Acids and Synthetic Reagents

<p>Applications ethyl 3-aminobutanoate (cas# 5303-65-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A potent, selective and orally bioavailable Smoothened (SMO) antagonist; it inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO). Antineoplastic. Potent Hedgehog inhibitor.<br>References Berman, D., et al.: Science, 297, 1559 (2002), Varjosalo, M., et al.: Cell, 133, 537 (2008), Theunissen, J., et al.: Cancer Res., 69, 6007 (2009),<br></p>

<p>Applications 2,3-Diaminopyridine is used as a reagent in the synthesis of novel imidazopyridine derivatives which can exhibit cytotoxic activity against MCF-7 human breast adenocarcinoma cell line. 2,3-Diaminopyridine is also used in the preparation of non-camptothecin topoisomerase I inhibitors which exhibit antitumor activity.<br>References Puskullu, M.O., et al.: Chem. Heterocyc. Compd., 51, 723 (2015); Zhang, C., et al.: Bioorg. Med. Chem. Lett., 25, 4693 (2015)<br></p>

<p>Applications Lithium Trifluoromethylsulfonate has been shown to improve the cycling performance of lithium-oxygen batteries.<br>References Nasybulin, E., et. al.: J. Phys. Chem. C, 117, 2635 (2013)<br></p>

<p>Applications N-(4-Methoxybenzyl)-N-methylamine is used in the synthetic preparation of many types of compounds, including the synthesis of trifluoromethyl-sulfonimidamides from sulfinamides as well as the preparation of piperazinylquinazoline amine compounds as toll-like receptor 9 signaling antagonists for treatment of immune disorders.<br>References Richards-Taylor, C.S.; et al.: J. Org. Chem, 82, 9898 (2017); Talukdar, A.; et al.: PCT Int. Appl. 89pp. Patent 2017 CODEN:PIXXD2<br></p>

<p>Applications An intermediate in the production of Zolpidem metabolites<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klupsch, F., et al.: Chem. Pharm. Bull., 54, 1318 (2006), Epple, R., et al.: Bioorg. Med. Chem. Lett., 16, 5488 (2006),<br></p>

<p>Applications 5-Methylisoxazole-3-carboxylic Acid is a metabolite of UTL-5b, a structural analog of the anti-arthritic drug, Leflunomide (L322750).<br>References Shaw, J. et al.: Eur. J. Drug. Metab. Ph., 37, 83 (2012)<br></p>

<p>Applications Cediranib is a drug for blocking angiogenesis, study on cervical cancer molecular targeted drug and clinical application progress, value of correlative biomakers in the understanding of tumor biology.<br>References Shao, J., et al.: Shiyong Yixue Zazhi, 31, 4143 (2015); Gerstner, E. R., et al.: Transl. Cancer Res., 5, 211 (2016)<br></p>

<p>Stability Hygroscopic<br>Applications PHA-793887 is a potent CDK (cyclin-dependent kinase) inhibitor. Recent studies shows that PHA-793887 has promising therapeutic activity against acute leukemias in vitro and in vivo. PHA-793887 was used to successfully modulate E2F transcriptional factor-dependent cell cycle, DNA replication, mitosis and apoptosis related gene in both tumors and skin biopsy from patients with solid tumors.<br>References Alzani, R. et al.: Exp. Hematol., 38, 259 (2010); Locatelli, G. et al.: Mol. Cancer Ther., 9, 1265 (2010); Brasca, M. et al.: Bioorg. Med. Chem., 18, 1844 (2010);<br></p>

<p>Applications GBR 12935 dihydrochloride is a DAT and SLC6A2 inhibitor.<br></p>

<p>Applications Nickel(II) Bromide, is used as a source of bromide ion. It is also an important raw material used in various chemical synthesis and also as a catalyst in cross-coupling reactions.<br>References Pramanik, M. et al.: RSC Adv. 2015, 5 (53), 42762-42767.<br></p>

<p>Stability Air Sensitive (Oxidize)<br>Applications 3,3-Dimethylbutyraldehyde is an intermediate used to prepare spiro-oxindoles as potent, specific small-molecule Inhibitors of the MDM2-p53 Interaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ding, K., et al.: J. Med. Chem., 49, 3432 (2006); Yu, S., et al.: J. Med. Chem., 52, 7970 (2009)<br></p>

<p>Applications Sildenafil (S435000) derivative.<br></p>

<p>Applications A useful wittig reagent.<br></p>

<p>Applications Mdivi-1 is an inhibitor of mitochondrial division DRP1 and Dynamin I.<br></p>

