Biochemicals and Reagents

<p>Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.</p>

<p>RANTES antibody (biotin) was raised in rabbit using highly pure recombinant human RANTES as the immunogen.</p>

<p>Z-Gln-Gly-OH is a synthetic dipeptide, which is a modified amino acid sequence commonly used in biochemical applications. It consists of a carbobenzoxy-protected glutamine and a glycine residue. This compound originates from custom organic synthesis, derived through specific chemical protocols to introduce protective groups that block reactive sites on the amino acids. This controlled modification alters the peptide's stability and solubility.The mode of action involves the protection of active sites during complex syntheses, enabling the sequential construction of peptide chains without unintended reactions. This protection is critical in solid-phase peptide synthesis methodologies where precision and specificity of reactions are paramount. The Z-group (benzyloxycarbonyl) ensures the stability of glutamine under various chemical conditions, preventing side reactions that may compromise the integrity of peptide constructs.In research, Z-Gln-Gly-OH finds applications in the design of peptide-based inhibitors, structural studies, and the synthesis of longer chain peptides that mimic biologically relevant structures. The protection strategy allows scientists to develop and manipulate peptides with high fidelity, facilitating advancements in understanding protein functions and interactions in physiological contexts.</p>

<p>Creatinine Conjugate for use in immunoassays</p>

<p>H-EAPWEYQK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EAPWEYQK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EAPWEYQK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EAPWEYQK-OH at the technical inquiry form on this page</p>

<p>BDC2.5 mimotope 1040-51 is a mimotope of BDC2.5 T cells which can recognise glutamic acid decarboxylase epitopes.</p>

<p>GNA002 is a selective inhibitor of viral RNA-dependent RNA polymerases, which is a synthetic antiviral compound. Its source is a series of rationally designed molecules targeting viral replication machinery, specifically tailored to hinder the replication of RNA viruses by obstructing the activity of their RNA polymerases. The mode of action involves binding to a site on the viral RNA-dependent RNA polymerase that is distinct from the nucleotide-binding site, which results in a disruption of the elongation of the viral RNA strand.</p>

<p>Purified Recombinant Human Troponin I protein (Cardiac)</p>

<p>Region of FGF16 protein corresponding to amino acids MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH QKFTHFLPRP VDPSKLPSMS RDLFHYR.</p>

<p>AU1 tag antibody was raised in goat using AU1 (DTYRYI) conjugated to KLH as the immunogen.</p>

<p>Cathepsin D protein is a cytotoxic protein that acts as an inhibitory factor in various biological processes. It can be targeted by anti-ACTH antibodies or monoclonal antibodies for research purposes in the field of Life Sciences. Cathepsin D protein plays a role in the degradation of extracellular matrix components such as fibronectin and collagen. It has also been studied for its interaction with tyrosinase, insulin, and antiphospholipid antibodies. This acidic protein is involved in processes related to transferrin and isothiocyanate metabolism. For researchers looking to study native proteins and antigens, Cathepsin D protein can be a valuable tool.</p>

<p>Cytokeratin 20 antibody was raised in mouse using electrophoretically purified cytokeratin 20 from human intestinal mucosa as the immunogen.</p>

<p>Ac-CELSKTQNSISR-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CELSKTQNSISR-NH2 is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CELSKTQNSISR-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CELSKTQNSISR-NH2 at the technical inquiry form on this page</p>

<p>Peptide H-SIEQSIEQEEGLNR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-EIAEAYLGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-EEYNESIAFFYNRSG-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EEYNESIAFFYNRSG-OH is provided at greater that &gt;75% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EEYNESIAFFYNRSG-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EEYNESIAFFYNRSG-OH at the technical inquiry form on this page</p>

<p>Lamin B1 (321-330) is derived from the nuclear envelope protein, Lamin B1 which plays a role in the regulation of epigenetic chromatin. The lysine residue at position 10 is isotopically labelled with carbon-13 (6) and nitrogen-15 (2).</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Selective and reversible inhibitor of the multicatalytic 26S proteasome. The inhibition of protein breakdown affects several metabolic pathways and leads to cell death. The compound is effective in treating multiple myeloma because it prevents the binding of myeloma cells to bone marrow stroma and inhibits osteoclast differentiation.</p>

