Toxicology

<p>Applications An antibacterial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Piipari, R., et al.: Clin. Exp. Allergy, 28, 358 (1998), Kanerva, L., et al.: Contact Dermatitis, 44, 193 (2001), Frauen, M., et al.: J. Pharm. Biomed. Anal., 25, 965 (2001),<br></p>

<p>Applications 2-Hydroxy-5-(trifluoromethyl)pyridine (cas# 33252-63-0) is a compound useful in organic synthesis.<br></p>

<p>Impurity Levofloxacin USP Related Compound B<br>Applications Levofloxacin intermediate.<br>References Liu, Bo; Y., et al.: Bioorg. Med. Chem., 13, 2451 (2005), Lalitha D., et al.: J. Pharm. Biomed. Anal., 50, 710 (2009),<br></p>

<p>Applications Propaquizafop is used in the studies of the pesticides residue in tomatoes and cucumbers and the associated health risks.<br>References Lozowicka, B., et al.: Environ. Monit. Assess., 187, 1 (2015)<br></p>

<p>Stability Moisture Sensitive<br>Applications Naled is a cholinesterase inhibitor. Insecticide; acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>

<p>Stability Hygroscopic<br>Applications Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsuboi, T., et al.: Arch. Int. Pharmacodyn., 247, 89 (1980), Adaikan, P.G., et al.: Prostaglandins Med., 6, 449 (1981), Kottegoda, S.R., et al.: Prostaglandins Leukotrienes Med., 8, 343 (1982), Ishizaki, T., et al.: Chest, 85, 382 (1984),<br></p>

<p>Applications Scopolamine Hydrobromide Hydrate is an acetylcholine antagonist. Used in treatment of motion sickness; antiemetic; antispasmodic; mydriatic; preanesthetic medicant. Neuroprotective &amp; Neuroresearch Product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brand, J.J., et al.: Lancet, 2, 232 (1970); Bowles, J.B., et al.: Anaesthesia, 34, 476 (1979); Clissold, S.P., et al.: Drugs, 29, 189 (1985); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 19, 477 (1990);<br></p>

<p>Applications Octanoyl L-Carnitine Chloride is a metabolite of Carnitine (C184110, L-Carnitine).<br>References Huang, Z., et al.: Anal. Biochem., 199, 98 (1991), Friolet, R., et al.: J. Clin. Invest., 94, 1490 (1994), Rashed, M., et al.: Pediatr. Res., 38, 324 (1995), Costa, C., et al.: J. Lipid Res., 38, 173 (1997),<br></p>

<p>Applications Algestone Acetophenide is a progestational steroid that has been shown to increase the proteins in milk and serum in goats and decrease the weight gain of kids. Algestone Acetophenide is used as an injectable steroid contraceptive in Chile and Mexico.<br>References Abdel, K., et. al.: J. Drug Res., 7, 79 (1975); Thomas, D.B., et. al.: AM. J. Epidemiol., 130, 237 (1989)<br></p>

<p>Applications Phthalimide-d4 is the isotope labelled analog of Phthalimide (P384550); a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities.<br>References Sharma, U., et al.: Med. Chem., 10, 678 (2010); Reddy, P.Y., et al.: J. Org. Chem., 62, 2652 (1997); Le, Z.G., et al. Synthesis., 208 (2004)<br></p>

<p>Applications A novel labelled intermediate of Fexofenadine (F322470).<br>References McTavish, D., et al.: Drugs, 39, 552 (1990), Honig, P., et al.: Clin. Pharmacol. Ther., 52, 231 (1992), Yun, C., et al.: Drug Metab. Dispos., 21 403 (1993),<br></p>

<p>Applications Semi-synthetic cephalosporin antibiotic. Antibacterial.A representative lot contains some d5.<br>References Buck, R.E., et al.: Antimicrob. Agents Chemother., 11, 324 (1977),<br></p>

