
Toxicology
Found 13565 products of "Toxicology"
Brivaracetam-d7
CAS:Controlled ProductApplications Brivaracetam-d7, is the labeled analogue of Brivaracetam (B677645), which is a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.
References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007);Formula:C11H13D7N2O2Color and Shape:Off White SolidMolecular weight:219.334-(1,1-Dimethylpropyl)-α-methyl-benzenepropanal
CAS:Formula:C15H22OColor and Shape:NeatMolecular weight:218.33γ-Hydroxybutyric Acid Sodium
CAS:Controlled ProductApplications An agonist to both GHB and GABAB neural receptors, exhibiting neurotransmitter-like effects. It has been used as a general anesthetic in treatment for sleep disorders and clinical depression, but also has been identified as a “date rape drug”.
References Mamelak, M., et al.: Prog. Neurobiol., 89, 193 (2009), Zhang, L., et al.: App. Microbiol. Biotechnol., 84, 909 (2009), Pedraza, C., Int. J. Neuropsychopharmacol., 12, 1165 (2009), McGonigle, I., et al.: Biochem., 49, 2897 (2010),Formula:C4H7O3·NaColor and Shape:WhiteMolecular weight:126.086Aminoacetonitrile Hydrochloride
CAS:Controlled ProductApplications Aminoacetonitrile is a useful synthetic intermediate. It is a reagent used to synthesize dipeptide nitriles as reversible and potent cathepsin S inhibitors. It can also used to prepare substituted cyclic ureas as possible HIV protease inhibitors.
References Ward, Y., et al.: J. Med. Chem., 45, 5471 (2002); Wilkerson, W., et al.: J. Med. Chem., 40, 4079 (1997)Formula:C2H5ClN2Color and Shape:White To Off-WhiteMolecular weight:92.53Indoleacetic Acid
CAS:Controlled ProductApplications Indoleacetic Acid is the most common and naturally occuring plant hormone in the auxin class of hormones. It effects cell elongation, cell division as well as plant growth and development.
Formula:C10H9NO2Color and Shape:Off-White To Light BeigeMolecular weight:175.18Elvitegravir-d6 (Major)
CAS:Controlled ProductApplications A novel labelled inhibitor of human immunodeficiency virus type 1 integrase.
References Chou, T., et al.: Eur. J. Biochem., 115, 207 (1981), Baba, M., et al.: Antimicrob. Agents Chemother., 31, 1613 (1987), Craigie, R., et al.: J. Biol. Chem., 276, 23213 (2001), Chen, X., et al.: J. Mol. Biol., 380, 504 (2008),Formula:C23H17D6ClFNO5Color and Shape:NeatMolecular weight:453.91Flumethasone Acetate
CAS:Controlled ProductApplications An anti-inflammatory corticosteroid.
References Weber, D., et al.: J. Pharm. Sci., 61, 689 (1972), Biagi, G., et al.: J. Med. Chem., 18, 873 (1975),Formula:C24H30F2O6Color and Shape:NeatMolecular weight:452.493-Deazauridine
CAS:Controlled ProductApplications Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.
References Teh, A.-H., et al.: Biochemistry, 45, 7825 (2006),Formula:C10H13NO6Color and Shape:NeatMolecular weight:243.21Raltegravir
CAS:Controlled ProductApplications Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN.
References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)Formula:C20H21FN6O5Color and Shape:NeatMolecular weight:444.42Metalaxyl metabolit CGA 108906
CAS:Controlled ProductFormula:C14H17NO6Color and Shape:White To Off-WhiteMolecular weight:295.29Apixaban-13C, d3
CAS:Controlled ProductApplications Apixaban-13C, d3 is labelled Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.
References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);Formula:C2413CH22D3N5O4Color and Shape:Off WhiteMolecular weight:463.512'-Deoxyadenosine Monohydrate
CAS:Controlled ProductApplications 2'-Deoxyadenosine Monohydrate is used in the synthesis of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.