<p>Baricitinib is a Janus kinase inhibitor (JAK) currently used as monotherapy in the treatment of rheumatoid arthritis. Barictinib is also recommened for the treatment of atopic dermatitis and systemic lupus erythematosus. In mice interestingly, the administration of baricitinib reduced the inflammatory effects induced by a high-sugar diet on the metabolism.</p>

<p>H-QEAVALLQGQR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-QEAVALLQGQR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-QEAVALLQGQR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-QEAVALLQGQR-OH at the technical inquiry form on this page</p>

<p>FSH beta antibody (HRP) was raised in mouse using human FSH beta as the immunogen.</p>

<p>Ac-ARGESPTPSFGQRNEC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-ARGESPTPSFGQRNEC-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-ARGESPTPSFGQRNEC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-ARGESPTPSFGQRNEC-NH2 at the technical inquiry form on this page</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>E. coli O157 antibody was raised in mouse using the 'O' antigen of E. coli serotype O157 as the immunogen.</p>

<p>H-Phe-Met-Arg-Phe-NH2 acetate is a high quality reagent that is useful in the synthesis of complex compounds. It can be used as an intermediate for the production of fine chemicals and speciality chemicals, as well as being a versatile building block in the synthesis of organic compounds. H-Phe-Met-Arg-Phe-NH2 acetate can also be used to make research chemicals or reaction components.</p>

<p>Peptide H-LPGTYVVVLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Purified native Bovine 200 kDa Neurofilament protein</p>

<p>Please enquire for more information about C.I.Solvent Violet 56 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cardiac Troponin T (cTnT) Mouse Monoclonal Antibody, Recombinant</p>

<p>Mumps virus protein is a highly immunogenic composition that contains specific antibodies against the mumps virus. This protein is proteolytic in nature and consists of acid residues that are crucial for its activity. It can be used as a vaccine adjuvant composition to enhance the immune response against the mumps virus. The protease activity of this protein allows it to cleave specific target molecules, making it an effective tool in phenotypic assays. Monoclonal antibodies generated against the recombinant virus expressing this protein can be used to detect and neutralize the mumps virus. With its ability to stimulate antibody-secreting cells, this protein holds great potential for developing vaccines and therapeutic interventions against mumps infections.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Residues 1-10 of the gastrointestinal hormone motilin, secreted from endocrine cells in the small intestines, mainly from the jejunum and duodenum, in response to the fasting, drinking water or the mechanical stimulus of eating.</p>

<p>Human IgG2 antibody was raised in mouse using human IgG2 from myeloma patient serum as the immunogen.</p>

<p>Highly purified native Human RBP protein</p>

<p>The 6-Fluoro-3-indoxyl-beta-D-galactopyranoside is a potent antituberculosis drug from the rifamycin class. It is highly effective in treating tuberculosis infections due to its bactericidal activity. This compound works by binding to DNA-dependent RNA polymerase, preventing transcription and replication of bacteria. Its efficacy has been demonstrated through transcription-quantitative polymerase chain reactions and patch-clamp techniques. Additionally, it undergoes various metabolic transformations, including hydrolysis, oxidation, reduction, and conjugation with glucuronic acid. Furthermore, it specifically targets Mycobacterium tuberculosis strains by binding to markers expressed at high levels in these strains.</p>

<p>Substance P antibody was raised in rat using substance-P-BSA as the immunogen.</p>

<p>H-QNQLQFNRNVPTNPRNLAVR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-QNQLQFNRNVPTNPRNLAVR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-QNQLQFNRNVPTNPRNLAVR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-QNQLQFNRNVPTNPRNLAVR-OH at the technical inquiry form on this page</p>

<p>Nef is an accessory protein highly conserved amongst all primate lentiviruses, it is essential for viral replication in vivo- it is expressed by human immunodeficiency virus (HIV) HIV-1 and HIV-2. Nef acts as a downregulator of class I human leukocyte antigens (HLA) expression in HIV-infected cells to help circumvent the immune response, such as Cytotoxic T lymphocytes (CTL) activity. An intact nef gene is critical for high viral loads, linked to development of acquired immunodeficiency syndrome (AIDS). Certain alleles of HLA have been associated with maintaining a seronegative status such as HLA-A*1101.This nef peptide sequence contains the region considered to be a a C-proximal adaptor-protein (AP) interaction site. The presence of various nef motifs such as this are an intense area of investigation to understand if they are a factor in patients who remain clinically asymptomatic. This nef fragment is provided with an N-terminal acetyl group to increase its stability.</p>

