Toxicology

Stability Hygroscopic
Applications Fensulfothion Sulfone is a metabolite of the insecticide fensulfonthion (F265490), an inhibitor of cholinesterase activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Solly, S.R.B., et al.: New. Zea. J. Agri. Res., 14, 88 (1971); Hansch, C., et al.: Biochem. Toxicol. Insectic. Proc., 33 (1970);

Applications Antiemetic, antipsychotic; used in treatment of vertigo.
References Taylor, W.B., et al.: Br. J. Clin. Pharmacol., 23, 137 (1987), Ward, A.E., Br. J. Clin. Pract., 42, 228 (1988),

Applications A reagent used to synthesize various dyes used in the textile industry. This is the labeled analog.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rosenkranz, H.S. et al.: Mutagen., 5, 137 (1990);

Stability Hygroscopic
Applications A metabolite of Deferiprone (D474000).
References Choudhury, R., et al.: Drug Metab. Dispos., 23, 314 (1995),

Applications Platycodin D is a known inhibitor of the proliferation of human gastric cancer cells as well as inducing apoptosis. It also causes anti-atherosclerotic.
References Wu, J. et al.: Biol. Pharm. Bull. 35, 1216 (2012); Chun, J. et al.: J. Cell. Biochem., 114, 456 (2013);

Applications Veratramine is useful as signal transduction inhibitor for treating tumors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Imamura, L., et al.: J. Trad. Med., 12, 129 (1995), Ingolfsdottir, K., et al.: Antimicrob. Agents. Chemother., 1997, 41, 215 (1997), Tezuka, Y., et al.: J. Nat. Prod., 61, 1397 (1988)

Applications (3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptane acid (+)-phenylethylamine salt (CAS# 147511-70-4) is a useful research chemical compound.

Applications Tyloxapol, is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity.
References Sehgal, S. S., et al.: J. National Med. Assoc., 86 (1), 46 (1994); Rubin, B. K., et al.: 101 (4), 1080 (1992);

Applications Tolfenpyrad is used as foliar insecticide for the control of green peach aphids in broccoli.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Thurman, E., et al.: Food Addit. Contam., 23, 1169 (2006), Mezcua, M., et al.: Food Chem., 112, 221 (2009)

Applications Acetochlor ESA Sodium Salt is an amido sulfonate compound for proteomics research.
References Zhang, Q., et al.: Science of Total Environment, 580, 1268-1275 (2017);

Applications Thiometon Sulfoxide is a metabolite from Thiometon (D231370) pesticides, used as an insecticide. Cholinesterase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Edson, E.F., et al.: Pharm. J., 185, 365 (1960), Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1765 (2007), Mezcua, M., et al.: Anal. Chem., 81, 913 (2009),

Applications Oleuropein Aglycone is a natural phenol that is abundant in extra virgin olive oil. Studies show that Oleuropein Aglycone could provide protective and therapeutic effects against a number of pathologies including Alzheimer's disease, as well as obesity, type 2 diabetes, and non-alcoholic hepatitis.
References Casamenti, F., et al.: J. Alzheimers Dis., 45, 679 (2015)

Applications A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),

Applications Succinic Acid-1,4-13C2 (cas# 79864-95-2) is a compound useful in organic synthesis.

Stability Temperature sensitive
Applications O4-Desacetyl Vinblastinic Acid is an impurity of Vinblastine Sulfate (V314000), an Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.
References Lu, C., et al.: Cancer Research, 39, 3575 (1979), Gobbi, P.G., et al.: J. Clin. Oncol., 14, 527 (1996), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs. Excip., 21, 611 (1992),

Stability Light Sensitive
Applications 1,2,3,6-Tetrahydrophthalimide, is shown to be urinary metabolites of the fungicide Captan (C175725) in rat and humans.
References Van Welie, R. T. H., et al.: Int. Archives. Ocuup. Envir. Health, 63, 181 (1991); Afful, S., et al.: Res. J. App. Sci., Eng. Technol., 2, 592 (2010);

Applications rac-Paroxetine-d4 Hydrochloride is a racemic labeled analogue of Paroxetine Hydrochloride (P205750), a selective serotonin reuptake inhibitor. Used as an antidepressant.
References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978); Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982)

Stability Hygroscopic
Applications Labelled Fluoxastrobin (F596700). Leaf-systemic broad-spectrum fungicide for use in cereal and food crops; member of methoxy-imiodihydro-dioxazines. Agricultural fungicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Milus, E., et al.: Plant Dis., 78, 697 (1994), D'Mello, J., et al.: Eur. J. Plant Pathol., 104, 745 (1998), Domijan, A., et al.: Food Addit. Contam., 22, 677 (2005),

