Heterocycles with Nitrogen (N)

<p>Applications 2-[4-(3-Pyrrolidinyl)1,3-thiazol-2yl]guanidine is a reagent which is used in biological studies as antiulcer agent.<br>References Gupta, S., et al.: J. Chem. Info. Comp. Sci, 39, 272 (1999)<br></p>

<p>Applications Piperonylamine is a metabolite of dopamine analogs.<br>References Goodwin, B.L., et al.: Xenobiotica, 24, 129 (1994),<br></p>

<p>Applications Labelled N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide (F595365). Rosuvastatin intermediate.<br></p>

<p>Applications 4,6-Dimethyl-2-(methylthio)pyrimidine is a useful reactant for the synthesis of substituted heterocycles via nickel-catalyzed cross-coupling reaction.<br>References Melzig, L., et al.: J. Org. Chem., 75, 2131-33 (2010);<br></p>

<p>Applications 6-Bromopicolinic acid<br></p>

<p>Applications 6-Chloro-2,3-dimethoxypyridine (cas# 1087659-30-0) is a useful research chemical.<br></p>

<p>Applications Succinimidyl Nervonate (cas# 191354-88-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(3-Aminophenyl)-1H-benzo[d]imidazol-6-amine (cas# 13676-49-8) is a useful research chemical.<br></p>

<p>Applications 5-(Trifluoromethyl)-1H-pyrazole-4-carboxylic acid (cas# 543739-84-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-​Hydrazinyl-​4-​methylbenzoxazole is a useful research chemical.<br></p>

<p>Applications 6-Bromo-2-fluoropyridin-3-ol (cas# 850142-72-2) is a useful research chemical.<br></p>

<p>Applications N-3-Piperidinylcarbamic Acid 1,1-Dimethylethyl Ester is used in the synthesis of highly selective spleen tyrosine kinase inhibitors. Also used in the synthesis of a potent NHE1 inhibitor displaying cardioprotective effects.<br>References Lucas, M. et al.: J. Med. Chem., 55, 10414 (2012); Huber, J. et al.: J. Med. Chem., 55, 7114 (2012);<br></p>

<p>Applications 5-Ethyl-2-pyridineethanol (cas# 5223-06-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YLBORONIC ACID (cas# 1194483-04-9) is a useful research chemical.<br></p>

<p>Applications 2,4-Dihydroxypyridine (cas# 626-03-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 5-Hydroxy-2-benzimidazolecarbamate-d3, is a labeled analogue of Methyl 5-Hydroxy-2-benzimidazolecarbamate (M312585), which is a derivative of Carbendazim (C175900).<br>References Zeng, Z., et al.: J. Agric. Food Chem., 44, 3374 (1996), Lewis, D., et al.: Xenobiotica, 28, 235 (1998), Hodgson, E., et al.: J. Biochem. Mol. Toxicol., 21, 182 (2007),<br></p>

<p>Applications 1-isobutyl-1H-pyrazole-3-carboxylic acid (cas# 1006493-64-6) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 4,5-Dihydroxytetrahydro-2h-Imidazol-2-One (cas# 3720-97-6) is a useful research chemical.<br></p>

<p>Applications 1-(2,2-Dihydroxyethyl)-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic Acid is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Applications 1-Cbz-piperazine is used in the synthesis of serotonin 5-HT6 and dopamine D2 receptor ligands (1,2). It can also be used for the synthesis of a 11-C labelled ligands for imaging vesicular acetylcholine transporter.<br>References (1) Kindahl, T. et al.: Org. Biomol. Chem., 12, 4461 (2014) (2) Krogsgaard-Larsen, N., et al.: J. Med. Chem., 57, 5823 (2014)<br></p>

<p>Applications 7-Bromo-5-(pyridin-2-yl)-1H-benzo[e][1,4]diazepine-2(3H)-thione is used in the preparation of triazolobenzodiazepines with antianxiety and antidepressant activity.<br>References Hester, J.B., et. al.: J. Med. Chem., 23, 392 (1980)<br></p>

<p>Applications 6-Desamino-6-oxo Phenazopyridine is a Phenazopyridine (P313751) degradation product/impurity, and is a useful synthetic intermediate.<br>References Nickerson, B., et al.: J. Liq. Chromatogr., 18, 3947 (1995)<br></p>

<p>Applications N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide is an intermediate for the synthesis of dTAG-7 (D710015), which is a degradation tag, was tested for its efficiency at depleting FKBP12F36V -MELK(sg3R) and was found to have significantly degraded FKBP12F36V -MELK(sg3R) within 4 hours.Used in the study of cancer research.<br>References Hai-Tsang Huang., eLife, 1-29, (2017)<br></p>