<p>Stability Moisture Sensitive<br>Applications Fluorescein Isothiocyanate is a fluorescent reagent with incompletely defined position of the NCS. Fluorescein Isothiocyanate is used in multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance, fluorescence imaging. and drug delivery. Dyes and metabolites.<br>References Kim, J., et al.: Angew. Chem. Int. Ed., 47, 8438 (2008);<br></p>

<p>Applications Benzenesulfonyl Chloride is used in the synthesis of cecloprotoberberine derivatives as antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, Y. et al.: Eur. J. Med. Chem., 68, 463 (2013);<br></p>

<p>Applications 2-Bromobenzyl Alcohol acts as a reagent for the synthesis of alkoxy tetrasubstituted chiral amino acids via three-component reaction of (diazo)oxindoles, alcohols and benzhydrylimino ester involving enantioselective trapping of oxonium ylides by benzhydrylimino ester. Also acts as a reagent for the preparation of orally active and liver-targeted prodrug of 5-fluoro-2'-deoxyuridine for treatment of hepatocellular carcinoma.<br>References Jia, S., et al.: Chin. Chem. Lett., PagesAhead of Print (2016); Peng, Y., et al.: J. Med. Chem., 59, 3661 (2016)<br></p>

<p>Applications rac 2-Lauroyl-3-chloropropanediol-d5 (cas# 1330055-73-6) is a compound useful in organic synthesis.<br></p>

<p>Applications NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors<br>References Arris, C.E., et. al.: J. Med. Che., 43, 2797 (2000); Peasland, A., et. al.: Brit. J. Cancer, 105, 372 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications Vasodilator (cerebral and peripheral). Neuroprotective agent.<br>References Carron, C., et al.: Arzneim.-Forsch., 21, 1992 (1971),<br></p>

<p>Stability Air and Moisture Sensitive<br>Applications Diethyl Chlorophosphite is used in the synthesis of organophosphates and are considered anticholinesterase agents through observation in studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Segall, Y. et al.: Chem. Res. Toxicol., 16, 350 (2003);<br></p>

<p>Applications tert-Butyl 2-(diethylphosphono)acetate is a chemical reagent used in the synthesis of pharmaceuticals such as Clopidogrel (C587250), s prodrug anticoagulant.<br>References Shaw, S. et al.: J. Org. Chem., 80, 7019 (2015);<br></p>

<p>Impurity Atomoxetine EP Impurity D<br>Applications m-Methyl Atomoxetine Hydrochloride (Atomoxetine EP Impurity D) is an impurity of Atomoxetine (A791400), a norepinephrine reuptake inhibitor.<br>References Farid, N.A., et al.: J. Clin. Pharmacol., 25, 296 (1985), Gehlert, D.R., et al.: J. Neurochem., 64, 2792 (1995), Hwamg. et al.: Neurosci. Lett., 265, 151 (1999), Ring, B.J., et al.: Drug Metab. Dispos., 30, 319 (2002),<br></p>

<p>Applications Diethyl L-(+)-Tartrate is used as a chiral reagent in a host of chemical reactions, such as the synthesis of isoquinoline alkaloids and arundic acid, which has been used in acute ischemic stroke therapy.<br>References Ziolkowski, M. et al.: Tetrahedron Lett., 41, 1963 (2000); Fernandes, R. et al.: Tetrahedron Lett. 50, 5903 (2009);<br></p>

<p>Applications A metabolite of Cilostazol (C441500), used as internal standard.<br>References Akiyama, H., et al.: Arzneim.-Forsch./Drug Res., 35, 1133 (1985), Akiyama, H., et al.: J. Chromatogr., 338, 456 (1985),<br></p>

<p>Applications Lithium Chloride is primarily used in the synthesis of lithium metal by electrolysis. Also acts as a prescribed drug for bipolar mood disorder, it may also exhibit anti-inflammatory properties. Anti-cancer agent.<br>References Tsao, N. et al.: Antimicrob. Agents Chemother., 59, 1525 (2015); Cockle, J. et al.: 112, 693 (2015);<br></p>

<p>Applications (R)-tert-Butyl 2-hydroxypropanoate is an intermediate used in the stereo controlled synthesis of hydroxy carboxylic acids from L-amino acids.<br>References Kunz, H., et al.: Tetrahedron Lett., 28, 1873 (1987)<br></p>

