Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(4-Chlorobenzenesulfonyl)phenol is a potassium salt that is used as an intermediate for the production of polymers. It is mainly used as a polymerization inhibitor and can be used in the production of polyurethane. 4-(4-Chlorobenzenesulfonyl)phenol has a melting point of about 95°C, and it is soluble in water, alcohols, ketones, ethers, chloroform, acetone, benzene, toluene and some other solvents. The molecular weight of 4-(4-chlorobenzenesulfonyl)phenol is 254.3 g/mol.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-N,N-diisopropylacetamide is a quinoline derivative that has been shown to be a potent ligand for lanthanide metal ions. It has been used as a fluorescent probe for nitrate anions and shows constant fluorescence intensity over a wide range of pH values. 2-Chloro-N,N-diisopropylacetamide also exhibits luminescence properties and can be used as a sensor for amide anions. The compound has been shown to enhance the emission of lanthanide metal ions in the near infrared region when excited. 2-Chloro-N,N-diisopropylacetamide is also an efficient catalyst for desulfurization reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Diethylamino)acetamide is an aliphatic hydrocarbon that inhibits the replication of viruses. It also has anti-inflammatory activity and can be used to treat respiratory allergies, such as asthma and hay fever. 2-(Diethylamino)acetamide may be used as a scrubbing agent in the removal of pollutants from industrial emissions. The compound is stable at high temperatures and has been shown to inhibit the growth of bacteria by interfering with their respiration process. 2-(Diethylamino)acetamide also inhibits the production of monocarboxylic acids such as formic acid, acetic acid, and lactic acid in bacteria, which are important for their survival.</p>

<p>3-(Methylthio)-4H-1,2,4-triazole is a compound that belongs to the class of triazoles. It is an insecticide with a broad spectrum of activity against coleoptera, diptera, and lepidoptera. 3-(Methylthio)-4H-1,2,4-triazole is also a solid catalyst for organic synthesis reactions. This compound has been shown to be capable of catalyzing the reaction time in solvents such as dimethylformamide. The tautomeric forms of 3-(methylthio)-4H-1,2,4-triazole are important for understanding the molecular mechanism and quantum theory of this molecule. The tautomers are classified into two groups based on the symmetry between them: meso compounds and racemic compounds.</p>

<p>2-(3,5-Dimethoxymethyl)ethanol is a chemical compound that has been shown to have antiproliferative effects. It inhibits the growth of cells by binding to and inhibiting the activation of growth factor receptors. 2-(3,5-Dimethoxymethyl)ethanol is also a nitro derivative that can be reduced with sodium borohydride to form 3,5-dimethoxyacetophenone. This conversion is facilitated by the presence of an acid catalyst such as hydrochloric acid or acetic acid. The synthesis of 2-(3,5-dimethoxymethyl)ethanol has been shown to follow a functional theory whereby the reactant is converted into the product in one step with no intermediate compounds formed.</p>

<p>N-(2-Nitrophenyl)formamide is a nucleophilic carbonyl compound that can be used as a catalyst in reactions involving acid solutions. It is activated by the addition of an acid or base, and can react with anions to form covalent bonds. The nucleophilicity of N-(2-nitrophenyl)formamide is high and it has been shown to be unreactive towards anhydrous ammonia gas. This molecule also reacts with nucleophiles to form new molecules, which are then either stable or unstable. The rate of reaction for this compound is determined by the kinetics and the concentration of the reactants.</p>

<p>4-Hydroxypyridine-3-carboxamide is an amide of 4-hydroxypyridine and carbamic acid. It is a metabolite of tryptophan that is synthesized in the liver. Deficient patients may have elevated levels of this compound, which can cause renal transplantation failure. 4-Hydroxypyridine-3-carboxamide is produced by the oxidation of pyridones and aldehydes. This compound also produces carbon dioxide and water when it reacts with chloride ions, producing carbonation. In addition, this molecule contains a ribonucleotide at its C4 position, which can be hydrolyzed to form ammonium ion and ribonucleotide monophosphate (AMP). Ammonolysis then converts the molecule into a pyridine ring.</p>

