Toxicology

<p>Applications Antitumor agent.<br>References Morse, M., et al.: Cancer Res., 50, 2613 (1990), Staretz, M., et al.: Carcinogenesis, 18, 1715 (1997), Henderson, C., et al.: J. Biol. Chem., 278, 13480 (2003), Jalas, J., et al.: Chem. Res. Toxicol., 16, 794 (2003), Su, T., et al.: Toxicol. Appl. Pharmacol., 199, 285 (2004),<br></p>

<p>Applications Isoprothiolane is a dithiolane pesticide. Isoprothiolane is commonly used in agriculture as a fungicide to control planthoppers and blast disease in rice plants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chin, K.M.: Malay. Agric. J., 50, 221 (1975); Ikeda, Y. et al.: Biosci. Biotech. Biochem., 57, 288 (1993); Nakamura, H.: Rev. Plant Prot. Res., 10, 1 (1977); Reddy, A.P.K. et al.: Pesticide, 22, 21 (1988);<br></p>

<p>Applications N-Methyl Esomeprazole is an impurity of Omeprazole (O635000); a compound that binds covalently to proton pumps and inhibits gastric secretion. Also used as an antiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications MMAE is an effective and synthetic cytotoxic analog of Dolastatin 10 which is a potent antimitotic polypeptide isolated from a marine animal.<br>References Bai R. et al.: J. biol. Chem., 265, 17141 (1990); Giddens, A. et al.: Bioorg. Med. Chem., 24, 6075 (2016);<br></p>

<p>Applications Antipsychotic.<br>References Flanagan, T.L., et al.: J. Pharm. Sci., 51, 996 (1962), Post., A., et al.: Anal. Profiles Drug Subs., 9, 543 (1980)<br></p>

<p>Stability Hygroscopic<br>Applications Fensulfothion Sulfone is a metabolite of the insecticide fensulfonthion (F265490), an inhibitor of cholinesterase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Solly, S.R.B., et al.: New. Zea. J. Agri. Res., 14, 88 (1971); Hansch, C., et al.: Biochem. Toxicol. Insectic. Proc., 33 (1970);<br></p>

<p>Applications Antiemetic, antipsychotic; used in treatment of vertigo.<br>References Taylor, W.B., et al.: Br. J. Clin. Pharmacol., 23, 137 (1987), Ward, A.E., Br. J. Clin. Pract., 42, 228 (1988),<br></p>

<p>Applications A reagent used to synthesize various dyes used in the textile industry. This is the labeled analog.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosenkranz, H.S. et al.: Mutagen., 5, 137 (1990);<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Deferiprone (D474000).<br>References Choudhury, R., et al.: Drug Metab. Dispos., 23, 314 (1995),<br></p>

<p>Applications Platycodin D is a known inhibitor of the proliferation of human gastric cancer cells as well as inducing apoptosis. It also causes anti-atherosclerotic.<br>References Wu, J. et al.: Biol. Pharm. Bull. 35, 1216 (2012); Chun, J. et al.: J. Cell. Biochem., 114, 456 (2013);<br></p>

<p>Applications Analgesic.<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002), Chiu, P., et al.: J. Pharmacol. Sci., 95, 311 (2004), Dubin, A., et al.: J. Biomol. Screen, 10, 168 (2005),<br></p>

<p>Applications Veratramine is useful as signal transduction inhibitor for treating tumors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Imamura, L., et al.: J. Trad. Med., 12, 129 (1995), Ingolfsdottir, K., et al.: Antimicrob. Agents. Chemother., 1997, 41, 215 (1997), Tezuka, Y., et al.: J. Nat. Prod., 61, 1397 (1988)<br></p>

<p>Applications Tyloxapol, is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity.<br>References Sehgal, S. S., et al.: J. National Med. Assoc., 86 (1), 46 (1994); Rubin, B. K., et al.: 101 (4), 1080 (1992);<br></p>

<p>Applications Tolfenpyrad is used as foliar insecticide for the control of green peach aphids in broccoli.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thurman, E., et al.: Food Addit. Contam., 23, 1169 (2006), Mezcua, M., et al.: Food Chem., 112, 221 (2009)<br></p>

<p>Applications Acetochlor ESA Sodium Salt is an amido sulfonate compound for proteomics research.<br>References Zhang, Q., et al.: Science of Total Environment, 580, 1268-1275 (2017);<br></p>

