Biochemicals and Reagents

<p>Stability Very Very Hygroscopic<br>Applications α-Glycosidase inhibitor.<br>References Paulsen, H., et al.: Chem. Ber., 113, 2601 (1980),<br></p>

<p>Stability Hygroscopic<br>Applications Bis(4-hydroxyphenyl) Sulfone O-β-D-Glucuronide is the glucuronide derivative of Bis(4-hydroxyphenyl) Sulfone (B447390); a compound that is commonly used as a reactant in epoxy reactions. It is also used as a latent thermal catalyst for epoxy resin.<br>References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012)<br></p>

<p>Stability Light Sensitive, Temperature Sensitive, Toxic<br>Applications A labelled metabolite of Vitamin D2 (V676040).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Barnes, P., et al.: J. Clin. Invest., 83, 1527 (1989), Holick, M., et al.: J. Cell Biochem., 88(2), 296 (2003), Maunsell, Z., et al.: Clin. Chem., 51, 1683 (2005),<br></p>

<p>Applications Brilliant Green is a stain used in bacteriological media. Dyes and metabolites, Environmental Testing<br></p>

<p>Applications L-Cystine Bis(T-butyl Ester) Dihydrochloride is used as a reagent in the synthesis of chelate oxorhenium to create new integrin antagonists.<br>References Le Gal, J., et al.: J. Inorg. Biochem., 105, 880 (2011);<br></p>

<p>Applications (3β)-3,25-Dihydroxycholest-5-en-7-one is a useful synthetic intermediate in the synthesis of 3β,7α,25-Trihydroxycholest-5-ene (T795075); a potent agonist of GPR183 that induces specific activation of the receptor.<br>References Antunes, L., et al.: Antimicrob. Agents. Chemtherap., 55, 1494 (2011); Schwarz, M., et al.: J. Cin. Invest., 106, 1175 (2000); Zhang, J., et al.: BIochem. J., 322, 175 (1997)<br></p>

<p>Applications Labelled analogue of L-Phenylalanine, an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine. L-Phenylalanine is produced for medical, feed, and nutritional applications such as in the preparation of Aspartame.<br>References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);<br></p>

<p>Applications L-Carnitine-d9 is the isotope labelled analog of L-Carnitine (C184110); an essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthesized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications 1,​6,​13,​18-​Tetraoxacyclotetraco​sane-​7,​12,​19,​24-​tetrone can be used in degradation process investigation of thermoplastic polyurethane elastomer in supercritical methanol.<br>References Liu, L., et al.: Polym Degrad Stabil, 98, 2520 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of Acrylonitrile (ACN).<br>References Guengerich, F., et al.: Cancer Res., 41, 4925 (1981), Leonard, A., et al.: Mutation Res., 436, 263 (1999), Stadler, R., et al.: J. Agric. Food Chem., 52, 5550 (2004), Dybing, E., et al.: Food Chem. Toxicol., 43, 365 (2005), Rice, J., et al.: Mutation Res., 580, 3 (2005),<br></p>

<p>Applications (8Z,11Z,14Z)-8,11,14-Heptadecatrienoic Acid, is a naturally occurring hydroxylated fatty acid that is found in Acinetobacter species. It acts as a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40) and GPR84 receptors in vitro. It also inhibits bovine hepatic ligase (Ki = 4.4 μM) and mouse kidney mitochondrial medium-chain acyl-CoA synthetase by 48% at a concentration of 40 μM.<br>References Moss, C.W., et al.: J. Clin. Microbiol. 26(3), 484-492 (1988).; Kaspersen, M.H., et al.: Med. Chem. Commun. 8(6), 1360-1365 (2017).<br></p>

<p>Applications 4-Aminobiphenyl-d9 (CAS# 344298-96-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 12-Hydroxystearic Acid is used in edible vegetable oils and organogels.<br>References Rogers, M. et al.: Soft. Matt., 4, 1483 (2008); Hughes, N. et al.: Trends. Food. Sci. Tech., 20, 470 (2009);<br></p>

<p>Stability Light Sensitive<br>Applications The metabolites of o-Aminoazotoluene has been shown to be strongly mutagenic but the mutagenesis is inhibited by 7,8-benzoflavone. Dyes and metabolites, Environmental Testing<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Degawa, M., Kanazawa, C., Hashimoto, Y.: Carcinogenesis, 3, 1113 (1982)<br></p>