<p>Tetanus Toxoid Antigen is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Tetanus Toxoid Antigen including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Peptide LCBiot-VPWMEPAYQRFL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LFDSDPITVTVPVEVSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Influenza B antibody was raised in mouse using Influenza B as the immunogen.</p>

<p>Histone 4 (H4) is one of the four core histones (H2A, H2B, H3 and H4) which are essential for compacting eukaryotic DNA into the nucleosome. Due to the high lysine and arginine content, histones have a net positive charge and therefore electrostatically interact with negatively charged DNA. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Like other core histones, H4 has a globular domain and a flexible N-terminal domain, the histone tail, which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination.Gene transcriptional activation or inactivation is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes. Both processes function to alter the positioning of the nucleosome, allowing the DNA within to be either accessible to the transcription machinery or inaccessible. H4 lysine rich tail plays a role in the higher order chromatin folding.The lysine at position 16 has been acetylated, which neutralizes the positive charge on the amino acid, loosening the chromatin structure. This alteration to the accessibility of chromatin promotes the initiation of transcription.Acetyl-Histone H4 (1-23) K16Ac-GG-[Lys(5-FAM)] has a C-terminal GGK linker labelled with 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag. Additionally, this peptide has an uncharged C-terminal amide and is protected from N-terminal modifications by a covalently bonded acetyl group.</p>

<p>H-RVGTEDIPS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-RVGTEDIPS-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-RVGTEDIPS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-RVGTEDIPS-OH at the technical inquiry form on this page</p>

<p>ANA IgG Positive, EBV VCA &amp; EBNA IgG Negative EDTA Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about ANA IgG Positive, EBV VCA &amp; EBNA IgG Negative EDTA Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Transmitted by mosquito vectors, Chikungunya is a positive-stranded RNA, alpha virus infecting human musculoskeletal tissues. The two glycoproteins E1 and E2 of the Chikungunya virus, to which this Mab is complementary to E2, are responsible for viral entry into host cells and both contain a transmembrane domain. Furthermore E2 has the three globular domains A, B and C which are linked by a β-ribbon connector region. While E2 is essential for mediating viral attachment, E1’s β-sheet structure and class II viral glycoproteins: DI, DII and DIII domains enable the virus to fuse with the host’s membrane. This primarily occurs through the insertion of the DII domain’s fusion loop into the host’s cell membrane.<br>Together E1 and E2 form a viral spike protein which when binding with high affinity to host alphavirus receptors such as Mxra8, allow this receptor to be inserted into E1 and E2. This results in Mxra8 contact between E2’s A and B domains and E1’s fusion loop. Neutralizing antibodies can target these domains, in particular A and B domains within E2, hence preventing viral attachment to host cells.This antibody can be used in the development of diagnostic assays for detection of Chikungunya virus.See also our other Chikungunya virus diagnostic reagents</p>

<p>MOPS is a morpholinic buffer with an optimal pH range of 6.5-7.9 and a pKa of 7.14. It does not coordinate metal ions and can be used in cell culture and electrophoresis.</p>

<p>Goat anti-human IgM is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Goat anti-human IgM including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Purified recombinant HOXB13 protein (His tag)</p>

<p>HAMA Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about HAMA Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>H-Arg-Arg-AMC hydrochloride salt is a proteolytic inhibitor that binds to the active site of aminopeptidases and prevents their proteolytic activity. This inhibition leads to increased muscle mass in juveniles, as well as higher concentrations of magnesium ions in sarcoplasmic and myofibrillar proteins. H-Arg-Arg-AMC hydrochloride salt also has an inhibitory effect on ion exchange and chloride transport in muscle cells. The biochemical effects of this drug are due to its ability to inhibit the aminopeptidase enzymes, which play a role in the metabolism of amino acids.</p>

<p>Competitive, reversible inhibitor of α-glucosidases used for the control of postprandial hyperglycaemia in patients with type 2 diabetes mellitus. It inhibits digestive enzymes with α-glucosidase activity, which breakdown complex sugars to absorbable monosaccharides. It also reduces the levels of glycated haemoglobin (HbA1c).</p>

<p>ATP6V1E2 antibody was raised in Rabbit using Human ATP6V1E2 as the immunogen</p>

