Toxicology

<p>Impurity USP Azithromycin Related Impurity H /Azithromycin EP Impurity H<br>Stability Hygroscopic<br>Applications 3'-N-[[4-(acetylamino)phenyl]sulfonyl]-3'-N-demethyl Azithromycin is an impurity of Azithromycin (A927000).<br>References Debremaeker, D. et al.: Rap. Comm. Mass. Spec., 17, 342 (2003);<br></p>

<p>Applications Labelled Sulfadoxine (S699070). Used as an antibacterial.<br>References Kapoor, V.K., et al.: Anal. Profiles Drug Subs., 17, 571 (1988)<br></p>

<p>Applications 2-Methoxypropene is used in the synthesis of Macrolactin A, a 24-member macrolide typically employed as an antibiotic. Also used in the synthesis of phenylalanine derivatives used as α4β1 and α4β7 receptor antagonists in the treatment of allergic asthma.<br>References Marino, K. et al.: J. Am. Chem. Soc., 12, 1664, (2002); Tilley, J. et al.: Bioorg. Med. Chem. Lett., 23, 1036 (2013);<br></p>

<p>Applications Oxantel Pamoate is used as an anthelmintic drug.<br>References Reitzer, L., et al.: J. Biol. Chem., 1979, 254, 2669 (1979), Huber, R., et al.: J. Neurosci. Res., 75, 441 (2004), Kim, J., et al.: Cell Metab. 3, 177 (2006), Bonnet, S., et al.: Cancer Cell., 11, 37 (2007),<br></p>

<p>Applications Isotope labelled enantiomer of Voriconazole (V760000), an antifungal agent and an ergosterol biosynthesis inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sanati, H., et al.: Antimicrob. Ag. Chemother., 41, 2492 (1997),<br></p>

<p>Applications Prazosin is a useful α1 and α2B-adrenoceptor antagonist.<br></p>

<p>Stability Moisture Sensitive, Temperature Sensitive<br>Applications 2-O-Methyl-α-D-N-acetylneuraminic Acid is a model compound for studies of binding of influenza virus hemagglutinin and metal ions.<br>References Sauter, N.K., et al.: Biochemistry, 28, 8388 (1989), Sharon, N., et al.: Science, 246, 227 (1989), Nagy, J.O., et al.: J. Med. Chem., 35 (23), (1992), Knibbs, R.N., et al.: J. Biol. Chem., 268 (25), 18524 (1993)<br></p>

<p>Applications Clindamycin Palmitate is a semi-synthetic antibiotic with high bioavailability. Clindamycin Palmitate is an antibacterial.<br>References Platzer, D., et al.: J. Pharm. Biomed. Anal., 41, 84 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.<br>References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),<br></p>

<p>Applications Moxifloxacin is an antibiotic for the treatment of bacterial infections like bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.<br>References Zhang, H., et al.: Linchuang Junyi Zazhi, 43, 182 (2015); Fernandes, M. J., et al.: Chemosphere, 239, 124729 (2020); Yilancioglu, K., et al.: Sci. Rep., 9, 1 (2019)<br></p>

<p>Applications Histrelin is a gonadotropin releasing hormone analog used with the potential to improve height prospects.<br>References Brauner, R. et al.: Nat. Rev. Endocrinol., 11, 386 (2015);<br></p>

<p>Stability Light Sensitive<br>Applications An impurity of Minocycline (M344800). Used in the preparation of calpain inhibitors.<br>References Sokoloski, T.D., et al.: J. Pharm. Sci., 66, 1159 (1977), Naidong, W., et al.: J. Pharm. Biomed. Anal., 13, 905 (1995),<br></p>

<p>Applications Sulfacetamide-d4 is the isotope labelled analog of Sulfacetamide. Sulfacetamide is an antibiotic used for the treatment of skin infections and urinary tract infections. Sulfacetamide is also used to treat acne and seborrheic dermatitis. Sulfacetamide was investigated for potential anti-inflammatory properties<br>References Wittwer, M.B., et al.: J. Med. Chem., 56, 781 (2013); Wang. X., et al.: Afr. J. Micriobiol., 6, 4533 (2012); Yu, B., et al.: Euro. J. Med. Chem., 46, 5833 (2011);<br></p>

