Toxicology

Applications Anastrozole Acid Amide is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic.
References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)

Applications Labelled Talinolol. Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.
References Assmann, I., et al.: Curr. Med. Res. Opin., 13, 325 (1995), Trausch, B., et al.: Biopharm. Drug Dispos., 16, 403 (1995),

Stability Light Sensitive
Applications alpha-Tocotrienol is an antioxidant.

Applications Testosterone 17β-Carboxylic Acid is an intermediate in the synthesis of the drugs Dutasteride (D735000) and Finasteride.
References Brooks, J., et al.: Annu. Drug Data Rep., 14, 996 (1992), Lam, J., et al.: Urology, 61, 354 (2003), Tarter, T., et al.: Curr. Pharm. Des., 12, 775 (2006), Aggarwal, S., et al.: Steroids, 75, 109 (2010),

Applications A labelled antipruritic. Antibacterial, antimicrobial agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Robinson, et al.: J. Pharm. Pharmacol., 18, 19 (1966); Abdel-Moety, E., et al.: Eur. J. Pharm. Sci., 5, 1 (1997); Basavaiah, K., et al.: Chem. Pharm. Bull., 47, 1351 (1999);

Applications Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic.
References Yamamoto, M., et al.: Neuropharmacology, 21, 945 (1982), Grewe, C.W., et al.: Eur. J. Pharmacol., 81, 149 (1982), Satoh, K., et al.: Int. Clin. Psychopharmacol., 11, 279 (1996)

Applications Lofentanil is a very potent and long-acting opiate agonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lembeck, F., Donnerer, J.: Eur. J. Pharmacol., 114, 241 (1985)

Applications The main basic metabolite of Diethylpropione.
References Banci, F., et al.: Arzneim.-Forsch., 21, 1616 (1971), Mikhailova, D., et al.: Eur. J. Med. Chem., 13, 49 (1978),

Applications Flurbiprofen (1S,2R,5S)-(+)-Menthyl Ester is an isomer version of Flurbiprofen rac-Menthyl Ester (M221723), a Flurbiprofen (F598700) derivative. Flurbiprofen is an anti-inflammatory used as an analgesic
References Chalmers, et al.: Ann. Rheum. Dis., 31, 319 (1972), Nishizawa, et al.: Thromb. Res., 3, 577 (1973)

Applications 1,2,4,5-Tetrahydrotestolactone is a steroid with estrogenic properties. A steroid lactone.
References Pollard, I., et al.: Steroids, 11, 897 (1968), Volovel'skii, L. N., et al.: Zh. Obshch. Khim., 43, 1414 (1973)

Impurity Fluocinolone Acetonide EP Impurity I
Applications 14,15-Dehydro Fluocinolone Acetonide is an impurity of Fluocinolone Acetonide (F455800); a glucocorticoid and anti-inflammatory agent.
References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964); Emerson, M.V., et al.: BioDrugs, 21, 245 (2007)

Applications A metabolite of Quinidine.
References Small, D.L., et al.: J. Chem. Med., 22, 1014 (1979), Guentert, T.W., et al.: Eur. J. Drug Metab. Pharmacokinet., 7, 31 (1982), Rakhir, A., et al.: J. Pharmacokinet. Biopharm., 12, 1 (1984), Christie, D.J., et al.: J. Lab. Clin. Med., 112, 92 (1988),

Applications Mepanipyrim Phenyl-d5 is deuterium labelled Mepanipyrim (M223600).Mepanipyrim (M223600) is an anilinopyrimidine fungicide which have been used in the management of fungal diseases in strawberries.
References Tetada, M., et al.: Toxicol. Appl. Pharmacol., 154, 1 (1999); Hauke, K., et al.: Commun. Agri. Appl. Biol. Sci., 69, 743 (2004);

Applications An intermediate of SCH 51048, an antifungal agent.
References Lovey, R.G., et al.: Bioorg. Med. Chem. Lett., 12, 1739 (2002), Lovey, R., et al.: J. Med. Chem., 35, 4221 (1992),