<p>Applications An adenosine deaminase inhibitor used as an anti-cancer therapeutic drug. Shown to be effective in the treatment of hairy cell leukemia as well as having use in the treatment of other types of cancer such as chronic lymphocytic leukemia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rogler-Brown, T. et al.: Biochem. Pharmacol., 28, 201 (1979); Johnston, J.B. et al.: J. Natl. Canvcer Inst., 80, 765 (1988); Fortune, A.F. et al.: Leuk. and Lymph., 51, 839 (2010); Robak, T. et al.: Drugs, 69, 2415 (2009);<br></p>

<p>Applications (E)-2-Octenoyl-L-carnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases especially glucose related ones.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007); Anderson, K. et al.: Mol. Endocrinol., 26, 281 (2012);<br></p>

<p>Applications 14,15-Dehydro Triamcinolone Acetonide is a derivative of Triamcinolone acetonide. A corticosteroid.<br></p>

<p>Applications Glycocholic Acid (cas# 475-31-0) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin(N490240) is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate (H826800); a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).<br>References Kaczka, E.A., et al.: Science, 112, 354 (1950); Friedrich, W., et al.: Vitamins, 837 (1988); Forsyth, J.C., et al.: Clin. Toxicol., 31, 277 (1993)<br></p>

<p>Stability Hygroscopic, moisture sensitive<br>Applications Stearoyl L-α-Lysolecithin is an bioactive lysophosphatidylcholine derived compound found to be released by bronchial epithelial cells. Stearoyl L-α-Lysolecithin have also been utilized in the development of liposomes and michelles by drug transdermal delivery devices.<br>References Zhuge, Y., et al.: Allergy Asthma Immunol Res., 6, 66 (2014)<br></p>

<p>Applications 4α-Methyl-cholest-5-en-3β-ol is a derivative of Cholesterol (C432501), a major component of all biological membranes; ~25% of total brain lipid is Cholesterol. Cholesterol is the principal sterol of the higher animals. Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol is the main constituent of gallstones.<br>References Rosin, Z., et al.: Physiol. Chem., 124, 282 (1923), Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934), Gemant, et al.: Life Sci., 1, 233 (1962), Johnson, K., et al.: 4, 457 (1964),<br></p>

<p>Stability Hygroscopic<br>Applications One of the biologically active forms of nicotinic acid. Serves as a coenzyme of hydrogenases and dehydrogenases. NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions. Occurs in 2 forms, α-NAD and β-NAD, distinguished by the configuration of the ribosyl nicotinamide linkage. Only the β-anomer is bioactive.<br>References Bartlett, G.R., et al.: J. Biol. Chem., 234, 449 (1959), Dixon, M., et al.: Science, 132, 1548 (1960), Heyes, D., et al.: Biochemistry, 43, 8265 (2004), Dietzek, B., et al.: Chem. Phys. Chem., 7, 1727 (2006),<br></p>

<p>Stability Light Sensitive<br>Applications γ-Tocotrienol exhibits antioxidant properties and belongs to the vitamin E family. It is naturally found in wheat germ oil and bran. In addition, α-tocopherol and γ-tocotrienol derivatives are potential lead compounds for developing anticancer and antiproliferative agents against MCF-7 and MDA-MB-231 breast cancer cells and the A549 lung cancer cells.<br>References Gagic, Z., et al.: Eur. J. Pharm. Sci. 88, 59 (2016); Guardiola, F., et al.: Food Chem. Toxicol., 34, 193 (1996); Kong, S., et al.: Food Chem., 120, 278 (2010); Aggarwal, B., et al.: Biochem. Pharmacol., 80, 1613 (2010)<br></p>

<p>Applications Useful in the study of tyrosine-phosphorylation, which has been linked with the malignant transformation of cells by some RNA tumour viruses.<br>References Sefton, B.M., et al.: Cell, 20, 807 (1980), Erikson, R., et al.: Perspect. Virol., 11, 93 (1981), Lee, E-S, et al.: J. Org. Chem., 59, 2086 (1994)<br></p>

<p>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 600. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);<br></p>

<p>Applications PSA sorbent is useful in food residue cleanup removing food matrix interferences.<br>References F.J. Schenck, et al.: J. Chromatogr. A., 868, 51-61 (2000);F.J. Schenck, et al.: J. Sep. Sci. 25, 883-890 (2002)<br></p>