<p>Applications [1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (cas# 3176-50-9) is a useful research chemical.<br></p>

<p>Applications (R)-3-Aminopiperidine-2-one<br></p>

<p>Applications 1-p-Tolyl-pyrimidine-2,4,6-trione (cas# 16348-04-2) is a useful research chemical.<br></p>

<p>Applications 3-Bromopropionic Acid N-Hydroxysuccinimide (cas# 101314-84-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Hydroxypiperidine-d9 is labelled 4-Hydroxypiperidine (H950845) which is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.<br>References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999)<br></p>

<p>Applications {2-[(Pyridin-4-ylmethyl)thio]-1,3-thiazol-4-yl}acetic acid (cas# 1040631-48-8) is a useful research chemical.<br></p>

<p>Applications 2-Fluoropyridine-5-carbonyl chloride<br></p>

<p>Applications N-[1-[1-(4-Methoxyphenyl)-1H-tetrazol-5-yl]-1-methylpropyl]-1H-indole-3-ethanamine,<br></p>

<p>Applications 2,4-Dichloro-5-bromopyrimidine (cas# 36082-50-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,6-di-tert-Butylpyridine is used in the preparation of polymers with n-type nitroxide side groups to be used in organic radical batteries.<br>References Jaehnert, T., et. al.: Eur. Polymer J., 61, 105 (2014)<br></p>

<p>Applications N-Boc-3-(1-cyano-2-ethoxy-2-oxoethylidene)-1-piperidine is a useful synthetic intermediate.<br></p>

<p>Applications 2-(5-Ethylpyridin-2-yl)prop-2-en-1-ol is a key intermediate in the synthesis of pioglitazone hydrochloride.<br>References Mohanty, S., et al.: Org. Process Res. Dev., 18, 168 (2014)<br></p>

<p>Applications 5-Aminopyrazine-2-boronic acid pinacol ester is a reagent for the synthesis of amino-pyrido-indol-carboxamides that acts as a JAK2 inhibitor used in the treatment of myeloproliferative disorder.<br>References Lim, J., et al.: J. Med. Chem., 54, 7334 (2011)<br></p>

<p>Applications 2,2,6,6-Tetramethylpiperidine-1,4-diol is related to 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy (H956500), which is a free radical scavenger. 2,2,6,6-Tetramethylpiperidine-1,4-diol has also been shown to be an in vitro and in vivo radioprotector. It is used as a reagent in stereoselective preparation of tetrasubstituted triarylated olefins via Pd-catalyzed sequential oxidative Heck arylation of alkenes with arylboronic acids using nitroxides as oxidants.<br>References Flather, M., et al.: Lancet, 355, 1575 (2000); Sasso, F., et al.: Metabolism, 52, 675 (2003); Kass, D., et al.: Circ. Res., 94, 1533 (2004); Murdoch, C., et al.: Cardiovasc Res., 71, 208 (2006); Hahn, M., et al.: Free Radic. Biol. Med., 28, 953 (2000); He, Z., et al.: Angew. Chem. Int. Ed., 51, 3699 (2012);<br></p>

<p>Applications 6-Fluoro-4-methyl-2-pyridinamine can be synthesized from 2,6-Dichloro-4-methylpyridine (39621-00-6).<br></p>

<p>Applications N-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-carboxamide hydrochloride (cas# 1219957-27-3) is a useful research chemical.<br></p>

<p>Applications Methyl 6-Amino-3,5-dibromopyridine-2-carboxylate is used as a reagent in the synthesis of imidazopyridines as Syk inhibitors. Also used as a reagent in the synthesis of quinoline, quinoxaline and naphthyridine derivatives as antibacterial agents.<br>References Blomgren, P., et al.: PCT Int. Appl. WO 2011112995 A1 20110915. Sep 15, 2011; Daines, R.A., et al.: PCT Int. Appl. WO 2007016610 A2 20070208. Feb 8, 2007<br></p>

<p>Applications 3-Amino-5-ethyl-5-phenylimidazolidine-2,4-dione (cas# 1139-11-3) could be useful for biological studies. An anticonvulsant.<br>References Lange, J., et al.: Pol. (1982), PL 123138 B1<br></p>

<p>Applications 6,7-Dihydro-Imidazo[1,5-a]pyrazin-8(5H)-one is a useful research chemical.<br></p>

<p>Applications 1,2-Benzisoxazole has therapeutic uses. It could be useful for treating parkinsonism.<br>References Panza, F., et al.: Expert Opin. Pharmacother., (2020)<br></p>