<p>Applications Thiometon Sulfoxide is a metabolite from Thiometon (D231370) pesticides, used as an insecticide. Cholinesterase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Edson, E.F., et al.: Pharm. J., 185, 365 (1960), Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1765 (2007), Mezcua, M., et al.: Anal. Chem., 81, 913 (2009),<br></p>

<p>Applications Oleuropein Aglycone is a natural phenol that is abundant in extra virgin olive oil. Studies show that Oleuropein Aglycone could provide protective and therapeutic effects against a number of pathologies including Alzheimer's disease, as well as obesity, type 2 diabetes, and non-alcoholic hepatitis.<br>References Casamenti, F., et al.: J. Alzheimers Dis., 45, 679 (2015)<br></p>

<p>Applications Amino acid substitute tumor growth.<br>References Villiers, C.L., et al.: Eur. J. Biochem., 140, 421 (1984);<br></p>

<p>Stability Hygroscopic<br>Applications Metazachlor Ethane Sulfonic Acid-d6 Sodium Salt is deuterium labelled form of Metazachlor Ethane Sulfonic Acid Sodium Salt (M226233), which is a metabolite of chloroacetanilide herbicide Metazachlor (M225855).<br>References Laue, H., et al.: Environ. Sci. Technol., 30, 1129 (1996); Matthies, M., et al.: Environ. Sci. Technol., 43, 9223 (2009); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010); Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010);<br></p>

<p>Applications 3,4-Dimethyl-2,6-dinitroaniline is a metabolite and a degradation product of the herbicide pendimethalin.<br>References Kole, R. K., et al.: Bull. Environ. Contam. Toxicol., 52, 779 (1994); Singh, S. B., et al.: J. Environ. Sci. Health B., B26, 309 (1991)<br></p>

<p>Applications Tinopal RBS 200 is a fluorescent whitening agent used in laundry detergents.<br>References Jasperse, J.L., Steiger, P.H.: J. Am. Oil Chem. Soc., 69, 621 (1992)<br></p>

<p>Stability Very Hygroscopic<br>Applications Labelled Metaproterenol (M225835). Bronchodilator.<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),<br></p>

<p>Applications 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Third generation synthetic pyrethroid. Insecticide, acaricide. Useful in cannabis testing kits as a component in pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Fenoterol (F248850). An β2-adrenergic agonist. Bronchodilator; tocolytic.<br>References Schuster, B., et al. Arzneim.-Forsch., 19, 1905 (1969), Gerris, J., et al.: Eur. J. Clin. Pharmacol., 18, 443 (1980), Heel, R.C., et al.: Drugs, 15, 3 (1978),<br></p>

<p>Applications Skeletal muscle relaxant.<br>References White, R.L., et al.: J. Med. Chem., 30, 263 (1987)<br></p>

<p>Applications Teflubenzuron is an benzoylphenylurea chitin synthesis inhibitor used to control a wide range of insect pests and mites in fruit, vegetable, cereal and seed crops. Teflubenzuron is used in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Carro, A.M., et al.: J. Separat. Sci., 35, 2866 (2012); Brock, T.C.M., et al.: Environ. Sci. Pollu. Res., 19, 3610 (2012);<br></p>

<p>Applications N-Nitrosodiisopropylamine ia a nitrosoamine compound that shows carcinogenic effect.<br>References Scanlan, R., et al.: Cancer Res., 43, 2435 (1983), Spiegelhalder, B., et al.: Carcinogenesis, 4, 1147 (1983), Lijinsky, W., et al.: Mutat. Res., 443, 129 (1999), Robichova, S., et al.: Chem. Biol. Interact., 148, 163 (2004)<br></p>

<p>Applications Ketorolac-d5 is a labeled analogue of Ketorolac, a Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.<br>References Rooks, W.H., et al.: Agents Actions, 12, 684 (1982); Guzman, A., et al.: J. Med. Chem., 29, 589 (1986); McQuary, H.J., et al.: Clin. Pharmacol. Ther., 39, 89 (1986)<br></p>

<p>Applications A labelled analog of Lorazepam (L469850). Sedative, hypnotic.Controlled substance (depressant).<br>References Nudelman, A., et al.: J. Pharma. Sci., 63, 1886 (1974), Humpel, M., et al.: Eur. J. Drug Metab. Pharmacokinet., 4, 237 (1979), Girkin, R., et al.: Xenobiotica, 10, 401 (1980),<br></p>