Applications Amino acid substitute tumor growth.
References Villiers, C.L., et al.: Eur. J. Biochem., 140, 421 (1984);

Stability Hygroscopic
Applications Metazachlor Ethane Sulfonic Acid-d6 Sodium Salt is deuterium labelled form of Metazachlor Ethane Sulfonic Acid Sodium Salt (M226233), which is a metabolite of chloroacetanilide herbicide Metazachlor (M225855).
References Laue, H., et al.: Environ. Sci. Technol., 30, 1129 (1996); Matthies, M., et al.: Environ. Sci. Technol., 43, 9223 (2009); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010); Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010);

Applications 3,4-Dimethyl-2,6-dinitroaniline is a metabolite and a degradation product of the herbicide pendimethalin.
References Kole, R. K., et al.: Bull. Environ. Contam. Toxicol., 52, 779 (1994); Singh, S. B., et al.: J. Environ. Sci. Health B., B26, 309 (1991)

Stability Very Hygroscopic
Applications Labelled Metaproterenol (M225835). Bronchodilator.
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),

Applications 2,2-Difluoro-1,3-benzodioxole-4-carboxylic acid
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Labelled 5-FU, a potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 221 (1973), Miyashita, O., et al.: Chem. Pharm. Bull., 29, 3181 (1981), Hansen, R.M., et al.: Cancer Invest., 9, 637 (1991),

Stability Hygroscopic
Applications L-Penicillamine Hydrochloride is a salt form of L-Penicillamine (P2230005). L-Penicillamine is a metabolite of penicillin. L-Penicillamine is used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.
References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010), Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010),

Applications Third generation synthetic pyrethroid. Insecticide, acaricide. Useful in cannabis testing kits as a component in pesticide mixes (P698230).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),

Stability Hygroscopic
Applications Labelled Fenoterol (F248850). An β2-adrenergic agonist. Bronchodilator; tocolytic.
References Schuster, B., et al. Arzneim.-Forsch., 19, 1905 (1969), Gerris, J., et al.: Eur. J. Clin. Pharmacol., 18, 443 (1980), Heel, R.C., et al.: Drugs, 15, 3 (1978),

Applications 3-Methyl-4-(methylthio)phenol is a metabolite of Fenamiphos (F245700), a Systemic broad spectrum nematocide with anticholinesterase activity. Nematocide.
References Simon, L., et. al.: J. Agr. Food Chem., 40, 312 (1992); Brown, M.J., et al.: J. Agric. Food Chem., 29, 1129 (1981); Read, D.C., et al.: J. Econ. Entomol., 69, 429 (1976)

Applications Skeletal muscle relaxant.
References White, R.L., et al.: J. Med. Chem., 30, 263 (1987)

Stability Hygroscopic
Applications A metabolite of 1-Naphthol.
References Redegeld, F., et al.: J. Pharmacol. Exp. Ther., 244, 263 (1988), Lohr, J., et al.: Pharmacol. Rev., 50, 107 (1998), Yokota, H., et al.: Biochem. J., 340, 405 (1999), Daidoji, T., et al.: Drug Metab. Dispos., 31, 993 (2003),

Applications Mydriatic.
References Bhargava, K., et al.: Br. J. Pharmcol., 24, 641 (1965), Bolton, T., et al.: J. Physiol., 570, 5 (2006),

Applications (-)-Carbovir, is a nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) caused mitochondrial toxicity in human hepatoma carcinoma cell.
References Suo, Z., et al.: J. Biol. Chem., 273, 27250 (1998), Ray, A., et al.: Antimicrob. Agents Chemother., 48, 1089 (2004), Lynx, M., et al.: Biochem. Pharmacol., 71, 1342 (2006),

Applications Teflubenzuron is an benzoylphenylurea chitin synthesis inhibitor used to control a wide range of insect pests and mites in fruit, vegetable, cereal and seed crops. Teflubenzuron is used in cannabis testing kits as a component of pesticide mixes (P698240).
References Carro, A.M., et al.: J. Separat. Sci., 35, 2866 (2012); Brock, T.C.M., et al.: Environ. Sci. Pollu. Res., 19, 3610 (2012);

Applications Imazamethabenz-methyl is used in combined herbicides formulations, screening pesticides in foods using gas chromatography and mass spectrometry.
References Hansen, P., et al.: Den., Util. Model Appl. (2010), DK 201000204 U1 20101112.; Yi, X., et al.: Sepu, 34, 1097 (2016)

