Toxicology

<p>Applications N,N-Diethyl-3-methyl-d3-benzamide-2,4,5,6-d4 (CAS# 1219799-37-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Chinomethionate is a quinoxaline fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Speck-Planche, A., et al.: Ectoxicol. Environ. Safety, 80, 308 (2012); Stensvand, A., et al.: J. Agri. Food Chem., 48, 917 (2000)<br></p>

<p>Applications 1-N-Methyl Omeprazole is an impurity from the synthesis of Omeprazole (O635000). Omeprazole covalently binds to proton pump. It inhibits gastric secretion and it is used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983), Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984), Morii, M., et al.: J. Biol. chem., 268, 21553 (1993), Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications Deferiprone 3-O-β-D-Glucuronide Ammonium Salt, is a metabolite of Deferiprone (D474000).<br>References Choudhury, R., et al.: Drug Metab. Dispos., 23, 314 (1995),<br></p>

<p>Applications 1,1,2,3,4,5,6-Heptachlorocyclohexane is an organochloride which is one of the isomers of hexachlorocyclohexane and is an byproduct of insecticide Lindane (L465990).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bist, R., et al.: Int. J. Pharm. Pharma. Sci., 4, 117 (2012); Heinz, M., et al.: Human. Health. Handbook., 1, 355 (2012); Bay, S.M., et al.: Enviro. Toxciol. Chem., 31, 2711 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications trans-Crotoxyphos is an organophosphorous insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nillos, M.G., et. al.: Environ. Toxicol. Chem., 26, 1949 (2007); Miller, J.A., et. al.: J. Control Release, 8, 73 (1988)<br></p>

<p>Applications A labelled metabolite of Repaglinide (R144500(P)), which is a non-sulfonylurea oral hypoglycemic agent and used as an antidiabetic.<br>References Jarvis, B., et al.: Drugs, 59, 891 (2000); Niemi, M., et al.: Clin. Pharmacol. Ther., 70, 58 (2001); Hatorp, V., et al.: Clin. Pharmacokinet., 41, 471 (2002); Walsky, R., et al.: Drug Metab. Dispos., 33, 413 (2005); Wolffenbuttel, B.H.R., et al.: Eur. J. Clin. Pharmacol., 45, 113 (1993); Ampudia-Blasco, F.J., et al.: Diabetologia, 37, 703 (1994)<br></p>

<p>Applications A Quinidine labelled metabolite.<br>References Small, D.L., J. Chem. Med., 22,1014 (1979), Guentert, T.W., et al.: Eur. J. Drug Metab. Pharmacokinet., 7, 31 (1982), Chang, Y.F., et al.: Neurochem. Res., 13, 455 (1988),<br></p>

<p>Applications Famoxadone is a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Speck- Planche, A., et al.: Excotoxicol. Enviro. Safety., 80. 308 (2012).<br></p>

<p>Applications The active metabolite of Irinotecan (carboxylate form). SN-38 lactone and carboxylate may be considered pharmacokinetically distinct agents.<br>References Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000), Teiber, J., et al.: Biochem. Pharmacol., 66, 887 (2003), Ashley, G., et al.: J. Antibiot., 57, 224 (2004),<br></p>

<p>Applications (R)-Diclofop-methyl is a stereo-isomer of Diclofop-methyl(D431555) which isused as the active ingredient in many herbicides that are used to control weed growth in plants such as wheat and wild oats.<br>References Marzouk, E., et al.: J. Appl. Sci. Res., 9, 4907 (2013)<br></p>

<p>Applications Tiglylcarnitine Hydrochloride is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Tiglylcarnitine Hydrochloride can be diagnostic for a number of ß-oxidation defects.<br>References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications A labelled isotpe of Isopropyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate (I485580). A short-acting intravenous anaesthetic agent used for dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy.<br>References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),<br></p>

<p>Applications 4,4'-Dichlorodiphenyldichloroethane - d8 is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyldichloroethane- d8 is a metabolite of 4,4'-Dichlorodiphenyltrichloroethane - d8 (D434197). 4,4'-Dichlorodiphenyldichloroethane - d8 is a probable carcinogen (Group B2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tao, S. et al.: Environ. Sci. Technol., 39, 2494 (2005); Zhou, Q. et al.: J. Chrom. A, 1216, 6680 (2009); Weiderpass, E. et al.: Cancer Epidemiol. Biomark. Prev,., 9, 487 (2000)<br></p>

