Chiral Organic Compounds

Chiral organic compounds are molecules that possess non-superimposable mirror images, a property known as chirality, which plays a crucial role in various chemical and biological processes. These compounds are essential in the development of pharmaceuticals, agrochemicals, and fine chemicals, where the specific orientation of molecules can significantly impact their function and efficacy. At CymitQuimica, we offer a comprehensive range of high-purity chiral organic compounds, including enantiomers and diastereomers, meticulously sourced and tested to meet the stringent demands of both research and industrial applications. Our catalog includes chiral catalysts, auxiliaries, and building blocks that are pivotal in asymmetric synthesis and stereoselective reactions. By providing top-quality chiral organic compounds, we support researchers and professionals in achieving precise and efficient stereochemical outcomes, driving advancements and innovation in fields such as medicinal chemistry, biotechnology, and materials science.

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Product data	Purity	Price range	Estimated delivery
[1(Z),2E,8[2S,3S(1S,2S)]]- 5,9-Anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-L-talo-Non-2-enonic Acid 9-Methoxy-9-oxo-5-nonenyl Ester REF: TR-A656025CAS: 89254-47-7	- - -	- - -	Discontinued product
7,10-Bis-O-triethylsilyl-10-deacetyl-14b-hydroxy-13-oxo Baccatin III REF: TR-B585530	- - -	- - -	Discontinued product
(S)-3-Boc-Amino-butylamine Hydrochloride REF: TR-B601580CAS: 176982-57-3	- - -	- - -	Discontinued product
Dechloro Lorcaserin (>50% ee) REF: TR-D226580CAS: 929297-55-2	- - -	- - -	Discontinued product
5Beta-Pregnane-3Alpha,11,17Alpha,20Alpha-tetrol REF: TR-P705230	- - -	- - -	Discontinued product
N-Benzyl-(S)-proline Hydrochloride REF: TR-B288645CAS: 92086-93-6	- - -	- - -	Discontinued product
3-Ethoxyoxalyl-4-oxopiperidine-1-carboxylic Acid tert-Butyl Ester REF: TR-E892465CAS: 18990-24-4	- - -	- - -	Discontinued product
(4R,6R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2,2,6-trimethyl-cyclohexanone REF: TR-D723455CAS: 130583-95-8	- - -	- - -	Discontinued product
(8aS)-8a-Bromoalbomitomycin A REF: TR-B679360CAS: 132830-44-5	- - -	- - -	Discontinued product
Sodium (3R)-2-((2S,3R)-4-((1-(4,5-Dihydrothiazol-2-yl)azetidin-3-yl)thio)-3-methyl-5-(((pivaloyloxy)methoxy)carbonyl)-2,3-dihydro-1H-pyrrol-2-yl)-3-hydroxybutanoate REF: TR-S674320	- - -	- - -	Discontinued product
Hypaconine REF: TR-H998470CAS: 63238-68-6	- - -	- - -	Discontinued product
N-Stearoyl-L-cysteine REF: TR-S686550CAS: 67603-50-3	- - -	- - -	Discontinued product
6’-Carboxy Simvastatin REF: TR-C182400CAS: 114883-30-6	- - -	- - -	Discontinued product
cis-7-Hydroxy Didesmethyl Sibutramine Hemifumarate Salt REF: TR-H952150CAS: 186521-91-5	- - -	- - -	Discontinued product
7,10-Bis[O-(triethylsilyl)]-10-deacetyl-13-O-trimethylsilyl Baccatin III REF: TR-B585460CAS: 159383-93-4	- - -	- - -	Discontinued product
(2R,5R)-N-Benzyl-2,5-dimethylpyrrolidine REF: TR-B276275CAS: 119008-53-6	- - -	- - -	Discontinued product
5-(2-Ethoxy-2-oxoethyl)-4-oxo-3,4-dihydropyridine-1(2H)-carboxylic Acid tert-Butyl Ester REF: TR-E892535	- - -	- - -	Discontinued product