<p>Applications N-Desmethylthiamethoxam-D4 is an impurity of thiamethoxam and an isotope labelled compound of N-Desmethylthiamethoxam (D292485). Thiamethoxam is a hepatotoxic insecticide in mice.<br>References Swenson, T. L., et al.: Toxicol. Lett., 216, 139 (2013); Karmakar, R., et al.: Pest Manag. Sci, 65, 931 (2009)<br></p>

<p>Applications Deuterated Zolpidem, a selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant).<br>References Arbilla, S., et al.: Arch. Pharmacol., 330, 248 (1985), Cashman, J.N., et al.: Brit. J. Clin. Pharmacol., 21, 205 (1986)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Iopromide. Nonionic, injectable radio-contrast medium. Diagnostic aid (radiopaque medium).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Muetzel, W., et al.: Am.J. Neuroradiol., 4, 350 (1983), Dawson, P., et al.: Acta Radiol. Diagn., 25, 253 (1984),<br></p>

<p>Applications Tricyclazole is an common active ingredient in several commercial fungicide products used to control rice blast fungus, in transplanted and direct-seeded rice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dhingani, J.C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Jeong, S.A., et al.: Bull. Environ. Contamin. Toxicol., 89, 1181 (2012);<br></p>

<p>Applications Hydroxydiazinon is an organophosphorus pesticide.<br>References Xu, H.: Shijie Nongyao, 29, 42 (2007).<br></p>

<p>Applications A muscarinic receptor used as nootropic agent.<br>References Wolf-Pflugmann, M., et al.: Arzneim-Forsch./Drug Res., 39(1), 5, 539 (1989),<br></p>

<p>Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications Ezetimibe-d4 is the labeled analogue of Ezetimibe (E975000), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>

<p>Applications Systemic agricultural fungicide.<br>References Ozer, N., et al.: J. Phytopathol., 158, 744 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),<br></p>

<p>Applications Picoxystrobin is a methoxyacrylate strobilurin fungicide designed for the control of wide range of cereal diseases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Walorczyk, S., et al.: J. Chromatograph. A., 1251, 219 (2012); Roszko, M., et al.: J. Am. OIl. Chemist. Soc., 89, 389 (2012);<br></p>

<p>Applications Ethoprophos is an organophosphate non-systemic nematicide and soil insecticide (1). Ethoprophos is an acetylcholinesterase (AChE) inhibitor (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Used as a standard for Pesticide detection. Ethoprophos is also useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Wing, K. et al.: Pest. Biochem. Physiol. 1984. Feb:21(1) pp22-302. Opperman, C. et al.: J. Nematol. 1990 Oct;22(4):481-83. Nordmeyer, D. et al.: Plant. Dis. J. 1985 Jan:69: 67-69<br></p>

<p>Applications Tetraoctyltin was coupled to C-H bonds of 2-aryl- and 2-benzyl-substituted 4,4-​dimethyl-​2-​oxazolines and pyridines to give the benzene ring-​alkylated products in good yields by using 5 mol % Pd(OAc)​2 as the catalyst.<br>References Chen, X., et al.: J. Am. Chem. Soc., 128, 78 (2006).<br></p>

<p>Applications A labelled cholinesterase inhibitor. Insecticide; acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>

<p>Applications β-Alanine is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of dihydrouracil (D449990) and carnosine. β-Alanine is also the rate-limiting precursor of carnosine, as a result supplementation with β-alanine increases the concentration of carnosine in muscles.<br>References Derave, W. et al.: J. Appl. Physiol., 103, 1736 (2007); Xia, J.-F. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 977, 1930 (2009); Artioli, G.G. et al.: Med. Sci. Sports Exer.,42, 1162 (2010);<br></p>

