Biochemicals and Reagents

<p>Applications C.I.Reactive Black 5 (CAS# 17095-24-8) is a useful research chemical compound.<br></p>

<p>Applications 2-Phenylethylamine hydrochloride (cas# 156-28-5) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity.<br>References Hecht, S., et al.: Chem. Res. Toxicol., 17, 588 (2004); Choi, J., et al.: J. Biol. Chem., 281, 38244 (2006); Lao, Y., et al.: Chem. Res. Toxicol., 20, 246 (2007);<br></p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ANA. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ANA. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ANA, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ANA in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Applications 3-Amino-4-methoxybenzanilide (CAS# 120-35-4) is a useful research chemical compound.<br></p>

<p>Applications o-Dianisidine (cas# 119-90-4) is a useful research chemical. Dyes and metabolites, Environmental Testing.<br></p>

<p>Applications 1-Ethyl-1-methylcyclopentane, is one of the chemical components of Gas-Phase organic carbon emissions from motor vehicles. It is also a volatile component of frying oils.<br>References Gentner, D. R., et al.: Environ. Sci. Tech., 47, 11937 (2013); Prevot, A. Frying Food, 155 (1988);<br></p>

<p>Applications 3’,5’-Diiodo-L-thyronine is a thyroid hormone that has been shown to increase malic enzyme activity, and the activity of glucose-6-phosphate dehydrogenase in teleost Anabas testudineus. Thus, showing short term effect on lipid metabolism.<br>References Davey, K.G.: Insect Biochem. Mol. Bio., 30, 877 (2000); Shameena, B., et. al.: Endocr. Res., 26, 431 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications (R)-Butyryl Carnitine is a potential prodrug of Carnitine, used for treating seizure disorders.<br>References Fei, Y., et al.: J. Biol. Chem., 275, 23707 (2000), Duran, J., et al.: J. Membr. Biol., 185, 65 (2002), Brown, A., et al.: J. Biol. Chem., 278, 11312 (2003), Gupta, N., et al.: Life Sci., 78, 2419 (2006),<br></p>

<p>Stability Light Sensitive<br>Applications Rhodamine B is used in biological studies for an anti-reactive oxygen species/hepatic fibrosis drug delivery system based on salvianolic acid B loaded mesoporous silica nanoparticles. Dyes and metabolites, Environmental Testing.<br>References He, Q., et al.: Biomaterials, 31, 7785 (2010)<br></p>

<p>Stability Light Sensitive<br>Applications Used in the manufacturing plastics; synthetic rubber; resins; insulator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meyer. H.J., et al.: Arzneim.-Forsch., 19, 617 (1969), Pahwa, R., et al.: Vet. Hum. Toxicol., 35, 516 (1993),<br></p>

<p>Applications ThioGlo1 is thiol-reactive dye used for fluorescence labeling of proteomic samples.<br>References Tyagarajan, K., et al.: Electrophoresis, 24, 2348 (2003);<br></p>

<p>Applications Isoindigo has proven successful as an electron-accepting building block for the preparation of electroactive materials for organic electronics. Meisoindigo, as a functionalized Isoindigo, has been used as an indirubin substitute for the treatment of chronic myeloid leukemia (CML).<br>References Stalder, R., et al.: Chem. Mater., 26, 664 (2014); Wee, X., et al.: ChemMedChem, 7, 777 (2012); Wee, X., et al.: Bioorg. Med. Chem., 17, 7262 (2009)<br></p>

<p>Applications Victoria Blue R (C.I. 44040) (cas# 2185-86-6) is a useful research chemical. Dyes and metabolites.It is used in preparation and photocatalytic activity of tio2/ppy/go for degrdation of rose bengal and victoria blue dye in visible light in aqueous solution.<br>References Pandey, G., et al.: Desalination and Water Treatment, 114, 265-284 (2018);<br></p>

<p>Applications Benzidine-d8 is involved in the enhancements in ion abundances in high-performance liquid chromatography, thus improving chromatography efficiency and particle-beam process.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bellar, T. A., et al.: J. Am. Soc. Mass. Spectrom., 1, 92-8 (1990)<br></p>

<p>Stability Light Sensitive<br>Applications cis-7,10,13,16-Docosatetraenoic Acid has been identified as a protein kinase inhibitor, affecting serotonin levels in studies.<br>References Mirnikjoo, B. et al.: J. Biol. Chem., 276, 10888 (2001);<br></p>

<p>Applications JTV 519 Fumarate is a useful intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ursodeoxycholic Acid-d4 is a deuterated form of Ursodeoxcholic Acid (U850000), which is used as an anticholelithogenic. Ursodeoxcholic Acid is an epimer with Chenodiol with respect to the hydroxyl group at C7. Ursodeoxycholic Acid-d4 was used as an internal standard for rapid quantification of bile acids by liquid chromatography-tandem mass spectrometry.<br>References Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986), Poupon, R.E, et al.: N. Engl. J. Med., 324, 1548 (1991), MacKenzie, P., et al.: J. Biol. Chem., 283, 36205 (2008); Scherer, M., et al.: J. Chromatogr. B, 877, 3920 (2009(<br></p>

<p>Applications Tetrahydro 11-Deoxycorticosterone is a metabolite of 11-Deoxycorticosterone (DOC) (D232590).<br>References Fedele, E., et al.: J. Neurochem., 75, 782 (2000), Adkins, C., et al.: J. Biol. Chem., 276, 38934 (2001), Erceg, S., et al.: Brain Res., 1036, 115 (2005),<br></p>