References Gordon, C., et al.: J. Med. Chem., 48, 1 (2005), Ikejiri, M., et al.: Bioorg. Med. Chem., 15, 6882 (2007),Formula:C10H13N5O3·H2OColor and Shape:NeatMolecular weight:269.26Deshydroxy Azide Cyclosporin
Controlled ProductFormula:C62H110N14O12Color and Shape:NeatMolecular weight:1243.62Sodium 2-((2-Ethyl-6-methylphenyl)amino)-2-oxoethanesulfonate
CAS:Controlled ProductApplications Sodium 2-((2-Ethyl-6-methylphenyl)amino)-2-oxoethanesulfonate is a pesticide metabolite found in surface water and groundwater. It is a degradation product of herbicide Acetochlor (A162500).
References Thurman, E., et al.: J. Chromatogr. A, 957, 3 (2002); Thurman, E., et al.: ACS Symp. Ser., 850, 128 (2003); Hamer, K., Freudenberger, U.: Wasser und Abfall, 13, 42 (2011); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);Formula:C11H14NO4S·NaColor and Shape:WhiteMolecular weight:279.29Retapamulin
CAS:Controlled ProductApplications Retapamulin is an antibacterial agent used as a substitute for the more commonly known Penicillin (P223505).
References Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Dunham, J.M., et al.: Anal. Profiles Drug Subs., 1, 249 (1972),Formula:C30H47NO4SColor and Shape:NeatMolecular weight:517.764-Hydroxymelatonin-d4
CAS:Controlled ProductFormula:C13D4H12N2O3Color and Shape:NeatMolecular weight:252.3Itraconazole-d9
CAS:Controlled ProductApplications Itraconazole-d9, is the labeled analogue of Itraconazole (I937500, an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M., et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),Formula:C35H29D9Cl2N8O4Color and Shape:Off-White To BeigeMolecular weight:714.69Gibberellic Acid, 90%
CAS:Applications Gibberellic Acid is a pentacyclic diterpene acid. Gibberellic Acid is a hormone that is found in plants which promotes the growth and elongation of cells. Gibberellic acid acts as a plant growth regulator on account of its physiological and morphological effects in extremely low concentrations. Generally Gibberellic acid affects only the plant parts above the soil surface.
References Bayle, J. et al.: Chem. Biol., 13, 99 (2006); Ihara, S. et al.: J. Cell Sci., 119, 500 (2006); Suh, B. et al.: Science, 314, 1454 (2006); Rinaudo, K. et al.: Nat. Biotechnol., 25, 795 (2007);Formula:C19H22O6Purity:90%Color and Shape:White To Off-WhiteMolecular weight:346.3711-Hydroxytestosterone-[9,11,12,12-D4]
CAS:Controlled ProductApplications 11-Hydroxytestosterone-[9,11,12,12-2H4] is a metabolite of Testosterone (T155000), a principal hormone of the testes, produced by the interstitial cells.
References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499Formula:C19H24D4O3Color and Shape:White To Off-WhiteMolecular weight:308.45CloBetasol
CAS:Impurity Clobetasol Propionate EP Impurity G / Betamethasone EP Impurity B
Applications Clobetasol (Clobetasol Propionate EP Impurity G) is a topical corticosteroid. Glucocorticoid; anti-inflammatory.
References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),Formula:C22H28ClFO4Color and Shape:NeatMolecular weight:410.91Ritonavir-d6
CAS:Controlled ProductFormula:C372H6H42N6O5S2Color and Shape:NeatMolecular weight:726.98Dopamine 3-Beta-D-Glucuronide Sodium Salt
CAS:Controlled ProductStability Hygroscopic
Applications A metabolite of Dopamine.
References Johnson, G., et al.: Life Sci., 26, 1591 (1980), Eisenhofer, G., et al.: J. Clin. Endocrinol. Metab., 82, 3864 (1997), Strassburg, C., et al.: Biochem. J., 338, 489 (1999), Alonen, A., et al.: Drug Metab. Dispos., 33, 657 (2005),Formula:C14H18NNaO8Color and Shape:NeatMolecular weight:351.28cis-trans Nepetalactone
CAS:Controlled ProductApplications cis-trans-Nepetalactone, is an organic compound, isolated from the plant catnip,which acts as a cat attractant. Nepetalactone can also be effective on some insects. It repels cockroaches and mosquitos.
References Kingsley, D, ABC Science Online, Feb 14, 2009; McElvain, S.M., et al.: J. Am.Chem.Soc, 63, 1558 (1941);Formula:C10H14O2Color and Shape:ColourlessMolecular weight:166.22Niclosamide Monohydrate
CAS:Controlled ProductFormula:C13H8Cl2N2O4·H2OColor and Shape:WhiteMolecular weight:345.135Baricitinib
CAS:Controlled ProductApplications Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.