<p>Applications A deuterated metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.This compounds contains Sodium Chloride. Water content not determined.<br></p>

<p>Applications 2,5-Dimethoxy-4-methylamphetamine (DOM, STP) is one of the potent hallucinogenic phenylalkylamines with neurotoxic properties. Hallucinogen.<br>References Monte, A., et al.: J. Med. Chem., 39, 2953 (1996), Pedersen, W., et al.: Addiction, 94, 1695 (1999), Kanamori, T., et al.: J. Anal. Toxicol., 26, 61 (2002),<br></p>

<p>Stability Hygroscopic<br>Applications Mepiquat Chloride is a plant growth regulator used to improve crop quality and maximize yield.<br>References Xiaoming, R., et al.: Field Crops Res, 149, 1-10 (2013)<br></p>

<p>Applications A labelled derivative of Vincamine with vasodilating activity. Vasodilator (cerebral).<br>References Han, et al.: J. Biol. Chem., 274, 22337 (1999), O’Donnell, et al.: Pharmacol. Biochem. Behav., 63, 185 (1999),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Valproic acid.<br>References Rudy, A., et al.: J. Pharmacol. Exp. Ther., 259, 1133 (1991), Nagai, K., et al.: J. Antimicrob. Chemother., 39, 295 (1997), Yamamura, N., et al.: Drug Metab. Dispos., 27, 724 (1999)<br></p>

<p>Applications Avibactam (NXL104) is a novel β-lactamase inhibitor with a non-lactam structural scaffold. NXL104 irreversibly inhibits lactamase from Mycobacterium tuberculosis.<br>References Iland, C., et al.: J. Pathol. Bacteriol., 58, 495 (1946), Flores, A., et al.: Microbiology, 151, 521 (2005), Livermore, D., et al.: J. Antimicrob. Chemother., 62, 1053 (2008), Tremblay, L., et al.: Biochemistry, 49, 9685 (2010),<br></p>

<p>Applications Dimoxystrobin is a pesticide component used for its antifungal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hvezdova, M. et al.: Sci. Total. Env., 613-614, 361 (2018);<br></p>

<p>Applications 25-Deacetyl-21-acetyl Rifampicin is a structural isomer, and impurity, of Rifampicin (R508000), a semisynthetic antibiotic. Antibacerial (tuberculostatic).<br>References Furesz, et al.: Antibiot. Chemother., 16, 316 (1970), Gallo, G.G., et al.: Anal. Profiles Drug Subs., 5, 467 (1976),<br></p>

<p>Applications Labelled analogue of (S)-(-)-Nicotine, a prototype nicotinic acetylcholine receptor agonist. (S)-(-)-Nicotine is the naturally occurring isomer. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Geffken, D. et al.: Am. J. Epidemiol., 153, 242 (2001); Bolego, C. et al.: Cardiovasc. Res., 53, 568 (2002); Leone, A. et al.: Curr. Pharm. Des., 1, 2199 (2005);<br></p>

<p>Applications Polythiazide is a thiazide diuretic. Polythiazide is used in the treatment of hypertension as well as nephrotic syndrome, cirrhosis of the liver, and nutritional edema.<br>References Kaur, J. et al.: J. Ind. Med. Assoc., 48, 13, (1967); Lund-Johansen, P.: Acta Med. Scand., 187, 509 (1970); O'Brien, E.T. et al.: Br. Heart J., 34, 1042 (1972);<br></p>

<p>Applications Cabotegravir O-β-D-Glucuronide is a metabolite of Cabotegravir (C050100), a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.<br>References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015)<br></p>