<p>Versatile small molecule scaffold</p>

<p>The major product of the reaction is tert-butyl 3-methyl-2-oxocyclopentane-1-carboxylate, which can be converted to ethyl 3-methylcyclohexane carboxylate by treatment with lithium aluminium hydride. The reaction proceeds in high yield and provides a convenient route to the cyclic ketone, quinine. The synthesis of the axial fragment is also enantioselective, giving an almost racemic mixture of both diastereoisomers. The tertiary alcohol functions as a nucleophile in this process.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Hydroxy-6-methylpyridine-3-carboxylic acid (5HMP) is a water soluble compound that is used as a substrate binding agent in enzymatic reactions. 5HMP is dissolved in water, then added to the substrate and enzyme mixture. The reaction mechanism of 5HMP is via ring opening, which is catalyzed by the enzyme flavin reductase. The kinetic constants for this reaction are Km=0.2 mM and Vmax=32 nmol/min/mg of protein. 5HMP has been shown to have antibiotic properties against P. aeruginosa, an opportunistic pathogen that can cause serious infections in people with cystic fibrosis or chronic obstructive pulmonary disease. 5HMP also binds to tetracycline, preventing the drug from binding to ribosomes and inhibiting protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N,N-Bis(2-hydroxyethyl)acetamide is a nonionic surfactant which is used as an emulsifier and dispersing agent. It is often used in detergents, textile processing, papermaking, and for the production of cosmetics. N,N-Bis(2-hydroxyethyl)acetamide has been shown to suppress the growth of Candida parapsilosis and other microbial strains. It also inhibits the production of fluconazole by wild-type Candida albicans. N,N-Bis(2-hydroxyethyl)acetamide may be used in conjunction with benzyl alcohol as an antifungal agent for topical application.br&gt;br&gt;NMR spectra have shown that this molecule has acetal groups that can copolymerize with other molecules. These acetal groups are resistant to degradation by enzymes such as beta-glucosidase and alpha-amylase.</p>

<p>Versatile small molecule scaffold</p>

<p>Trans-cyclobutane-1,3-dicarboxylic acid (trans-CBA) is a cycloalkane that is used as a reagent in organic synthesis. It has been shown to react with malonic acid to form a 1:1 adduct, which can be used for the synthesis of other cycloalkanes. Trans-CBA can also react with sodium salt of furfural to form the corresponding trans-CBA sodium salt. This reaction system has been optimized and is suitable for laboratory use. The molecular formula for trans-CBA is C4H4O4. The molecular weight of trans-CBA is 104.12 g/mol. Pharmacokinetic studies have been done on rats and dogs, showing that this molecule can be absorbed orally and distributed throughout the body quickly. Trans-CBA has a half life of 3 hours when administered orally, with an elimination half life of 6 hours when given intravenously.</p>

Versatile small molecule scaffold

<p>Methyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate is a reactive intermediate that can be used in the synthesis of aldehydes. It is prepared by reacting benzaldehyde with formaldehyde and methanol in a three-step process. Methyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate is stable at room temperature and has been shown to form stable complexes with racemic or optically pure alcohols. The product can react with aniline under acid catalysis to form imines.</p>

<p>Diaminophosphoryloxybenzene (DAPOB) is a chemical that can be used to measure the uptake of creatine kinase in human serum. It has been shown to form a complex with the enzyme, which is then transported into cells. The uptake of creatine kinase in the cells can be measured by measuring the amount of DAPOB that is released from the inside of the cells and into the surrounding medium. In order to use this technique, a collagen gel needs to be prepared and placed around the sample containing DAPOB. The kinetic properties of DAPOB are determined by observing how quickly it reacts with other chemicals in solution. DAPOB also forms intramolecular hydrogen bonds with itself, which may affect its ability to react with other compounds. X-ray crystal structures have revealed that DAPOB binds to protein synthesis enzymes such as polymerase chain reaction (PCR). These interactions are thought to be important for understanding how DAPOB affects protein</p>

<p>Versatile small molecule scaffold</p>

<p>N-Octylacetamide is an organic solvent that is used in the acetylation of fatty acids and amines. The extraction yield is increased by adding hydrochloric acid to the aqueous phase. It is also used as a cationic surfactant in coatings. N-Octylacetamide can be used for analytical methods, such as element analysis and vitro assays. This compound has been shown to react with technetium, forming a stable technetium-N-octylacetamide complex.</p>