References Greenwald, L.J., et al.: Int. J. Clin. Rheumatol., 6, 401 (2011); Fridman, J.S., et al.: J. Immunol., 184, 5298 (2010);Formula:C16H17N7O2SColor and Shape:White SolidMolecular weight:371.42Ethynyl Estradiol 17-β-D-Glucuronide
CAS:Controlled ProductFormula:C26H32O8Color and Shape:NeatMolecular weight:472.53α-Endosulfan
CAS:Controlled ProductApplications α-Endosulfan is the alpha isomer of Endosulfan (E555505), an insecticide that poses health risks to humans and animals that acquire it through ingension, inhalation, and percutaneous contact. One of the new POPs under the Stockholm Convention. Useful in cannabis testing kits as a component of pesticide mixes (P698230).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bhalerao, T. & Puranik, P.: Int. Biodeter. Biodegr., 59, 315 (2007); Kalender, S., et al.: Toxicology, 202, 227 (2004); Naqvi, S. & Vaishnavi, C.: Comp. Biochem. Phys. C, 105, 347 (1993)Formula:C9H6Cl6O3SColor and Shape:White To Off-WhiteMolecular weight:406.93Chloridazon
CAS:Applications Herbicide, active by perturbing cell membranes
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009), Bollman, S., et al.: Weed Technol., 23, 264 (2009), Goudarzi, N., et al.: J. Agric. Food Chem., 57, 7153 (2009),Formula:C10H8ClN3OColor and Shape:NeatMolecular weight:221.642,4,6-Trichlorophenol-13C6
CAS:Applications 2,4,6-Trichlorophenol-13C6 is the labelled anaolgue of 2,4,6-Trichlorophenol which is used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nunes, C., et al.: J. Env. Biol., 29, 733 (2008), Carucci, A., et al.: Water Sci. Technol., 58, 309 (2008), Fu, W., et al.: Env., Toxicol., Chem., 28, 1372 (2009), Osborne, R., et al.: Biochem., 48, 4231 (2009), Campoy, S., et al.: Env. Microbiol., 11, 99 (2009),Formula:C6H3Cl3OColor and Shape:Off-WhiteMolecular weight:203.4Cefixime-13C,15N2
CAS:Controlled ProductApplications Labelled Cefixime (C242800). Orally active, third generation cephalosporin antibiotic.
References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),Formula:C1513CH15N315N2O7S2Color and Shape:Beige SolidMolecular weight:456.43Faropenem Sodium Salt Hemipentahydrate
CAS:Controlled ProductFormula:C12H14NO5SNaH2OColor and Shape:NeatMolecular weight:704.67Trinexapac-ethyl
CAS:Applications Trinexapac-ethyl
Formula:C13H16O5Color and Shape:WhiteMolecular weight:252.26Drotaveraldine
CAS:Controlled ProductApplications A metabolite of Drotaverine (D689700).
References Lalla, J.K., et al.: J. Pharma. Biomed. Anal., 11, 385 (1993),Formula:C24H29NO5Color and Shape:BeigeMolecular weight:411.492-(Diethylamino)ethyl 4-(2-Hydroxybenzamido)benzoate
CAS:Controlled ProductFormula:C20H24N2O4Color and Shape:NeatMolecular weight:356.42Tamoxifen-d5
CAS:Controlled ProductApplications Labelled Tamoxifen (T006000). A nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a protein kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines.
References Sutherland, R., et al.: Nature, 267, 434 (1977), Lerner, L., et al.: Cancer Res., 50, 4177 (1990), Love, R., et al.: J. Clin. Oncol., 20 2559 (2002),Formula:C26D5H24NOColor and Shape:NeatMolecular weight:376.55ent-Voriconazole-d3
CAS:Controlled ProductApplications Isotope labelled enantiomer of Voriconazole (V760000), an antifungal agent and an ergosterol biosynthesis inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sanati, H., et al.: Antimicrob. Ag. Chemother., 41, 2492 (1997),Formula:C16H11D3F3N5OColor and Shape:NeatMolecular weight:352.33Prazosin
CAS:Applications Prazosin is a useful α1 and α2B-adrenoceptor antagonist.