<p>Applications rac-Clopidogrel-d3 Hydrogen Sulfate is the labeled analogue of rac-Clopidogrel Hydrogen Sulfate (C587248), which is used in the synthesis of Clopidogrel derivatives as platelet aggregation inhibitors.<br>References Chen, J., et. al.: Hecheng Huaxue, 18, 586 (2010)<br></p>

<p>Stability Moisture Sensitive<br>Applications Orthosulfamuron can be used in biological study and agricultural use of herbicidal composition comprising erlukuilincaotong, cyhalofop-​butyl and sulfonylurea herbicide, and its application in controlling annual weed of rice field.<br>References Wang, L., et al.: Faming Zhuanli Shenqing, CN 106386836 A 20170215 (2017)<br></p>

<p>Applications Codeine 6-β-D-Glucuronide-d6 is the labelled analogue of Codeine 6-β-D-Glucuronide (C634090), a metabolite of Codeine (C634075). Analgesic (narcotic); antitussive.<br>References Frances, B., et al.: J. Pharm. Exp. Ther., 25, 262 (1992), Osborne, R., et al.: Br. J. Clin. Pharm., 34, 130, (1992),<br></p>

<p>Applications Benzamide is a compound that is widely used as a starting material for various organic syntheses and reactions. Benzamide derivatives are prevalent in the pharmaceutical industry, for example Raclopride (R070800), a Dopamine (D533780) D-2 agonist that is used to treat patients with Parkinson’s Disease. Benzamide derivatives are also used in chemistry, for example N-nitrophenyl benzamide derivatives are used as chromosensors to detect cyanide in aqueous environments.<br>References Ehrin, E., et al.: Int. J. Appl. Rad. Isot., 36, 269 (1985); Sun, Y., et al.: Tetrahedron, 65, 3480 (2009); Terai, M., et al.: Eur. J. Pharm., 173, 177 (1989)<br></p>

<p>Stability Unstable in DMSO solution<br>Applications Chlorimuron-ethyl is used in weed control method as herbicide.<br>References Sada, Y., et al.: PCT Int. Appl. 45 pp. (2020)<br></p>

<p>Applications Tropine derivative with anticholinergic activity. Antispasmodic; used in treatment of urinary incontinence.<br>References Antweiler, H., et al.: Arzneim.-Forsch., 16, 1581 (1966), Lux, G., et al.: Fortschr. Med., 96, 2113 (1978), Madersbacher, H., et al.: Br. J. Urol., 75, 452 (1995), Zinner, N.R., et al.: Expert Opin. Pharmacother., 6, 1409 (2005),<br></p>

<p>Impurity Clobetasol Propionate EP Impurity A / Betamethasone Dipropionate EP Impurity B<br>Applications Betamethasone 17-Propionate (Clobetasol Propionate EP Impurity A) is a degradation product of Betamethasone. Glucocorticoid.<br>References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),<br></p>

<p>Applications A chloroacetanilide herbicide used on vegetable crops.<br>References Matthies, M., et al.: Environ. Sci. Technol., 43, 9223 (2009); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010); Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010);<br></p>

<p>Applications Macitentan-d4 is an isotopic form of Macitentan (M105005). Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic.This compound contains aproximately 2% d0.<br>References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),<br></p>

<p>Applications Labelled antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen.<br>References Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 6, 457 (1977), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984),<br></p>

<p>Applications Isotope labelled Acephate (A130850) acts as a contact and systemic insecticide in agriculture through pesticide formulations. Through perinatal exposure studies, it has been linked to hyperglycemia, changes in lipid metabolism and type 2 diabetes (1). Acephate exposed Drosophila melanogaster potentially display an L-ascorbic acid mediated defense (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Ribeiro, T., et al.: Toxicology, 372, 12-21 (2016); Rajak, P., et al.: J. Hazard. Mater., 321, 690-702 (2017)<br></p>

<p>Applications Quinethazone is a thiazide diuretic used to treat hypertension.<br>References DeLuca, F.M.: Sett. Med., 54, 747 (1966); Dettli, L. et al.: Ann. N.Y. Acad. Sci., 139, 471 (1966);<br></p>

