Heterocycles with Nitrogen (N)

<p>8-Hydroxyquinoline sulfate is a drug that has been used to study the cancer tissue response to various drugs. The 8-hydroxyl group in the molecule interacts with metals and forms chelate complexes, which may be the reason for its cytotoxic effect. 8-Hydroxyquinoline sulfate also inhibits mitochondrial membrane potential and blocks the receptor activity of some cell types. It has been shown to be significantly cytotoxic to HL-60 cells, as well as other cell lines.</p>

<p>3-Hydroxypiperidine is a chemical compound that contains an asymmetric carbonyl group. It has been used in the synthesis of enantiopure pharmaceuticals, and is also a competitive inhibitor for some enzymes. 3-Hydroxypiperidine can be synthesized by hydrogenation reduction or hydroxylation of piperidine. This compound has been shown to have pharmacokinetic properties in rats and mice, as well as inhibitory effects on brain functions such as memory retention and learning. 3-Hydroxypiperidine has also been shown to induce apoptosis in breast cancer cells, which may be due to its ability to inhibit protein synthesis in these cells.</p>

<p>4-Cyanopyridine is an organic compound with the chemical formula (CN)N. It is a white solid that is soluble in water and polar solvents. When exposed to hydrochloric acid, 4-cyanopyridine undergoes a reaction that converts it to picolinic acid. This reaction proceeds through a mechanism in which the nucleophilic hydroxyl group of 4-cyanopyridine attacks the protonated nitrogen atom of hydrochloric acid. The resulting intermediate then loses a proton and becomes picolinic acid. Kinetic data on this reaction has been obtained from UV-vis spectroscopy, X-ray diffraction, and mass spectrometry experiments. The crystal structures of the bound form of 4-cyanopyridine and its quinoline derivatives have also been determined by x-ray crystallography.</p>

<p>1-(4,6-dimethylpyrimidin-2-yl)-3-benzoylthiourea is a versatile compound that can be used in various research applications. It is commonly used as a condensation reagent in the synthesis of sulfonamide derivatives. This compound is also utilized in the development of research chemicals and reagents for various purposes.</p>

<p>N-Nitrosopiperidine is a nitrated aromatic amine that can be found in the environment. It has been shown to induce genotoxic effects and to inhibit liver microsomal enzyme activity. It is also shown to cause DNA damage in hl-60 cells and in the model system. N-Nitrosopiperidine may act by causing an increase in reactive oxygen species (ROS) production, which results in oxidative stress and cellular dysfunction. This compound has been shown to induce congestive heart failure, as well as chronic oral toxicity and maternal toxicity. N-Nitrosopiperidine has also been associated with hepatic tissues changes and fetal bovine abnormalities.</p>

<p>N-[(3R)-1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea (GZ4081) is a drug that inhibits gastrin secretion by blocking the G protein coupled receptor. It has been shown to be effective in treating cancer and also has an inhibitory effect on tissue samples. GZ4081 has been shown to have long term treatment effects as well as being effective for prognosis. The effective dose of GZ4081 is not yet known but it is believed to be at least 10 times lower than the doses used for other drugs in its class.</p>

<p>2-Pyridinecarboxylic acid is a chemical compound that has been shown to have minimal toxicity. It is a potent inducer of various enzymes, including c-jun phosphorylation and enzyme activities. This compound has also been shown to bind to picolinic acid and picolinate, which are chemical compounds that have been associated with many physiological effects. 2-Pyridinecarboxylic acid may also be able to regulate the activity of growth factor-β1, which plays an important role in energy metabolism. Molecular docking analysis has shown that 2-pyridinecarboxylic acid may bind to chromium picolinate, a form of chromium with antioxidant properties.</p>

<p>Intermediate in the synthesis of baricitinib</p>

<p>3H-Imidazo[4,5-c]pyridine-7-carboxylic acid is a useful chemical that can be used as a reaction component for the synthesis of other compounds. It is an intermediate in the synthesis of many other chemicals. 3H-Imidazo[4,5-c]pyridine-7-carboxylic acid is a high quality chemical with a CAS number of 1234616-39-7.</p>

