Toxicology

<p>Applications A metabolite of Demeton-S (D231360).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Szeto, S.Y., et al.: J. Agric. Food Chem., 30, 1082 (1982),<br></p>

<p>Applications A deuterated 4-chloro Bupropion (B689625) analogue used in the preparation of compounds for indirect dopamine agonist pharmacotherapy for treating cocaine, methamphetamine, nicotine, and other drugs of abuse addiction.<br>References Carroll, F.I. et al.: J. Med. Chem., 52, 6768 (2009);<br></p>

<p>Applications Plumbagin-d3 is labelled Plumbagin (P627000) which induces apoptosis in cancer cells. It also inhibits NADPH oxidase 4 in a time- and dose-dependent manner.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klotz, L., et al.: Molecules, 19 14902 (2014); Gupta, S., et al.: Cancer Metastasis Rev., 29, 405 (2010); Schramm, A., et al.: Vascul. Pharmacol., 56, 216 (2012)<br></p>

<p>Applications A metabolite of Bufuralol, a β-Adrenergic blocker with peripheral vasodilating activity.<br>References Francis, R.J., et al.: Eur. J. Clin. Pharmacol., 23, 529 (1982), Pringle, T.H., et al.: Br. J. Clin. Pharmacol., 22, 527 (1986),<br></p>

<p>Applications Afatinib N-Oxide is a derivative of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.<br>References Ham, J. et al.: Cancer Cell., 29, 159 (2016);<br></p>

<p>Applications Desamino Chloro Carbamazepine-d2 is an intermediate in the synthesis of Carbamazepine-d2,15N (C175841), the labeled analogue of Carbamazepine (C175840), used in treatment of pain associated with trigeminal neuralgia. Anticonvulsant.<br>References Stenger, E.G., et al.: Med. Exp., 11, 191 (1964), Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979), Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)<br></p>

<p>Applications 4-Methylsulfonyl-2-nitrobenzoic acid is a metabolite of Mesotrione.<br>References Guengerich, F., et al.: Drug Metab. Rev., 34, 607 (2002), Kurian, J., et al.: Chem. Res. Toxicol., 19, 1366 (2006), Yang, C., et al.: Biotechnol. Lett., 29, 487 (2007), Beaudegnies, R., et al.: Bioorg. Med. Chem., 17, 4134 (2009),<br></p>

<p>Applications Thiamine Hydrogen Succinate is an intermediate in the synthesis of Vitamin B1 O-Succinic Acid-N-Hydroxy Succinimide which is a useful synthetic intermediate and a related compound of thiamine (T344185). Thiamine or vitamin B1 is an essential nutrient required for carbohydrate metabolism and it is also involved in nerve function.<br>References Kawaski, T., et al.: Methods Enzymol., 122, 15 (1986); Mascher, H., et al.: J. Pharm. Sci., 82, 56 (1993)<br></p>

<p>Applications Isotope labelled cis-5-Dodecenoyl Carnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases especially glucose related ones.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007);<br></p>

<p>Applications O-Desmethyl-N-deschlorobenzoyl Indomethacin-d3, is the labeled analogue of O-Desmethyl-N-deschlorobenzoyl Indomethacin (D291620), a metabolite of Indomethacin (I641000).<br>References O'Brien, W., et al.: Clin. Pharmacol. Ther., 9, 94 (1968), Duggan, D., et al.: J. Pharmacol. Exp. Ther., 181, 563 (1972), Abourashed, E., et al.: Curr. Med. Chem., 6, 359 (1999), Chatterjee, P., et al.: J. Nat. Prod., 62, 761 (1999);<br></p>

<p>Applications 2,3,4-Tri-O-benzoyl Propofol-β-D-glucuronide Methyl Ester is a compound useful in organic synthesis.<br></p>

<p>Applications 7-Chlorokynurenic acid is an NMDA receptor antagonist and inhibitor of EAAT.<br></p>

<p>Applications Clothianidin-d3, 13C1 is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),<br></p>

<p>Applications Tetrahydrocortisol 21-O-(1-Ethoxy Ethyl) Ether-d6 is an isotope labelled intermediate in the synthesis of Tetrahydro Cortisone-d6 (T293377), which is a normal mammalian metabolite of Cortisone (C696500).<br>References Schneider, et al.: J. Biol. Chem., 183, 365 (1950), Barkemeyer, et al.: Appl. Microbiol., 8, 237 (1960),<br></p>

<p>Applications Sorbic Acid-13C2 is an isotope labelled compound of Sorbic Acid (S676890). Sorbic Acid is a naturally occurring organic compound first isolated from unripe berries. Sorbic acid has been used as a food preservative and as an inhibitor of Clostridium Botulinum bacteria in meat products in order to reduce the amount of nitrites which produce carcinogenic nitroamines.<br>References Van, M.C., et al.: Int. J. Food. Microbiol., 160, 124 (2012); Li, J., et al.: J. Am. Soc. Mass. Spec., 23, 1625 (2012);<br></p>