Applications S 23 is a selective androgen receptor modulator.
References Thevis, M., et al.: Drug Testing and Analysis, 2, 589 (2010); Jones, A., et al.; Endocr., 150, 385 (2009)

Applications Antitumor agent.
References Morse, M., et al.: Cancer Res., 50, 2613 (1990), Staretz, M., et al.: Carcinogenesis, 18, 1715 (1997), Henderson, C., et al.: J. Biol. Chem., 278, 13480 (2003), Jalas, J., et al.: Chem. Res. Toxicol., 16, 794 (2003), Su, T., et al.: Toxicol. Appl. Pharmacol., 199, 285 (2004),

Applications rac-Glutethimide is a hypnotic sedative which was once used to treat insomnia. When taken with codeine, it has an intense euphoric effect on the subject due to the body’s increased ability to convert codeine to morphine.
References Popa, D., et al.: J. Pharmaceut. Biomed., 32, 867 (2002);

Applications cetohydrazide-D3 is a labelled analogue of Acetohydrazide (A163770). Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Metushi, I.G., et al.: Chem. Res. Toxciol., 25, 2567 (2012); Fukino, K., et al.: J. Toxicol. Sci., 33, 667 (2008)

Applications A hydroxylated analogue of Tamoxifen (T006000) with anti-estrogenic properties.
References Ruenitz, P.C. et al.: J. Med. Chem., 25, 1056 (1982)

Applications Pranoprofen is an anti-inflammatory used in ophthalmology.
References Ayaki, M., et al.: Biocont. Sci., 15, 97 (2010); Lee, X., et al.: For. Toxicol., 28, 96 (2010);

Applications A hydroxylated derivative of Voriconazole (V760000), a systemic antifungal and ergosterol biosynthesis inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sanati, H., et al.: Antimicrob. Ag. Chemother., 41, 2492 (1997).

Stability Hygroscopic
Applications GW 501516 Sulfone is a urinary metabolite of GW1516 (G931500), a drug candidate potentially enhancing athletic performance. GW 501516 Sulfoxide may be used or doping control purposes.
References Thevis, M., et. al.: Anal. Bioanal. Chem., 396, 2479 (2010)

Applications Testosterone 17-Decanoate, is an ester of Testosterone (T155000). Testosterone 17-Decanoate, can be used as a potential long-acting male contraceptive, with the combination of subcutaneous etonogestrel implants .
References Brady, B. M., et al.: Human Reproduction, 21 (1), 285 (2006); Themmen, A., et al.: Endocr. Rev. 21, 551 (2000);

Applications O-Hydroxyethyl Metronidazole is the hydroxy ethyl analogue and impurity of the antiprotozoal agent Metronidazole (M338880). O-Hydroxyethyl Metronidazole as well as other 1-substituted-2-methyl-5-nitroimidazoles showed potential antitrichomonal activity.
References Kajfez, F. et al.: J. Med. Chem., 11, 167 (1968);

Applications Labelled Nitisinone. Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.
References Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),

Impurity Fluconazole EP Impurity D
Applications 2-Desfluoro Fluconazole (Fluconazole EP Impurity D) is an impurity of the antifungal agent Fluconazole (F421000).
References Ramesh, B. et al.: J. Pharm. Res., 4, 1401 (2011); Al-Rimawi, F.: Jor. J. Chem., 4, 357 (2009);

Applications A protected metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.

Impurity Ampicillin EP Impurity A ; Amoxicillin USP Related Compound A
Applications (+)-6-Aminopenicillanic Acid (Amoxicillin EP Impurity A) is the core structure in penicillins, obtained from the fermentation brew of the Penicillium mold. (+)-6-Aminopenicillanic Acid is used as the main starting block for the preparation of numerous semisynthetic penicillins.
References Zel'tser, I.Z. et al.: Gig. Truda Prof. Zabol., 5, 59 (1983); Hamilton-Miller, J.M.T.: Int. J. Antimicrob. Agents, 31, 189 (2008); Novikova, N.D. et al.: Mikol. Fitopatol., 7, 101 (1973);