<p>High purity (&gt;99%) Triiodothyronine sodium salt</p>

<p>Purified recombinant Treponema pallidum TmpA protein</p>

<p>Tocainide is a class 1b antiarrhythmic agent that is used in the treatment of ventricular arrhythmias. This drug acts on sodium channels to decrease the excitability of myocardial cells. This drug also prevents the depolarization of cardiac muscle cells and prolongs their refractory period.</p>

<p>Mouse monoclonal DO11.10 TCR antibody (biotin)</p>

<p>Peptide H-TTGDPPFPGQPPPVANDTR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Toxocara Canis IgG Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Toxocara Canis IgG Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Peptide H-AVL^TIDKK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-VVVGAVGV-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VVVGAVGV-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VVVGAVGV-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VVVGAVGV-OH at the technical inquiry form on this page</p>

<p>Peptide UUU-GGFL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Goat anti-rat IgG/IgA/IgM (H+L) (HRP) was raised in goat using rat IgG, IgA and IgM whole molecules as the immunogen.</p>

<p>Please enquire for more information about Dengue Type 4 antibody including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Mycoplasma Pneumoniae IgG Negative Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Mycoplasma Pneumoniae IgG Negative Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Anti-TRPA1 antibody</p>

<p>The 6-Fluoro-3-indoxyl-beta-D-galactopyranoside is an antituberculosis drug that falls under the class of rifamycins. It is highly effective in treating tuberculosis infections. This active compound exhibits bactericidal activity by binding to DNA-dependent RNA polymerase, preventing transcription and replication. Studies have confirmed its potency using a patch-clamp technique on human erythrocytes. The drug undergoes several metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Additionally, it specifically targets markers expressed in Mycobacterium tuberculosis strains and inhibits their growth in culture.</p>

<p>RF Ig Total Positive, EBV VCA &amp; EBNA IgG Negative EDTA Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about RF Ig Total Positive, EBV VCA &amp; EBNA IgG Negative EDTA Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Camstatin is an adjuvant therapy that has been shown to inhibit the activation of protein kinase A (PKA) in cells. It also inhibits phosphorylation of the cAMP-dependent protein kinase, which leads to a potentiation of effects. Camstatin also has a potent inhibitory effect on cellular protein synthesis and phosphate uptake. Camstatin can be used as an inhibitor of the phosphodiesterase enzyme, which is involved in the hydrolysis of intracellular cyclic nucleotides. This prevents the breakdown of cAMP and therefore increases its concentration in the cell and activates PKA.</p>

<p>CD144 antibody was raised in rat using mouse VE cadherin (CD144) as the immunogen.</p>

<p>HRP antibody was raised in mouse using peroxidase from horseradish as the immunogen.</p>

<p>CEA antibody was raised in mouse using human colon adrenocarcinoma as the immunogen.</p>

<p>C.I. Solubilised Sulphur Blue 7 is a research chemical that belongs to the group of copolymers. It is commonly used in the field of biomaterials and cellulose research. This compound has been found to have neuroprotective properties, making it potentially beneficial for the treatment of neurological disorders. C.I. Solubilised Sulphur Blue 7 has also been used in various applications such as dyeing, staining, and as an indicator or probe in scientific experiments. It can be dissolved in solvents like methanol or isooctane for ease of use. This compound has shown interactions with substances like buserelin, xylose, arachidonic acid, and aluminum, indicating its versatility and potential for further research.</p>

<p>H-CGGEISRGTHNFS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CGGEISRGTHNFS-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CGGEISRGTHNFS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CGGEISRGTHNFS-OH at the technical inquiry form on this page</p>

<p>Mouse monoclonal Hygromycin phosphotransferase antibody</p>

<p>Toxoplasma gondii P30 protein is a crucial component of the alpha-fetoprotein, Proteins and Antigens family. This recombinant protein acts as a growth factor and plays a vital role in various biological processes. It has been extensively studied for its potential therapeutic applications.</p>

<p>H-MSPINMLYFNDK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-MSPINMLYFNDK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-MSPINMLYFNDK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-MSPINMLYFNDK-OH at the technical inquiry form on this page</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

Vegfb

<p>Mouse monoclonal Influenza B antibody raised against inactivated Influenza B virus (B/Malaysia/2506/2004)</p>