<p>Stability Hygroscopic<br>Applications Dihydro Caffeic Acid 3-O-β-D-Glucuronide is a glucuronide metabolite of Caffeic Acid (C080000).<br>References Clifford, M., et al.: J .Agric. Food Chem., 53, 3821 (2005), Lafay, S., et al.: J. Nutr., 136, 1192 (2006), Poquet, L., et al.: Drug Metab. Dispos., 36, 190 (2008)<br></p>

<p>Applications Cefoxitin is a semi-synthetic antibiotic derived from Cephamycin C, possessing high resistance to β-lactamase inactivation. An antibacterial.<br>References Wallick, H., et al.: Antimicrob. Agents Chemother., 5, 25 (1974), Brenner, G.S., et al.: Anal. Profiles Drug Subs., 11, 169 (1982),<br></p>

<p>Applications Isotope labelled analogue of Bifendate (B382890), a synthetic intermediate of Schisandrin C and also a anti-HBV drug used in the treatment of chronic hepatitis B.<br>References Pan, S.Y., et al.: Euro. J. Pharmacol. 522, 170 (2006); Zeng, Y., et al.: Acta. Pharmacol. Sinica., 30, 478 (2009);<br></p>

<p>Applications A metabolite of Testosterone (T155000) in human. Controlled substance.<br>References Seckl, J., et al.: Steroids, 62, 89 (1997), Reynolds, R., et al.: J. Clin. Endocrinol. Metab., 86, 245 (2001), Wolf, C., et al.: Toxicol. Sci. 65, 71 (2002), Borlak, J., et al.: Drug Metab. Dispos., 32, 675 (2004),<br></p>

<p>Applications 2,4,6-Trichlorophen-3,5-d2-ol is an impurity in the synthesis of isotope labelled Triclosan which is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2). This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br></p>

<p>Applications Dorzolamide Maleic Acid Adduct, is the isomeric adduct resulting from the nucleophilic addition of Dorzolamide (D535100) to Maleic Acid. Dorzolamide, is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent, and acts by decreasing the production of aqueous humour. It is used in the form of eye drops.<br>References Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991), Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991), Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991), Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998),<br></p>

<p>Stability Material darkens in storage with no loss in purity<br>Applications 3-Chlorobenzenamine is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity. Also used in the synthesis of novel COX-2 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yang, H. et al.: Eur. J. Med. Chem., 63, 558 (2013); Penning, T. et al.: J. Med. Chem., 40, 1347 (1997);<br></p>

<p>Applications Gingerenone A is an antifungal and antiparasitic diarylheptenone that is isolated from Zingiber officinale (more commonly known as ginger), a medicinal plant that is used to treat inflammation and musculoskeletal disorders.<br>References Ali, B., et al.: Food Chem. Toxicol., 46, 409 (2008); Bordia, A., et al.: Prost. Leuk. Ess. Fat. Acids, 56, 379 (1997); Choi, W., et al.: J. Appl. Biomed., 11, 15 (2013); Riaz, T., et al.: Nat. Prod. Res., 24, 1131 (2010); Srivastava, K. &amp; Mustava, T.: Med. Hypoth., 39, 342 (1992)<br></p>

<p>Applications 3'-Deoxyadenosine 5’-Triphosphate Triethylamine Salt is a salt form of 3'-Deoxyadenosine 5’-Triphosphate(D232070). 3'-Deoxyadenosine 5’-Triphosphate is a nucleotide and was shown to inhibit the replication of hepatitis C virus in human hepatoma cells.<br>References Arnold, Jamie J., et al.: PLoS Pathogens, 8(11), e1003030 (2012)<br></p>

<p>Applications A labelled metabolite of Cortisol (H714615).<br>References Aguilera, R., et al.: Clin. Chem., 47, 292 (2001), Pujos, E., et al.: Anal. Bioanal. Chem., 381, 244 (2005), Flenker, U., et al.: Steroids, 73, 408 (2008),<br></p>