<p>Applications tert-Butyl (2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-[(1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate is an orally anti-diabetic agent as a inhibitors of dipeptidylpeptidase IV (DPP-4).<br>References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705-5719 (2012);<br></p>

<p>Impurity Ursodeoxycholic Acid EP Impurity A<br>Applications Chenodeoxycholic Acid (Ursodeoxycholic Acid EP Impurity A) is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Facilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.<br>References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),<br></p>

<p>Applications Hydrocortisone 17-Valerate is a derivative of Hydrocortisone (H714615) which is a glucocorticoid that is produced by the zona fasciculata of the adrenal gland.<br>References Ponec, M. et. al.: J. Pharm. Sci., 75, 973 (1986); Vigore, L., et al.: Cancer Ther., 6, 699 (2008)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive, Temperature Sensitive<br>Applications A stable folate lyophilized compound suitable for use in the treatment of cancer and other therapies.<br>References Park, H., et al.: Science, 268, 1866 (1995), Banerjee, R., et al.: J. Biol. Chem., 282, 14916 (2007), Klar, T., et al.: J. Mol. Biol., 366, 954 (2007),<br></p>

<p>Applications DL-p-Hydroxyphenyllactic Acid is used as a reagent in the synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid, an important intermediate of rosmarinic acid biosynthesis.<br>References Matsuno, M., et al.: Chem. Pharm. Bull., 49, 1644 (2001)<br></p>

<p>Applications 2-Phenylbenzothiazole is an organic compound that was detected in water and sediment from sedimentation ponds as a contaminant.<br>References Grung, M., et al.: Sci. Total Environ., 751, 141808 (2021)<br></p>

<p>Applications L-alloisoleucine is a stereo-isomer of L-isoleucine (I820175) and is produced as a byproduct of isoleucine via transamination.  L-allo-isoleucine has been suggested to induce epithelial β-defensin expression. In addition, L-allo-isoleucine is utilized in the biosynthesis pathway for coronamic acid.<br>References Fehlbaum, P., et al.: Proc. Natl. Acad. Sci. USA 97, 12723 (2000); Parry, R. J., et al.: J. Am. Chem. Soc. 113, 1849 (1991)<br></p>

<p>Applications Disperse Blue 106 is a textile dye that causes allergic contact dermatitis. It is very rarely used in textiles nowadays.<br>References Wentworth, Ashley B., et al.: Dermatitis, 23(6), 269-274 (2012); Malinauskiene, Laura., et al.: Contact Dermititis, 67(3), 141-148 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Adenosine 5'-diphosphate monosodium salt (cas# 20398-34-9) is a useful research chemical.<br></p>

<p>Applications 2-Ethyl-3,6-dimethylpyrazine is a flavour-active and non-volatile compound identified in thermally treated yeast extracts. It is also useful in the synthesis of new flavour additive species of pyrazines.<br>References Alim, A., et al.: J. Sci. Food Agric., 98, 3774 (2018); Lai, M., et al.: J. Therm. Anal. Calorim., 128, 1627 (2017)<br></p>

<p>Applications Arainosine is used in the preparation of 5'-O-D-valyl adenine 9-β-D-arabinofuranoside, a potential prodrug for improving the oral bioavailability of the antiviral agent Vidarabine (V305030).<br>References Shen, W., et al.: Nucleos. Nucleot. Nucl., 28, 43 (2009)<br></p>

<p>Applications Uvinul A Plus-d4 is the labelled compound of Uvinul A Plus(U850300) which is a component of cosmetic emulsion with UV protection.<br>References Chang, M., et al.: J. Food Drug Anal., 9, 199 (2001), Simeoni, S., et al.: J. Pharm. Biomed. Anal., 38, 250 (2005), Vielhaber, G., et al.: Photochem. Photobiol. Sci., 5, 275 (2006), Lee, S., et al.: J. Cosmet. Sci., 59, 469 (2008),<br></p>

<p>Applications A sulfhydryl reactive protein crosslinking reagent. Dimeric adducts can be cleaved with TCEP.<br></p>

<p>Applications A fluorescent reagent.<br>References Doyle, E.L., et al.: J. Am. Chem. Soc., 125, 4593 (2003), Hwang, S., et al.: Bioorg. Med. Chem. Lett., 16, 5773 (2006),<br></p>

<p>Applications A metabolite of Cyclophosphamide (CPA) (C988580).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Takamizawa, A., et al.: J. Med. Chem., 18, 376 (1975), Jones, R.J., et al.: J. Hematother., 1, 343 (1992), Biggs, D., et al.: Prog. Clin. Biol. Res., 389, 9 (1994),<br></p>

<p>Applications M1G is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose. It is a guanine adduct formed by reaction of malondialdehyde with DNA.<br>References Ham, A., et al.: Chem. Res. Toxicol., 13, 1243 (2000), Sharma, R., et al.: Clin. Cancer Res., 7, 1452 (2001), Jeong, Y., et al.: Chem. Res. Toxicol., 18, 51 (2005),<br></p>

<p>Applications Butyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Applications β-Alanine-13C3,15N is the isotope labeled analogue of β-Alanine (A637320), which is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of Dihydro Uracil (D449990) and Carnosine. β-Alanine is also the rate-limiting precursor of Carnosine, as a result supplementation with β-Alanine increases the concentration of Carnosine in muscles.<br>References Derave, W. et al.: J. Appl. Physiol., 103, 1736 (2007); Xia, J.-F. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 977, 1930 (2009); Artioli, G.G. et al.: Med. Sci. Sports Exer.,42, 1162 (2010);<br></p>