Heterocycles with Nitrogen (N)

<p>Applications 2-Piperazinone (cas# 5625-67-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-methyl-2-oxo-4-[(5,6,7,8-tetrahydronaphthalen-2-yl)amino]-1,2-dihydropyridine-3-carboxylic acid (cas# 1239521-17-5) is a useful research chemical.<br></p>

<p>Applications 4-Cyclohexyl-2-piperidinecarboxylic Acid is a compound useful in organic synthesis.<br></p>

<p>Applications (4,6-Dimethyl-pyrimidin-2-yl)-hydrazine<br></p>

<p>Applications 2-Azido-1-(3-chloro-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)ethan-1-one (CAS# 2097997-88-9) is a derivative of 3-​Chloro-​5,​6-​dihydro-​imidazo[1,​2-​a]​pyrazine-​7(8H)​-​carboxylic Acid 1,​1-Dimethylethyl Ester (CAS# 1253801-37-4), which is a useful compound for preparing P2X7 modulators.<br>References Dean, D. K., et al.: U.S. (2013), US 8513248 B2<br></p>

<p>Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.<br>References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)<br></p>

<p>Applications 1-isobutyl-1H-pyrazole-3-carboxylic acid (cas# 1006493-64-6) is a useful research chemical.<br></p>

<p>Applications Pioglitazone (P471000) intermediate.<br>References Kletzien, R., et al.: Mol. Pharmacol., 41, 393 (1992),<br></p>

<p>Applications A chiral fluoro-pyridine derivative used in the preparation of dihydropyrrolopyrimidinone derivatives for use as MARK inhibitors.<br></p>

<p>Applications 6-Chloro-2-methoxypyridine-3-boronic acid<br></p>

<p>Applications 1H-1,2,4-triazol-5-ol (cas# 930-33-6) is a useful research chemical.<br></p>

<p>Applications 5-(1-Piperazinyl)-2-Benzofurancarboxylic Acid Ethyl Ester Diydrochloride Hydrate cas# 1422956-31-7) is a useful research chemical.<br></p>

<p>Applications 2-Octylpyridine (cas# 33841-61-1) is a useful research chemical.<br></p>

<p>Applications 6-cyclopropyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid (cas# 150190-28-6) is a useful research chemical.<br></p>

<p>Applications 5,6-Dichloro-1,3-benzoxazol-2-amine<br></p>

<p>Applications 3-(2,5-dimethyl-1H-pyrrol-1-yl)-2-thiophenecarboxylic Acid (cas# 477888-48-5) is a useful research chemical.<br></p>

<p>Applications 7-Bromo-5-(pyridin-2-yl)-1H-benzo[e][1,4]diazepine-2(3H)-thione is used in the preparation of triazolobenzodiazepines with antianxiety and antidepressant activity.<br>References Hester, J.B., et. al.: J. Med. Chem., 23, 392 (1980)<br></p>

<p>Applications (3S,​4S)​-​4-​Hydroxy-​3-​pyrrolidinyl Carbamic Acid 1,​1-​Dimethylethyl Ester was used as a chiral pyrrolidine to sense chirality with a liquid crystalline dynamic helical poly(phenylacetylene) bearing ethyl phsophonate pendant groups.<br>References Morimoto, M., et al.: J Polym Sci, 48, 1383 (2010).<br></p>

<p>Applications 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine is an intermediate in the synthesis of Blonanserin (B595850), a 5-HT2 serotonin receptor and D2 dopamine receptor antagonist, used as an antipsychotic.<br>References Oka, T., et al.: Life Sci., 76, 225 (2004), Singh, A., et al.: Int. Med. J., 12, 175 (2005), Ochi, T., et al.: Bioorg. Med. Chem., Lett., 15, 1055 (2005),<br></p>

<p>Applications 6-Methyl-3-pyridoyl-2-pyrrolidinone (cas# 1076198-57-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloro-5-(phenylsulfonyl)pyridine is a starting material and useful building block of various pharmaceuticals.<br></p>

<p>Applications 2-Chloropyrimidine-d3 was used in the study of IR vibrational spectroscopy of [Ru(bpy)2(bpm)]2+ and [Ru(bpy)3]2+ in the excited triplet state.<br>References Mukuta, T., et al.: Inorg. Chem., 53, 2481 (2014)<br></p>

