Building Blocks

Applications (2E)-3-(4-Bromophenyl)-1-[4-(4-methoxybenzoyl)-1-piperazinyl]-2-propen-1-one recently known as NIBR 189, is a selective Epstein-barr virus-induced gene 2 (EBI-2) receptor antagonist, resulting in a modulation of immune responses related to auto-immune diseases.
References Gessier, F. et al.: J. Med. Chem., 57, 3358 (2014);

Applications Pyrrole-d5 (CAS# 18430-85-8) is a useful isotopically labeled research compound.

Applications 2-Bromothiophene (cas# 1003-09-4) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 3-Chloro-6-methylpyridazine is used for preparation of heterocyclic compounds as integrase inhibiting antiviral agents.
References Betail, G., et al.: Ann. Pharm. Fr., 36, 317 (1978), Elben, U., et al.: J. Chem. Res., 316 (1978),

Stability Store FROZEN
Applications Material that was assayed to be approximately 80% pure was diluted to 5% in benzene.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2,4-dichlorobromobenzene

Applications 5,6,7,8-tetrahydroquinazoline-6-carboxylic acid (cas# 1369096-46-7) is a useful research chemical.

Applications trans-4-(Dimethylamino)-3-buten-2-one is an reagent used in the synthetic preparation of various substances.
References Maggiulli, C.A., et al.: Org. Prep. Pro. Int., 16, 31 (1984); Afarinkia, K., et al.: Sci. Syn., 14, 275 (2003);

Applications 3-Bromothioanisole (cas# 33733-73-2) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Light Sensitive
Applications (2E)-1,4-Dibromo-2-butene, is used as a reagent in the preparation of diaminoalkenes though copper-mediated diamination reaction.
References Martinez, C., et al.: Eur. J. Org Chem., 2014, 2017 (2014)

Applications 4-Hydroxychlorpropham is an intermediate in synthesizing 4-Hydroxychlorpropham Sulfate Sodium Salt (H825075), which is a chemical herbicide used in the protection of crops. It also maintains the ability to induce mitochondrial dysfunction in rat hepatocytes.
References EPA.: Fed. Reg., 72, 37646 (2007); Nakagawa, Y. et al.: Toxicol., 200, 123 (2004);

Applications 2-[4-(Bromomethyl)phenyl]propionic Acid is a key intermediate for the synthesis of loxoprofen sodium a nonsteroidal anti-inflammatory drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wu, R., et al.: Zhongguo Yiyao Gongye Zazhi, 46, 806 (2015); Zhang, X., et al.: Zhongguo Yaowu Huaxue Zazhi, 20, 25 (2010)

Applications 10-Undecenoic Acid Ethyl Ester is used to make luminescent silicon quantum dots for imaging of cancer cells.
References Erogbogbo, F., et. al.: ACS Nano, 2, 873 (2008)

Applications N-Methylhydroxylamine is used as an inorganic catalyst used in the transamidation of primary amides with amines.
References Allen, C.L. et al.: Ange. Chem. Int. Ed., 51, 1383 (2012);

Applications 3-Fluorobenzoic Acid (cas# 455-38-9) is a compound useful in organic synthesis.

Applications beta-Iminodi(propionic-2,2,3,3-d4 Acid) (CAS# 1219803-81-2) is a useful isotopically labeled research compound.

Applications tert-Butyl 6-amino-3,4-dihydroquinoline-1(2H)-carboxylate (cas# 1152923-36-8) is a useful research chemical.

Applications Homoveratric Acid is a dopamine metabolite that inhibits brain mitochondrial respiration via monoamine oxidase/H2O2-dependent or non-dependent pathway.
References Gluck, M.R. et al.: J. Neurochem., 91, 788 (2004); Morikawa, N. et al.: J. Neurochem., 66, 1174 (1996); Goodwin, B.L. et al.: Xenobiotica, 24, 129 (1994);

Applications This compound is an impurity in the synthesis of Etoricoxib (E934100), a specific inhibitor of COX-2. It is also used in the synthesis of selective GlyT1 inhibitors.
References Pinard, E. et al.: J. Med. Chem., 53, 4603 (2010); McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003);

Applications Benzyl-alpha,alpha-d2 Bromide (CAS# 51271-29-5) is a useful isotopically labeled research compound.

Applications 2,6-Naphthalenedicarboxylic-d6 Acid (CAS# 682321-46-6) is a useful isotopically labeled research compound.