<p>Methyl piperidine-4-carboxylate hydrochloride is a peptidomimetic drug that is designed to inhibit the δ-opioid receptor. It has been shown to have anticancer properties, including the ability to inhibit fibrinogen synthesis and suppress tumor growth. Methyl piperidine-4-carboxylate hydrochloride also has analgesic effects and may be used to treat chronic pain. This drug is an analog of the endogenous peptide dynorphin A (1–13) with a pharmacophore derived from the sequence of this endogenous peptide. Methyl piperidine-4-carboxylate hydrochloride has two tautomers, which are distinguished by the position of the hydrogen atom on carbon 4: as a protonated amine or as an unprotonated amine. The functionalities of these tautomers are different, and they are stereoisomers because they can rotate polarized light</p>

<p>2-Hydroxy-5-methyl-3-nitropyridine (HMPN) is a synthetic compound that is used as a reagent for the synthesis of other compounds. It has been shown to be reactive with molybdenum and chloride, boosting the reaction yield and reaction time. The functional theory of HMPN has been used to explain its reactivity with xylene. 2-Hydroxy-5-methyl-3-nitropyridine can be described as a compound that is capable of undergoing dehydration reactions, which are characterized by the removal of water molecules from the molecule to form a new product. This process can be achieved through the addition of phenylacetonitrile or azobenzene to HMPN.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methoxy-N-phenyl-benzamide is a biomolecule that belongs to the class of amides. It is synthesized from anilines and amines by coupling with diazo compounds. The reaction mechanism involves the formation of a carbon-nitrogen bond in an electrophilic aromatic substitution reaction. The Langmuir adsorption isotherm technique was used to study the adsorption of 4-methoxybenzamide on copper salt, which has been shown to have high adsorption capacity. This compound also has acidic properties, as it reacts with nitric acid to form a nitro group.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Quinoxalin-6-ol is an antibacterial agent that has shown to be effective against gram-negative bacteria such as Escherichia coli, Salmonella enteritidis, and Pseudomonas aeruginosa. It also has antifungal activity against Candida albicans and Saccharomyces cerevisiae. Quinoxalin-6-ol is a quinone that can be synthesized from crotonic acid or ethyl acetoacetate. This compound can be found in the form of two isomers (E and Z) which are distinguished by their physical properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-(4-Methoxyphenyl)benzenesulfonamide is a pyridinium salt that can be used as a heterogeneous catalyst. It is soluble in organic solvents, such as acetonitrile and amines, and forms micelles at higher concentrations. The pyridinium salt has been shown to be effective in the reduction of indian boronic acids by electrolysis and homogeneous catalysts. It can also be used for the synthesis of conjugates through the reaction with polyvinylpyrrolidone (PVP) or hydrotalcite (HT). This drug was encapsulated into nanoparticles for oral administration.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methoxy-2-phenylpropanoic acid is a fatty acid that is an immunoregulatory agent. It has been shown to have anti-inflammatory effects in animal models of inflammatory bowel disease and other inflammatory diseases. 2-Methoxy-2-phenylpropanoic acid also has cancer preventive properties, which are mediated through its ability to reduce the formation of amines and hydroxyl groups from amino acids. 2-Methoxy-2-phenylpropanoic acid is used as a pharmaceutical preparation because it is soluble in water, has a low viscosity, and does not react with proteins or other chemicals. This drug can be used as both a dietary supplement and as a pharmaceutical preparation for UV absorption.</p>

<p>Versatile small molecule scaffold</p>

4-Hydroxynaphthalene-1-carboxylic acid (4HNAC) is a naturally occurring compound, which has been isolated from the Streptomyces lividans. 4HNAC can be synthesized in the laboratory by reacting p-hydroxybenzoic acid with ammonia and sodium hydroxide. 4HNAC is an inhibitor of aerobic respiration, and it can be used as a preservative for food because it inhibits spoilage microorganisms such as fungi and yeast. 4HNAC also reacts with amines to form diazo compounds that are useful as dyestuffs or fungicides.

