Heterocycles with Nitrogen (N)

<p>Applications 1H-pyrrolo[2,3-b]pyridin-1-amine (cas# 161264-46-6) is a useful research chemical.<br></p>

<p>Applications 3,4-Dimethyl-5-pyrazolone (cas# 6628-22-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1H-1,2,3 Triazole-1-ethanol (cas# 74731-63-8) is a useful research chemical.<br></p>

<p>Applications 6-(3-aminophenoxy)pyridine-3-carbonitrile (cas# 1099689-56-1) is a useful research chemical.<br></p>

<p>Applications (4-Acetyl-Piperazin-1-Yl)-Acetic Acid is a useful research chemical. It is used in the preparation of phenylpiperidines as neurokinin NK1 and NK3 antagonists for treatment of neurokinin-mediated diseases<br>References O'Neill, B. T., et al.: From U.S. Pat. Appl. Publ. (2005), US 20050256164 A1 20051117<br></p>

<p>Applications 1-[(1-Acetyl-4-piperidinyl)carbonyl]-4-piperidinecarboxylic Acid is a useful synthetic intermediate.<br></p>

<p>Applications 2-(1-Adamantyl)-4,5-dihydro-1H-imidazole (cas# 52725-79-8) is a useful research chemical.<br></p>

<p>Applications Methyl Dl-2-(1-Boc-Piperidin-4-Yl)-Beta-Glycinate (cas# 362703-57-9) is a useful research chemical.<br></p>

<p>Applications 4,6-Dichloroimidazo[4,5-c]pyridine (cas# 2589-12-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Dimethyl-N-(phenyl(pyridin-3-yl)methyl)pyrimidine-5-carboxamide is a useful research chemical.<br></p>

<p>Applications 4-Butylpiperidine Hydrochloride is an intermediate in the synthesis of AC 42 (A115600), an allosteric agonist of acetylcholine orthosteric site.<br>References Jacobson, M.A., et al: Mol. Pharmacol., 78, 648 (2010);<br></p>

<p>Applications 5-Bromo-2-aminopyrimidine (cas# 7752-82-1) is a compound useful in organic synthesis.<br>References Robins, M., et al.: J. Med. Chem., 50, 3897 (2007),<br></p>

<p>Applications Methyl 1-Methyl-1,2,3-triazole-5-carboxylate (cas# 105020-38-0) is used as a reagent in the composition and method for treating cognitive impairments in Down syndrome subjects.<br>References Potier, M. C., et al.: U.S. (2015) CODEN:USXXAM<br></p>

<p>Applications 1-Benzyl-4-butylpiperidine is an intermediate in the synthesis of AC 42 (A115600), an allosteric agonist of acetylcholine orthosteric site.<br>References Jacobson, M.A., et al: Mol. Pharmacol., 78, 648 (2010);<br></p>

<p>Applications 6-Chloro-2-methoxypyridine-3-boronic acid<br></p>

<p>Applications B-(2-Cyclopropyl-4-pyridinyl)-boronic Acid Hydrochloride, can be used in synthesis of isoindole carboxamides, pyrrolopyridine carboxamides, and similar compounds as inhibitors of phosphodiesterase type 10A for treating neurological and psychiatric disorders.<br>References Geneste, H., et al.: PCT Int. Appl. (2013), WO 2013000994 A1 20130103<br></p>

<p>Applications Intermediate in the production of mutagenic pyrolyzates.<br>References Grassy, G., et al.: Eur. J. Med. Chem., 17, 109 (1982),<br></p>

<p>Applications 2-Chloromethyl-3,5-dimethylpyridin-4-ol (cas# 220771-03-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-ethoxy-3-ethylpyrazine (cas# 35243-43-7) is a useful research chemical.<br></p>