<p>Applications B-(2-Cyclopropyl-4-pyridinyl)-boronic Acid Hydrochloride, can be used in synthesis of isoindole carboxamides, pyrrolopyridine carboxamides, and similar compounds as inhibitors of phosphodiesterase type 10A for treating neurological and psychiatric disorders.<br>References Geneste, H., et al.: PCT Int. Appl. (2013), WO 2013000994 A1 20130103<br></p>

<p>Applications 2-Thiohydantoin is a useful synthetic intermediate. It is a reactant for synthesis of drugs with antidiabetic activity, barbituric acid and thiohydantoin derivatives with antimicrobial activity, and possible anticancer agents.<br>References Ceylan-Ünlüsoy, M., et al.: J. Enzyme. Inhib. Med. Chem., 25, 784 (2010); Hassanein, M., et al: Mol. Human Reprod., 15, 433 (2009); Subtel’na, I., et al.: Bioorg. Med. Chem., 18, 5090 (2010)<br></p>

<p>Stability Hygroscopic<br>Applications 6-Oxopiperidine-3-carboxylic acid (cas# 22540-50-7) is a useful research chemical.<br></p>

<p>Please enquire for more information about 4-Chloro-3-iodopyridin-2-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Tris(2-phenylpyridine)iridium (IrCl) is a coordination compound that is used as a catalyst to initiate cationic polymerization of biphenyl. It is also used as an analytical reagent for determining the content of fatty acids in oils and fats. The steric interactions between the phenyl groups and the electron-rich iridium atoms lead to a high degree of conversion of ethylene oxide to ethylene glycol, which can be observed by UV absorption. The synthesis of IrCl occurs in two steps: first, the reaction of chloroacetone with phenylmagnesium bromide followed by addition of hydrated iridium chloride. The product crystallizes in red needles, which are analyzed using x-ray crystal structures. Analysis using nmr spectroscopy reveals that IrCl contains four nitrogen atoms and three oxygen atoms. Its redox potentials are -0.9 volts for oxidation and +1.3 volts for reduction, making</p>

<p>Piperidine-2,5-dione is a synthetic compound that is used for the synthesis of benzyl esters, stereospecific chiral compounds, and amides. It can be used as a building block in the synthesis of natural products. Piperidine-2,5-dione has been shown to inhibit the activity of enzymes such as lactamases and amidases. The mechanism by which piperidine-2,5-dione inhibits these enzymes is not yet known. This compound also can react with potassium hydride to form radical species or alkylate boronic acids to form stereochemically pure products.</p>

<p>Please enquire for more information about 4-(2-Fluorophenyl)-4-piperidinol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-[(2-Pyridyl)methyl]piperazine is a fluorescent organic solvent. It is a piperazine derivative with low detection limit, which can be used for the detection of metal ions. 1-[(2-Pyridyl)methyl]piperazine has also been shown to be a hyperpolarizing agent in organic solvents and has been used as an optical sensor for 4-chloro-7-nitrobenzofurazan, which is a compound that exhibits fluorescence properties. 1-[(2-Pyridyl)methyl]piperazine can be used as a linker in microscopy techniques to immobilize biomolecules on the surface of glass slides.</p>

<p>3-Vinylpyridine, also known as vinylpyridine, is a colorless, crystalline solid that forms hydroxide solutions. It has been shown to have antifungal activity in the presence of fatty acids and can be used for the treatment of urinary tract infections caused by Candida albicans. The chemical ionization technique was used to analyze 3-vinylpyridine in urine samples from nonsmokers and smokers. Long-term exposure to 3-vinylpyridine may lead to surface-enhanced Raman spectroscopy signals on the surface of metal oxides due to alkoxy radical formation. The crystallization process of 3-vinylpyridine can take place at a temperature range between 135°C and 150°C with an addition of polyethylene glycol or sulfuric acid. Reaction intermediates are formed during this process which are important for the formation of 3-vinylpyridinium ions.</p>

<p>Please enquire for more information about 1-(2-Methoxylphenyl)-piperazine monohydrobromide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-(3,5-Dimethoxyphenyl)piperazine (1DMPP) is a phenylpiperazine derivative that has shown anticancer activity in vitro against human cancer cells. It is orally bioavailable and has been found to inhibit the growth of cancer cells in vivo. 1DMPP is metabolized by the liver into a number of metabolites that are excreted via the kidneys. The pharmacokinetic properties of 1DMPP have been studied in rats and mice, which revealed that it is well absorbed when administered orally and has a short terminal half-life. In vitro studies have demonstrated that 1DMPP inhibits cell growth through inhibition of protein synthesis and DNA replication.</p>