Applications Methyl Undecanoate-d21 (CAS# 1219804-96-2) is a useful isotopically labeled research compound.

Applications 2,5-Dibromothiophene (cas# 3141-27-3) is a compound useful in organic synthesis.

Applications 4-Phenoxyphenol is a porous organic material with dumbbell channels that appear throughout its structure. These channels can also host solvent molecules during crystal growth. 4-Phenoxyphenol is also part of a group of phenolic compounds that have potential apoptotic activity, which can be used in the development of new treatments for cancer therapy.
References Hansch, C., et al.: Bioorg. Med. Chem., 11, 617 (2003); Thomas, L., et al.: Cryst. Growth. Des., 12, 1746 (2012)

Applications Benzimidazole-4,5,6,7-d4 (CAS# 64531-29-9) is a useful isotopically labeled research compound.

Applications 2-Bromo-3'-nitroacetophenone is a reagent used the preparation of arylthiazolidinone derivatives which have BRD4 bromodomain inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhao, L., et al.: J. Med. Chem., 56, 3833 (2013);

Applications 1,1,1-Trifluoro-2-iodoethane (cas# 353-83-3) is a compound useful in organic synthesis.

Applications 4'-Chloroacetophenone-d7 (CAS# 1174565-85-5) is a useful isotopically labeled research compound.

Applications 2,4,5-Trichloroaniline-d4 (CAS# 1219804-61-1) is a useful isotopically labeled research compound.

Applications A benzimidazole derivative that exhibits corrosion inhibiting properties against strong acids.
References Popova, A., Bull. Electrochem., 23, 137 (2007), Popova, A., et al.: Corros. Sci., 46, 1333 (2004),

Applications A brominated phenethanol derivative used as a building block in the preparation or bicyclic and tricyclic heterocycles.
References Lemen, G. et al.: Org. Lett., 13, 3218 (2011); Allin, S. et al.: Tetrahedron, 61, 2689 (2005);

Applications Benzilic-d10 Acid (rings-d10) (CAS# 1219799-12-8) is a useful isotopically labeled research compound.

Applications 2'-Hydroxypropiophenone (cas# 610-99-1) is a useful research chemical.

Applications (4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid (CAS# 53587-33-0) is a useful isotopically labeled research compound.

Applications Chlorotrianisene-d9 (trimethoxy-d9) (CAS# 1276197-26-2) is a useful isotopically labeled research compound.

Applications Heterocyclic compound used in cosmetic compositions.
References Windheuser, J., et al.: J. Pharm. Sci., 71, 121 (1982), Davis, E., et al.: J. Med. Entomol., 22, 237 (1985), Osimitz, T., et al.: J. Toxicol., 35, 435 (1997), Ross, E., et al.: Drug Metab. Dispos., 32, 783 (2004),

Applications A phenylhydrazone derivative with fungicidal activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications (±)-2-Chlorobutane-d9 (CAS# 175540-77-9) is a useful isotopically labeled research compound.

Applications 1-Chloropropane-d7 (CAS# 761374-88-3) is a useful isotopically labeled research compound.

Applications 3,5-Dibromopyridine-d3 (CAS# 1219799-05-9) is a useful isotopically labeled research compound.

Applications Naphthalene-2,3,4,5,6,7,8-d7 (CAS# 887-68-3) is a useful isotopically labeled research compound.

Applications p-Azoxyanisole-d6 (O,O-dimethyl-d6) (CAS# 34172-21-9) is a useful isotopically labeled research compound.

Applications 1-Bromotetradecane-1,1,2,2-d4 (CAS# 1219798-81-8) is a useful isotopically labeled research compound.

Applications Octadecanoic-2,2-d2 Acid (CAS# 19905-58-9) is a useful isotopically labeled research compound.

Applications 2-Hydroxy-3-methyl-butanedioic Acid is used as a sole C source when metabolized by soil bacterium; Also, it is an intermediate used in the synthesis of 5-Methyl-2’-deoxy Cytidine-13C,15N2 (M295904), which is an isotopic analog of 5-Methyl-2’-deoxy Cytidine (M295900), a Cytidine (C998300) analog and also an isostere of Thymidine (T412000).
References Nakano, H., et al.: J. Biochem., 70, 429-440 (1971); Sabini, E., et al.: J. Med. Chem., 51, 4219 (2008), Sabini, E., et al.: J. Mol. Biol., 378, 607 (2008)

Impurity Metronidazole EP Impurity B
Applications Antibiotic substance produced by an unidentified Streptomyces.
References Maeda, et al.: J. Antibiot., 6A, 182 (1953),

Applications N-Benzoylglycine-2,2-d2 (CAS# 208928-78-3) is a useful isotopically labeled research compound.