<p>Applications A metabolite of Testosterone (T155000).CONTROLLED SUBSTANCE<br>References Brandon, E., et al.: Toxicol. Appl. Pharmacol., 189, 233 (2003), Froehlich, A., et al.: Drug Metab. Dispos., 33, 1532 (2005), Schmelzer, E., et al.: Xenobiotica, 6, 693 (2006), Jasmund, I., et al.: Biomol. Eng., 24, 59 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications 3-Hydroxyhexadecanoylcarnitine Inner Salt is a derivative of Carnitine, essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Also 3-Hydroxyhexadecanoylcarnitine works similar to the endogenous non-toxic molecule L-Carnitine (C184110) whose bioavailablity is improved due to the transport systems in place for Carnitine.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978), Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001), Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002), Karlic, H., et al.: Nutrition, 20, 709 (2004), O. Piermatti. et al.: Bioorg. Med. Chem., 16, 1444 (2008);<br></p>

<p>Applications Febuxostat-d7, is the labeled analogue of Febuxostat-d7 (F229000), a Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications 5-Aminoimidazole-4-carboxamide Lactose Adduct is a lactose adduct of 5-Aminoimidazole-4-carboxamide (A611690), a metabolite of Temozolomide (T017775).<br>References Jaeken, J., et al.: Lancet, 2, 1058 (1984), Baggott, J., et al.: Biochem. J., 236, 193 (1986), Baggott, J., et al.: Arch. Dermatol., 135, 813 (1999)<br></p>

<p>Applications A metabolite of polycyclic aromatic hydrocarbons in humans.<br>References Jacob, J., et al.: Xenobiotica, 12, 45 (1982), Becher, G., et al.: Cancer Lett., 17, 301 (1983), Hoffmann, D., et al.: Cancer Treat. Res., 72, 1 (1995), Einolf, H., et al.: Chem. Res. Toxicol., 10, 609 (1997),<br></p>

<p>Applications Bone metabolism modulator; inhibits bone resorption while maintaining bone formation. Antiosteoporotic.<br>References Buehler, J., et al.: Bone, 29, 176 (2001), Henrotin, Y., et al.: J. Bone Miner. Res.,16, 299 (2001), Meunier, P.J., et al.: N. Engl. J. Med., 350, 459 (2004),<br></p>

<p>Stability Moisture Sensitive<br>Applications Phoxim is an organophosphate insecticide. It is an analogous dimethyl ester and an organothiophosphate acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, Y., et al.: Nature, 487, 362 (2012); Jokanovic, M., et al.: Arch. Toxicol., 70, 119 (1995); Wang, W., et al.: Pest. Biochem. Physiol., 84, 180 (2006)<br></p>

<p>Applications Ranitidine-d6 is a labeled histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.<br>References Bradshaw, J., et al.: Brit. J. Pharmacol., 66, 464 (1979); Berstad, A., et al.: Scand. J. Gastroenterol, 15, 637 (1980); Hohnjec, M., et al.: Anal. Profiles Drug Subs., 15, 533 (1986)<br></p>

<p>Stability Hygroscopic<br>Applications Orally active acyclic labelled nucleoside with inhibitory activity towards several herpes viruses. Antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>

<p>Applications 2-Ethylhexyl (2,4-dichlorophenoxy)acetate is used in herbicidal compositions.<br>References Zhang, M., et al.: Nongyao, 51, 745 (2012), Praczyk, T., et al.: Weed Science, 60, 189 (2012)<br></p>

<p>Applications Isotope labelled N-Nitrosodiphenylamine (N525775), which is the N-nitroso analogue of diphenylamine that was once used as a rubber additive but is no longer due to undesirable carcinogenic effects (1). N-Nitrosodiphenylamine may have potential carcinogenic activity and is currently classified as a probable carcinogen by EPA with genetic toxicity (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Boyland, D. et al.: Eur. J. Cancer. 1968. May;4(2):233-2342. Iversen, O. et al.: Eur. J. Cancer. 1980 May;16(5):695-8.3. McGregor, D. et al.: Mutat. Res. Rev. Gen. Toxicol. 1994 Jun:317(3):195-211<br></p>

<p>Applications Labelled Clopidogrel, an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>

<p>Applications Methyprylon is a sedative/hypnotic drug used for treating insomnia.<br>References Reinke, L. A., et al.: Res. Commun. Chem. Path., 11, 45 (1975); Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976)<br></p>