<p>Applications N-Methyl Esomeprazole-d3 is the isotope labelled analog of N-Methyl Esomeprazole (M304640); an impurity of Omeprazole (O635000) which a compound that binds covalently to proton pumps and inhibits gastric secretion. Also used as an antiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications Diquat Dibromide is a herbicidal desiccant.<br>References Ergin, N.: Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 48, 1465 (2020); Nagai, T.: J. Pestic. Sci., 44, 225 (2019)<br></p>

<p>Applications Oxymorphone-13Cd3 is the labelled analogue of Oxymorphone (Cat. O876800). This opiate can be used as a analgesic.<br>References Gimbel, J., et al.: Anesth. Analg., 99, 1472 (2004)<br></p>

<p>Applications Isotope labelled 4-Bromoaniline is a brominated aniline used as a building block in the preparation or pharmaceutial and organic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abdel-M. et al.: J. Org. Chem., 61, 3849 (1996); Sridhar, S.. et al.: Eur. J. Med. Chem., 36, 615 (2001);<br></p>

<p>Stability Hygroscopic<br>Applications Mycophenolic Acid β-D-Glucuronide Disodium Salt is A metabolite of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.<br>References Senda, M., et al.: Transplantation, 60, 1143 (1995); Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996); Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999)<br></p>

<p>Applications Testosterone derivative. Controlled substance.<br></p>

<p>Applications Acetophos is used as an insecticide.<br>References Saito, T., et al.: Bochu Kagaku. 31, 77 (1966)<br></p>

<p>Applications Isotope labelled 1,2-Phenylenediamine, an amino substituted benzene used in the manufacture of dyes. Potential use in sensitive immunosensor for cancer biomarker.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wu, Y. et al.: Anal. Bioanal. Chem., 400, 2141 (2011); Du, D. et al.: Anal. Chem., 82, 2989 (2010);<br></p>

<p>Applications Selective pre- and post-emergence herbicide. A restricted use pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bradford, D., et al.: Environ. Sci. Technol., 44, 4609 (2010), Trtic-Petrovic, T., et al.: Anal. Bioanal. Chem., 397, 2233 (2010), Stewart, C., et al.: Weed Biol. Man., 10, 40 (2010),<br></p>

<p>Applications Isotope labelled (R,R,S,R)-Nebivolol Hydrochloride is a stereoisomer of rac Nebivolol (N387900) which is a β1-Adrenergic blocker. Nebivolol is used as an antihypertensive.<br>References Van de Water, A., et al.: J. Cardiovasc. Pharmacol., 11, 552 (1988); De Cree, J., et al.: Angiology, 41, 95 (1990)<br></p>

<p>Applications Triasulfuron<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications An anlogue of β-Carotene (C184250). Decapreno-β-carotene is used as an internal standard for the quantification of the hydrocarbon carotenoids by HPLC.<br>References Hemley, R., et al.: Biophysical J., 20, 377 (1977), Taylor, R.F, et al.: Methods Enzymol., 67, 233 (1980),<br></p>

<p>Applications 5R,6R-Benzylpenicilloate Disodium Salt is a derivative of Benzyl Penicillinate Potassium Salt (B288601), which is an antibiotic substance produced by Penicillium sp. Antibacterial.<br>References Fleming, A., et al.: Br. J. Exp. Pathol., 10, 226 (1929), Clutterbuck, P.W., et al.: Biochem. J., et al.: 26, 1907 (1932), Chain, E., et al.: Lancet, 2, 226 (1940),<br></p>

<p>Applications 2,2'-((6,6'-(2,4-Di(pyridin-2-yl)cyclobutane-1,3-diyl)bis(1H-indazole-6,3-diyl))bis(sulfanediyl))bis(N-methylbenzamide) is an impurity of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.<br>References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003), Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002), Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003),<br></p>

<p>Applications ((2S,3S,4R,5S)-4-Fluoro-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl Benzoate is an impurity of antiviral drug Clevudine (C574150), which is used for the treatment of Hepatitis B.<br>References Kwon, S., et al.: J. Virol., 84, 4494 (2010); Daga, P., et al.: Protein Sci., 19, 796 (2010);<br></p>

<p>Applications 10β-Hydroxyl Dextrorphan 3-O-β-D-Glucuronide is a metabolite of Dextrorphan.<br>References Thurman, E. Michael., et al.: J. Chrom. A., 1259, 158-166 (2012)<br></p>

<p>Stability Air Sensitive<br>Applications MGK 11 is an insect repellent most commonly used commercially as a mosquito repellent.<br>References Rutledge, L., et. al.: J. Med. Entomol., 20, 506 (1983);Steltenkamp, R., et. al.: Eur. Pat. Appl. 9 pp. Patent (1994) CODEN:EPXXDW;Buescher, M., et. al.: J. Med. Entomol., 19, 176 (1982)<br></p>