<p>Applications Yoda 1 is a piezo1 channel activator, sensitizes piezo1 to activation by pressure and slows the inactivation phase of transient currents in human embryonic kidney (HEK) cells.<br></p>

<p>Applications Mirin is an MRN-ATM pathway inhibitor blocking 3’ and 5’ exonuclease activity associated with Mre11, inducing G2 cell cycle arrest.<br>References Shibata, A. et al.: Mol Cell., 53, 7 (2014);<br></p>

<p>Applications A reactant used in the preparation of Duloxetine (D721000) metabolites.<br>References Kuo, F. et al.: Bioorg. Med. Chem. Lett., 14, 5233 (2004)<br></p>

<p>Applications Diethylenetriamine-pentaacetic acid calcium trisodium salt<br></p>

<p>Stability Very Hygroscopic<br>Applications Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3).<br>References (1) Klamer, D., et al.: Eur. J. Pharmacol. (2004) 503: 103-107(2) Marletta, M.A.: J. Med. Chem., 37(13), 1899 (1994)(3) Zhang, H.Q., et al.: J. Med. Chem., 40, 3869 (1997)<br></p>

<p>Applications: Trimethoxy(2-phenylethyl)silane is used in the loading and releasing of two anti-cancer drugs, 9-Aminoacridine (9AA) and Camptothecin (CPT) from magnetic mesoporous silica nanoparticle materials.<br>References Knezevic, N. Z., et al.: ChemPlusChem, 77, 48-55 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Ytterbium(III) Trifluoromethanesulfonate functions as a catalyst in the organic synthesis of heterocycles. Also functions as a Lewis acid in variety of organic reactions.<br>References Sakhuja, R., et al.: Synthesis, 48, 4305 92016); Molander, G. A., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis, 1 (2004)<br></p>

<p>Applications Diphenyl Diselenide is an organoselenium compound with pharmacological properties, including antioxidant, glutathione peroxidase-mimetic, and neuroprotective effects. Studies show that Diphenyl Diselenide has demonstrated anxiolytic effects in rodents and can inhibit biofilm formation by Candida albicans, increasing both ROS production and membrane permeability.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hassan, W., et al.: Eur. J. Pharmacol., 761, 341 (2015); Rosseti, I.B., et al.: J. Trace Elem. Med. Bio., 29, 289 (2015); Ibrahim, M., et al.: Prog. Neuro-Psychoph., 54, 187 (2014)<br></p>

<p>Applications Tin(II) Oxalate is used in stannous oral care compositions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Surerus, K., et al.: Biochemistry, 1994, 33, 4980 (1994),<br></p>

<p>Applications 2,2,2-Triphenylacetophenone is an endocrine disrupter that is medicated through estrogen receptors.<br>References Roncaglioni, A., et al.: SAR. QSAR. Environ. Res., 19, 697 (2008); Kuzmanich, G., et al.: Photochem. Photobiol., 10, 1731 (2011);<br></p>

<p>Applications (R)-1,2-Propylene Carbonate (cas# 16606-55-6) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)-5,6-Dehydro Pregabalin is derived from rac 5,6-Dehydro Pregabalin (D230055), which is an impurity of the anti-convulsant, Pregabalin (P704800).<br>References Dousa, M, et al.: J. Pharmac. Biomed. Anal., 53, 717 (2010);<br></p>

<p>Stability No Data available<br>Applications An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. GW 501516 has been found to enhance endurance in mice without any training.<br>References Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001), Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2003), Wang, Y.X., et al.: Cell, 113, 159 (2003); Chem. and Eng. News, p. 9, May 8, 2017<br></p>

<p>Applications Used in the preparation of benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia.<br>References Chang, A., et al.: Diabetes, 32, 830 (1983), Goldstein, B. et al.: Cell Biochem., 48, 33 (1992), Sredy, J., et al.: Metabolism, 44, 1074 (1995),<br></p>

<p>Applications 2-Amino-5-methylphenyboronic acid, pinacol ester<br></p>

<p>Applications α-Phenyllongifolol is an impurity in the synthesis of Longifolene (L469455) which is a constituent of black cumin seed and may exhibit anticancer and antibacterial activities.<br>References Hajhashemi, V., et al.: Phytother. Res 18, 195 (2004); Bourgou, S., et al.: S Afr J Bot 76, 210 (2010)<br></p>

<p>Applications A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral). PDE inhibitor (non-selective).<br>References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983), Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986), Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988),<br></p>