Applications Glutaurine Sodium Salt is the salt of Glutaurine (G597350) which has been observed to display antiepileptic effects with anti-amnesia properties. Mimics anxiolytic drug Diazepam (D416855).
References Bittner, S. et al.: Amino Acids., 28, 343 (2005); Uemura, S. et al.: Brain. res., 594, 347 (1992);

Applications Intermediate in the preparation of imidazole antifungal agents.
References Albet, C. et al.; J. Pharmaceut. Biomed. 10, 205 (1992); Raga, M. et al.; Eur. J. Med. Chem. 21, 329 (1986)

Applications Labelled δ-Tocopherol. One of the naturally occurring forms of Vitamin E. Isolated from soybean oil.
References Emerson, et al.: Science, 83, 421 (1936), Bieri, J.G., et al.: J. Nutr., 104, 850 (1974), Jiang, Q., et al.: Am. J. Clin. Nutr., 74, 714 (2001),

Applications Triethylamine Trihydrofluoride is used in the synthesis of modified siRNA’s in vivo used to inhibit hepatitis B replication (1). Used in RNA synthesis in the removal of t-butyldimethylsilyl protection (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Marimani M. et al.: Bioorg Med Chem. 2013 Oct 15;21(20):6145-55. 2. Westman, E. et al.: Nucleic Acids Res. 1994 Jun 25;22(12):2430-1

Applications A novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent.
References Sun, et al.: J. Med. Chem., 41, 4648 (1998), Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001),

Impurity Abacavir EP Impurity A
Applications ent-Abacavir (Abacavir EP Impurity A) is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Applications 3’-N-Didesmethyl-3’-N-tosyl Azithromycin is a derivative of Azithromycin (A927000, dihydrate) which is a semi-synthetic macrolide antibiotic.
References Langtry, H.D., et al.: Drugs, 56, 273 (1998)

Applications Second-generation cephalosporin antibiotic. Antibacterial.
References Gray, B.M., et al.: Antimicrob. Agents Chemother., 13, 988 (1978), Lorenz, L.J., et al.: Anal. Profiles Drug Subs., 9, 107 (1980), Hori, R., et al.: J. Pharm. Pharmacol., 40, 646 (1988),

Applications Sinigrine, is a glucosinolate which is found naturally in Cruciferae including the genus Brassica. When enzymatically hydrolysed, Sinigrine yields isothiocyanates and give a pungent taste. Both Sinigrine, and isothiocyanates, have been shown to have anticancer activity as well as antifungal and antibacterial properties.
References Cools, K., et al.: J. Chromatograohy B., 901, 115 (2012); Okullcz, M., et al.: Materiae Veg., 65 (3), 217 2010;

Applications Primary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal).
References Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 12, 547 (1983), Kremsner, P.G., et al.: J. Infect. Dis., 169, 467 (1994),

Impurity Ceftazidime EP Impurity A
Stability Hygroscopic, Light Sensitive
Applications ∆2-Ceftazidime, 90% (Ceftazidime EP Impurity A) is a Ceftazidime isomer, an impurity of Ceftazidime (C244100).
References Vilanova, B., et al.: Helv. Chim. Acta, 76, 2789 (1993), Zhou, M., et al.: J. Pharm. Sci., 84, 534 (1995), Baertschi, S., et al.: Chemother. 8, 353 (1997), Porra, R., et al.: J. Pharm. Biomed. Anal., 18, 241 (1998),

Applications 6-O-Des(6-Amino-α-D-gluocopyranosyl) Amikacin Sulfate is a derivative of Amikacin (A578500), semisynthetic aminoglycoside antibiotic derived from Kanamycin A. Antibacterial.
References Cabana, T., et al.: Antimicrob. Agents Chemother., 3, 478 (1973), Cappelletti, L.M., et al.: J. Antibiot., 36, 328 (1983), Monteleone, P.M., et al.: Anal. Profiles Drug Subs., 12, 37 (1983),