<p>GPRC5B</p>

<p>Opioid analgesic</p>

<p>Kynurenine aminotransferase (Kat) enzymes convert Kynurenine (KYN) to kynurenic acid (KYNA) as part of the oxidative metabolism of tryptophan. KYNA is an endogenous antagonist of glutamate in the central nervous system. It is most active as an antagonist at receptors sensitive to N-methyl-D-aspartate (NMDA), which regulates neuronal excitability, plasticity, brain development, and behaviour. KYNA is also thought to play a causative role in hypo-glutamatergic conditions such as schizophrenia and a protective role in several neurodegenerative disorders, notably Huntington's disease. Of the 4 isoforms, Kat2 is the most active. Kat2 is a member of the Class-I pyridoxal-phosphate-dependent aminotransferase family. Kat2 is primarily located in brain tissue, believed to be in the mitochondria; accumulation of KYNA has been associated with schizophrenia. Selective inhibitors of Kat2 are being investigated as therapeutic targets for the management of schizophrenia and cognitive impairment.</p>

<p>CA 19-9 antibody was raised in mouse using purified CA 19-9 as the immunogen.</p>

<p>Peptide H-FSTVAGESGSADTVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Anti-TNFSF15 antibody</p>

<p>Musk active human is a natural substance that belongs to the group of fatty acids. It is found in the musk gland of various animals, including deer, beaver, and otter. Musk active human has been shown to regulate protein glycosylation, which is important for biological function. Musk active human's function in the endoplasmic reticulum is to stabilize proteins and control the process of protein synthesis. A study on an acetylcholine receptor found that it can activate tyrosine kinase, which leads to pathogenic mechanisms. This compound has been expressed in a variety of tissues and seems to play a role in muscle activity. A silico analysis has also shown that this chemical may inhibit the production of sulfoxide through its interaction with enzymes such as cyclooxygenase-2.</p>

<p>TORC-2</p>

<p>H-EARIKEKIE-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-EARIKEKIE-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-EARIKEKIE-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-EARIKEKIE-OH at the technical inquiry form on this page</p>

<p>Promotes binding of vWf to glycoproteins on platelets, inducing aggregation</p>

<p>The HAMA blocking reagent is a highly effective medicament used in immunoassays to block interference caused by human anti-mouse antibodies (HAMA). It contains specific acid residues that neutralize the binding sites of HAMA, preventing them from interfering with the assay. The HAMA blocking reagent is commonly used as a diluent or blocker in various applications, including cytometry analysis and life sciences research. It is particularly useful when working with monoclonal antibodies or autoantibodies, as it ensures accurate and reliable results by eliminating false positives or negatives. Additionally, this reagent can be used in combination with other buffers or assay reagents to optimize assay performance. With its ability to effectively neutralize HAMA, the HAMA blocking reagent is an essential tool for researchers and scientists in the field of immunology and diagnostics.</p>

<p>ASMA/Actin/F-Actin Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about ASMA/Actin/F-Actin Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Donkey anti-goat IgG (H + L) (HRP) was raised in donkey using goat IgG (H &amp; L) as the immunogen.</p>

<p>Microcide compound for broad-spectrum antimicrobial activity against bacteria and fungi and are compatible with most formulations.</p>

<p>Ligand binding to type I receptors with a common subunit gamma result in local cytoplasmic Jak3 being recruited to the cytoplasmic tails of the receptor. The tail becomes phosphorylated creating STAT protein binding sites. The STAT complex then also becomes phosphorylated to form a homo/heterodimer and translocate to the nucleus to bind to DNA to activate transcription. For example, interleukin IL2 binds type I receptor ILR2 resulting in Jak1 with Jak3 recruitment to the cytoplasmic gamma subunit. This interaction leads to tyrosine phosphorylation of the receptor for Stat5A with Stat5B docking. These STATs are then phosphorylated and activated by Jak1 and Jak3 leading to their dimerization and translocation for activation of specific gene transcription.Jak3 also has vital roles in immune cell signalling pathways; IL2 binds IL2R on T cells and natural killer cells. It has been found that in these immune cells Jak3 is critical to facilitate tyrosine phosphorylation of the cytoplasmic IL2R subunit. Throughout T cell differentiation Jak3 is required for IL7 induced activation of IL7R to activate PI3k and STATs. Ablation of Jak3 completely halted T cell proliferation.  JAK3-deficient models have phenotypes like human severe combined immunodeficiency (SCID), due to the lack of developed lymphocytes. This was linked to the interaction found between Jak3 and the T cell protein tyrosine phosphatases (TCPTP) key to cytokine signalling in haematopoietic cells.</p>

