Heterocycles with Nitrogen (N)

<p>Applications 4-Aminothieno[3,2-d]pyrimidine is a useful research intermediate<br>References Robba, M., et al.: Tetrahedron, 27, 487 (1971); Park, J. H., et al.: Heterocycles, 91, 835 (2015)<br></p>

<p>Applications 3-isobutylisoxazole-5-carboxylic acid (cas# 910321-93-6) is a useful research chemical.<br></p>

<p>Applications Ethyl 2-fluoropyridine-3-carboxylate<br></p>

<p>Applications 2-Acetyl-6-bromopyridine is used in the synthesis of some embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.<br>References Kantevari, S. et al.: Bioorg. Med. CHem., 19, 4772 (2011);<br></p>

<p>Applications 5-Aminopyrazine-2-boronic acid pinacol ester is a reagent for the synthesis of amino-pyrido-indol-carboxamides that acts as a JAK2 inhibitor used in the treatment of myeloproliferative disorder.<br>References Lim, J., et al.: J. Med. Chem., 54, 7334 (2011)<br></p>

<p>Applications Intermediate in the preparation of Losartan derivatives.<br></p>

<p>Applications 4,4'-Diamino-2,2'-bipyridine is a bidendate chelator.<br></p>

<p>Applications Isotope labelled B-[1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]boronic Acid is used in the preparation of ALK receptor mediators.<br></p>

<p>Applications 3-(difluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (cas# 1394042-15-9) is a useful research chemical.<br></p>

<p>Applications 2,6-Dimethyl-3,5-dicarboxy-4-(2-nitrophenyl)-1,4-dihydropyridine is used as a reactant in the preparation of hydroxyindolecarboxylate and hydroxycarbolinecarboxylate from nifedipine analogous cyanoethyl ester.<br>References Gorlitzer, K., et al.: Pharmazie, 55, 35 (2000)<br></p>

<p>Applications 2-Fluoroimidazole is a chemical reagent used in the synthesis of cephalosporins.<br>References Jung, F. et al.: J. Antibio., 46, 992 (1993);<br></p>

<p>Applications OXAZOLE-5-CARBOXYLIC ACID HYDRAZIDE (cas# 885274-30-6) is a useful research chemical.<br></p>

<p>Applications 1,3-Bis[2,6-bis(1-methylethyl)phenyl]-2-carboxy-1H-imidazolium Inner Salt is synthesized from 1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride(B426650). 1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is used as a reagent in the synthesis of NHC Copper(I) complexes bearing dipyridylamine ligands which exhibit interesting luminescent properties and are potential candidates for organic light-emitting diode applications. 1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride is also used as a reagent in the synthesis of 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic Acid Methyl Ester (D476595); the methyl ester derivative of the drug Vadimezan (V084950).<br>References Marion, R., et al.: Inorg. Chem., 53, 9181 (2014); Buchanan, C.M., et al.: Clin. Sci., 122, 449 (2012); Fruh, M., et al.: Clin. Lung. Cancer., 14, 34 (2013)<br></p>

<p>Applications 4-Ethyl-1,3-Oxazolidin-2-One (cas# 16112-60-0) is a useful research chemical.<br></p>

<p>Applications 5-fluoro-4-hydrazino-2-methoxypyrimidine (cas# 166524-64-7) is a useful research chemical.<br></p>

<p>Applications 4-Amino-2-chloro-3-methylbenzonitrile is a reagent used in synthesis of imidazolin-2-ones, which is designed and synthesized as highly potent, orally active and muscle selective androgen receptor modulators (SARMs).<br>References Li, J. J., et al.: J. Med. Chem., 50, 3015-3025 (2007)<br></p>

<p>Stability Hygroscopic, Unstable in Solution<br>Applications 3-Hydroxymethyl-(1-oxy-2,2,5,5-tetramethylpyrroline) (cas# 55738-75-5) is a compound useful in organic synthesis.<br>References Qin, P.Z., et al.: Biochemistry, 40, 6929 (2001)<br></p>

<p>Stability Volatile<br>Applications C6H8N2O2 (cas# 19213-72-0) is a useful research chemical.<br></p>