<p>Please enquire for more information about Finerenone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>6-Methoxypyrimidine-2,4(1H,3H)-dione is a nucleophilic compound that is formed by the reaction of an electron with a carbon atom in an organic molecule. It is used as a reagent in organic synthesis. 6-Methoxypyrimidine-2,4(1H,3H)-dione can be synthesized from 2-amino-5-methoxybenzaldehyde and chloroacetic acid in three steps. The chloride ion reacts with the 6-methoxypyridine to form the desired product. 6-Methoxypyrimidine-2,4(1H,3H)-dione can also be used as a reagent to catalyze chemical reactions such as alkylation and allylation reactions. 6-Methoxypyrimidine-2,4(1H,3H)-dione has been shown to have barbiturate activity</p>

<p>2-Ethoxy-5-fluoro-1H-pyrimidin-4-one is a chemical compound that can be synthesized in ethanol, ether, and ethyl formate. It is a white crystalline solid with a melting point of 164°C. The impurities are filtered out using filtration. This compound reacts with substance to produce crystallization. 2-Ethoxy-5-fluoro-1H-pyrimidin-4-one can also be synthesized by reacting trimethylamine and isourea.</p>

<p>Please enquire for more information about 2-(((4,6-dimethylpyrimidin-2-yl)amino)ethylidene)indane-1,3-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4,5-Diamino-6-hydroxy-2-mercaptopyrimidine is a primary amino that binds to the sulfur in a molecule. It has potent antibacterial activity and can be used for desulfurization of petroleum products. 4,5-Diamino-6-hydroxy-2-mercaptopyrimidine has been shown to react with some cancer cells in vitro and may be used as an anticancer agent. It can also be used as a catalyst for the oxidation of organic compounds in wastewater treatment or hydrochloric acid production. 4,5-Diamino-6-hydroxy-2-mercaptopyrimidine can be synthesized by reacting 3 mercapto propionic acid with 5 aminopyrimidines. The synthesis was optimized using a kinetic method and coordination chemistry. It has also been shown to inhibit cell growth when used on human erythrocytes using patch clamp experiments and assays.br&gt;br</p>

<p>SB-525334 is a synthetic compound that has been shown to be an inhibitor of the actin molecule. It has been used in cell-based assays to investigate the effects of SB-525334 on renal proximal tubule cells. The compound inhibits the growth and proliferation of carcinoma cells and virus cells, as well as the activity of various types of cell growth factors. SB-525334 is being investigated as a potential diagnostic tool for cancer and other diseases.</p>

<p>5-Bromo-4-chloroindolyl 1,3-diacetate (5BCDA) is a clinical response predictor of postoperative radiotherapy. It is an acr20 response predictor for the diagnosis of chronic hepatitis C and the disease activity index in women with genital herpes. 5BCDA has been found to be effective in reducing levels of IL-17a and IL-17f, which are cytokines that are important for immune responses. 5BCDA has also been shown to be effective in treating infectious diseases such as malaria and tuberculosis.</p>

<p>Please enquire for more information about 1-[(5-Methoxy-1-methyl-1H-indol-3-yl)methyl]piperidine-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-Bromo-2,4-dimethoxypyrimidine is a compound that functions as a potent inhibitor of L-glutamic acid amidohydrolase. This enzyme is essential for the synthesis of gamma-amino butyric acid (GABA) and glutamine, which are neurotransmitters in the central nervous system. 5-Bromo-2,4-dimethoxypyrimidine inhibits the formylation of l-glutamic acid to glutamate by inhibiting the enzyme L-glutamate formate lyase. It also inhibits herpes simplex virus type 1 (HSV1) replication by preventing viral DNA polymerization. 5-Bromo-2,4-dimethoxypyrimidine has been shown to be an effective inhibitor of chloride ion transport in some bacteria. The compound also shows photochromism when exposed to ultraviolet light or visible light under certain conditions. 5BROMO 2, 4 -DIM</p>

4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl free radical (ATMPO) is a hydroxyl radical that has been used as a diagnostic agent for oxidative injury. ATMPO reacts with the amino groups on proteins to form an adduct and changes their color from red to blue. This reaction can be used to identify the type of oxidative injury and the degree of injury in cells. ATMPO also interacts with integrin receptors on cell surfaces and causes neuronal death. This effect is reversible when ATMPO is removed from the cells. The molecular weight of this compound is 614 g/mol and it has biocompatible properties because of its long ester linkages and fatty acid chains.