<p>Applications 6-Methoxy-4-pyrimidinamine is used in the synthesis of carbamothiolacrylamides as selective EP2 antagonists in the treatment of neurodegenerative peripheral diseases. Also used in the preparation of PARP-1 inhibitors.<br>References Ganesh, T. et al.: ACS Med. Chem. Lett., 4, 616 (2013); Rhee, H. et al.: Bioorg, Med. Chem., 17, 7537 (2009);<br></p>

<p>Applications Intermediate in the preparation of Omeprazole metabolites<br></p>

<p>Applications 5-(BROMOMETHYL)-2-NITROPYRIDINE (cas# 448968-52-3) is a useful research chemical.<br></p>

<p>Applications 5-phenyl-1H-1,2,3-triazole-4-carboxylic acid (cas# 830-78-4) is a useful research chemical.<br></p>

<p>Applications 4-hydroxy-1H,2H-pyrrolo[1,2-d][1,2,4]triazin-1-one (cas# 50269-88-0) is a useful research chemical.<br></p>

<p>Applications 1-ACETYL-2-PIPERIDINEACETIC ACID (cas# 25393-20-8) is a useful research chemical.<br></p>

<p>Applications 1-​Pyrrolidineacetic Acid is a useful reactant and reagent in organic reactions. It can be found used in cosmetic products such as wrinkle-​preventive​/ameliorating products.<br>References Londregan, A.T., et al.: ACS Comb. Sci., 18, 651-54 (2016); Tsunenaga, M., et al.: PCT Int. Appl. (2007), WO 2007013662 A1<br></p>

<p>Applications Ethyl 4-aminopiperidine-1-carboxylate is a reagent used in various biosynthetic reactions.<br>References Fang, R.Q., et al.: Bioorg. Medn. Chem. Letters., 22, 5134 (2012);<br></p>

<p>Applications Benzotriazol-1-ylacetic Acid is used as a reagent in the synthesis of benzotriazole imidazoline compounds which are used as metal corrosion inhibitors. Benzotriazol-1-ylacetic Acid is also a reagent in the synthesis of N-(benzo[1,2,3]triazol-1-yl)-N-((benzyl)acetamido)phenyl carboxamides which are used as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors.<br>References Turlington, M., et al.: Bioorg, Med. Chem. Lett., 23, 6172 (2013); Chen, Y., et al.: Faming Zhuanli Shenqing. CN 103664902 A 20140326. Mar 26, 2014<br></p>

<p>Applications O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.<br>References Murray, P. et al.: Bioorg. Med. Chem. Lett., 11, 773 (2001); Roy, R. et al.: J. Am. Chem. Soc., 123, 1809 (2001);<br></p>

<p>Applications 6-NITROPIPERONYL ALCOHOL (cas# 15341-08-9) is a useful research chemical.<br></p>

<p>Applications Tris(4-pyridyl)-s-triazine is used in the preparation of metal-metallite coordination polymers as well as porphyrin prisms.<br>References Youm, K. et al.: Chem. Comm., 29, 3375 (2008); Li, M. et al.: CrystEngComm., 15, 1225 (2013);<br></p>

<p>Applications N-​(3-​chloro-​4-​methoxyphenyl)​-​1-​(methylsulfonyl)​-4-​Piperidinecarboxamid​e is a useful research chemical used in the alteration of the lifespan of eukaryotic organisms.<br>References Goldfarb, D. S.: US 20090163545 (2009).<br></p>

<p>Applications 2,5,6-Triaminopyrimidin-4(1H)-one sulphate (cas# 39267-74-8) is a useful research chemical.<br></p>

<p>Applications N-[1-(pyridin-3-yl)ethyl]hydroxylamine (cas# 887411-44-1) is a useful research chemical.<br></p>

<p>Applications 4-Pyridinecarboxamide 1-Oxide (cas# 38557-82-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole is a useful reagent for developing dipeptidyl peptidase IV inhibitors for treatment or prevention of diabetes.<br>References Nakajima, Y., et al.: J. Mol. Cell Cardiol., 129, 257-265 (2019)<br></p>