<p>Applications N1,N4-Di-p-tolylbenzene-1,4-diamine is a useful intermediate for the preparation of some chemically active substances for polymeric materials.<br>References Belorossova, A. G., et al.: Uchenye Zapiski Yaroslavskogo Tekhnologicheskogo Instituta, 11, 200 (1969)<br></p>

<p>Stability Moisture Sensitive<br>Applications A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2.<br>References Inoue, T., et al.: J. Biol. Chem., 284, 9566 (2009), Kang, J., et al.: Bioorg. Med. Chem., 17, 1498 (2009), Rath, G., et al.: Int. J. Biochem. Cell Biol., 41, 1165 (2009),<br></p>

<p>Applications 2,5-Diaminotoluene is an aromatic compound that is commonly used in permanent hair-dye formulations. 2,5-Diaminotoluene is weakly mutagenic and is also partially responsible for causing allergic contact dermatitis in humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chung, K., et al.: Mutat. Res./Rev. Mutat. Res., 387, 1 (1997); Inouye, M. &amp; Murakami, U.: Food Cosm. Toxicol., 15, 447 (1977); Yazer, K., et al.: Cont. Derm., 66, 27 (2012)<br></p>

<p>Stability Hygroscopic, Temperature Sensitive<br>Applications Vitamin D4 is the active analogue of Vitamin D.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Holick, M., et al.: J. Biochemistry, 10, 2799 (1971), Haddad, J., et al.: J. Bone Miner. Res., 4, 243 (1989), Palmieri, G., et al.: J. Clin. Endocrin. Metab., 82, 3516 (1997),<br></p>

<p>Applications Capecitabine is an antineoplastic agent. Capecitabine is a prodrug of Doxifluridine (D556750).<br>References Muss, H., et al.: New Eng. J. Med., 360, 2055 (2009), Takahashi, S., et al.: Drug Metab. Disposition, 37, 956 (2009), Saltz, L., et al.: J. Clin. Oncol., 27, 653 (2009), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),<br></p>

<p>Applications Celgosivir is an α-glucosidase I inhibitor.<br></p>

<p>Applications N,O-Dibenzoyl-DL-tyrosyl-N',N'-dipropylamide is a metabolite of the antispasmodic agent Tiropramide (T446900). Tiropramide impurity B.<br>References Janssen, et al.: J. Pharm. Pharmacol., 9, 381 (1956), Bertaccini, et al.: Br. J. Pharmac., 34, 310 (1968),<br></p>

<p>Applications UDP-3-O-[R-3-Hydroxymyristoyl]-N-[R-3-hydroxymyristoyl] Glucosamine Tris Salt is the salt version of [2(R),3(R)]-P'-[2-Deoxy-3-O-(3-hydroxy-1-oxotetradecyl)-2-[(3-hydroxy-1-oxotetradecyl)amino]-α-D-glucopyranosyl] Ester Uridine 5'-(trihydrogen diphosphate) (CAS 90293-60-0) which can be used in biological study for reconstruction of metabolic network in bovine mammary gland tissue. Potent drug or API metabolite.<br>References Wang, C., et al.: Mol. Biol. Rep., 39, 7311-7318 (2012);<br></p>

<p>Applications L-Glutamic Acid α-tert-Butyl Ester is an ester of L-Glutamic Acid used in the synthesis of enantiopure isotopomers of amino acids.<br>References Chauvel, E., et al.: J. Med. Chem., 37, 2950 (1994),<br></p>

<p>Applications Indole-3-acetyl-L-glutamic Acid is an indole-3-acetyl-amino acid conjugate involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses.<br>References Ostrowski, M., et al.: J Plant Physiol, 191, 63-72 (2016)<br></p>

<p>Applications Scleroglucan is a natural polymer produced by fungi, especially those of the genus Sclerotium. Scleroglucan fluids have been used to trap and treat Cr(VI) in environmental applications.<br>References Brigand, G.: Industrial Gums (Third Edition), pp. 461 (1993); Pensini, E.; et al.: Colloids Surf., A, 559, 191 (2018);<br></p>