<p>3,6-Dibromopyridazine is a heterocyclic organic compound that can be used as an acceptor in electron transfer reactions. It can also be used for the synthesis of cinnolines. The uptake of 3,6-dibromopyridazine by plants has been studied using structural analysis and microscopy techniques. This molecule is also useful for kinetic studies due to its high concentration in trifluoroacetic acid. 3,6-Dibromopyridazine is a nitrogenous organic compound that contains two pyridine rings. Electron paramagnetic resonance (EPR) spectroscopy has shown that this molecule has photocatalytic activity.</p>

<p>3-Hydroxy-2-hydroxymethyl-6-methylpyridine is an intermediate in the synthesis of a variety of organic compounds. It can be prepared by the cross-coupling reaction of 3,4-dihydroquinoline with aniline, which is catalyzed by copper (II) chloride. This compound has a chlorine atom and a hydroxyl group that are both trisubstituted with alkyl groups and it can be oxidized to produce different oxidation products. 3-Hydroxy-2-hydroxymethyl-6-methylpyridine also reacts with halides and triflates to form enolates, which are activated for nucleophilic substitution reactions. The molecular ion [M+H]+, which corresponds to the neutral molecule, can be observed by mass spectrometry when this compound is ionized in the gas phase. The chemical formula is C8H5NClO2.</p>

<p>Applications Hydrochloride salt of N-(β-Chloroethyl)piperidine is used in the inhibition of sickle-cell hemoglobin.<br>References Stubbins, J. et al.: Eur. J. Med. Chem., 14, 219 (1979);<br></p>

<p>Applications 2-Bromopyridine n-oxide hydrochloride<br></p>

<p>Applications ((4S,5S)-4-Isopropyl-2,2,5-trimethyl-1,3-dioxolan-4-yl)methanone 1H-Imidazol-1-yl is an intermediate in the synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile.<br>References Senter, T. J., et al.: Org. Lett., 14, 1869 (2012);<br></p>

<p>Applications 1-Propylpiperazine dihydrobromide (cas# 64262-23-3) is a useful research chemical.<br></p>

<p>Applications 4-[2-(1-Piperidinyl)ethoxy-d4]benzoic Acid, Hydrochloride Salt (cas# 1246815-60-0) is a compound useful in organic synthesis.<br></p>

<p>Applications A useful synthetic intermediate for solid phase synthesis of polyamides containing imidazole.<br>References Baird., E.E. and Dervan, P.B.: J. Am. Chem. Soc., 118, 6141 (1996)<br></p>

<p>Applications 1-(4-Cyanophenyl)piperazine<br></p>

<p>Stability Very Moisture Sensitive<br>Applications Cyanoacetic Acid N-Hydroxysuccinimide Ester is used as a pharmaceutical intermediate. It is used in the preparation of substituted pyrrolopyrimidinamines as selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection.<br>References Flanagan, M. E., et al.: J. Med. Chem., 53, 8468 (2010)<br></p>

<p>Applications 5-Amino-3-(1-naphthyl)-4-cyano-1-tert-butylpyrazole (cas# 221243-34-1) is a compound useful in organic synthesis.<br>References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999)<br></p>

<p>Applications 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-pyrazole-5-carboxylic Acid Hydrochloride is an intermediate for the synthesis of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase. Inhibits collagen-stimulated platelet aggregation in vitro.<br>References Kotzki, S. et al.: J. Pharm. Exp. Ther., 346, 424 (2013); Selwood, D&gt; et al.: J. Med. CHem., 44, 78 (2001)<br></p>

<p>Applications tert-Butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate is a useful intermediate used in the preparation of biologically active molecules with pharmacological applications.<br>References Lowe, P. T., et al.; ChemBioChem, 18, 2156 (2017); Brocklesby, K. L., et al.: Tetrahedron Lett., 58, 1467 (2017); Wei, H., et al.: Molecules, 21, 1693 (2016)<br></p>