<p>Applications Enalapril Diketopiperazine Acid is a degradation product of Enalapril (E555250).<br>References Bhardwaj, S. et al.: J. Pharmac. Biomed. Anal., 46, 113 (2008);<br></p>

<p>Applications 1-[4-Bromo-2-(1,1-dimethylethyl)phenyl]-1H-pyrrole-2,5-dione is derived from 2-(tert-Butyl)aniline (B809793), which is used as an intermediate in various reactions including towards substituted indole-2-carboxylic acids as inhibitors of bacterial metallo-beta-lactamases, which ultimately results in the potential for the use in the treatment of bacterial infection.<br>References Brem, J.; et al.: PCT Int. Appl. 171pp. Patent 2017 CODEN:PIXXD2<br></p>

<p>Applications 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetic Acid is a reactant or reagent used in the synthesis of the blood coagulating enzyme factor Xa (FXa) inhibitor.<br>References Xue, T., et al.: J. Med. Chem., 57, 7770 (2014);<br></p>

<p>Applications 1-(1-phenylcyclobutanecarbonyl)piperidine-4-carboxylic acid (cas# 1099048-69-7) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 5-Bromo-pyridine-2-sulfonyl chloride<br></p>

<p>Applications Imidazole rings are found in numberous natural compounds such as enzymes, nucleic acid, and alkaloids that play a role in biological processes.<br></p>

<p>Applications 5-[4-Bromo-1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-chloro-4-fluorobenzoic Acid is an intermediate in the synthesis of Fluazolate (F407500), the active ingredient in the preparation of agrochemicals and drugs in amorphous form.<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 1-Octyl-4-(1-octylpyridin-1-ium-4-yl)pyridin-1-ium dibromide is a viologen and chromophore used in low-energy driven electrochromic devices comprising of polymeric ionic liquids.<br>References Lu, H.; et al.: ACS Appl. Mater. Interfaces, 8, 30351 (2016).<br></p>

<p>Applications 5-METHYLPYRROLIDIN-3-OL (cas# 94134-94-8) is a useful research chemical.<br></p>

<p>Applications 1-[4-(4-Fluorophenyl)-2-thiazolyl]-3,5-dimethyl-1H-pyrazole-4-propanoic Acid (cas# 1172940-17-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-5-ethylpyrazine<br></p>

<p>Applications 4-Chloro-2-(chloromethyl)-3,5-dimethylpyridine has been used as a reactant in the preparation of 2-amino-6-halopurine Hsp90 inhibitors that exhibit antitumor activity.<br>References Kasibhatla, S.R., et. al.: J. Med. Chem., 50, 2767 (2007)<br></p>

<p>Applications 6-​Fluoro-​3-​[(trimethylsilyl)​oxy]​-2-​pyrazinecarboxamide is an intermediate in synthesizing T-705RTP (T003210), a derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses. T-705RTP which has the triphosphate group, gets strongly inhibited by the influenza virus RNA polymerase activity in comparison with T-705RMP (T003202).<br>References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010);<br></p>

<p>Applications rac-α-N-Boc-Amino-4-pyridineaceic Acid is a reagent used in the preparation of lactam-containing diaminoalkanes, β/α-amino acids and derivatives of Xa inhibitors.<br></p>

<p>Applications 5-(4-methylphenyl)imidazolidine-2,4-dione (cas# 69489-37-8) is a useful research chemical.<br></p>

<p>Applications 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide (cas# 1189858-48-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.<br>References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)<br></p>

<p>Applications 2-(4-Chlorophenyl)-4,5-dihydro-1H-imidazole is used in preparation of Arylimidazoline for use as antiobesity agents.<br>References Haga, Y., et al.: U.S. Pat. Appl. Publ. (2012), US 20120029041 A1<br></p>

<p>Applications 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinol, can be used for the synthesis of a novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists.<br>References Lowe, J. A., et al.: Bioorg. Med. Chem. Lett., 20, 4749 (2010);<br></p>