<p>Applications 2,4'-Dichlorobenzophenone is used in the synthesis of triarylcarbinol analogs of fenarimol as potent inhibitors of Trypanosoma cruzi. It can also be used to prepare fatty acid amide hydrolase inhibitors.<br>References Keenan, M., et al.: J. Med. Chem., 55, 4189 (2012); Roughley, S., et al.: Bioorg. Med. Chem. Lett., 22, 901 (2012)<br></p>

<p>Applications Dopamine D2-receptor antagonist with anticholinesterase activity. Gastroprokinetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwanaga, Y., et al; Jpn. J. Pharmacol., 56, 261 (1991), Mushiroda, T., et al.: Drug Metab. Dispos., 28, 1231 (2000),<br></p>

<p>Applications 1,8-Naphthoic Anhydride is used in the synthesis of napthalimide analogues as anticancer agents.<br>References Verma, M. et al.: Eur, J, Med. Chem., 68 (2013); Quintana-E,. et al.: Bioorg, Med. Chem., 21, 6484 (2013);<br></p>

<p>Applications Chlorthiamid<br></p>

<p>Applications Quinclorac is a disubstituted quinolinecarboxylic acid that is part of a new class of highly selective auxin herbicides. Quinclorac is used in rice to control dicotyledonous and monocotyledonous weeds, particularly barnyardgrass (Echinochloa crus-galli). Quinclorac is also used for weed control in turfgrasses.<br>References Haden, E. et al.: Proc. Br. Corp. Prot. Conf. Weeds, 1, 77 (1985); Chism, W.J. et al.: Weed Sci., 39, 62 (1991); Grossmann, K. et al.: Weed Sci., 46, 707 (1998);<br></p>

<p>Applications Labelled tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.<br>References Checkley, S.A, et al.: Br. J. Psychiatry, 138. 248 (1981), Zhu, M.Y., et al.: J. Neurochem., 70, 1547 (1998), Okugawa, G., et al.: J. Neuroindocrinol., 11, 887 (1999), Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003),<br></p>

<p>Stability Hygroscopic<br>Applications A cell-permeable DNA-binding dye. Binds preferentially to DNA rich in adenine and thymine. Used in flow cytometry for measuring nuclear DNA content or for sorting isolated chromosomes.<br>References Jpeeesen, C, and Nielsen, P.E.: Eur. J. Biochem., 182, 437 (1989), Li,J., et al.: J. Exp. Biol., 200, 1499 (1997), Zaitsev, E.N., and Kowalczykowsi, S.C.: Nucl. Acids Res., 26(2), 650 (1998), Germ, M., et al.: Biochem. Biophys. Res. Commun., 261, 452 (1999),<br></p>

<p>Applications Naloxone-d5 3-β-D-Glucuronide is a labelled metabolite of Naloxone ((N285000). Narcotic antagonist.<br>References Scheurer, U., et al.: J. Pharmacol. Exp. Ther., 252, 1324 (1990), Yuan, C., et al.: Clin. Pharmacol. Ther., 59, 469 (1996), Ulens, C., et al.: Biochem. Pharmacol., 62, 1273 (2001), Comert, M., et al.: Eur. J. Pharmacol., 511, 183 (2005),<br></p>

<p>Applications Benzyldecyldimethylammonium Chloride is a biocide.<br>References Lee, M., et al.: Appl. Micro. Biotech., 87, 1109 (2010); Campanac, C., et al.: Antimicrob. Agents Ch., 46, 1469 (2002); Shen, J., et al.: Anal. Chem., 62, 116 (1990)<br></p>

<p>Applications 4-Chlorophenylacetic Acid is a chlorinated phenyl acetic acid that is an antitumor differentiation inducer and may be an effective therapeutic agent in neuroblastoma therapy. 4-Chlorophenylacetic Acid shows plant growth-regulating activity.<br>References Chamberlain, V.K. et al.: Ann. Appl. Biol., 69, 65 (1971); Cai, G. et al.: Sheng. Wu. Xue., 15, 661 (1999); Pineau, T. et al.: Biochem. Pharmacol., 52, 659 (1996); Sidell, N. et al.: Br. J. Cancer, 412 (2003);<br></p>

<p>Impurity Oxytetracycline Hydrochloride EP Impurity B<br>Applications Tetracycline is a compound that has been shown to induce apoptosis in various cells. Tetracycline was a useful compound to study drug resistance of pathogens of infections in patients with severe liver disease.<br>References Yao, L., et al.: Zhongguo Linchuang Yanjiu, 29, 1510 (2016)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled analogue of Cloxacillin, an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.<br>References Gibbs, D.L. et al.: Curr. Microbiol., 2, 239 (1979); Dmitrova, D. et al.: Farmat., 48, 28 (2001); Craven, N. et al.: Res. Vet. Sci., 29, 57 (1980);<br></p>