<p>Applications 2-[[(3aR,4S,6R,6aS)-6-[7-Chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol is used as a reagent in the synthesis of Ticagrelor (T437700); an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.<br>References Springthorpe, B., et al.: Bioorg. Med. Chem. Lett., 17, 6013 (2007)<br></p>

<p>Applications Ethyl 5-Methyl-1-phenyl-1H-pyrazole-4-carboxylate (cas# 89193-16-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine-13C2 is a labelled 2,6-Diamino-4-hydroxy-5-nitrosopyrimidine (D416350), used in the preparation of pterin-based inhibitors.<br>References Hevener, K. et al.: J. Med. Chem., 53, 166 (2010)<br></p>

<p>Applications Reactant in the preparation of CB1 cannabinoid receptor agonists and brain imaging agents.<br>References Deng, H. et al; J. Med. Chem. 48, 6386 (2005)<br></p>

<p>Applications 4-Iodopyrazole is used in the synthesis of (pyrazolyl)oxobenzocycloheptapyridinyl acetamides that act as inhibitors of c-Met.<br>References Northrup, A. et al.: J. Med. Chem., 56, 2294 (2013);<br></p>

<p>Applications 2-Amino-4,6-dihydroxy-5-nitropyrimidine (cas# 80466-56-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Intermediate in the preparation of (+/-)-Iso Myosmine (I821350).<br></p>

<p>Applications 5-Cyanopyrimidine (cas# 40805-79-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,2,5,5-Tetramethyl-3-amino-pyrrolidine-1-oxyl Free Radical is a highly reactive spin-label compound.<br></p>

<p>Applications 2-(2-Thenylamino)pyridine is an intermediate in the synthesis of Methapyrilene Hydrochloride (M259970). Methapyrilene is used as antihistaminic agent.<br>References Calandre, E.P., et al.: Clin. Pharmacol. Ther., 29, 527 (1981); Eastmond, D., et al.: Mutagenesis, 24, 341 (2009); Dertinger, S., et al.: Toxicol. Sci., 115, 401 (2010)<br></p>

<p>Applications Labelled Anabaseine intermediate.<br></p>

<p>Applications (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone-D3 is an intermediate in the synthesis of (S)-3-Hydroxy-2-methylpropanoic Acid-d3 sodium salt (H997291), which is the labelled version of 3-hydroxy-2-methyl-Propanoic acid sodium salt (CAS# 1893416-17-5), a useful building block used in the synthesis of aminotriazine derivatives.<br>References Du, Z.; et al.: WO 2016049211 (2016).<br></p>

<p>Applications N-Acetyl-3-acetoxy-5-phenylpyrrole (cas# 100750-39-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Dinitro-3-pyridinol is an impurity in the synthesis of 2,6-Diamino-5-hydroxy-3-(phenylazo)pyridine which is a novel metabolite of Phenazopyridine (P313751).<br>References Bailey, K., et al.: Drug Metab. Dispos., 11, 277 (1983), Thomas, B. H., et al.: J. Pharm. Sci., 79, 321 (1990), Thomas, B.H., et al.: Xenobiotica, 23, 99 (1993),<br></p>

<p>Applications 2-Amino-4-chloro-5-nitropyridine (cas# 24484-96-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Octahydro-6-(phenylmethyl)-1H-Pyrrolo[3,4-b]pyridine-d4 is an isotope labelled intermediate in the synthesis of moxifoxacin (M745000), a fluorinated quinolone antibacterial.<br>References Somisetti, N. et al.: Org. Chem. Indian J., 7, 123 (2011);<br></p>

<p>Applications Pyridinium Chlorochromate is used in the synthesis of potent antitumor antibiotics and agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hurley, L. et al.: Chem. Res. Toxicol., 1, 258 (1988);<br></p>

<p>Applications 1-Cyclohexyl-1-(4-benzyloxycyclohexyl)-2-(2-pyridinyl)ethanol-d11_x000D_(Mixture of Diastereomers) (cas# 1189891-05-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Imidazol-1-yl-acetic Acid-15N2,13C2 (cas# 1184983-00-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,2,6,6-Tetramethyl-4-piperidinone (cas# 826-36-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Chloropyridine n-oxide (cas# 1121-76-2) is a useful research chemical.<br></p>