Applications 4-Fluorobenzyl-alpha,alpha-d2 Chloride (CAS# 1219804-18-8) is a useful isotopically labeled research compound.

Applications p-Fluorobenzyl Chloride is a chemical intermediate in the synthesis of various pharmaceutical and agricultural goods.
References Wang, J., et al.: J. Agr. Food. Chem., 59, 9892 (2011); Wang, J.M., et al.: J. Chem. Info. Model., 47, 1395 (2007); Yang, E., et al.: Rapid. Commu. Mass. Spectro., 19, 759 (2005); Cronin, M.T.D., et al.: Sci. Total. Environ., 204, 75 (1997);

Applications Naphthalene-1-d1 (CAS# 875-62-7) is a useful isotopically labeled research compound.

Applications 4-Fluorobenzoyl-d4 Chloride (CAS# 1071809-52-3) is a useful isotopically labeled research compound.

Applications 1-Bromotetradecane-14,14,14-d3 (CAS# 347840-09-9) is a useful isotopically labeled research compound.

Applications 4-Bromophenol tert-Butyldimethylsilyl Ether (cas# 67963-68-2) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1-Chloropropane-1,1-d2 (CAS# 125640-23-5) is a useful isotopically labeled research compound.

Applications Imidazolinone derivatives as CGRP receptor antagonists used in the treatment of migraine.
References Sikazwe, D., et al.: Bioorg. Med. Chem., 17, 1716 (2009), Stump, C., et al.: Bioorg. Med. Chem. Lett., 19, 214 (2009),

Applications Ethyl-1,1-d2 Alcohol-OD (CAS# 22544-42-9) is a useful isotopically labeled research compound.

Stability Moisture Sensitive
Applications 4-Fluorobenzoyl Chloride is used in the synthesis of tryphostins which act as inhibitors of EGF receptor and Erb82/neu tyrosine kinases. Also used in the synthesis of 1,2,4-triazole-3-thiones as antidepressant agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gazit, A. et al.: J. Med. Chem., 34, 1896 (1991); Kane, J. et al.: J. Med. Chem.,

Applications Ethyl-1-d1 Alcohol (CAS# 1624-36-8) is a useful isotopically labeled research compound.

Applications n-Undecyl-d23-amine (CAS# 1219805-57-8) is a useful isotopically labeled research compound.

Applications Ethyl-1,2,2,2-d4 Alcohol (CAS# 22544-43-0) is a useful isotopically labeled research compound.

Applications TRIMETHYLSULFOXONIUM IODIDE (cas# 1774-47-6) is a useful research chemical.

Applications Ethyl-2-d1 Alcohol (CAS# 6181-08-4) is a useful isotopically labeled research compound.

Applications n-Undecyl-d23 Alcohol (CAS# 349553-88-4) is a useful isotopically labeled research compound.

Applications (4-Fluorophenyl)acetic-alpha,alpha-d2 Acid (CAS# 113715-48-3) is a useful isotopically labeled research compound.

Applications Eicosanoic-17,17,18,18-d4 Acid (CAS# 1219803-69-6) is a useful isotopically labeled research compound.

Applications (±)-Glyceryl 1-Monooctadecanoate-d35 (CAS# 333748-53-1) is a useful isotopically labeled research compound.

Applications 5-Oxohexanoic Acid Ethyl Ester is a useful synthetic intermediate. It is used to prepare tyrosine-derived RGD peptidomimetics containing oligoethylene glycol (OEG) spacers. It is also used to synthesize constrained glycyl amides derived from RGD tripeptide as nonpeptide αvβ3 antagonists.
References Rerat, V., et al.: J. Med. Chem., 52, 7029 (2009); Meissner, R., et al.: Bioorg. Med. Chem. Lett., 12, 25 (2001)

Applications Eicosanoic-2,2-d2 Acid (CAS# 232600-70-3) is a useful isotopically labeled research compound.

Applications 1H-indazole-7-carboxylic Acid is an inhibitor of nitric oxide synthases.
References Cottyn, B., et al.: Bioorg. Med. Chem., 16, 5962 (2008)

Applications Ethanol-1,1,2,2-d4-amine HCl is a useful isotopically labeled compound of 2-Aminoethanol Hydrochloride (A576798)