Formula:C19H21N5O4Color and Shape:NeatMolecular weight:383.4Benzalazine
CAS:Controlled ProductApplications Intermediate used in the synthesis of a variety of antibacterial and antifungal activities of symmetric and asymmetric azines.
References Veena, K., et al.: E-J.Chem, 8, 354 (2011),Formula:C14H12N2Color and Shape:NeatMolecular weight:208.26Oxyisofenphos
CAS:Controlled ProductApplications Oxyisofenphos is a stable degredation product of Isofenphos, a soil insecticide.
References Felsot, A.: J. Environ. Sci. Health. B, B19, 13 (1984); Hsin, C.Y., Coats, J.R.: Pestic. Biochem. Phys., 25, 336 (1986)Formula:C15H24NO5PColor and Shape:Light YellowMolecular weight:329.33Des-(N-Phenyl)Carbamoyl Atorvastatin Calcium Salt
CAS:Controlled ProductFormula:(C26H29FNO4)•CaColor and Shape:NeatMolecular weight:917.12Cephalexin Sodium Salt
CAS:Controlled ProductFormula:C16H16N3NaO4SColor and Shape:NeatMolecular weight:369.37Cefuroxime-d3
CAS:Controlled ProductApplications Labelled Cefuroxime (C248050). Antibacterial.
References O’Callaghan, C.H., et al.: Antimicrob. Agents Chemother., 9, 511 (1976), Norrby, R., et al.: J. Antimicrob. Chemother., 3, 355 (1977), Brogden, R.N., et al.: Drugs, 17, 233 (1979), Wozniak, J.R., et al.: Anal. Profiles Drug Subs., 20, 209 (1991),Formula:C16H13D3N4O8SColor and Shape:White To BeigeMolecular weight:427.42-(1h-1,2,4-Triazol-1-yl)acetic Acid
CAS:Controlled ProductApplications 2-(1h-1,2,4-Triazol-1-Yl)Acetic Acid (cas# 28711-29-7) is a useful research chemical.
Formula:C4H5N3O2Color and Shape:NeatMolecular weight:127.13-Hydroxybutyrylcarnitine Chloride
CAS:Controlled ProductStability Hygroscopic
Applications 3-Hydroxybutyrylcarnitine is a reagent used to study acylcarnitine profile in thyroid disease.
References Wong, S., et al.: Clinical Biochem., 46, 180 (2013); Alu, F., et al.: Heredity, 110, 253 (2013); Adam, B., et al.: Clinical Biochem., 44, 1445 (2011)Formula:C11H22ClNO5Color and Shape:Colourless To Light YellowMolecular weight:283.759,10-Dihydroergocristine Methanesulfonate
CAS:Controlled ProductApplications 9,10-Dihydroergocristine Methanesulfonate is an nontoxic and well tolerated drug that exerts agonistic and antagonistic activity on dopaminergic and adrenergic receptors. 9,10-Dihydroergocristine Methanesulfonate is known to exhibit protective properties to the brain against metabolic effects of ischemia by acting at a cellular level.
References Setti, M., et al.: Angiologia., 30, 98 (1978); Brunhofer, G., et al.: Bioorg. Med. Chem., 20, 6669 (2012); Benzi, G., et al.: Neurobiol. Aging., 9, 371 (1988);Formula:C35H41N5O5·CH4O3SColor and Shape:NeatMolecular weight:707.84Tabimorelin
CAS:Controlled ProductApplications NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.
References Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988), Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1996), Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1999),Formula:C32H40N4O3Color and Shape:NeatMolecular weight:528.68Phenothrin (>85%)
CAS:Controlled ProductApplications Phenothrin is a pesticide used in the control of pests and insects. It is used in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, Y. et al.: Chemopshere, 90, 848 (2013); Hirahara, Y. et al.: Japan. J. Toxicol. Env. Health, 44, 451 (1998);Formula:C23H26O3Purity:>85%Color and Shape:Light YellowMolecular weight:350.45rac Efavirenz
CAS:Applications rac Efavirenz is a mixture of both enantiomers for Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.
References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995); Hadaruga, D. et al.: J. Med Chem., 48, 2432 (2005);Formula:C14H9ClF3NO2Color and Shape:NeatMolecular weight:315.68