<p>Impurity Ampicillin EP Impurity C Sodium Salt;<br>Applications Ampicillin Diketopiperazine Sodium Salt (Mixture of Diastereomers), is a a metabolite and impurity of the semi-synthetic antibiotic Ampicillin (A634300).<br>References Suwanrumpha, S. et al.: Biomed. Environ. Mass Spec., 18, 983 (1989); Zhu, Y. et al.: J. Pharmac. Biomed. Anal., 14, 631 (1996); Haginaka, J. et al.: J. Pharm. Pharmacol., 39, 5 (1987);<br></p>

<p>Applications Used as an antiseptic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B. and Linder, R.E.: Fundam. Appl. Toxicol., 7, 299 (1986)<br></p>

<p>Applications 3-Carboxy-N,N,N-trimethyl-2-[(1-oxo-2-hexen-1-yl)oxy]-1-propanaminium chloride salt is used to increase the gastrointestinal absorption of drugs. It is used also to diagnose specific metabolic diseases.<br>References Yang, S. et al.: J. Chrom., 857, 251 (2007);<br></p>

<p>Applications Prenalterol is a β1-adrenergic agonist and used as an cardiotonic (1,2,3).<br>References (1) Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)(2) Scheiber, J., et al.: J. Med. Chem., 52, 3103 (2009(3) Broadley, K., et al.: Biochem. Pharmacol., 80, 1537 (2010)<br></p>

<p>Applications S-(-)-Warfarin-d5 is the labelled analog of S-(-)-Warfarin, an enantiomer of Warfarin (W498500). Coumarin anticoagulant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),<br></p>

<p>Applications Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.<br>References Cherian., et al.: Br. J. Anaesthesia, 87, 502 (2001),<br></p>

<p>Applications Strobilurin fungicide; inhibits mitochondrial respiration by blocking electron transfer between cytochromes b and c1. Agricultural fungicide. Used in Pesticide detection.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smalling, K., et al.: Environ. Toxicol. Chem., 29, 2593 (2010), Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),<br></p>

<p>Applications Thallium sulfate is an inorganic compound used in the preparation of luminescent extended one-​dimensional heterobimetallic chain compounds with relativistic metal-​metal bonds, by reaction with gold thiophosphinomethyl complexes.<br>References Wang, S.; et al.: Inorg. Chem., 28, 4623 (1989);<br></p>

<p>Applications Isotope labelled 2,4-Dihydroxybenzophenone is an metabolite of Benzophenone (B204980), an compound used in the manufacturing of antihistamines, hypnotics and insecticides.<br>References Li, M.H., et al.: Toxicol. Environ. Chem., 94, 566 (2012); Leon, Z.. et al.: Anal. Bioanal. Chem., 398, 831 (2010); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008);<br></p>

<p>Applications Isotope labelled 4-Chlorobenzoic Acid is a benzoic acid analogue that showed antifungal activity against strains of Aspergillus flavus, Aspergillus fumigatus and Aspergillus terreus, causative agents of human aspergillosis, in in vitro bioassays. It is used as a preservative.<br>References Rep, M., et al.: J. Biol. Chem., 275, 8290 (2000), Jaeger, T., et al.: Biofactors, 27, 109 (2006), Kim, J., et al.: Fungal Biology, 114, 817 (2010),<br></p>

<p>Applications (±)-Diclofop is an Acetyl-CoA carboxylase (ACCase) inhibiting herbicide.<br>References Zhang, H., et al.: Proc. Natl. Acad. Sci. U.S.A., 101, 5910 (2004); Yu, Q., et al.: Plant Physiol., 145, 547 (2007);<br></p>

<p>Applications Imidaclothiz is an action body of nicotinic acid acetylcholinesterase enzyme acceptor. It can be used as a pesticide. After pests contact the product, the normal conduction of their central nerves is inhibited and pests are numbed to death.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jeschke, P., et al: PCT Int. Appl. (2009), WO 2009135613 A1 20091112; Kagabu, S., et al.: J. Agricultural Food Chem., 55, 812 (2007); Wang, Y., et al.: Pest Management Sci., 68, 1564 (2012)<br></p>