(2S,3R,4E,11Z)-2-((tert-Butoxycarbonyl)amino)-3-hydroxyoctadeca-4,11-dien-1-yl REF: TR-B693020	- - -	- - -	Discontinued product
2-Amino-7-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodo-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one REF: TR-A580023CAS: 172163-62-1	- - -	- - -	Discontinued product
3Alpha-Hydroxydesoxy Artemether REF: TR-H939050CAS: 174097-70-2	- - -	- - -	Discontinued product
Deoxytubercidin REF: TR-A608823CAS: 60129-59-1	- - -	- - -	Discontinued product
5'-Amino-5'-deoxythymidine REF: TR-A604318CAS: 25152-20-9	- - -	- - -	Discontinued product
cis-(-)-4-Amino-3-(3,4-dimethoxyphenyl)-1-methylpiperidine REF: TR-A605125CAS: 26722-58-7	- - -	- - -	Discontinued product
[(4R)-2,2-Dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic Acid REF: TR-D476420CAS: 113278-68-5	- - -	- - -	Discontinued product
rel-(3R,4S)-3-Hexyl-4-[2-hydroxytridecyl]-2-oxetanone REF: TR-H296540CAS: 1795791-38-6	- - -	- - -	Discontinued product
(2R,3R,4E,11Z)-Ethyl 2-amino-3-hydroxyoctadeca-4,11-dienoate REF: TR-E898400	- - -	- - -	Discontinued product
(S)-N-[2-[(3-Hydroxypropyl)amino]-1-methylethyl]-4-methyl-benzenesulfonamide REF: TR-H809770CAS: 194032-20-7	- - -	- - -	Discontinued product
11beta,17alpha-Dihydroxy-17beta-formyl-6alpha-methylandrosta-1,4-diene-3-one REF: TR-D678995	- - -	- - -	Discontinued product
(3R,5S)-5-[(R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl]-3,5-dihydroxypentanoic Acid Sodium Salt REF: TR-F592060CAS: 854898-48-9	- - -	- - -	Discontinued product
4-Bromo-3-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylic Acid tert-Butyl Ester REF: TR-B685085	- - -	- - -	Discontinued product
7-Bromoacetylaminocephalosporanic Acid REF: TR-B679125CAS: 26973-80-8	- - -	- - -	Discontinued product
Zotarolimus, >90% REF: TR-Z700800CAS: 221877-54-9	>90%	- - -	Discontinued product
3’,5’-Dihydrodiol Simvastatin Acid Sodium Salt(Mixture of Diastereomers) REF: TR-D452695CAS: 1346601-34-0 618116-57-7	- - -	- - -	Discontinued product
7-Benzoyloxy-hesperetin 3’-O-(2’,3’,4’-Tri-O-acetyl)-b-D-glucuronide Methyl Ester REF: TR-B208320	- - -	- - -	Discontinued product
(S,E)-7-(Benzyloxy)-2-(3-hydroxy-4-methoxyphenyl)-4-(((S)-1-phenylethyl)imino)chroman-5-ol REF: TR-B279150	- - -	- - -	Discontinued product
3-Chloromelphalan Hydrochloride (>50% ee) REF: TR-C368660CAS: 2724878-98-0	- - -	- - -	Discontinued product
(R)-Methyl 2-(((Benzyloxy)carbonyl)amino)-5-oxonon-8-enoate REF: TR-M302235CAS: 690211-35-9	- - -	- - -	Discontinued product
D-Methionine Sulfoxide REF: TR-M216950CAS: 21056-56-4	- - -	- - -	Discontinued product
(aR)-a-[(3S)-3-(tert-Butyloxycarbonylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester REF: TR-B693655CAS: 862414-82-2	- - -	- - -	Discontinued product
2-Hydroxy Atorvastatin Acyl-Beta-D-glucuronide 60%, contains up to 35% lactone REF: TR-H828940	- - -	- - -	Discontinued product
N-[2-[(1S)-1-(3-Ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide REF: TR-E892255CAS: 1384441-38-6	- - -	- - -	Discontinued product
2-Benzyl-1-(2,2-dimethyl-8,8a-dihydro-3a,H-indeno[1,2-d]oxazol-3yl)-3-oxiranyl-propan-1-one REF: TR-B276235CAS: 158512-24-4	- - -	- - -	Discontinued product
Pivampicillin Hydrochloride REF: TR-P551800CAS: 26309-95-5	- - -	- - -	Discontinued product
25-Hydroxy Vitamin D3 3,3'-(Carboxyfluorescein)aminopropyl Ether REF: TR-H995865	- - -	- - -	Discontinued product
