Heterocycles with Nitrogen (N)

<p>Applications 4-Chloro-1H-imidazo[4,5-c]pyridine is used as a reagent in the synthesis of 3-bromo-3-deazaneplanocin and 3-bromo-3-deazaaristeromycin, compounds which exhibit antiviral activity.<br>References Liu, Ch., et al.: Bioorg. Med. Chem. Lett., 22, 5182 (2012)<br></p>

<p>Applications 5-(Chloromethyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]pyridine 97% (cas# 906352-80-5) is a useful research chemical.<br></p>

<p>Applications 2,3-dihydro-8-(boronic acid)-1,4-Dioxino[2,3-b]pyridine-d4 is labelled 2,3-dihydro-8-(boronic acid)-1,4-Dioxino[2,3-b]pyridine (D448690) which is a derivative of 2,3-dihydro-1,4-Dioxino[2,3-b]pyridine. 2,3-dihydro-1,4-Dioxino[2,3-b]pyridine is used to prepare benzanilide derivatives for use as anticancer agents.<br></p>

<p>Applications (4-Chlorobenzo[b]thiophen-2-yl)(piperazin-1-yl)methanone is a useful research chemical.<br></p>

<p>Applications 4-Hydroxypyridine, is a building block used in various chemical synthesis. It is used for the synthesis of bicyclic pyridinol analogues acting as antioxidants and capable of preserving mitochondrial function.<br>References Xiaoqing, X. C., et al.: Bioorg. Med. Chem., 20 (11), 3584 (2012);<br></p>

<p>Applications 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile (cas# 33097-13-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Methyl-2,3'-bipyridine (cas# 78210-78-3) is a useful research chemical.<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 4-Amino-3,5-bis(4-pyridyl)-1,2,4-triazole can be used to prepare cadmium aminoisophthalate pyridinyltriazolamine metal-organic frameworks for detection applications. It has also been utilized to synthesize a linear trinuclear Cu(II) complex with magnetic properties.<br>References Wang, H., et al.: RSC Adv. 5, 48881 (2015); Zhang, Q., et al.: J. Coord. Chem. 64, 2110 (2011)<br></p>

<p>Applications 5-Bromo-1-[2-Fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione is an intermediate in the synthesis of Elagolix, a gonadotropin-releasing hormone antagonist (GnRH) used in the treatment of endometriosis.<br>References Tukun, F. et al.: Molecules, 22, 12 (2017);<br></p>

<p>Applications N-BOC-Piperidin-4-ylmethyleneboronic acid pinacol ester is a useful research chemical.<br></p>

<p>Applications 6-methyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid (cas# 10176-79-1) is a useful research chemical.<br></p>

<p>Applications 4-(chloromethyl)-3,5-dimethyl-1H-pyrazole (cas# 152239-41-3) is a useful research chemical.<br></p>

<p>Applications 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinol, can be used for the synthesis of a novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists.<br>References Lowe, J. A., et al.: Bioorg. Med. Chem. Lett., 20, 4749 (2010);<br></p>

<p>Applications 2-Pyrimidinemethanamine (cas# 75985-45-4) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxypiperidine-3,3,4,5,5-d5 (CAS# 1219799-35-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Azidobutyrate-N-hydroxysuccinimide ester (cas# 943858-70-6) is a useful research chemical.<br></p>

<p>Applications 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide (cas# 1189858-48-7) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications 2-(2-Fluorophenyl)pyrrolidine<br></p>

<p>Applications Homopiperazine acts as a corrosion inhibitor for iron. It has also been used in the preparation of potent H3 receptor antagonists for use as treatments for neurodegenerative conditions such as Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Granese, S. et al.: Corrosion., 44, 322 (1988); Pippel, D. et al.: Org. Proc. Res. Devel., 15, 638 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications 2-Aminopyrimidine-5-boronic acid<br></p>

<p>Applications 3,4-Dihydro-2(1H)-pyridinone is used as a reactant for the regio- and stereoselective preparation of lactam-fused quinoline derivatives via Povarov-type multicomponent reaction of aldehydes, anilines, and unsaturated lactams followed by oxidation or fragmentation reactions.<br>References Vicente-Garcia, E., et al.: Org. Lett., 12, 860 (2010)<br></p>

<p>Applications A pyrazole derivative used as an intermediate in the preparation of herbicides.<br></p>

<p>Applications 5-Bromo-6-chloropyridine-3-sulfonyl Chloride (cas# 216394-05-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Cyano-4-(trifluoromethyl)pyridine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide is an intermediate for the synthesis of dTAG-7 (D710015), which is a degradation tag, was tested for its efficiency at depleting FKBP12F36V -MELK(sg3R) and was found to have significantly degraded FKBP12F36V -MELK(sg3R) within 4 hours.Used in the study of cancer research.<br>References Hai-Tsang Huang., eLife, 1-29, (2017)<br></p>