<p>Applications Mefenacet is an acetanilide herbicide which is used for pre- and post emergence control of annual weeds in paddy oil. Mefenacet has been widely used and repeated in Asian countries and is frequently detected in river or lake water.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Saka, M., et al.: Ectoxicol. Environ. Saf., 73, 1165 (2010); Ye, Y-F., et al.: J. Environ. Sci., 16, 343 (2004);<br></p>

<p>Applications 2-Amino-6-methylpyrimidin-4(3H)-one (cas# 3977-29-5) is a useful research chemical.<br></p>

<p>Applications Simetyrn is an methylthiotriazine based herbicide used in rice paddy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Inoue, T. et al.: J. Agri. Food. Chem., 59, 3857 (2011); Wang, S., et al.: Environ, Sci. Technol., 47, 4768 (2013);<br></p>

<p>Applications E/Z mixture of Fenaminstrobin is used as a fungicide.<br></p>

<p>Applications Bromopropylate is a chemical compound used as an acaricide against spider mites in apiaries and on fruit crops such as citrus and grapes.<br>References Van Leeuwen, T., et al.: Pest Management Sci., 61, 499 (2005); Kim, Y., et al.: J. Econ. Entomol., 99, 954 (2006)<br></p>

<p>Applications 4-Chlorophenylamine is an organic chemical reagent and precursor in the synthesis of various drugs and dyestuffs. It is a building block and a degredation product of Chlorhexidine (C335045), an antiseptic as well as azo dyes and pigments in printing and textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leucea, D. et al.: Ind. Text., 61, 304 (2010); Below, H. et al.: Microchim. Acta 146, 129 (2004);<br></p>

<p>Applications Nelfinavir Mesylate is an antiviral. HIV protease inhibitor. It is a COVID19-related research product.<br>References Patick, A.K., et al.: Antimicrob. Agents Chemother., 40, 292 (1996), Bardsley-Elliot, G.L., et al.: Drugs, 59, 581 (2000)<br></p>

<p>Impurity Fluocinolone Acetonide EP Impurity E<br>Stability Hygroscopic<br>Applications (6α,9β,11β,16α)-9,11-Epoxy-6-fluoro-21-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione, can be used in the production of fluocinolone acetonide (F455800).<br>References Grinenko, G.S, Khimiko-Farmatsevticheskii Zhurnal, 12, 110 (1978), Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Bentazepam is a thienodiazepine which is a benzodiazepine analog. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.<br>References Gonzalez Lopez, F., et al.; Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 482 (1986); Marino, E., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 25, 627 (1987)<br></p>

<p>Applications Fenoxaprop-P is an agro-product, used in pesticide formulations.<br>References Han, Y. et al. et al.: J. Sep. Sci., 40, 878 (2017);<br></p>

<p>Applications Inhibits the enzyme HMG-CoA reductase in vitro.<br>References Endo, A., et al.: J. Antibiot., 32, 852 (1979), Alberts, A.W., et al.: Drug Invest., 2 (Suppl. 2), 9 (1990), Kuroda, M., et al.: Biochim. Biophys. Acta, 486, 70 (1977),<br></p>

<p>Applications Anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Becker, A., et al.: J. Int. Med. Res., 8, 333 (1980), Child, R.G., et al.: Arzneim.-Forsch., 30, 695 (1980), Bolte, H.F., et al.: Arzneim.-Forsch., 30, 721 (1980).<br></p>

<p>Applications Labelled Clonazepam (C587080). Antiepileptic agent with anxiolytic and antimanic properties. Anticonvulsant.This is a controlled substance (depressant).<br>References Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)<br></p>