<p>Applications Lactoferrin is a multifunctional protein of transferin family. A glycoprotein present in various secretions including milk, saliva and tears. Antiviral agent, it binds to liproproteins of cell membranes dispersing virus molecules from host cells.<br>References Sánchez L. et al.: Arch. Dis. CHild., 67, 657 (1992); Harmsen MC. et al.: J. Infect. Dis., 172, 380 (1995);<br></p>

<p>Applications A lipid biomarker for stable and unstable heart disease.<br>References Gaziano, J., et al.: Circulation, 96, 2520 (1997), Thomas, A., et al.: Anal. Chem., 82, 6687 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications 1-O-Octadecanoyl-sn-glycerol is a monoacylglycerol (MAG) based saturated fatty acid derivative.<br>References Garcia, P. et al.: J. Sep. Sci., 34, 999 (2011); Takagi, T. et al.: LIpids, 25, 398 (1990);<br></p>

<p>Applications Important gaba mimetic agent. It evokes neurological responses similar to those elicited by g-aminobutyric acid.<br>References Riv. Farmacol. Ter., 7, 155 (1976), Neuropharmacology, 17, 13 (1978), Br. J. Pharmacol., 59 373 (1977)<br></p>

<p>Applications N-Iodoacetyltyramine is used in iodine-125 labelling of various molecules for chemical analysis.<br>References Lin, C. et al.: Anal. Biochem., 179, 389 (1989);<br></p>

<p>Applications 5-Bromo-2'-deoxyuridine is a thymidine analogue used as a mutagen in genetic research. Selectively incorporated into cellular DNA during S-phase.<br>References Boccadoro, M., et al.: Tumor, 72, 135 (1986), Fivan, A. L.: Flow Cytometry, First Principles, New York, (1992),<br></p>

<p>Applications Poly(ethylene Glycol) ~400 is a polymer of ethylene oxide with a molecular weight of ~400 Daltons. Poly(ethylene Glycol) ~400 is considered a low molecular weight polyethylene glycol, and is used as a hydrophilic molecular probe for measuring intestinal permeability. Poly(ethylene Glycol) ~400 is also used as a hydrophilic plasticizer.<br>References Lu, E., et al.: J. Control. Release, 92, 375 (2003); Ma, T., et al.: Gastroenterology, 98, 39 (1990)<br></p>

<p>Applications A novel glucosylation enzyme.<br>References Kuriki, T., et al.: J. Biosci. Bioeng., 87, 557 (1999), Meulenbeld, G., et al.: Biotechnol. Bioeng., 70, 363 (2000), Moon, Y., et al.: J. Agric. Food Chem., 54, 1230 (2006),<br></p>

<p>Stability Moisture Sensitive: Desiccate<br>Applications A heterobifunctional sulfhydryl cross-linking reagent.<br></p>

<p>Applications 2-Methylbutyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several “inborn errors of metabolism” (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Applications 4,6-Di(methyl-d3)benzen-2,3,5-d3-amine is a useful isotopically labeled research compound.<br></p>

<p>Applications A triphenylmethane dye with fungicidal and limited antiseptic activity. The term Malachine green applies to the oxalate as well as the chloride. Harmful if swallowed. Avoid release to the environment. Dyes and metabolites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Carter, S.G., et al.: J. Biochem. Biophys. Methods, 7, 7 (1982), Saikan, S., et al.: J. Chem. Phys., 79, 4154 (1983), Clemmensen, S., et al.: Arch. Toxicol., 56, 43 (1984),<br></p>

<p>Applications 1,2-Dipalmitoyl-rac-glycero-3-phosphoethanolamine is a long chain fatty acid, acting as a luminescence marker. Is used in enhancing radiotherapy for cancer treatment<br>References Dotsikas, Y. et al.: Anal. Sci., 28, 753 (2012); Choi, J. et al.: J. Nanomet., 8, 863704, (2012);<br></p>

<p>Applications Thyroxine 4’-O-Sulfate Disodium Salt, is a metabolite and sulfoconjugated derivative of Thyroxine (T425600).<br></p>

<p>Applications Andrographolide is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.<br>References (1) Chander, R. et al.: Int. J. Pharmacog. (1995) 33, 135-8 (2) Chen, H.-W. et al.: J. Nat. Prod. (2011) 74, 2408-13<br></p>