<p>Applications Phenyl 4-Bromo-2-(ethyl-d3)pyridine-1(2H)-carboxylate is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications 6-ACETYL-PICOLINIC ACID ETHYL ESTER (cas# 114578-70-0) is a useful research chemical.<br></p>

<p>Applications 2-Pyridin-4-ylmethyl-morpholine is a useful intermediate.<br></p>

<p>Stability Hygroscopic<br>Applications 4,5-Dihydroxytetrahydro-2h-Imidazol-2-One (cas# 3720-97-6) is a useful research chemical.<br></p>

<p>Applications 5-Nitropyridin-2(1H)-one can be used for molecular crystal optical materials.<br>References Uemya, T., et.al., Jpn. Kokai Tokkyo Koho, 22, (1995);<br></p>

<p>Applications 6-Methyl-3-pyridinol is a reagent in the preparation of anilino(pyridyl)quinolinecarbonitriles which has Src kinase inhibitiion and antitumor properties.<br>References Zhang, N., et al.: Bioorg. Med. Chem. Lett., 19, 5071 (2009); Blume-Jensen, P., et al.: Nature, 411, 355 (2001)<br></p>

<p>Applications 2,4,6-trimethyl-5-pyrimidinol (cas# 71267-12-4) is a useful research chemical.<br></p>

<p>Applications 2-Cyano-3-hydroxypyridine<br></p>

<p>Applications 4-Amino-3,5-dichloro-6-fluoropyridin-2-ol Potassium Salt is an intermediate for the synthesis of Fluroxypyr-d2,13C2 (F598782), which is the labeled analogue of Fluroxypyr (F598780), a systemic and selective herbicide. Fluroxypyr is used for the control of broad-leaved weeds in small grain cereals, maize, pastures, range land and turf. Fluroxypyr is also a synthetic auxin.<br>References Radivojevic, L. et al.: Pesticidi, 16, 181 (2001); Roberts, H.A. et al.: Tests Agrochem. Cult., 6, 96 (1985); Sanders, G.E. et al.: Ann. Appl. Biol., 111, 385 (1987)<br></p>

<p>Applications 1-Butylpyrrolidine (cas# 767-10-2) is a useful research chemical.<br></p>

<p>Applications 3-Bromo-2-hydroxypyridine is used in the synthesis of pyrazolopyridines as γ-secratase modulators.<br>References Qin, J. et al.: ACS Med. Chem. Lett., 2, 471 (2011);<br></p>

<p>Applications N-(3-{[2-chloro-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)prop-2-enamide (cas# 1374507-25-1) is a useful research chemical.<br></p>

<p>Applications 2,4-Dihydroxypyridine (cas# 626-03-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Hydrazino-1H-1,3-benzimidazole<br></p>

<p>Applications 5-Ethyl-2-vinylpyridine (cas# 5408-74-2) is a compound useful in organic synthesis.<br></p>

<p>Applications α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxybenzeneacetic acid is used in the preparation of Cefoperazone an antibiotic.<br>References Xu, Y., et al.: Zhongguo Yaoke Daxue Xuebao, 28, 264 (1997);<br></p>

<p>Applications 6-(Piperidin-1-yl)pyridin-3-ylboronic Acid Hydrochloride Salt is a useful research chemical.<br></p>

<p>Applications 2-Chloro-4-piperidinopyrimidine<br></p>

<p>Applications 4-Amino-2,6-dichloropyridine (cas# 2587-02-2) is a compound useful in organic synthesis.<br>References Altenbach, R., et al.: J. Med. Chem., 51, 6571 (2008), Namba, K., et al.: Bioorg. Med. Chem., 16, 6131 (2008),<br></p>

<p>Applications 1-(4-Hydroxyphenyl)piperidin-2-one (cas# 79557-03-2) is a compound useful in organic synthesis.<br></p>

<p>Applications (3E)-4-(5-Ethoxy-3-pyridinyl)-3-buten-1-ol is an intermediate in the synthesis of TC 2559 Fumarate (T012005), which is a partial agonist for AChR α4β2.<br></p>

<p>Applications 1-Isopropyl-d7-piperazine (CAS# 2089679-76-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Piperidine-d10-carbonyl Chloride (CAS# 1219803-31-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dimethyl 2,6-Pyridinedicarboxylate (cas# 5453-67-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 2-(1H-Pyrrol-2-yl)acetate is an intermediate in the synthesis of rac Ketorolac 6-Benzoyl Isomer (K235620). rac Ketorolac 6-Benzoyl Isomer (Ketorolac EP Impurity C) is an isomeric impurity of Ketorolac (K235620).<br></p>

<p>Applications Imidazole rings are found in numberous natural compounds such as enzymes, nucleic acid, and alkaloids that play a role in biological processes.<br></p>