<p>Applications L-Leucic Acid-d3 is the isotope labelled analog of L-Leucic Acid, a reagent in the synthesis of cryptophycins based macrocyclic depsipeptides which are used as tubulin inhibitors.<br>References Kumar, A., et al.: Eur. J. Med. Chem., 93, 55 (2015)<br></p>

<p>Applications A major metabolite of Sulfadiazine.<br>References Woolley, J., et al.: Drug Metab. Dispos., 7, 94 (1979), Nielsen, P., et al.: Biochem. Pharmacol., 35, 2509 (1986), Anari, M., et al.: Anal. Chem., 76, 823 (2004), Edlund, P., et al.: J. Pharm. Biomed. Anal., 34, 1079 (2004),<br></p>

<p>Applications Alginic Acid is used in the synthesis of tissue engineering, or vesicles for drug delivery.<br>References Augst, A. et al.: Macromol. Bio. 6, 623 (2006); Chen, S. et al.: J. Contorl. Rel., 96, 285 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications Organic reagent used to synthesize phthalates.<br>References Duchowicz, P.R., et al.: Bioorg. Med. Chem., 16, 7944 (2008), di Luccio, E., et al.: Biochem., 47, 4039 (2008), Lopez, Z., et al.: App. Microbiol. Biotechnol., 78, 739 (2008), Hong, Y., et al.: Toxicol. Lett., 184, 139 (2009),<br></p>

<p>Applications Labelled fluorinated quinolone antibacterial.<br>References Monk, J.P., et al.: Drugs, 33, 346 (1987), Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>

<p>Applications A reagent used in the preparation of hepatitis C virus NS3 protease inhibitors and PMPA prodrugs with antiretroviral activity.<br>References Sheng, X. et al.: Bioorg, Med. Chem. Lett., 169, 3453 (2009); Arimilli, M.N. et al.: Antiviral Chem. Chemother., 8, 557 (1997);<br></p>

<p>Applications Ethacrynic Acid is a diuretic used to treat high blood pressure and swelling caused by congestive heart failure, liver failure and kidney failure.<br>References Beyer, et al.: J. Pharmacol. Exp. Ther., 147, 1 (1965); Kim., et al.: Am. J. Cardiol., 27, 407 (1971); Williamson, H.E., et al.: J. Clin. Pharmacol., 17, 663 (1977);<br></p>

<p>Applications Clindamycin 2-Phosphate Sulfoxide is a degradation product of Clindamycin phosphate (C580005) after the stressing test.Clindamycin phosphate impurity.<br></p>

<p>Impurity USP Cefdinir Related Compound A Sodium Salt<br>Stability Hygroscopic<br>Applications (2(R)-2-[(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-2-[(2RS,5RS)-5-methyl-7-oxo-2,4,5,7-tetrahydro-1H-furo[3,4-d][1,3]thiazin-2-yl]acetic Acid is an impurity in the synthesis of Cefdinir (C242670), a Cephalosporin antibiotic structurally similar to Cefixime (C242800).<br>References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),<br></p>

<p>Applications Glecaprevir is an antiviral drug used in the treatment of patients with hepatitis C virus (HCV) genotype 1-6, of special interest for the treatment of patients with chronic kidney disease also suffering from HCV.<br>References Kwo, P., et. al.: J. Hepatol, 67, 263 (2017)Gane, E., et. al.: N. Engl. J. Med, 377, 1448 (2017)<br></p>

<p>Applications Ketoconazole-d3 is the labeled analogue of Ketoconazole (K186000), which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986); Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989); Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988); Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>

<p>Applications Olodaterol is a long acting β-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD).<br>References Cazzola, M., et al.: Pharmacol. Rev., 64, 450 (2012); Bouyssou, T., et al.: Bioorg. Med. Chem. Lett., 20, 1410 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Semisynthetic aminoglycoside antibiotic derived from Kanamycin A. Antibacterial.<br>References Cabana, T., et al.: Antimicrob. Agents Chemother., 3, 478 (1973), Cappelletti, L.M., et al.: J. Antibiot., 36, 328 (1983), Monteleone, P.M., et al.: Anal. Profiles Drug Subs., 12, 37 (1983),<br></p>