Applications N-Nitrosodiisopropylamine ia a nitrosoamine compound that shows carcinogenic effect.
References Scanlan, R., et al.: Cancer Res., 43, 2435 (1983), Spiegelhalder, B., et al.: Carcinogenesis, 4, 1147 (1983), Lijinsky, W., et al.: Mutat. Res., 443, 129 (1999), Robichova, S., et al.: Chem. Biol. Interact., 148, 163 (2004)

Applications Ketorolac-d5 is a labeled analogue of Ketorolac, a Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
References Rooks, W.H., et al.: Agents Actions, 12, 684 (1982); Guzman, A., et al.: J. Med. Chem., 29, 589 (1986); McQuary, H.J., et al.: Clin. Pharmacol. Ther., 39, 89 (1986)

Applications A labelled analog of Lorazepam (L469850). Sedative, hypnotic.Controlled substance (depressant).
References Nudelman, A., et al.: J. Pharma. Sci., 63, 1886 (1974), Humpel, M., et al.: Eur. J. Drug Metab. Pharmacokinet., 4, 237 (1979), Girkin, R., et al.: Xenobiotica, 10, 401 (1980),

Applications A metabolite of Testosterone (T155000).CONTROLLED SUBSTANCE
References Brandon, E., et al.: Toxicol. Appl. Pharmacol., 189, 233 (2003), Froehlich, A., et al.: Drug Metab. Dispos., 33, 1532 (2005), Schmelzer, E., et al.: Xenobiotica, 6, 693 (2006), Jasmund, I., et al.: Biomol. Eng., 24, 59 (2007),

Applications Acetohexamide is a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.
References Yu, T-F. et al.: Metab. Clin. Exp., 17, 309 (1968); Harrower, A.D.B. et al.: Clin. Pharmacokin., 31, 111 (1996); Hirota, Y. et al.: Diab. Med., 26, 948 (2009);

Applications A metabolite of Mycophenolic acid (phase 1 metabolite).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nowak, I., et al.: Ther. Drug Monit., 19, 358 (1997), Bullingham, R., et al.: Clin. Pharmacokinet., 34, 429 (1998), Van Gelder, T., et al.: Ther. Drug Monit., 23, 119 (2001), Wen, X., et al.: Drug Metab. Dispos., 30, 631 (2002), Shipkova, M., et al.: Ther. Drug Monit., 25, 1,(2003),

Stability Hygroscopic
Applications 3-Hydroxyhexadecanoylcarnitine Inner Salt is a derivative of Carnitine, essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Also 3-Hydroxyhexadecanoylcarnitine works similar to the endogenous non-toxic molecule L-Carnitine (C184110) whose bioavailablity is improved due to the transport systems in place for Carnitine.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978), Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001), Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002), Karlic, H., et al.: Nutrition, 20, 709 (2004), O. Piermatti. et al.: Bioorg. Med. Chem., 16, 1444 (2008);

Applications Febuxostat-d7, is the labeled analogue of Febuxostat-d7 (F229000), a Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.
References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),

Stability Hygroscopic
Applications 5-Aminoimidazole-4-carboxamide Lactose Adduct is a lactose adduct of 5-Aminoimidazole-4-carboxamide (A611690), a metabolite of Temozolomide (T017775).
References Jaeken, J., et al.: Lancet, 2, 1058 (1984), Baggott, J., et al.: Biochem. J., 236, 193 (1986), Baggott, J., et al.: Arch. Dermatol., 135, 813 (1999)

Applications A metabolite of polycyclic aromatic hydrocarbons in humans.
References Jacob, J., et al.: Xenobiotica, 12, 45 (1982), Becher, G., et al.: Cancer Lett., 17, 301 (1983), Hoffmann, D., et al.: Cancer Treat. Res., 72, 1 (1995), Einolf, H., et al.: Chem. Res. Toxicol., 10, 609 (1997),

Applications Bone metabolism modulator; inhibits bone resorption while maintaining bone formation. Antiosteoporotic.
References Buehler, J., et al.: Bone, 29, 176 (2001), Henrotin, Y., et al.: J. Bone Miner. Res.,16, 299 (2001), Meunier, P.J., et al.: N. Engl. J. Med., 350, 459 (2004),

Applications Demeton is a phosphorothioate insecticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lehotay, S., et al.: J. AOAC Int., 88, 595 (2005); Henderson, C., et al.: J. Econ. Entomol., 48, 157 (1955)