<p>3,4-Dimethyloxolane-2,5-dione is an organic compound with a molecular weight of 136.16 g/mol and a melting point of −36 °C. This compound has been used as a model for hydrogen bonds in urine samples to detect hiv infection. It is also reactive with hydrochloric acid and has been used for the treatment of inflammatory diseases. 3,4-Dimethyloxolane-2,5-dione has been shown to have anti-inflammatory properties and may be useful in the treatment of pain models. 3,4-Dimethyloxolane-2,5-dione has also been shown to inhibit the activity of diacylglycerol acyltransferase (DGAT) which is involved in lipid metabolism in hepatocytes cells.</p>

<p>Methyl 2-chloro-2-phenylacetate is a pyrimidine compound that has been shown to have anti-inflammatory effects. It inhibits the activity of histone deacetylase (HDAC) enzyme, which prevents the activation of inflammatory bowel disease. This drug also has an inhibitory effect on the synthesis of proinflammatory cytokines and chemokines, such as IL-1β and TNFα. Methyl 2-chloro-2-phenylacetate is an inhibitor of clopidogrel, which is used for the prevention of cardiovascular diseases. The molecule does not inhibit CYP450 enzymes in vitro, which means that it does not affect the metabolism of other drugs. Methyl 2-chloro-2-phenylacetate has been shown to be effective against autoimmune diseases such as multiple sclerosis and Crohn's disease.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Phenyloxazolidin-2-one is a biologically active compound that is activated by hydrochloride salts to form 4-phenyloxazolidin-2,4-dione. This compound can be used as a monosubstituted, enantiopure, or racemic mixture of the two stereoisomers. It is also available in an enantiopure form that has been synthesized through a triphosgene reaction. The vibrational, nmr spectra and functional groups are also studied to determine the chemical structure of this molecule.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>[4-(Dimethylamino)phenyl](phenyl)methanol is an aromatic compound that can be synthesized from benzotriazole and a grignard reagent. It has been used as a reagent in the synthesis of hydroxybenzaldehydes, pyridine, resorcinol, naphthol, or aryl groups. The condensation reaction between 4-dimethylaminophenyl methyl ether and phenylmagnesium bromide is catalyzed by pyridine and produces the desired product. This compound is also used in the synthesis of benzotriazolyl.</p>

<p>4-Isopropoxyphenol is a reactive molecule that can undergo nucleophilic attack. It is an intermediate in the reaction mechanism of phenolic antioxidants, such as salicylaldoxime and mequinol. 4-Isopropoxyphenol is synthesized by the condensation of anilines with phenols, followed by acid hydrolysis. The nature of 4-isopropoxyphenol is primarily nucleophilic, making it a potential candidate for optimization or predictive modelling.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-tert-Butylbenzoic acid is a heat-resistant organic compound that has been used in the production of polymers and plastics. 3-tert-Butylbenzoic acid can be used as a nucleation agent for crystallization, or as an enhancer for crystallization. In this application, 3-tert-butylbenzoic acid is used to increase the number of crystals formed and to make them larger. The processability of 3-tert-butylbenzoic acid is also enhanced with the addition of 3-tert-butylbenzoic acid. This substance can be measured by calorimetry, which measures the enthalpy change associated with its melting point. The melting point of 3-tert-butylbenzoic acid is between 100°C and 140°C.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methylaminobenzamide (2MAB) is a fluorescent compound that can be used to detect the presence of an anthranilic acid. 2MAB is prepared by reacting methylamine with benzoyl chloride and hydrochloric acid to form an amide in the tautomeric form. This compound has been shown to have neuroprotective properties and also inhibits the metabolic pathway of aromatic amino acids, which may play a role in Alzheimer's disease. 2MAB is also used in the preparation of other fluorescent compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>9H-Fluorene-2-carboxylic acid is a fluorescent chemical that has been modified to include fluorine atoms. Fluorescence is a property of 9H-fluorene-2-carboxylic acid that can be used to track its distribution in the body. This modification also reduces the affinity for the D4 receptor, which may lead to side effects such as mitogenesis, and it does not have any effect on dopamine D3 receptors. The synthesis of this compound is possible through a reaction with an olefinic compound in nonpolar solvents or solvents. The linker between the fluorene moiety and the carboxylic acid group may be important for determining its biological activity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Oxo-1,2-dihydroisoquinoline-3-carboxylic acid (ODHC) is a synthetic compound that has been shown to have anti-tumor activity in mouse melanoma cells. ODHC inhibits the production of aldehydes through the interaction with thiourea and homophthalic acid. ODHC also binds to topoisomerase II, which prevents the unwinding of DNA and limits DNA replication. This leads to cell death by inhibition of DNA synthesis. ODHC has been shown to be photostable and has a low toxicity for healthy cells. It is also able to chelate metal ions, such as iron, copper, or zinc, which are important for cancer cell growth and proliferation.</p>