<p>Applications Phensuximide is an anticonvulsant drug, used in the treatment of neurological disorders stemming from the brain. Antiepileptic.<br>References Ferrendelli, J. et al.: Annals Neuro., 5, 533 (1979); Bruno-Blanch, L. et al.: Bioorg. Med. Chem. Lett., 13, 2749 (2003);<br></p>

<p>Applications Alodane (cas# 2550-75-6) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications An active metabolite of Glimepiride (G410150).<br>References Groop, L., et al.: Diabetes Care, 15, 737 (1992), Muller, G., et al.: Diabetes, 42, 1852 (1993), Kramer, W., et al.: Biochem. Biophys. Acta, 119, 278 (1994),<br></p>

<p>Applications Labelled analogue of Flucloxacillin, a semisynthetic penicillin.<br>References Markovich, M. et al.: Antibiot. Med. Biotekhnol., 31, 603 (1986); Rahman, M. et al.: Biochem. Pharmacol., 46, 1721 (1993); Silva, D. et al.: Med. Biol. Res., 37, 963 (2004);<br></p>

<p>Applications Isotope labelled o-Cresol is a compound used as a disinfectant and have also been used as antiseptic in surgery.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Razavi, S.M., et al.: Nat. Prod. Res., 26, 2148 (2012); Asadollahi-B. M., et al.: Environ. Toxicol. Pharmacol., 34, 826 (2012);<br></p>

<p>Applications A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem., 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005), Bergman, A., et al: Clin. Ther., 28, 55 (2006).<br></p>

<p>Applications cis-Tetrahydrophthalimide is an intermediate to synthesize cis-Captafol (C175740), which was used as a fungicide.<br>References Knight, A., et al.: Regulatory Toxicol. Pharmacol., 55, 188 (2009); Rotroff, D., et al.: J. Toxicol. Environ. Health Part B Critical Rev., 13, 329 (2010)<br></p>

<p>Applications A Labelled metabolite of Dextrorphan.<br>References Gonzalez, F., et al.: Nature, 331, 442 (1988), Meyer, U., et al.: Pharmacol. Ther., 46, 297 (1990), Rogers, J., et al.: Am. J. Med., 113, 746 (2002), Huang, W., et al.: Drug Metab. Dispos., 32, 1434 (2004),<br></p>

<p>Applications 1-Hydroxypyridine-2-thione Zinc is a fungicide; used in preparation of UV antibacterial and mildew-proof topcoat with better yellowing resistance and wear resistance.<br>References Feng, S., et al.: Faming Zhuanli Shenqing, (2021);<br></p>

<p>Applications Controlled substance (opiate). Used in treatment of opioid dependence.<br>References Bishara, R.H., et al.: Anal. Profiles Drug Subs., 3, 365 (1974), Senay, E.C., et al.: Int. J. Addict., 20, 803 (1985), Inturrisi, C.E., et al.: Clin. Pharmacol. Ther., 41, 392 (1987), Sees, K.L., et al.: J. Am. Med. Assoc., 283, 1303 (2000),<br></p>

<p>Applications An active insecticidal constituent of pyrethrum flowers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Okey, A., et al.: Pharmacol. Ther., 45, 241 (1990), Barter, R., et al.: Toxicol. Appl. Pharmacol., 113, 36 (1992), Hood, A., et al.: Toxicol. Sci., 49, 263 (1999),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of (-)-Emtricitabine (E525000).<br>References Paff, M. et al.; Antimicrob. Agents Ch. 38, 1230 (1994)<br></p>

<p>Impurity Lamivudine EP Impurity A<br>Stability Hygroscopic<br>Applications Lamivudine Acid (Lamivudine EP Impurity A) is an impurity of Lamivudine (L172500). Impurity A per European Pharmacopoeia.<br>References Dwyer, O., et al.: Synlett, 11, 1163 (1995),<br></p>