<p>Applications N-Arachidonoyltaurine is a polyunsaturated lipid that inhibits the Cav3.3 current in T-type calcium channels.<br>References Cazade, M., et. al.: Mol. Phearmacol., 85, 218 (2014)<br></p>

<p>Applications Propafenone-d5 Hydrochloride is the labeled analogue of Propafenone Hydrochloride (P757500), a sodium channel blocker. Antiarrhythmic (class IC).<br>References Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983); Bryson, H. M., et al.:Drugs, 45, 85 (1993); Rae, A. P., et al.: Am. J. Cardiol., 82, 59N (1998)<br></p>

<p>Applications Serotonin 5HT3-receptor antagonist. Used in treatment of irritable bowel syndrome.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Camilleri, M., et al.: Lancet, 355, 1035 (2000), Nestorov, I., et al.: Drug Metab. Dispos., 30, 276 (2002), Lewis, D., et al.: Drug Metab. Rev., 35, 1 (2003), Tang, H., et al.: J. Pharm. Sci., 95, 1783 (2006), Gleeson, M., et al.: J. Med. Chem., 50, 101 (2007),<br></p>

<p>Applications Protected Morphine metabolite.<br></p>

<p>Applications Delachlor is a herbicide for weed control.<br>References Klassen, M., et al.: J. Am. Soc. Sugar Beet Technol., 16, 552 (1971), Mishra, R. K., et al.: Pesticides, 22, 10 (1988)<br></p>

<p>Applications N-Valerylglycine-13C2,15N is a labelled analogue of N-Valerylglycine (V091470).<br></p>

<p>Applications Bupirimate is a pyrimidine based fungicide with protective and curative activity for the control of fungal diseases by interfearing with nucleic acid synthesis.<br>References Belmonte, V. N., et al.: J. Chromatograph. A., 1264, 110 (2012); Attallah, E.R., et al.: J. Food. Agri. Envrion., 10, 755 (2012);<br></p>

<p>Applications An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>

<p>Stability Light, Moisture and Temperature Sensitive<br>Applications A metabolite of the potent hepatotoxin Monocrotaline.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mattocks, A.R.: J.C.S., 8, 1155 (1969), Tepe, J.J. and Williams, R.M.: JACS, 121, 13, 2951 (1999)<br></p>

<p>Applications A piperidine based pesticide<br>References Iwakubo, M., et al.: Bioorg. Med. Chem., 15, 350 (2007), Jia, P., et al.: Eur. J. Med. Chem., 44, 772 (2009),<br></p>

<p>Applications Pentachloroanisole-d3 (methoxy-d3) (CAS# 1219804-52-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications R-(-)-Norapomorphine Hydrochloride-d5 is the isotope labelled analog of R-(-)-Norapomorphine Hydrochloride (N661030); an (R)-Apomorphine (A727500) derivative as inhibitor of amyloid-β (Aβ) fibril formation and their use in amyloidosis based disease.<br>References Howlett, D., et al.: Biochem. J., 340, 283 (1999); Kuner, P., et al.: J. Biol. Chem., 275, 1673 (2000); Ono, K., et al.: J. Neurosci. Res., 75, 742 (2004)<br></p>

<p>Applications Fludiazepam is a drug which is a benzodiazepine derivative. Fludiazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.<br>References Fang, S.Y., et al.: Drug. Alcohol. Depend., 104, 140 (2009); Esteki, M., et al.: Chem. Biol. Drug. Design., 72, 409 (2008);<br></p>

<p>Applications 3-sec-Amylphenyl N-Methylcarbamate is a component of the carbamate insecticide Bufencarb (B689385).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kmellar, B., et al.: Food Addit. Contam., 27, 1415 (2010); Kaufmann, A., et al.: Anal. Bioanal. Chem., 403, 1233 (2012);<br></p>

<p>Applications A deuterated selective acetylcholinesterase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bickel, U., et al.: Clin. Pharmacol. Ther., 50, 420 (1991), Maelicke, A., et al.: Drugs Dis Today, 1, 53 (1996), Sauvaltre, T., et al.: J. Med. Chem., 50, 5311 (2007),<br></p>

<p>Applications (S,2E,6E)-Dehydroxy Pitavastatin is an impurity of Pitavastatin (P531000), a competitive inhibitor of HMG-CoA reductase and antilipemic agent.<br>References Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Park, S., et al.: Clin. Ther., 27, 1074 (2005),<br></p>