<p>Applications 2-Amino-3-pyridinecarbonitrile is used as a reagent in the synthesis of novel imidazo[1,2-a]pyridine derivatives as potent c-Met inhibitors and antimycobacterials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, C., et al.: ACS Med. Chem. Lett., 6, 507 (2015); Ramachandran, S., et al.: Bioorg. Med. Chem. Lett., 23, 4996 (2013)<br></p>

<p>Applications Contains up to 5 % Sodium Acetate by weight.<br></p>

<p>Applications 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid<br></p>

<p>Applications 5-Amino-4H-1,2,4-triazole-3-carboxylic Acid is a building block used in the synthesis of purine nucleotide analogs by a promiscuous hypoxanthine phosphoribosyltransferase.<br>References Scism, R.A., et. al.: Org. Lett., 9, 4179 (2007)<br></p>

<p>Applications 5-phenyl-1H-1,2,3-triazole-4-carboxylic acid (cas# 830-78-4) is a useful research chemical.<br></p>

<p>Applications [4-[(4-Methylpiperazin-1-yl)methyl]phenyl]boronic Acid is used to prepare N-(3-(pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamides as B-Raf kinase inhibitors.<br>References Berger, D., et al.: Bioorg. Med. Chem. Lett., 19, 6519 (2009)<br></p>

<p>Applications 1-(2-Chloroethyl)pyrrolidine is a haloalkyl substituted pyrrolidine used in the preparation of various pharmaceutical compound such as the estrogen receptor antagonist Nafoxidine (N212800) and its analogues.<br>References Neyyarapally, A.T. et al.: Ind. J. Chem., 11, 325 (1973); Jones, C.D. et al.: J. Med. Chem., 27, 1057 (1984); Nakata, K. et al.: Molecules, 15, 6773 (2010);<br></p>

<p>Applications 2,6-Difluoro-N-[4-[(4-fluorophenyl)methoxy]-2-pyridinyl]-benzeneacetamide was used to test its effect on 5'-inositol phosphatase 2 (SHIP2) as an inhibitor.<br>References Ichihara, Y., et. al.: Eur, J. Med. Chem., 62, 649 (2013)<br></p>

<p>Applications 5-Phenyl-2-piperidinecarboxylic Acid is a compound useful in organic synthesis<br></p>

<p>Applications 4-Chloro-1H-imidazole (cas# 15965-31-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Aminopyrazine-5-carboxylic Acid Methyl Ester (cas# 13924-94-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(1H-1,2,4-triazol-1-ylmethyl)benzoic acid (cas# 857284-23-2) is a useful research chemical.<br></p>

<p>Applications 2-(1H-Imidazol-1-yl)acetonitrile is a reactant that has been used in the synthesis of lanoconazole (L174500), an antifungal.<br>References Chen, Y., et. al.: Jiingxi Huagong Zhongjianti, 39, 28 (2009); Oka, H., et al.: Arzneim.-Forsch., 42, 345 (1992); Niwano, Y., et al.: Antimicrob. Agents Chemother., 38, 2204 (1994); Munt, L.: et al.: Oyo Yakuri, 43, 195 (1992)<br></p>

<p>Applications 5-Formyl-2-methylpyrimidine (cas# 90905-33-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(4-Bromophenyl)piperidin-2-one<br></p>

<p>Applications N-(5-formylpyrimidin-2-yl)glycine (cas# 915923-65-8) is a useful research chemical.<br></p>

<p>Applications 2,3-Diaminopyridine is used as a reagent in the synthesis of novel imidazopyridine derivatives which can exhibit cytotoxic activity against MCF-7 human breast adenocarcinoma cell line. 2,3-Diaminopyridine is also used in the preparation of non-camptothecin topoisomerase I inhibitors which exhibit antitumor activity.<br>References Puskullu, M.O., et al.: Chem. Heterocyc. Compd., 51, 723 (2015); Zhang, C., et al.: Bioorg. Med. Chem. Lett., 25, 4693 (2015)<br></p>