<p>Applications 6-[[2-(tert-Butyldimethylsilyloxy)ethyl]methylamino]pyridin-3-ol (cas# 326496-02-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(Tetrazol-1-yl)acetic Acid-13C2,15N is a reactant used in the preparation of labelled β-lactam antibiotics.<br>References Nys, P. et al.: App. Biochem. Biotech., 88, 221 (2000); Won, J. et al.: App. Biochem. Biotech., 69, 1 (1998); Kostadinov, M. et al.: App. Biochem. Biotech., 33, 177 (1992)<br></p>

<p>Applications An intermediate for the synthesis of labelled thiazolidinedione anti-diabetic drugs<br>References Cantello, B., et al.: Bioorg. Med. Chem. Lett., 4, 1181 (1994),<br></p>

<p>Applications 1-(2-Chloroethyl)-2-imidazolidinone (cas# 2387-20-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 5,6-Diamino-2,4-dihydroxypyrimidine-13C2 Bisulfite Salt is a compound useful in organic synthesis.<br></p>

<p>Applications 5-{4-[2-[(5-Benzyloxypyridin-2-yl)methylamino]ethoxy]benzylidine}thiazolidine-2,4-dione (cas# 1076199-05-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(tert-Butylamino)-4-chloro-6-cyclopropylamino-1,3,5-triazine-d9 (cas# 1189419-70-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,3-Dibutyl-3,6-dihydropyrimidin-1-ium Bromide is a byproduct in the synthesis of Carboplatin-d4 (C177502), which is an analog of Cisplatin with reduced nephrotoxicity. Antineoplastic.<br>References Harland, S.J., et al.: Cancer Res., 44, 1693 (1984), Smith, I.E., et al.: Cancer Treat. Rep., 69, 43 (1985), Lygidakis, N.J., et al.: Interferon Cytokine Res., 15, 467 (1995),<br></p>

<p>Applications Pyridine as novel substrate for regioselective oxygenation with aromatic peroxygenase from Agrocybe aegerita.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Colby, J., et al.: Biochem. J., 165, 395 (1977), Damani, L., et al.: Xenobiotica, 12, 527 (1982), Balzarini, J., et al.: J. Antimicrob. Chemother., 55, 135 (2005),<br></p>

<p>Applications Reactant used in the preparation of labelled Camptothecin derivatives.<br></p>

<p>Applications 2-[(5-Benzyloxypyridin-2-yl)methylamino]ethanol-d4 (cas# 1794786-87-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,6-Dibromopyridine is used as a starting material to synthesize 2,2’-bipyridines (such as 5-Cyano-1,6-dihydro-6-oxo-[3,4'-bipyridine]-2-carboxylic Acid [C979150]) via a Stille-type cross-coupling reaction. 2,6-Dibromopyridine is also used as a reagent to synthesize pyridylpyrimidine fungicides, compounds that eliminate fungi by cycling copper through the cell membrane, where it reaches toxic levels.<br>References Hargreaves, S., et al.: Tetrahedron Lett., 41, 1653 (2000); Heller, M. &amp; Schubert, U.: J. Org. Chem., 67, 8269 (2002); Simkovsky, N., et al.: J. Chem. Soc. Perk. Trans. 1, 16, 1847 (2002)<br></p>

<p>Applications 4-Chloro-2,6-dimethoxypyrimidine (cas# 6320-15-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Dichloro-5-nitropyrimidine (cas# 49845-33-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Nitro-1-(phenylmethyl)-1H-imidazole is an intermediate in the synthesis of nitroimidazole based compounds.<br>References Vidakovic, M., et al.: Antimicrob. Agents Chemother., 47, 302 (2003);<br></p>

<p>Applications Pyridine hydrobromide (cas# 18820-82-1) is a useful research chemical.<br></p>

<p>Applications N,1-Dimethyl-4-nitro-5-imidazolecarboxamide (cas# 858513-51-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Benzoyl-4-(2,3-dichlorophenyl)piperazine 4-Oxide is an intermediate in the synthesis of Aripiprazole (A771000) related compound.<br>References Satyanarayana, Bollikonda. et al., Heterocyclic. Commun., 11, 485 (2005);<br></p>

<p>Applications 4-Chloropyridine-2-carboxamide, is a versatile building block used in synthesis of various chemical compounds.<br></p>