<p>H-LLVSASQDGK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LLVSASQDGK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LLVSASQDGK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LLVSASQDGK-OH at the technical inquiry form on this page</p>

<p>PR3 Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about PR3 Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>PML/SP100/AMA Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about PML/SP100/AMA Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide involved in the regulation of specific neurons through control of neuronal growth, maintenance, proliferation, and survival. NGF protein functions as the extracellular ligand for the NTRK1 or the NGFR receptors on the surface of neurons, initiating signalling cascades inside the cell. Binding of NGF causes neurons to mature and differentiate; additionally, NGF is critical in the survival of sympathetic and sensory neurons, as in the absence of NGF these cells will undergo apoptosis.NGF is capable of binding with two classes of receptors, both tropomyosin receptor kinase A (TrkA) and low-affinity NGF receptor (LNGFR) act as ligands for NGF, activating signalling cascades. These receptors are associated with neurodegenerative diseases, implying the potential of NGF as a therapeutic drug target.</p>

<p>Janus kinase-2 (JAK2) is a non-receptor tyrosine kinase implicated in signalling via members of the type II cytokine receptor family (such as interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R). The JAK/signal transducer and activator of transcription (STAT) pathway is a key cellular pathway which is involved in immunity, cell division, cell death and tumour formation. The JAK/STAT pathway is activated by leptin and the leptin receptor and results in phosphorylation of STAT3 and its translocation to the nucleus where it activates the transcription of various target genes.Mutations and gene fusions involving JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders and leukaemia.</p>

<p>Pasireotide acetate is a synthetic cyclic peptide and a somatostatin analogue, which is derived from the chemical synthesis based on the structure of native somatostatins. It operates by binding to somatostatin receptors with high affinity, primarily targeting the sst1, sst2, sst3, and sst5 receptor subtypes. This binding inhibits the secretion of adrenocorticotropic hormone (ACTH), which can modulate the excess production of cortisol in conditions such as Cushing’s disease.</p>

<p>Peptide LCBiot-EDQVDPRLIDGK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-SLLSGNTELK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-SLLSGNTELK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-SLLSGNTELK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-SLLSGNTELK-OH at the technical inquiry form on this page</p>

<p>The hCG beta antibody is a monoclonal antibody that specifically targets the human chorionic gonadotropin (hCG) beta subunit. It is widely used in various assays to detect and measure levels of hCG in biological samples. This antibody recognizes the extracellular protein sclerostin, which is a morphogenetic protein involved in bone development and remodeling. The hCG beta antibody binds to specific polypeptide sequences on the hCG molecule, allowing for accurate and sensitive detection. It can be used in both colloidal gold-based assays and nuclear staining techniques to visualize the presence of hCG. This highly specific monoclonal antibody has applications in research, diagnostics, and therapeutic development related to pregnancy testing, fertility treatments, and certain types of cancer.</p>

<p>The Keratin 8 antibody is a highly specific and sensitive tool used in life sciences research. This antibody specifically targets and detects autoantibodies against skeletal myosin, cardiomyocyte antigens, and glucagon. It is available in both polyclonal and monoclonal forms, providing researchers with options to suit their specific needs.</p>

<p>Peptide H-NDPTQQIPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>HTLV-2 Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about HTLV-2 Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>H-NIQLPTNTEK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-NIQLPTNTEK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-NIQLPTNTEK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-NIQLPTNTEK-OH at the technical inquiry form on this page</p>

<p>Peptide H-LGFEDGSVLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>IGF1 antibody was raised in mouse using human IGF-I as the immunogen.</p>

<p>Neisseria Gonorrhoeae Positive Urine is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Neisseria Gonorrhoeae Positive Urine including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Peptide Ac-QVPLRPMTY-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Slc34a3</p>

<p>H-LLVLAVLLTVAAADSGISPR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LLVLAVLLTVAAADSGISPR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LLVLAVLLTVAAADSGISPR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LLVLAVLLTVAAADSGISPR-OH at the technical inquiry form on this page</p>

<p>The LDH antibody is a powerful tool used in the field of life sciences. It specifically targets peroxisomal beta-oxidation, which is an essential metabolic pathway involved in the breakdown of fatty acids. This monoclonal antibody has been extensively tested and validated for its specificity and sensitivity.</p>