3-[4-((1R)-Prop-2-ynyloxycarbonylethoxy)phenoxy] Clodinafop Propargyl REF: TR-P838455	- - -	- - -	Discontinued product
(AlphaS)-Cyclohexanebutanoic Acid Alpha-[[(1S)-1-Carboxyethyl]amino]cyclohexanebutanoic Acid Alpha-Ethyl Benzyl Diester REF: TR-C177955	- - -	- - -	Discontinued product
Fmoc-L-Leu-OH REF: TR-F625015CAS: 35661-60-0	- - -	- - -	Discontinued product
Isotetracycline REF: TR-I902500CAS: 3811-31-2	- - -	- - -	Discontinued product
(2S,3R,4E,11Z)-2-((tert-Butoxycarbonyl)amino)-3-((tert-butyldimethylsilyl)oxy)octadeca-4,11-dien-1-yl Pivalate REF: TR-B699205	- - -	- - -	Discontinued product
(S,S)-N-(1-Phenylethyl) Ibuprofen Amide REF: TR-P320900CAS: 81576-52-5	- - -	- - -	Discontinued product
Tilidine Hydrochloride (1.0 mg/mL in Methanol) REF: TR-KIT1010CAS: 27107-79-5	- - -	- - -	Discontinued product
Saxagliptin N-Carboxybenzyl REF: TR-S143525CAS: 1408335-73-8	- - -	- - -	Discontinued product
N-Des(4-methylbenzenesulfonamide) 4’-Nitro Tolafentrine REF: TR-D291140CAS: 35134-99-7	- - -	- - -	Discontinued product
(3S,4aS,8aS)-2-[(2R,3S)-3-tert-Butyloxycarbonylamino-2-hydroxy-4-phenylbutyl]-N-(1,1-dimethylethyl)decahydro-3-isoquinolinecarboxamide REF: TR-B693680CAS: 142580-65-2	- - -	- - -	Discontinued product
(3S)-1-Tosyl-alpha,alpha-diphenyl-3-pyrrolidineacetonitrile REF: TR-T662005CAS: 133099-09-9	- - -	- - -	Discontinued product
N-tert-Butoxycarbonyl Desmethyl Levofloxacin REF: TR-B690530CAS: 1330277-19-4	- - -	- - -	Discontinued product
(4Alpha)-7-Dehydro-4,25-dihydroxycholesterol REF: TR-D229540	- - -	- - -	Discontinued product
SR 58611A REF: TR-S684445CAS: 121524-09-2	- - -	- - -	Discontinued product
N-Formyl 10-Oxo 7-Epi-docetaxel REF: TR-F700768	- - -	- - -	Discontinued product
3-Dehydro Reserpine Chloride REF: TR-D230200CAS: 107052-60-8	- - -	- - -	Discontinued product
(S)-N-[2-(2,3-Dihydro-6-methoxy-1H-inden-1-yl)ethyl]propanamide REF: TR-D449315CAS: 178678-16-5	- - -	- - -	Discontinued product
9-Hydroxymethyl-10-hydroxy Camptothecin REF: TR-H947055CAS: 175613-38-4	- - -	- - -	Discontinued product
1-(sec-Butyl)-4-(4-(4-(4-(((2R,4R)-2-(chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one REF: TR-B802520CAS: 1949771-36-1 2396417-39-1 2396417-40-4 2508141-71-5	- - -	- - -	Discontinued product
2,5-Dimethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-benzo[h]chromen-6-yl Acetate REF: TR-D670190CAS: 19274-67-0	- - -	- - -	Discontinued product
2’-Benzoyloxycarbonyl 5-Acetyl D-seco-Taxol REF: TR-B287020CAS: 148930-35-2 148969-15-7	- - -	- - -	Discontinued product
(2Z,5S)-5-Amino-5-(3-pyridinyl)-2-penten-1-ol REF: TR-A629090CAS: 918625-36-2	- - -	- - -	Discontinued product
(1S,2R)-2-Aminocyclohexanol hydrochloride REF: TR-A596405CAS: 200352-28-9	- - -	- - -	Discontinued product
Desoxy-Palonosetron Dihydrochloride (>90%) REF: TR-D296975	>90%	- - -	Discontinued product
(+)-cis-Khellactone REF: TR-K432105CAS: 24144-61-4	- - -	- - -	Discontinued product
6'-Hydroxymethyl Simvastatin Acid Sodium Salt REF: TR-H948358CAS: 134452-13-4	- - -	- - -	Discontinued product
22-Dehydro 25-Hydroxy Cholesterol 3-Acetate REF: TR-D229840CAS: 157171-88-5	- - -	- - -	Discontinued product
(R)-Esmolol Hydrochloride REF: TR-E667990CAS: 118629-36-0	- - -	- - -	Discontinued product
