to cells through nucleotide transfer.</p>

<p>Please enquire for more information about (D-Ala3)-Dynorphin A (1-11) amide trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 2-Boc-2,9-Diazaspiro[5.5]undecane hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Trp3,Arg5)-Ghrelin (1-5) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>MPLP(139-151) is a peptide that is derived from the myelin proteolipid protein (PLP). MPLP(139-151) has been shown to inhibit macrophage inflammatory in vitro and brain inflammation in vivo. The inhibition of macrophages was mediated by the induction of apoptosis and inhibition of NF-κB. MPLP(139-151) also induced regression of experimental autoimmune encephalomyelitis in mice, which suggests that it might be useful as a therapeutic agent for multiple sclerosis or other inflammatory diseases.</p>

<p>2-Aminoacetophenone hydrochloride is a chemical compound that is used in analytical chemistry as a reagent for the determination of protein and amino acid concentrations. This reagent can be prepared in various forms, depending on the type of analysis being performed. 2-Aminoacetophenone hydrochloride is used to determine the concentration of free amino acids in a sample by binding to it. It can also be used for determining the concentration of bound amino acids by reacting with them with hydrochloric acid. 2-Aminoacetophenone hydrochloride is an excellent substrate for matrix effect, which may cause errors in measurement due to interference from other substances present in the sample. The use of light exposure reduces this problem by removing interfering substances from the sample.</p>

<p>Please enquire for more information about Amyloid beta/A4 Protein Precursor770 (586-595) (human, mouse, rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1,4,5,8-Tetrachloroanthraquinone is a chlorinated aromatic compound that has been shown to have anticancer activity in vitro. This compound is an effective inhibitor of the production of reactive oxygen species from nitric oxide and hydrogen peroxide. It also inhibits the growth of cancer cells by binding to their cell membranes. 1,4,5,8-Tetrachloroanthraquinone binds to the carboxylate and functional groups on the surface of cancer cells and changes the conformation of their cell membrane proteins. The structural analysis revealed that this compound contains cycloalkyl groups with chlorine substituents on each ring. Immobilized 1,4,5,8-tetrachloroanthraquinone has been shown to be an effective agent against denitrification in soil samples containing nitrate.</p>

<p>Please enquire for more information about Neuropeptide W-30 (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-Bromo-3,5,7-trimethyladamantane is a hydroxy adamantane. It is the simplest member of the class of compounds known as adamantanes. Adamantanes are electrophilic and react with nucleophiles to form adducts. 1-Bromo-3,5,7-trimethyladamantane has a bridgehead methyl group that reacts with nucleophiles such as hydroxide ion, forming an ether adduct of the type (CH)O-(CH)Br (1). The carboxylic acid group can be deprotonated by strong bases to form the corresponding anion (CH)O-(CH)COH (2), which reacts with nucleophiles such as amines to give salts of the type (CH)N+(CH)COH (3).</p>

<p>(S)-(-)-3-Chloro-1-phenyl-1-propanol is an efficient method for the synthesis of chiral propiophenone. It is synthesized by reacting a mixture of borane and tetrahydrofuran with (S)-(-)-3-chloro-1-phenylpropanol. This reaction produces the desired compound in good yield and high diastereoselectivity. The synthesis of this compound has been shown to be useful for the production of antidepressant drugs, such as κ-opioid receptor ligands, which are used to treat depression, anxiety, and chronic pain.</p>

<p>Please enquire for more information about APL1b25 trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Bromo-2-chloropyridine is a piperazine derivative that has potent inhibitory activity against 5-HT2C receptors. This compound is an amide and has been shown to have the ability to cross-couple with various other compounds, such as fatty acids. It is also used in clinical development for the treatment of obesity, depression, and Parkinson's disease. The purity of 4-bromo-2-chloropyridine can be determined by liquid chromatography methods.</p>