<p>Applications Mandestrobin is a novel fungicide having a methoxyacetamid structure. Mandestrobin also shows safer profiles for human health and the environment.<br>References Hirotomi, D., &amp; Kiguchi, S.: PCT Int. Appl., WO 2017026526 A1 20170216 (2017)<br></p>

<p>Applications Isotope labelled Cefalonium (C236800) is a first-generation cephalosporin antibiotic used as a long-acting intramammary cerate for infusion of dairy cows.<br>References Endo, T.: Kach. Kokin. Kenk., 12, 8 (1991); Berry, E.A. et al.: J. Dairy Sci., 90, 760 (2007); Bradley, A.J. et al.: J. Dairy Sci., 93, 1566 (2010);<br></p>

<p>Applications 4-Bromo-2-chlorophenol<br></p>

<p>Applications Ropinirole-d7 Hydrochloride is the labeled analogue of Ropinirole Hydrochloride (R641000), an antiparkinsonian agent. A selective dopamine D2-receptor agonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eden, R.J., et al.: Pharmacol. Biochem. Behav., 38, 147 (1991); Rascol, O., et al.: Mov. Disord., 13, 39 (1998),<br></p>

<p>Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product.<br>References Williams, M., et al.: Bioorg. Med. Chem. Lett., 7, 1837 (1997),<br></p>

<p>Applications Used in the synthesis of labelled 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.<br>References Gordon, C., et al.: J. Med. Chem., 48, 1 (2005), Ikejiri, M., et al.: Bioorg. Med. Chem., 15, 6882 (2007),<br></p>

<p>Applications Triflusulfuron-methyl, is a widely used sulfonylurea herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Song, N., et al.: Huanjing Kexue, 33, 4400 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Found in many plants, especially the buckwheat plant. Identity with Ilixanthin. Capillary protectant. Rutin is colored brown by tobacco enzyme under experimental conditions.<br>References Harrison, et al.: J. Am. Pharm. Assoc., 39, 557 (1950), Humphreys, et al.: Econ. Bot., 18, 195 (1964), Khalifa, T.I., et al.: Anal. Profiles Drug Subs., 12, 623 (1983).<br></p>

<p>Applications Tembotrione is one of the pesticides found in surface waters. It can also be found as pesticide residues in fruits and vegetables.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moschet, C., et al.: Environ. Sci. Technol., 48, 5423 (2014); Wang, J., et al.: J. Agric. Food Chem., 62, 10375 (2014);<br></p>

<p>Applications The labelled trans-isomer of the third generation synthetic pyrethroid insecticide, Bifenthrin (B383000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Applications Labelled Melperone, a neuroleptic butyrophenone. Melperone is also an antiarrhythmic agent. Melperone is an effective atypical antipsychotic drug used in the treatment of schizophrenia.<br>References Petersen, E.N. et al.: Acta Pharmacol. Toxicol., 42, 388 (1978); Platou, E. et al.: Acta Pharmacol. Toxicol., 50, 108 (1982); Bjerkenstedt, L. et al.: Acta Psych. Scand. Supp., 352, 35 (1989); Meltzer, H.Y. et al.: Psych. Res., 105, 201 (2001);<br></p>

<p>Applications 2,3,5-Trichloropyridin-4-amine (cas# 28443-69-8) is a useful research chemical.<br></p>

<p>Applications A metabolite of Chlorpyrifos (C425300).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Barron, M.G., et al.: Environ. Toxicol. Chem., 12, 1469 (1993), Tang, J., et al.: Drug Metab. Dispos., 29, 1201 (2001),<br></p>

<p>Applications Lynestrenol is an orally available progestogen hormone used in contraception to avoid hereditary angiodema as well as in treatment of ischemic stroke.<br>References Saule, C. et al.: Clin. Exp. Allergy, 43, 475 (2013); Beraki, S. et al.: PLoS One., 8, e69233 (2013);<br></p>

<p>Applications Phthalimide is a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities. Dyes and metabolites, Environmental Testing.<br>References Sharma, U., et al.: Med. Chem., 10, 678 (2010); Reddy, P.Y., et al.: J. Org. Chem., 62, 2652 (1997); Le, Z.G., et al. Synthesis., 208 (2004);<br></p>