<p>Applications 2,3-Dichloropyridine-5-boronic acid<br></p>

<p>Applications 2-(3-Aminophenyl)pyridine Dihydrochloride<br></p>

<p>Applications (4S)​-4-​Carboxy-​5,​5-​dimethyl-​α-​[[(5-​methyl-​3-​phenyl-​4-​isoxazolyl)​carbonyl]​amino]​-2-​thiazolidineacetic acid is a useful reactant for organic reactions.<br></p>

<p>Applications 2-Aminopyrimidine-5-boronic Acid Pinacol Ester is used in the preparation of phosphoinositide-3-kinases (PI3K) inhibitors.<br>References Burger, M.T. et al.: ACS Med. Chem. Lett., 2, 774 (2011); Heffron, T.P. et al.: J. Med. Chdem., 55, 8007 (2012);<br></p>

<p>Applications 3,4-Dihydro-2(1H)-pyridinone is used as a reactant for the regio- and stereoselective preparation of lactam-fused quinoline derivatives via Povarov-type multicomponent reaction of aldehydes, anilines, and unsaturated lactams followed by oxidation or fragmentation reactions.<br>References Vicente-Garcia, E., et al.: Org. Lett., 12, 860 (2010)<br></p>

<p>Applications 2-Aminomethyl-3-nitropyridine is a derivative of 2-Methyl-3-nitropyridine (M320425).<br></p>

<p>Applications 4-Chloropyridine is used to synthesize Thrombin inhibitors, compounds that have potent anticoagulant activity. 4-Chloropyridine is also used as a reagent to synthesize Botryllazine A, a pyrazine alkaloid that exhibits cytotoxicity against human tumour cells.<br>References de Candia, M., et al.: J. Med. Chem., 56, 8696 (2013); Kodimuthali, A., et al.: Tetrahedron Lett., 50, 1618 (2009); Singh, P., et al.: J. Org. Chem., 78, 2639 (2013)<br></p>

<p>Applications N-[[2'-(1H-Tetrazol-5-Yl)[1,1'-Biphenyl]-4-Yl]Methyl]Amine (cas# 147225-68-1) is a useful research chemical.<br></p>

<p>Applications 4-Ethylpyridine is a general chemical reagent used in the synthesis of substituted pyridines as well as diverse azacyclic compounds.<br>References Gandhamsetty, N. et al.: J. Am. Chem. Soc., 137, 15176 (2015); Chen, X. et al.: J. Coord. Chem., 68, 2835 (2015);<br></p>

<p>Applications 5-Hydroxy-4,6-dimethyl-3-pyridinemethanol is used in the study of sphingosine-1-phosphate is a major chemoattractant and stem cell mobilization factor.<br>References Ratajczak, M.Z., et al.: Leukemia, 24, 976 (2010)<br></p>

<p>Applications N-Chloropiperidine is an intermediate used in the synthesis of 1-Piperidin-2-ylacetone (B449983), which is a useful research chemical.<br></p>

<p>Applications Reagent used in Guanidino transfers.<br></p>

<p>Applications N-Tosylpyrrole (cas# 17639-64-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(Phenylmethyl)-2-imidazolidinone (cas# 2385-38-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Boronopicolinic acid<br></p>

<p>Applications Tris(4-pyridyl)-s-triazine is used in the preparation of metal-metallite coordination polymers as well as porphyrin prisms.<br>References Youm, K. et al.: Chem. Comm., 29, 3375 (2008); Li, M. et al.: CrystEngComm., 15, 1225 (2013);<br></p>

<p>Applications 6-Bromopiperonal is a disubstituted 1,3-benzodioxole that displayed synergistic activity with carbaryl on houseflies. 6-Bromopiperonal is used as an intermediate in the preparation of GPR30-selective agonist G-1.<br>References Wilkinson, C.F. et al.: J. Agric. Food Chem., 15, 139 (1967): Hewlett, P.S. et al.: J. Sci. Food Agric., 18, 279 (1967); Burai, R. et al.: Org. Biomol. Chem., 8, 2252 (2010);<br></p>

<p>Applications 2-chloro-1H-benzimidazole (cas# 4857-06-1) is a useful research chemical.<br></p>

<p>Applications 2-(3-Fluorophenyl)pyrrolidine<br></p>

<p>Applications Pyridinium Formate is used as a doping agent to study different form of EHD processing for use ewith viscous surface tension solutions.<br>References Larsen, G., et al.: Adv. Mat., 16, 166 (2004);<br></p>

<p>Applications 4-[5-(4-Pentyloxyphenyl)isoxazol-3-yl]benzoic Acidis used to optimize the side chain of the natural product FR901379.<br>References Tomishima, M., et al.: Bioorg. Med. Chem. Lett., 18, 2886 (2008)<br></p>

<p>Applications 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride is a key intermediate in the synthesis of Riociguat, a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.<br>References Arava, V., et al.: Pharma Chemica, 5, 232 (2013)<br></p>