<p>Applications methyl 2-amino-5-benzyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-3-carboxylate (cas# 1428234-04-1) is a useful research chemical.<br></p>

<p>Applications 4-PIPERAZIN-1-YL-QUINOLINE DIHYDROCHLORIDE (cas# 1350361-89-5) is a useful research chemical.<br></p>

<p>Applications 1-(3-Chloro-2-hydroxypropyl)-3,5-bis(2-oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione-d15 is an intermediate for the synthesis of Triglycidyl Isocyanurate-d15 (T793817). Isotope labelled Triglycidyl isocyanurate is a reagent used in the synthesis of N-Benzyl Metaxalone (B285000), which is a muscle relaxant used to relax muscles and relieve pain.<br>References Toth, P.E., et al.: Clin. Ther., 26, 1355 (2004)<br></p>

<p>Applications Used in the preparation of 2-naphthyl substituted diarylpyrimidines (DAPY) analogues.<br>References Gu, S. et al.; Bioorg. Med. Chem. 19, 5117 (2011)<br></p>

<p>Applications 2,2'-Bipyridine-4,4'-dicarboxylic acid<br></p>

<p>Applications 6-Amino-5-formylpyridine-3-carbonitrile is a useful research reagent<br>References Babaev, E.V., et al.: J. Am. Chem. Soc., 115, 2416 (1993)<br></p>

<p>Applications N-1H-Imidazol-2-yl-formamide is used as a reagent in the synthesis of N-pyridinyl-2-[(thienylcarbonyl)amino]benzamides and its analogs as anticoagulants.<br>References Arnaiz, D.O., et al.: U.S. US 6140351 A 20001031. Oct 31, 2000<br></p>

<p>Applications An intermediate in the production of labelled Enrofloxacin.<br>References Chao, Q., et al.: J. Med. Chem., 52, 7808 (2009), Bebbington, D., et al.: Bioorg. Med. Chem. Lett., 19, 3586 (2009),<br></p>

<p>Applications 4-Piperidinemethanol, is a building block that can be used for the synthesis of selective inhibitors of sphingosine kinase 1 (SK1), that may serve as therapeutic agents for proliferative diseases, including hypertension.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baek, D., et al.: Chem.l Commun., 49, 2136 (2013);<br></p>

<p>Applications 5-(Difluoromethyl)-1h-pyrazol-3-amine<br></p>

<p>Applications 3-​Methoxy-​4-​methyl-​1H-​1,​2,​4-​triazol-​5(4H)​-​one Hydrate, is a Triazole (T767410) derivative that was used in microwave synthesis of 1,2,4-triazolone derivatives possessing antifungal activity. 3-​Methoxy-​4-​methyl-​1H-​1,​2,​4-​triazol-​5(4H)​-​one is also a key intermediate for sulfonylurea herbicides, such as flucarbazone.<br>References Su, J., Shang, Z.: Nongyao, 49, 563 (2010); Sun, N., et al.: BioMed Res. Int., 1 (2015);<br></p>

<p>Stability Air Sensitive<br>Applications [1,2,4]Triazolo[4,3-a]pyridine-3-thiol (cas# 6952-68-7) is a useful research chemical.<br></p>

<p>Applications 2-Fluoro-5-pyrimidinol is a structural analog of 2-Methyl-5-pyrimidinol (M326115); a pyrimidinyl derivative used as an insecticide intermediate.<br>References Cox, R., et al.: J. Phys. Chem., 72, 1646 (1968); Norton, R., et al.: Mol. Cell Biochem., 12, 103 (1976); Imai, E., et al.: Science, 283, 831 (1999)<br></p>

<p>Applications Phenyl (4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamate Hydrochloride is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications (αR)-α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxy-benzeneacetic Acid is an intermediate used to prepare Cephalosporin derivatives with activities against both Gram-positive and Gram-negative bacteria.<br>References Albrecht, H., et al.: J. Med. Chem., 37, 400 (1994)<br></p>

<p>Applications 2-Amino-3-bromopyrazine-5-carboxylic Acid (cas# 887352-34-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloro-4-ethylpyridine (cas# 40325-11-9) is a compound useful in organic synthesis.<br></p>