<p>Applications Labelled antilipemic.<br>References Fuccella, L.M., et al.: Clin. Pharmacol. Ther., 28, 790 (1980), Lovisolo, P.P., et al.: Pharmacol. Res. Commun., 13, 151 (1981), Aktories, K., et al.: Arzneim.-Forsch., 33, 1525 (1983), Boatman, P., et al.: J. Med. Chem., 51, 7653 (2008), Rigazio, S., et al.: Am. J. Physiol., 295, E413 (2008),<br></p>

<p>Applications A labeled metabolite of Diosmetin (D485000) isolated and identified from Chrysanthemum morifolium L. v. Ramat leaves.<br>References Porra, R., et al.: Biochem. Biophys Acta, 975, 384 (1989), Watanabe, M., et al.: J. Agric. Food Chem., 47, 4500 (1999),<br></p>

<p>Applications Isoxaflutole is an pesticide used to selectively control both grass and broad-leaved weeds in maize and sugar cane. Isoxaflutole is known to work by inhibiting the enzyme 4-Hydroxyphenylpyruvate dioxygenase (HPPD) which results in the disruption of pigment biosynthesis.<br>References Fillosls, E.F., et al.: Int. Sugar. J., 115, 135 (2013); Laini, A., et al.: Sci. Total. Environ., 438, 312 (2012);<br></p>

<p>Applications A nonsteroidal estrogen antagonist.<br>References Gladek, A., et al.: J. Biol. Chem., 264, 16847 (1989), Han, X., et al.: Cancer Res., 52, 1360 (1992), Williams, G., et al.: Carcinogenesis, 14, 315 (1993),Coradini, D., et al.: Anticancer Res., 14, 1059 (1994),<br></p>

<p>Applications rac cis-Paroxetine N-Methyl is an impurity formed in the synthesis Paroxetine (P205750) related compounds.<br>References Gangula, S., et al.: Syn. Commun., 42, 3344 (2012);<br></p>

<p>Applications (aS,bR)-Bedaquiline is a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis.<br>References Cheepsattayakorn, A., et al.: Anti-Infect. Drug. Discover.,7, 141 (2012); de Jonge M.R. et al.: Proteins, 67, 971 (2007); Diacon A.H. et al.: N. Eng. J. Med., 360, 2397 (2009);<br></p>

<p>Applications Herbicide safener.<br>References Lee, H., et al.: Eur. J. Med. Chem., 40, 862 (2005), Wright, S., et al.: Bioorg. Med. Chem. Lett., 17, 5638 (2007), Brazier-Hicks, M., et al.: J. Biol. Chem., 283, 21102 (2008), Vinggaard, A., et al.: Chem. Res. Toxicol., 21, 813 (2008),<br></p>

<p>Applications Auxin-type herbicide.<br>References Ecker, J., et al.: Science, 268, 667 (1995), Grossmann, K., et al.: Pestic. Sci., 52, 111 (1998), Martin, P., et al.: Environ. Toxicol. Chem. 19, 2987 (2000), Grossmann, K., et al.: J. Exp. Bot., 52, 1811 (2001), van Eerd, L., et al.: Weed Res., 44, 355 (2004),<br></p>

<p>Applications Ibogaine Hydrochloride is a naturally occurring psychoactive substance. It is a β-carboline derivative that cause both hallucinations and tremor.<br>References O’Hearn, E., et al.: Neurosci., 55, 303 (1993)<br></p>

<p>Applications Tecloftalam Imide is a derivative of Tecloftalam (T013700), an agrochemical fungicide. Tecloftalam is used for the control of rice bacterial leaf blight.<br>References Nakagami, K. et al.: Nip. Noyak. Gak., 5, 511 (1980); Kirkpatrick, D. et al.: J. Agric. Food Chem., 29, 608 (1981); Takahi, Y. et al.: Jap. Past. Info., 46, 25 (1985);<br></p>

<p>Applications Triphenyltin Acetate is an organotin compound. Triphenyltin Acetate much like its hydroxide analogue is used as a fungicide and antifeeding compound for insect control. Recent studies show that Triphenyltin Acetate may have adverse effects on the reproductive and immune systems and may disrupt the endocrine system.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Soderquist, J.S. et al.: J. Agric. Food Chem., 28, 111 (1980); J. Toxicol. Environ. Health, 7, 281 (2004); Livingston, J.M. et al.: J. Georgia Entamol. Soc., 13, 148 (1978); Sarpa, M. et al.: J. Toxicol. Environ. Health, 73, 965 (2010);<br></p>