<p>Conjugated Benzoylecgonine-HRP hapten</p>

<p>Porcine Intrinsic Factor</p>

<p>CMV IgM (IgG Low Avidity) Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about CMV IgM (IgG Low Avidity) Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>EBNA IgG Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about EBNA IgG Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Raf1 forms part of the histone H3K9 methyltransferase complex CLRC, along with Clr4, Raf2, Cul4, and Rik1 and is required for heterochromatin formation. CLRC mediates H3K9 methylation, siRNA production and also displays E3-ubiquitin ligase activity in vitro.</p>

<p>E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme as a thioester and then directly transfer the ubiquitin to targeted substrates. DZIP3 is located in the cytoplasm and can bind RNA specifically. DZIP3 enables several functions, including phosphatase binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin-protein transferase activity. In addition, DZIP3 is involved in protein polyubiquitination._x000D_<br>_x000D_<br>The condition of azoospermia is associated with the deletion of DZIP3. High expression of DZIP3 is a biomarker for a poor outcome of several cancers, including gastric and breast cancer. DZIP3 is a crucial driver of cancer cell growth, migration, and invasion due to interacting with cyclin D1 during G1. In breast cancer, DZIP3 is a coactivator of oestrogen receptor α target gene expression and enhances their expression in breast cancer cells.</p>

<p>Acid Brown 85 is a reactive dye that is used to color paper, textiles and leather. It is an azo dye, which means it contains a benzene ring with two nitrogen atoms in the 1- and 2-positions. Acid Brown 85 is soluble in water and has good dispersibility. It can be used as an extender for other dyes or as a reactive dye for cellulose fibers. Acid Brown 85 may also be used as a pigment in paints and varnishes. The product has low energy reactivity, meaning it does not need to be heated before use.</p>

<p>Crimean-Congo Haemorrhagic Fever Virus is a tick-borne virus that causes Crimean-Congo Haemorrhagic Fever (CCHF), a serious disease that can have a case fatality rate of up to 40% during outbreaks. The virus is an RNA virus from the Nairoviridae family and is transmitted mainly through bites from infected ticks (especially Hyalomma species) or through contact with blood or tissues from infected animals or people. It is found across Africa, the Balkans, the Middle East, and parts of Asia. Symptoms can include fever, muscle aches, dizziness, neck pain, and backache and it can progress to internal and external bleeding, liver failure, and shock. Currently there is no vaccine to combat this disease, or an antiviral treatment that has been officially approved.<br>The Crimean-Congo Haemorrhagic Fever Virus nucleocapsid antigen is a structural protein of the virus. It wraps around the viral RNA genome to form the nucleocapsid, protecting the RNA and helping the virus replicate inside host cells. It's highly abundant, highly conserved, and produced early during infection. This protein is therefore a prime target for use in the development of new diagnostic assays for Crimean-Congo Haemorrhagic Fever Virus detection. The fact that the nucleocapsid protein is immunogenic it can also be used in vaccine research.Cymit Quimica's recombinant Crimean-Congo Haemorrhagic Fever Virus antigen is the full-length nucleocapsid protein from strain Nigeria/IbAr10200/1970 expressed in E. coli and containing a His-tag at the C-terminus. This antigen is potentially suitable for development of serological assays, such as ChLIA, ELISA and lateral flow, to detect the presence of antibodies to CCHF virus in patient samples.</p>

<p>P12 is a cleavage product from the murine leukaemia virus (MLV) Gag protein and is essential for various steps in viral replication and during both early and late stages of murine leukaemia virus (MLV) infection.</p>

<p>H-AETLQHVPS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-AETLQHVPS-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-AETLQHVPS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-AETLQHVPS-OH at the technical inquiry form on this page</p>

<p>Ac-YR-hexadecyl ester is a synthetic, nonsteroidal antiaging compound that has been shown to have cutaneous hydration effects in humans. This agent is thought to work by increasing the production of extracellular matrix proteins and by enhancing the water retention capacity of stratum corneum cells. Ac-YR-hexadecyl ester has also been shown to improve clinical signs of aging, such as wrinkles and age spots, by reducing oxidative stress and inflammation.</p>