<p>Stability Very Hygroscopic<br>Applications DL-Lactic Acid-13C2 Sodium Salt is the isotope labelled sodium salt of DL-Lactic Acid. DL-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity.<br>References He, W. et al.: Comp. Biochem. Phys. Part A: Mol. Int. Phys., 166, 308 (2013); Borsook, et al.: J. Biol. Chem., 102, 449 (1933); Brin, M., et al.: Ann. N.Y. Acad. Sci., 119, 851 (1965);<br></p>

<p>Applications A labelled metabolite of Cortisol.<br>References Abel, S., et al. J. Steroid Biochem. Mol. Biol., 45, 445 (1993), Yates, C., et al.: Pharm. Res., 20, 1794 (2003),<br></p>

<p>Stability Hygroscopic<br>Applications A mixture of 2 labelled metabolites of Styrene.<br>References Ryan, A., et al.: Drug Metab. Dispos., 5, 363 (1977), Delbressine, L., et al.: Xenobiotica, 11, 589 (1981), Truchon, G., et al.: J. Anal. Toxicol., 14, 227 (1990),<br></p>

<p>Applications 4-Bromoaniline is a brominated aniline used as a building block in the preparation or pharmaceutial and organic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abdel-M. et al.: J. Org. Chem., 61, 3849 (1996); Sridhar, S.. et al.: Eur. J. Med. Chem., 36, 615 (2001);<br></p>

<p>Applications Methyl 3,6-dichloropyridine-2-carboxylate<br></p>

<p>Applications Protected Propofol metabolite.<br></p>

<p>Applications Tecloftalam is an agrochemical fungicide. Tecloftalam is used for the control of rice bacterial leaf blight.<br>References Nakagami, K. et al.: Nip. Noyak. Gak., 5, 511 (1980); Kirkpatrick, D. et al.: J. Agric. Food Chem., 29, 608 (1981); Takahi, Y. et al.: Jap. Past. Info., 46, 25 (1985);<br></p>

<p>Applications Reagent used in the synthesis of herbicides.<br>References Mekenyan, O., et al.: Chem. Res. Toxicol., 10, 994 (1997), Brown, T., et al.: Environ. Sci. Technol., 42, 5202 (2008),<br></p>

<p>Applications Labelled Nabumetone. Anti-inflammatory. Antibacterial.<br>References Kumpulainen, H., et al.: J. Med. Chem., 49, 1207 (2006),<br></p>

<p>Applications Insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nishizawa, Y., et al.: Agric. Biol. Chem., 25, 605 (1961),<br></p>

<p>Applications 1,1'-Sulfonylbis[2-(methylthio)ethane]-d6 is the labelled analgoue of 1,1'-Sulfonylbis[2-(methylthio)ethane] which is an intermediate in synthesizing Bis(methylsulfinylethyl)sulfone (B494850), a sulfur mustard metabolite found in urine.<br>References Black, R., et al.: Xenobiotica, 22, 405 (1992); Li, C., et al.: J. Chromatogr. B, 917-918, 100 (2013);<br></p>

<p>Applications rac-Naproxen 2-Propyl Ester is an impurity of Naproxen (N377520) an non-steroidal antiinflammatory agent.<br>References Mermerian, A.H., et al.: J. Am. Chem. Soc., 127, 5604 (2005); Melgar-Fernande., et al.: Tetrahedron. Lett., 46, 1221 (2005);<br></p>

<p>Applications D-(+)-Carnitine Benzyl Ester Perchlorate is an intermediate used in the synthesis of 3-Hydroxybutyrylcarnitine Chloride (H830900), which is a reagent used to study acylcarnitine profile in thyroid disease.<br>References Wong, S., et al.: Clinical Biochem., 46, 180 (2013); Alu, F., et al.: Heredity, 110, 253 (2013); Adam, B., et al.: Clinical Biochem., 44, 1445 (2011)<br></p>

<p>Applications 21-Di[methylenebis(oxy)] 5α-Dihydrocortisol is an intermediate in the synthesis of Allo-3α-tetrahydro Cortisol 3-O-β-D-Glucuronide Sodium Salt-d7 (A548512), which is a metabolite of Cortisol (H714615) in human plasma.<br>References Ikegawa, S. et al.: Anal. Chem., 81, 10124 (2009); Kornel, L. et al.: J. Steroid. Biochem., 13, 751 (1980); Kornel, L. et al.: J. Steroid Biochem., 6, 1267 (1975);<br></p>

<p>Applications (1R,2S)-erythro-Dihydro Bupropion Maleate is a metabolite of Bupropion (B689625), a selective inhibitor of dopamine uptake. An antidepressant of the aminoketone class; aid in smoking cessation.<br>References Writer, J.H., et. al.: Sci. Total Environ., 461 (2013)<br></p>