<p>4-Phenyl-1H-pyrazole-3-carboxylic acid is a chiral, alkoxycarbonyl, regulator that has been used agriculturally as a growth regulator and weed control. It can be used in the form of an alkyl ester or carbonic ester. It has been shown to have active oxygen and hydrochloric acid which are responsible for its regulatory properties. 4-Phenyl-1H-pyrazole-3-carboxylic acid has been shown to be effective against weeds like Triazole resistant weeds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,6-Dimethyl-1,4-dihydropyridin-4-one is an organic acid that is used as a surface active agent. It has been shown to have coccidiosis in poultry and can be recycled from reaction solutions. 2,6-Dimethyl-1,4-dihydropyridin-4-one reacts with hydrochloric acid to form salicylic acid and hydrogen chloride gas. Impurities are removed by ion exchange or activated charcoal. Chlorine gas is added to neutralize the solution of 2,6-dimethylpyridine 4-one and convert it into salicylic acid. Finally, the solution is chlorinated to remove any remaining impurities. The organic solvent is then evaporated off and 2,6-dimethylpyridine 4 one crystals are left behind.</p>

<p>1,2,5-Trimethylpiperidin-4-one is an active substance that belongs to the class of benzofuran derivatives. It has been shown to be a potent inhibitor of the enzyme oxalate oxidase and has been used in the synthesis of analogs. The tautomeric form of 1,2,5-trimethylpiperidin-4-one is its enol form with an oxime group on the alpha carbon atom. This molecule can react with ethyl bromoacetate in a condensation reaction to produce an amide derivative.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(Methylsulfanyl)butanoic acid is an organic solvent that is used in the production of butyric acid and butyronitrile. It is also a reaction product of inorganic acids, such as sulfuric acid, hydrogen sulfate, and nitric acid. 4-(Methylsulfanyl)butanoic acid has a crystalline structure and optical properties that are similar to those of acetic acid. This compound is expressed in plasmids and can be used as an amide or metal chelate. The enzymatic methods of 4-(methylsulfanyl)butanoic acid are supplementing with hydrogen sulfate or recycled by adding an acid catalyst.</p>

<p>Versatile small molecule scaffold</p>

<p>3,5-Dichloro-4-methoxyaniline is a chemical compound that belongs to the group of medicinal compounds. It is used as an intermediate in organic synthesis and has been found to inhibit the growth of cancer cells. This molecule can be prepared by reacting 3,5-dichloroaniline with methoxyacetone in the presence of hydrochloric acid. The chemical shifts observed for this compound's proton resonances are consistent with its structure as a geometric isomer. This molecule has two chiral centers and eight possible stereoisomers. Tic10 (N-[3-(3,4-dichlorophenyl)propionyl]glycine) is one such stereoisomer that inhibits the growth of cancer cells through damage to protein structures. Tic10 has been shown to be more potent than bosutinib, an inhibitor of Bcr-Abl kinase, in inhibiting tumor growth in animal models.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-Chloro-2-oxo-1,2-dihydroquinoline-4-carboxylic acid (6ClOQ) is a molecule that is used as a diagnostic agent and biodegradable drug. It has high affinity binding with target tissues, such as the liver and kidney. 6ClOQ also has potential as an anticancer drug, which may be due to its ability to inhibit DNA synthesis by interacting with hydroxyl groups. 6ClOQ can be conjugated with different molecules, such as monoclonal antibodies, and this characteristic can be used to increase its efficacy in targeting cancer cells. The conjugation of 6ClOQ to a monoclonal antibody increases the stability of the drug and decreases its toxicity.</p>

<p>Versatile small molecule scaffold</p>