(2R,5S,10aS,10bS)-10b-hydroxy-5-isopropyl-2-methyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine-2-carboxylic Acid Ethyl Ester REF: TR-H946895CAS: 2854-39-9	- - -	- - -	Discontinued product
6-Bromo Norgestrel REF: TR-B685815	- - -	- - -	Discontinued product
Propylene Glycol 2-Alpha-Glucopyranosiduronic Acid Benzyl Ester 2,3,4-Triacetate REF: TR-P835220	- - -	- - -	Discontinued product
2’-O-(Benzyloxycarbonyl) Taxol REF: TR-B287015CAS: 148930-30-7	- - -	- - -	Discontinued product
Isopimaric Acid 2-Amino-2-methylpropanol Salt REF: TR-I822265CAS: 124162-06-7	- - -	- - -	Discontinued product
Deacetyl Vinorelbine Sulfate Salt REF: TR-D199010CAS: 126347-74-8	- - -	- - -	Discontinued product
2’-Benzyloxycarbonyl 15-Hydroxy Nortaxol REF: TR-B287030	- - -	- - -	Discontinued product
Methyl 15Alpha-OH Gibberellin A3 Diacetate REF: TR-M299575CAS: 105593-06-4	- - -	- - -	Discontinued product
ACTH (1-24, Human) Acetic Acid Salt REF: TR-A305290CAS: 60189-34-6	- - -	- - -	Discontinued product
(R)-4-[4-(Oxiranylmethoxy)-1,2,5-thiadiazol-3-yl]morpholine REF: TR-O847081CAS: 741719-53-9	- - -	- - -	Discontinued product
(S)-N-[2-[7-Allyl-5-bromo-2,3-dihydro-6-hydroxy-1H-inden-1-yl]ethyl]propanamide REF: TR-A549665CAS: 196597-86-1	- - -	- - -	Discontinued product
rac-Nornicotine Bitartrate REF: TR-N757020CAS: 5746-86-1	- - -	- - -	Discontinued product
(S)-Alpha-Methyl Benzenemethanamine (R)-Ethyl Methyl(phenylmethoxy)propanedioate REF: TR-M329275CAS: 73127-76-1	- - -	- - -	Discontinued product
(2S,5S)-Fmoc-5-amino-1,2,4,5,6,7-hexahydro-azepino [3,2,1-hi] indole-4-one-2-carboxylic Acid REF: TR-F603760CAS: 204326-24-9	- - -	- - -	Discontinued product
p-NO2-Bn-Cyclen REF: TR-N887355CAS: 116052-94-9	- - -	- - -	Discontinued product
18-O-Allyl Vinorelbine REF: TR-A569850	- - -	- - -	Discontinued product
Methyl 4-(Hydroxymethyl)cyclohexanecarboxylate REF: TR-M327123CAS: 110928-44-4	- - -	- - -	Discontinued product
(R)-1-(3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N,N-dimethylmethanamine REF: TR-D460425CAS: 765853-00-7	- - -	- - -	Discontinued product
(S)-1,2,3,4,5,6,7,8-Octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline REF: TR-O303560CAS: 30356-07-1	- - -	- - -	Discontinued product
Methyl 15-Oxo Gibberellin A3 Diacetate REF: TR-M299585CAS: 105593-11-1	- - -	- - -	Discontinued product
N-Nitroso Argatroban REF: TR-N769030	- - -	- - -	Discontinued product
N-[(6S)-8-Fluoro-5,6-dihydro-4-(1-methylethyl)-6-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]benzo[h]quinazolin-2-yl]-N-methylmethanesulfonamide REF: TR-F591045CAS: 854898-47-8	- - -	- - -	Discontinued product
N-a-Formyl-D-Leucine REF: TR-A353445CAS: 44978-39-4	- - -	- - -	Discontinued product
Methyl 2,3-Anhydro-4,6-O-benzylidene-a-D-allopyranose REF: TR-M327253CAS: 3150-15-0	- - -	- - -	Discontinued product
4-Methylumbelliferyl-Beta-D-lactoside REF: TR-M337750CAS: 84325-23-5	- - -	- - -	Discontinued product
O-Methyl 15b-OH Gibberellin A3 Diacetate REF: TR-M299565CAS: 105608-20-6	- - -	- - -	Discontinued product
Amoxycilloic Acid Trisodium Salt (Mixture of Diastereomers)See A634268 REF: TR-A634265CAS: 42947-63-7	- - -	- - -	Discontinued product
L-allo-Threonine Methyl Ester Hydrochloride Hydrate REF: TR-A548565CAS: 79617-27-9 79617-28-0	- - -	- - -	Discontinued product