<p>p62 antibody was raised in guinea pig using the C-terminal domain of human p62 protein as the immunogen.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>PDEs are a family of phosphohydrolyases, used to catalyse hydrolysis of 3' cyclic phosphate bonds in the second messengers adenosine and guanine 3', 5' cyclic monophosphates (cAMP and cGMP). Physiologically, PDE2A is a locus for communication between cAMP and cGMP signalling pathways, regulating this process through degradation of cAMP and cGMP. This is particularly noteworthy in cells where cAMP and cGMP regulate opposing cell functions. <br>PDE2A is expressed both in the periphery and central nervous system, but is found in highest concentration in the brain; implying that PDE2A is necessary in regulation of interneuronal cAMP and cGMP involved in emotion, sensory perception and memory. Alteration in cyclic nucleotide signalling is shown cause depression, bipolar disorder and schizophrenia; hence PDE2A, a molecule used to break down cyclic nucleotides, has the potential to be a novel biomarker or therapeutic target for such psychiatric conditions.</p>

<p>Peptide H-YSQAVPAVTEGPIPEVLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Antagonist of cardiac potassium channel HERG; anti-psychotic</p>

<p>RNA POL I/III Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about RNA POL I/III Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>PR3 Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about PR3 Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Tris-HCl is the same as Tris base with the addition of HCl. It is used as a buffering agent to prepare buffer solutions.</p>

<p>H-VDANQR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-VDANQR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-VDANQR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-VDANQR-OH at the technical inquiry form on this page</p>

<p>Peptide H-TVLQNWLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Encoded for by mitochondrial DNA, Humanin is an endogenous peptide known to be a ‘rescue factor’ with the ability to abolish neuronal cell death. This characteristic has promoted Humanin as a potential treatment for Alzheimer’s disease. Another function of Humanin is it can inhibit mitochondira-dependent apoptosis through preventing the formation of apoptotic bodies and the release of Cytochrome C.Humanin has been found to be related to aging related cardiovascular disease (ACVDs) due to evidence of Humanin serum levels as age increases. Furthermore Humanin increases the expression of antioxidant defense system proteins and impedes complexes I and III from their activity in the electron transport chain in myocardial cells and mitochondria, therefore decreasing oxidative stress damage caused by H2O2. Humanin further reduces reactive oxygen species production and protects cardiomyocytes and fibroblasts, from oxidative stress.Overall Humanin has a variety of protective functions such as mitochondrial homeostasis and redox systems regulation, anti-aging, prevention of myocardial fibrosis, anti-inflammation, metabolism improvement and autophagy promotion. It has also been found to improve beta-cell survival and thus can be used as a diabetes treatment due to it improving insulin secretion and resistance.</p>

<p>H-CAPPGYALLRCNDTN-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CAPPGYALLRCNDTN-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CAPPGYALLRCNDTN-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CAPPGYALLRCNDTN-OH at the technical inquiry form on this page</p>

<p>Peptide H-VQDSAPVETPR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>TetR antibody was raised in rabbit using residues 31-49 [AQKLGVEQPTLYWHVKNKR] of the 22 kDa tet repressor protein as the immunogen.</p>

<p>Mouse Monoclonal Malaria pan pLDH antibody</p>

<p>Anti-UCP1 antibody</p>

<p>Sunitinib is a tyrosine kinase inhibitor drug. It is a drug that is used as a treatment for renal cell carcinoma, gastrointestinal stromal tumor, and other solid tumors. This drug inhibits tyrosine kinases such as VEGFRs, this prevents tumour growth and pathologic angiogenesis.</p>

<p>C.I. Azoic Coupling Component 37 is a versatile compound with various applications. It is commonly used in research chemicals and as a catalyst in electrode reactions. Additionally, it has been found to have inhibitory effects on enzymes such as phosphatase, making it useful in enzymatic assays. C.I. Azoic Coupling Component 37 can also act as a photocatalyst and has been studied for its potential use in the degradation of herbicides and lipid peroxidation. Furthermore, it has been shown to have antioxidant properties, protecting against oxidative damage caused by hydrogen atoms. With its wide range of uses, C.I. Azoic Coupling Component 37 is an essential component in many industries and research fields.</p>

<p>Peptide H-VTEPISAESGEQVER^^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-IGEGTYGVVYK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-DTHFPICIFCCGCCHRSKCGMCCK^T-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Please enquire for more information about C.I.Reactive Orange 2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Peptide H-LASAYGAR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Anti-KCNK18/TRESK antibody</p>

<p>Thyroglobulin Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Thyroglobulin Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Cardiolipin IgA Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Cardiolipin IgA Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Peptide Ac-CFLSPEELQSLVPLSD-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>GLG1</p>