<p>Applications An epoxy fatty acid found in Pneumocystis carinii lipids.<br>References Gibson, G., et al.: Xenobiotica, 19, 1123 (1989), Pellegrini, L., et al.: Plant Physiol., 103, 509 (1993), Scheller, U., et al.: J. Biol. Chem., 273, 32528 (1998), Tijet, N., et al.: Biochem. J., 332, 583 (1998),<br></p>

<p>Stability Light and Temperature Sensitive<br>Applications Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 7 belongs to the class of K2-Vitamins homologs. Menaquinone 7 has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins such as osteocalcin and matrix-Gla protein, which plays a crucial role in building and maintaining overall bone health.<br>References Hugenholtz, P., et al.: J. Bacteriol., 180, 4765 (1998), Ginet, N., et al.: Biochemistry, 40, 1812 (2001), Cape, J., et al.: J. Biol. Chem., 280, 34654 (2005),<br></p>

<p>Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.<br>References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)<br></p>

<p>Applications A sulfhydryl cross-linking reagent.<br></p>

<p>Applications NF 279 is a potent and selective P2X1 antagonist.<br>References Kassack, M., et al.: Eur. J. Med. Chem., 39, 345 (2004); Damer, S., et al.: Eur. J. Pharm., 350, R5 (1998); Rettinger, J., et al.: Neuropharm., 39, 2044 (2000)<br></p>

<p>Applications Uvinul A Plus-d4 is the labelled compound of Uvinul A Plus(U850300) which is a component of cosmetic emulsion with UV protection.<br>References Chang, M., et al.: J. Food Drug Anal., 9, 199 (2001), Simeoni, S., et al.: J. Pharm. Biomed. Anal., 38, 250 (2005), Vielhaber, G., et al.: Photochem. Photobiol. Sci., 5, 275 (2006), Lee, S., et al.: J. Cosmet. Sci., 59, 469 (2008),<br></p>

<p>Applications Used in therapy of mouse leukemia L1210 in combinations with Nebularin and Nitrobenzylthioinosine 5’-monophosphate.<br>References Anderson, C., et al.: Neurosci. Lett., 219, 191 (1996), Allay, J., et al.: Nat. Med., 4, 1136 (1998),<br></p>

<p>Applications An essential amino acid for human development. Precursor for nitric oxide. Ammonia detoxicant (hepatic failure); diagnostic aid (pituitary function).<br>References Miura, T., et al.: Anal. Biochem., 139, 432 (1984), Jones, et al.: Adv. Enzyme Regul., 9, 19 (1970), Borders, C.L., et al.: Protein. Sci., 3, 541 (1994),<br></p>

<p>Stability Moisture Sensitive<br>Applications Chlorotrimethylsilane have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis. Chlorotrimethylsilane has been used for silylation and as a protection group in the process of various organic synthesis.<br> E0<br>References Casimiro, M., et al.: Org. Lett., 15, 2378 (2013); Lifchits, O., et al.: J. Am. Chem. Soc., 135, 6677 (2013);<br></p>

<p>Applications 10-Hydroxy-2-decenoic acid<br></p>

<p>Applications Arachidonic acid (AA) is an unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation.<br>References Peterson, J., et al.: J. Pediatr., 152, 788 (2008), Pichini, S., et al.: J. Pharm. Biomed. Anal., 48, 927 (2008),<br></p>

<p>Applications A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.<br>References Kodelja, V., et al.: J. Immunol., 160, 1411 (1998), Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (2003), Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (2004), Martinez, F., et al.: Front Biosci., 13, 453 (2008),<br></p>

<p>Applications Solvent Red 25 (cas# 3176-79-2) is a useful research chemical. Dyes and metabolites, Environmental Testing.<br></p>

<p>Applications Pararosaniline Hydrochloride is a red dye used for textiles. Dyes and metabolites, Environmental Testing.<br>References Abadulla, E., et al.: Appl. Environ. Microbiol., 66, 3357 (2000); Nyanhongo, G., et al.: Water Res., 36, 1449 (2002);<br></p>

<p>Applications Used as an anticancer and antiviral agent.<br>References Cancer Res., 20, 1362 (1960), Virology, 38, 26 (1969),<br></p>

<p>Applications The 22S-metabolite of Cholesterol (C432501). 22-Hydroxycholesterol inhibits chemokine receptor activity.<br>References Samson, M., et al.: J. Biol. Chem., 272, 24934 (1997), Mackay, C., et al.: Nature Immunol., 2, 95 (2001), Navenot, J., et al.: J. Mol. Biol., 313, 1181 (2001),<br></p>