<p>Applications Fluoxetine (F597100) derivative. A stereoselective inhibitor of serotonin re-uptake and phosphodiesterase. Potential antidepressants<br>References Cashman, J. et al.: Bioorgan Med. Chem. 17, 337 (2009)<br></p>

<p>Applications N-Nervonoyl Taurine is a metabolite from an active fraction of Cajanus cajan seeds which could be an antioxidant.<br>References Tekale, S., et al.: Food Chem., 211, 763-769 (2016)<br></p>

<p>Applications Propicillin, is a derivative of penicillin. Properties are similar to benzylpenicillin particularly used in streptococcal infections, not resistant to penicillinase.<br>References Fleming, A., et al.: Br. J. Exp. Pathol., 10, 226 (1929), Clutterbuck, P.W., et al.: Biochem. J., et al.: 26, 1907 (1932), Chain, E., et al.: Lancet, 2, 226 (1940),<br></p>

<p>Applications Deethylterbutryne-d9 is the deuterium labelled form of Deethylterbutryne (D228585), which is a pollutant and degradation product of herbicide Irgarol (I764100).<br>References Konstantinou, I., et al.: Environ. Sci. Technol., 35, 398 (2001); Thomas, K., et al.: Sci. Total Environ., 293, 117 (2002); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009);<br></p>

<p>Applications An antitussive. Controlled substance (opium derivative).<br>References Kabayashi, S., et al.: Arzneim.-Forsch., 20, 43 (1970), Yanagita, T., et al.: Bull. Narc., 29, 33 (1977),<br></p>

<p>Applications O-Methyl Oxazepam is an impurity of Oxazepam (O845700), which is an anxiolytic; muscle relaxant (skeletal); anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Controlled substance (depressant).<br>References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Sisenwine, et al.: Arzneim. Forsch., 22, 682 (1972), Shearer, C.M., et al.: Anal. Profiles Drug Subs., 3, 441 (1974), Greenblatt, D.J., et al.: Clin. Pharmacokinet., 6, 89 (1981),<br></p>

<p>Applications 7-Methyltryptophol is a metabolite of Tryptophan (T947200), an essential amino acid.<br>References Liu, F., et al.: Bioorg. Med. Chem., 18, 4167 (2010), Kumar, R., et al.: Eur. J. Med. Chem., 45, 2265 (2010), Cai, W., et al.: Bioorg. Med. Chem., 18, 1899 (2010),<br></p>

<p>Applications 5-cis-Tetradecenoyl-d3 Carnitine is labelled 5-cis-Tetradecenoyl Carnitine (T291425) which is one of the metabolites found in the lymph fluid collected from dietary stressed rats.<br>References Ardawi, M., et al.: Biochem. J., 212, 835 (1983), Otton, R., et al.: J. Endocrinol., 174, 55 (2002), Gu, H., et al.: Anal. Chem., 79, 89 (2007),<br></p>

<p>Applications Contact herbicide used also to produce desiccation and defoliation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Brian, et al.: Nature, 181, 446 (1958), Gaines, T.B., et al.: Fundam. Appl. Toxicol., 7, 299 (1986),<br></p>

<p>Applications Diethyl 2-(methylthio)-4,5-pyrimidinedicarboxylate<br></p>

<p>Applications 9-Methylstreptimidone is a member of the glutarimide family that exhibits antifungal and prophylactic antiviral activity.<br></p>

<p>Applications [1,3]Dioxolo[4,5-g]cinnolin-4-ol is an intermediate used in the synthesis of Cinoxacin (C475700), which is an antibacterial quinolone previously known for its use in the treatment of urinary tract infections.<br>References Vargas, F. et al.: Toxicol. Mec. Meth., 13, 221, (2003); Vargas, F. et al.: J. Photochem. Photobiol. B., 92, 83 (2008); Sisca, T. et al.: Drugs., 25, 544 (1983);<br></p>

<p>Applications A Nicotine metabolite. Carcinogen.<br></p>

<p>Stability Hygroscopic<br>Applications Raloxifene 6-Glucuronide Lithium Salt is A metabolite of Raloxifene (R100000), a nonsteroidal estrogen receptor mixed agonist/antagonist.<br>References Dodge, J., et al.: Bioorg. Med. Chem. Lett., 7, 993 (1997); Jeong, E., et al.: Drug Metab. Dispos., 33, 785 (2005); Trontelj, J., et al.: Pharmacol. Res., 52, 334 (2005); Oswald, S., et al.: Clin. Pharmacol. Ther., 79 206 (2006)<br></p>

<p>Applications Clindamycin 3-Palmitate Hydrochloride, is an impurity in the synthesis of Clindamycin Palmitate Hydrochloride (C580035), a semi-synthetic antibiotic with high bioavailability. Clindamycin Palmitate is an antibacterial.<br>References Bharathi, Ch. et al.: J. Pharm. Biomed. Anal., 48, 1211 (2008); Platzer, D., et al.: J. Pharm. Biomed. Anal., 41, 84 (2006);<br></p>