<p>Applications Hawkinsin is a urinary metabolite from the rare disorder of tyrosine metabolism, known as Hawkinsinuria; Also, it is derived from 4-Hydroxyphenylacetic Acid (H949060), which is a compound present in olive oil. An important fine chemical intermediate with broad prospects for application development.<br>References Gomez-Ospina, N., et al.: J. Inherit. Metab. Dis., 39, 821-829 (2016); Shu, Y., et al.: Guangdong Huagong, 37, 108 (2010), Papadopoulos, G., et al.: J Am Oil Chem Soc, 68, 669 (1991),<br></p>

<p>Stability Hygroscopic<br>Applications A 2,4-Diaminopyrimidine derivative as antimalarial agent.<br>References Andersson, K.J.I., et al.: Nature, 143, 720 (1939), Cecil, R., et al.: Biochem.J., et al.: 43, 592 (1948),<br></p>

<p>Applications An α2-Adrenergic agonist. Sedative; analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987), Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987), Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988), Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996),<br></p>

<p>Applications Cyclobarbital has been used as an anesthetic and sedative. Controlled substance (depressant).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hofrichter, G., et al.: Arzneim.-Forsch., 17, 242 (1967),<br></p>

<p>Applications It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.<br>References Ditchfield, C., et al.: J. Cell Biol., 161, 267 (2003), Long, Z.J., et al.: J. Cell Cycle, 7, 1473 (2008), Walsby, E., et al.: Haematologica, 93, 662 (2008),<br></p>

<p>Applications (R)-Enantiomer of Bicalutamide. Used as an antiandrogen, antineoplastic (hormonal).<br>References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),<br></p>

<p>Impurity Atorvastatin EP Impurity G<br>Applications Atorvastatin derivative.<br></p>

<p>Applications Tetrasul is a chlorinated diphenyl sulfide aracacide. Tetrasul is used for the control of mites and other pests in food and gardening crops.<br>References Hansen, T. et al.: Tids. Plant., 74, 618 (6970); Dittrich, V.: Zeitsch. Angew. Entomol., 61, 240 (1968);<br></p>

<p>Applications Adenosine 5'-Monophosphate is a natural occurring nucleotide and a useful ligand determinant that facilitate the binding of APS reductase inhibitors and activates adenosine receptor agonists.<br>References Hong, J.A. et al.: J. Med. Chem., 52, 5485 (2009); Korboukh I. et al.: J. Med. Chem., 55, 6467 (2012)<br></p>

<p>Applications 2-(Trifluoromethyl)benzoic Acid is used in biochemical genetics studies such as Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B.<br>References Eaton, Richard W., Journal of Bacteriology, 183, 3689-3703, (2001)<br></p>

<p>Applications Anilofos is an herbicide that is practically insoluble in water.<br></p>

<p>Applications Amphotericin B Methyl Ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B Methyl Esterin is a cholesterol binding compound that showed inhibiton of human immunodeficiency virus type 1 (HIV-1).<br>References Waheed, A.A. et al.: J. Biol. Chem., 281, 28699 (2006); Waheed, A. et al.: J. Virol., 82, 9776 (2008); Waheed, A., et al.: J. Biol. Chem., 281, 28699 (2006)<br></p>

<p>Applications A metabolite of Testosterone (T155000). It is a urinary metabolite of Androstenedione (A637550) in patients with Addison's disease and also used as a marker in blood plasma for detection of prostate cancer.<br>References Lokhov, P.G. et al.: Metabolomics, 6, 156 (2010); Bonnaire, Y. et al.: J. Anal. Toxicol., 19, 175 (1995); Tamm, J. et al.: Steroids, 8, 659 (1966);<br></p>

<p>Applications An oxidative product of the drug Norethindrone (N676000). Norethindrone impurity.<br>References Reif, V., et al.: Pharmaceutical Res., 4, 54 (1987), Rao, P., et al.: Steroids, 59, 621 (1994),<br></p>