<p>Stability Stable<br>Applications 2,4,5-Triamino-6-pyrimidinol-13C2,15N is an intermediate in the synthesis of labelled Guanine (G836000). Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA.<br>References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009); Manini, P., et al.: Toxicol. Lett., 190, 41 (2009); Gong, B., et al.: Biochem., 48, 11961 (2009); Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010)<br></p>

<p>Applications 4,6-Bis(4-nitrophenoxy)pyrimidine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Impurity Abiraterone Impurity 7<br>Applications 3-(Diethylboryl)pyridine is an intermediate used to prepare inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. It is also used in the synthesis of trisubstituted pyrimidines from polyhalopyrimidines via Suzuki coupling.<br>References Charrier, J., et al.; J. Med. Pharm. Chem., 54, 2320 (2011); Large, J., et al.: Synlett., 861 (2006)<br></p>

<p>Applications (S)-5-Chloro-3-(cyclopropylethynyl)-3-(trifluoromethyl)-1,3-dihydrobenzo[c]isoxazole is a proposed intermediate in the synthesis of (4S)-6-Chloro-4-(3-((4-chloro-2-((S)-4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)amino)pent-1-yn-1-yl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one (Mixture of Diastereomers) (C360045) which is an impurity of Efavirenz (E425000) which is a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications Phenyl 4-Bromo-2-cyclopropylpyridine-1(2H)-carboxylate is an intermediate in synthesizing B-(2-Cyclopropyl-4-pyridinyl)-boronic Acid (C989365), which is used in synthesis of isoindole carboxamides, pyrrolopyridine carboxamides, and similar compounds as inhibitors of phosphodiesterase type 10A for treating neurological and psychiatric disorders.<br>References Geneste, H., et al.: PCT Int. Appl. (2013), WO 2013000994 A1 20130103<br></p>

<p>Applications [4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methylsulfinyl)-5-pyrimidinyl]-ethyl Ester-d6 (cas# 1189487-47-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Chloro-4-(2,2,2-trifluoroacetyl)benzo[d]oxazol-2(3H)-one is an intermediate in the synthesis of 6-Chloro-4-[3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propyn-1-yl]-2(3H)-benzoxazolone (C365790), a impurity of Efavirenz (E425000) which is a nonnucleoside HIV-1 reverse transcriptase inhibitor.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications 5-Bromo-2-(1H-tetrazol-5-yl)pyridine is a reagent in the synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring.<br>References Jo, Y.W., et al.: Bioorg. Med. Chem., 12, 5909 (2004)<br></p>

<p>Applications N6-(2-Chloro-6-methyl-4-pyrimidinyl)-2-methyl-4,6-quinolinediamine is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.<br>References Gao, Y., et. al.: Proc. Natl. Acad. Sci. U.S.A., 101, 7618, (2004); Akbar, H., et. al.: Methods Enzymol, 406, 554 (2006)<br></p>

<p>Applications (1-Benzyl-1H-imidazol-5-yl)(2,3-dimethylphenyl)methanone is an intermediate in the synthesis of 1-Benzyl-5-(1-(2,3-dimethylphenyl)vinyl)-1H-imidazole (B251400), an impurity of Medetomidine (M203250, HCl); an α2-adrenergic agonist, sedative, and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996)<br></p>

<p>Applications 4-Iodo-1-tritylimidazole (cas# 96797-15-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3,7,8-Tetrachloro-[1,4]dioxino[2,3-b:5,6-b']dipyridine is used in analytical studies for the presence and formation of dioxin-like compounds in heat-treated chlorpyrifos herbicide, a potential precursor of pyridine analog of 2,3,7,8-Tetrachloro-p-dioxin (T291370).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakiyaama, T., et al.: Organohalogen Compounds, 73, 146 (2011);<br></p>

<p>Applications 4-Amino-6-hydroxypyrimidine (cas# 1193-22-2) is a compound useful in organic synthesis.<br></p>

<p>Applications A useful reactant in the preparation labelled Carbazeran (C175792), a phosphodiesterase inhibitor drug.<br></p>

<p>Applications 2-Chloro-3-iodopyridine (cas# 78607-36-0) is a compound useful in organic synthesis.<br></p>