1mg	Discontinued	Request information
250µg	Discontinued	Request information
500µg	Discontinued	Request information

1mg		Discontinued	Request information
10mg		Discontinued	Request information

1g	Discontinued	Request information
100mg	Discontinued	Request information
250mg	Discontinued	Request information

25mg		Discontinued	Request information
2500µg		Discontinued	Request information

5mg		Discontinued	Request information
50mg		Discontinued	Request information

Chiral Organic Compounds

[1(Z),2E,8[2S,3S(1S,2S)]]- 5,9-Anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-L-talo-Non-2-enonic Acid 9-Methoxy-9-oxo-5-nonenyl Ester

Ref: TR-A656025

7,10-Bis-O-triethylsilyl-10-deacetyl-14b-hydroxy-13-oxo Baccatin III

Ref: TR-B585530

(S)-3-Boc-Amino-butylamine Hydrochloride

Ref: TR-B601580

Dechloro Lorcaserin (>50% ee)

Ref: TR-D226580

5Beta-Pregnane-3Alpha,11,17Alpha,20Alpha-tetrol

Ref: TR-P705230

N-Benzyl-(S)-proline Hydrochloride

Ref: TR-B288645

3-Ethoxyoxalyl-4-oxopiperidine-1-carboxylic Acid tert-Butyl Ester

Ref: TR-E892465

(4R,6R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2,2,6-trimethyl-cyclohexanone