<p>Applications Imidacloprid-urea is a metabolite of Imidacloprid (I275990), a neonicotinoid; the active ingredient in certain neuro-active insecticides. Used in pest control.<br>References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Patial, A., et al.: Env. Ecol., 27, 320 (2009), Fernandez-Bayo, J., et al.: J. Agric., Food Chem., 57, 5435 (2009); Aregahegn, K. et al.: Env. Sci. Tech., 51, 2660 (2017);<br></p>

<p>Applications Anorexic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pinder, et al.: Drugs, 10, 241 (1975), Caccia, S., et al.: Eur. J. Clin. Pharmacol., 29, 221 (1985), Finner, N., et al.: Curr. Ther. Res., 38, 847 (1985),<br></p>

<p>Applications Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent.<br>References McDonald, M., et al.: Drugs Exp. Clin. Res., 10, 745 (1984), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 17, 221 (1988),<br></p>

<p>Applications Coumoxystrobin is a Coumarin (C755380) based fungicide.<br>References Guan, A., et al.: Pest Manag. Sci., 67, 647 (2011);<br></p>

<p>Stability Toxic<br>Applications Isotopopically Labelled analogue of Captan (C175725), which is an acetylcholinesterase inhibitor acting as a fungicide (1), often added to pesticide mixtures to control diseases among fruits and vegetables. Detected through various analytical techniques involving pesticide residues such as MS-PD and GC-MS (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Also used in cannabis testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Afful, S. et al.: Res. J. App. Sci. Eng. Tech. (2010) 14 Jul:2(6) 592-52. Engelen, K. et al.: J. Proteome. Res. 2010 Oct 1;9(10):4919-263. Lagunas-Allue, L. et al.: Anal. Bioanal. Chem. 2010 Oct;398(3):1509-23<br></p>

<p>Applications Isotope labelled Acetamide (A133060) which is often used as plasticizer and as industrial solvent (1). It can also be used for the transamidation of carboxamides in 1,4-dioxane in the absence of a catalyst (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Ma, X. et al.: Carb. Polym. 2004 Aug:57(2):197-2032. Vanjari, R. et al.: Tetrahedron. Lett. 2013 MayL54(20):2553-5<br></p>

<p>Applications Acrivastine is an allergy medication that is histamine H2 antagonists.<br>References Manna, V.K., et al.: J. Int. Med. Res., 20, 106 (1992);<br></p>

<p>Applications An impurity of Zolpidem (Z650000).<br></p>

<p>Applications Phenylguanidine anthelmintic. Anthelmintic.<br>References Williams, J.C., et al.: Am. J. Vet. Res., 46, 2188 (1985), Delatour, P., et al.: J. Vet. Pharmacol. Ther., 9, 230 (1986),<br></p>

<p>Applications Demephion is used in pesticidal compositions. A pesticide, and an organophosphate insecticide.<br>References Iacob, N., et al.: Analele Institutului de Cercetari pentru Protectia Plantelor, Academia de Stiinte Agricole si Silvice, 16, 357 (1981); Dimitrov, A., et al.: Bulgarski Tyutyun, 25, 16 (1980); Babrikova, T., et al.: Nauchni Trudove - Vissh Selskostopanski Institut--Plovdiv, 25, 31 (1980)<br></p>

<p>Applications Carbamate fungicide used in the agriculture industry<br>References Judelson, H., et al.: Mol. Plant Pathol., 7, 17 (2005), Grunwald, N., et al.: Phytopathol., 96, 1397 (2006), Celik, L., et al.: Chem. Res. Toxicol., 21, 2195 (2008),<br></p>

<p>Applications Sumatriptan Succinate is a selective 5-HT1B/1D-receptor agonist with anticonvulsant properties (1,2). Sumatriptan Succinate is used for migraine relief (2).<br>References (1) Razzaque, Z., et al.: Br J Clin Pharmacol. 47, 75 (1999) (2) Cady, R. K., et al.: J Headache Pain. 18, 17 (2017)<br></p>