<p>Applications N-Acetyl-L-alanine is used as a biomarker for prostate cancer.<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),<br></p>

<p>Applications 3,3'-Dichlorobenzidine-d6 is an isotope analog of 3,3'-Dichlorobenzidine. 3,3'-Dichlorobenzidine, is structurally similar to Benzidine (B121000), and thus is considered a carcinogen. It can be used in the production of azo dyes. Dyes and metabolites, Environmental Testing<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Min, Zh., et al.: Chem. Res. Toxic., 26, 741 (2013); Rainer, F., et al.: Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis, 691, 27 (2010);<br></p>

<p>Applications Phytosiderophores are produced in higher plants as iron chelating amino acids that promote uptake of iron from soil.<br>References Klair, S., et al.: J. Plant Nutr., 19, 1295 (1996),<br></p>

<p>Applications It is used as labelled biomarker for metabolic age.<br>References Selmer, T., et al.: Eur. J. Biochem., 268, 1363 (2001), Connelly, J., et al.: Drug Metab. Dispos., 30, 1357 (2002), Lindon, J., et al.: Pharm. Res., 23, 1075 (2006), Monteagudo, E., et al.: Xenobiotica, 37, 1000 (2007),<br></p>

<p>Applications Ligand used for the preparation of an affinity resin highly specific for glucosidase I purification. Glucosidase I is involved in the post-translational processing of N-linked glycoproteins.<br>References HettKamp, H., et al.: Eur. J. Biochem., 142, 85 (1984); Shailubhai, K., et al.: Biochem. J., 247, 555 (1987); Bause, E., et al.: FEBS, 278, 167 (1991)<br></p>

<p>Applications Carbamoyl-guanidine Amidino Urea Salt, Hydrochloride salt (cas# 926-72-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Demethyldihydrolanosterol, is a derivative of Lanosterol (L174580). It is also a sterol that activate oocyte meiosis.<br>References Byskov, A., et al.: Nature (London), 374, 559 (1995); Ma, L., et. al.: Food Chem., 139, 503 (2013);<br></p>

<p>Stability Moisture Sensitive<br>Applications 4,5-Bis(chloromethyl)-1,3-dioxol-2-one is an impurity of Olmesartan Medoxomil (O550000), which is an angiotensin II receptor antagonist. Used as an anti-hypertensive.<br>References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996), Puchler, K., et al.: J. Hypertens., 15, 1809 (1997),<br></p>

<p>Applications (25R)-26-Hydroxycholesterol is a desmosterol metabolite that is found in the brain. 26-Hydroxycholesterol has been used as a biomarker for carbon cycling in the northwestern Mediterranean Sea.<br>References Meljon, A., et. al.: J. Lipid Res., 53, 2469 (2012); Christodoulou, S., et. al.: Marine Chem., 113, 25 (2009)<br></p>

<p>Stability Store tightly sealed at 4°C; Light Sensitive<br>Applications 5-Iodotubercidin is an analogue of the antibiotic tubercidin, a pyrrolo[2,3-d]pyrimidine nucleoside antibiotic (1,2,3). A potent inhibitor of adenosine kinase from rat or guinea pig brain. Inhibits uptake of 3H-adenosine into brain slices. 5-Iodotubercidin is a nucleoside transporters inhibitor.<br>References (1) Long, M. and Parker, W. B.: Biochem. Pharmacol., 71, 1671 (2006) (2) Bonilla-Santiago, R., et al.: Mol. Biochem. Parasitol., 162, 149 (2008) (3) Caballero, J., et al.: Bioorg. Med. Chem., 16, 5103 (2008)<br></p>

<p>Applications Thionin Acetate Salt is a metachromic cationic histology dye. It can also be used in biological use and engineering or chemical process of controlled design and fabrication of SERS-SEF multifunctional nanoparticles for nanoprobe applications. Dyes and metabolites.<br>References Chang, S., et al.: J Phys Chem C, (2017)<br></p>

<p>Stability Hygroscopic<br>Applications EPTC is a pesticide, S-Ethyl-N,N-dipropylthiocarbamate<br></p>

<p>Applications Pentanoic-2,2,3,3-d4 Acid (CAS# 1219804-71-3) is a useful isotopically labeled research compound.<br></p>