Ref: TR-D723455

(8aS)-8a-Bromoalbomitomycin A

Ref: TR-B679360

Sodium (3R)-2-((2S,3R)-4-((1-(4,5-Dihydrothiazol-2-yl)azetidin-3-yl)thio)-3-methyl-5-(((pivaloyloxy)methoxy)carbonyl)-2,3-dihydro-1H-pyrrol-2-yl)-3-hydroxybutanoate

Ref: TR-S674320

Hypaconine

Ref: TR-H998470

N-Stearoyl-L-cysteine

Ref: TR-S686550

6’-Carboxy Simvastatin

Ref: TR-C182400

cis-7-Hydroxy Didesmethyl Sibutramine Hemifumarate Salt

Ref: TR-H952150

7,10-Bis[O-(triethylsilyl)]-10-deacetyl-13-O-trimethylsilyl Baccatin III

Ref: TR-B585460

(2R,5R)-N-Benzyl-2,5-dimethylpyrrolidine

Ref: TR-B276275

5-(2-Ethoxy-2-oxoethyl)-4-oxo-3,4-dihydropyridine-1(2H)-carboxylic Acid tert-Butyl Ester

Ref: TR-E892535

(2S,3R,4E,11Z)-2-((tert-Butoxycarbonyl)amino)-3-hydroxyoctadeca-4,11-dien-1-yl

Ref: TR-B693020

2-Amino-7-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodo-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

Ref: TR-A580023

3Alpha-Hydroxydesoxy Artemether

Ref: TR-H939050

Deoxytubercidin

Ref: TR-A608823

5'-Amino-5'-deoxythymidine

Ref: TR-A604318

cis-(-)-4-Amino-3-(3,4-dimethoxyphenyl)-1-methylpiperidine

Ref: TR-A605125

[(4R)-2,2-Dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic Acid

Ref: TR-D476420

rel-(3R,4S)-3-Hexyl-4-[2-hydroxytridecyl]-2-oxetanone

Ref: TR-H296540

(2R,3R,4E,11Z)-Ethyl 2-amino-3-hydroxyoctadeca-4,11-dienoate

Ref: TR-E898400

(S)-N-[2-[(3-Hydroxypropyl)amino]-1-methylethyl]-4-methyl-benzenesulfonamide

Ref: TR-H809770

11beta,17alpha-Dihydroxy-17beta-formyl-6alpha-methylandrosta-1,4-diene-3-one

Ref: TR-D678995

(3R,5S)-5-[(R)-8-Fluoro-4-isopropyl-2-(N-methylmethylsulfonamido)-5,6-dihydrobenzo[h]quinazolin-6-yl]-3,5-dihydroxypentanoic Acid Sodium Salt

Ref: TR-F592060

4-Bromo-3-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylic Acid tert-Butyl Ester

Ref: TR-B685085

7-Bromoacetylaminocephalosporanic Acid

Ref: TR-B679125

Zotarolimus, >90%

Ref: TR-Z700800

3’,5’-Dihydrodiol Simvastatin Acid Sodium Salt(Mixture of Diastereomers)

Ref: TR-D452695

7-Benzoyloxy-hesperetin 3’-O-(2’,3’,4’-Tri-O-acetyl)-b-D-glucuronide Methyl Ester

Ref: TR-B208320

(S,E)-7-(Benzyloxy)-2-(3-hydroxy-4-methoxyphenyl)-4-(((S)-1-phenylethyl)imino)chroman-5-ol

Ref: TR-B279150

3-Chloromelphalan Hydrochloride (>50% ee)

Ref: TR-C368660

(R)-Methyl 2-(((Benzyloxy)carbonyl)amino)-5-oxonon-8-enoate

Ref: TR-M302235

D-Methionine Sulfoxide

Ref: TR-M216950

(aR)-a-[(3S)-3-(tert-Butyloxycarbonylamino)-4-methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid 2-Propen-1-yl Ester

Ref: TR-B693655

2-Hydroxy Atorvastatin Acyl-Beta-D-glucuronide 60%, contains up to 35% lactone