<p>Applications (S)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane is often used in biosynthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Spelberg, J.H., Tetrahedron, Asy., 10, 2863 (1999);<br></p>

<p>Applications Galeterone is an androgen receptor antagonist and CYP17A1 enzyme inhibitor.<br>References Soifer, H.S., et al.: J. Biol. Chem., 287, 3777 (2012); Vasaitis, T., et al.: Molec. Cancer. Therap., 7, 2348 (2008);<br></p>

<p>Applications 3-Cyanobenzoic Acid, is a building block used for the synthesis of a variety of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids, that can be used for the synthesis of a metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.<br>References Ramu, T., et al.: Chem. Lett., 42, 722 (2013);<br></p>

<p>Applications Arimoclomol is a orally administered drug used to treat amyotrophic lateral sclerosis and was later discovered to be a potential insulin resistance treatment and diabetic complications.<br>References Kurthy, M., et al.: New. York. Acad. Sci., 967, 482 (2002); Kalmar, B., et al.: Exp. Neurol., 184, 636 (2003);<br></p>

<p>Applications 1-​Bromononane is a useful synthetic intermediate. It is used in the synthesis of cyclooxygenase-2 (COX-2), a new class of selective COX-2 inactivators. It is also used to prepare alkylimidazoles by N-alkylation of imidazoles as antibacterial agents.<br>References Kalgutkar, A., et al.: J. Med. Chem., 41, 4800 (1998); Khabnadideh, S., et al.: Bioorg. Med. Chem. Lett., 13, 2863 (2003)<br></p>

<p>Applications Bismuth Subnitrate is a compound used in the synthesis of anti-inflammatory and anti-microbial pharmaceuticals for use in mammals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parker, K.. et al.: J. Dairy, Sci., 91, 169 (2008); Lougheed, K. et al.: Tuberculo., 89, 364 (2009);<br></p>

<p>Applications Main metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Harvilchuck, J., et al.: Toxicol. Lett., 183, 28 (2008), Harvilchuck, J., et al.: Toxicol., 264, 171 (2009), Woo, J., et al.: App. Microbiol., Biotechnol., 82, 873 (2009),<br></p>

<p>Applications Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.<br>References Fagervall, I. et al.: Biochem. Pharmacol., 35, 1381 (1986); Horita, A.: Princ. Psychopharmacol., 279 (1970); O'Donnell, J.M. et al.: Psychopharmacology, 78, 214 (1982);<br></p>

<p>Stability Unstable in Solution, Moisture Sensitive, Hygroscopic<br>Applications (S)-(+)-2-Amino-4-bromobutyric Acid Hydrobromide is a building block used in stereoselective preparation of phosphinic acid phosphapeptide analogs of glutamyl-γ-glutamate as potent inhibitors of folylpolyglutamate synthetase. Also used in the synthesis of isoindoline carbamate and acylsulfonamide containing macrocyclic peptidomimetics as inhibitors of HCV NS3/4A protease.<br>References Bartley, D., et al.: J. Org. Chem., 70, 6757 (2005); Jiang, Y., et al.: J. Med. Chem., 57, 1753 (2014);<br></p>

<p>Applications 5-Amino-2-methylene-1,3,3-trimethylindoline (cas# 6872-05-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Bromobutyric Acid is used in the preparation of analgesic and anti-inflammatory agents as nitroalkyl ethers. It is also used in the synthesis of Autotaxin (ENPP2) inhibitors, used in tissue fibrosis regulation, cancer cell invasion and metastasis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anzini, M. et al.: J. Med. Chem., 56, 4821 (2013); Kawaguchi, M. et al.: ACS Chem. Biol. et al.: 8, 1713 (2013);<br></p>

<p>Applications Darodipine, is a calcium channel antagonist.<br>References Matucci, R., et al.: British J. Pharmacol., 122, 1353 (1997);<br></p>

<p>Applications Silver Acetate is used as a reagent in chemical synthesis in reaction such as carbonylation of primary and secondary amines as well as in woodward cis-hydroxylation converting alkenes into cis-diols. Also used in gum, lonzenges and sprays that are targeted to assist people in quitting the habit of smoking since it produces a bad taste when combined with cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wright, L., et al.: J. Phys. Chem., 59, 1060 (1955); Woodward, R., et al.: J. Am. Chem. Soc., 80, 209 (1958); Lancaster, T., et al.: Cochrane DB Syst. Rev., 2, 191 (2000);<br></p>